SG11201506397QA - Respirable agglomerates of porous carrier particles and micronized drug - Google Patents
Respirable agglomerates of porous carrier particles and micronized drugInfo
- Publication number
- SG11201506397QA SG11201506397QA SG11201506397QA SG11201506397QA SG11201506397QA SG 11201506397Q A SG11201506397Q A SG 11201506397QA SG 11201506397Q A SG11201506397Q A SG 11201506397QA SG 11201506397Q A SG11201506397Q A SG 11201506397QA SG 11201506397Q A SG11201506397Q A SG 11201506397QA
- Authority
- SG
- Singapore
- Prior art keywords
- carrier particles
- porous carrier
- micronized drug
- respirable agglomerates
- respirable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784842P | 2013-03-14 | 2013-03-14 | |
| PCT/IB2014/059739 WO2014141135A1 (en) | 2013-03-14 | 2014-03-13 | Respirable agglomerates of porous carrier particles and micronized drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201506397QA true SG11201506397QA (en) | 2015-09-29 |
Family
ID=50478894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201506397QA SG11201506397QA (en) | 2013-03-14 | 2014-03-13 | Respirable agglomerates of porous carrier particles and micronized drug |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9452139B2 (en) |
| EP (1) | EP2968570A1 (en) |
| JP (1) | JP6374414B2 (en) |
| KR (1) | KR20150129716A (en) |
| CN (1) | CN105188757B (en) |
| AU (2) | AU2014229265A1 (en) |
| BR (1) | BR112015021814A2 (en) |
| CA (1) | CA2905615A1 (en) |
| CL (1) | CL2015002632A1 (en) |
| EA (1) | EA201591729A1 (en) |
| GT (1) | GT201500295A (en) |
| HK (1) | HK1212616A1 (en) |
| IL (1) | IL240963A (en) |
| MA (1) | MA38397A1 (en) |
| MX (1) | MX2015012814A (en) |
| PE (1) | PE20151655A1 (en) |
| PH (1) | PH12015501882A1 (en) |
| SA (1) | SA515361055B1 (en) |
| SG (1) | SG11201506397QA (en) |
| TN (1) | TN2015000395A1 (en) |
| WO (1) | WO2014141135A1 (en) |
| ZA (1) | ZA201505768B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3219705T3 (en) | 2005-12-28 | 2020-04-14 | Vertex Pharma | PHARMACEUTICAL COMPOSITIONS OF THE AMORPHIC FORM OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMIDE |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| TWI433674B (en) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | Cyclopamine analogs |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| ES2858351T3 (en) | 2010-04-22 | 2021-09-30 | Vertex Pharma | Intermediate compound for the production process of cycloalkylcaraboxamido-indole compounds |
| US9682038B2 (en) * | 2013-01-31 | 2017-06-20 | Prosonix Limited | Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy |
| US9452139B2 (en) * | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
| CN106102724A (en) * | 2014-03-27 | 2016-11-09 | 诺华股份有限公司 | For sucking the spray-dried oil-in-water bag solids dispersion of active pharmaceutical ingredient |
| RU2744460C2 (en) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Pharmaceutical compositions for treating diseases mediated by cystic fibrosis transmembrane conductance regulator |
| JP6746569B2 (en) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| WO2016142708A2 (en) * | 2015-03-10 | 2016-09-15 | Cipla Limited | Pharmaceutical composition |
| US10423736B2 (en) * | 2015-08-28 | 2019-09-24 | University Of British Columbia | Methods and systems for simulating hydrodynamics in gas-solid fluidized beds |
| EP3335699A1 (en) | 2016-12-15 | 2018-06-20 | H e x a l Aktiengesellschaft | Selexipag formulation in liquisolid system |
| CN106943350A (en) * | 2017-03-14 | 2017-07-14 | 上海现代药物制剂工程研究中心有限公司 | Aerosol and preparation method containing muscarinic receptor antagonist and β 2 receptor agonist |
| WO2019060595A1 (en) * | 2017-09-20 | 2019-03-28 | Teva Branded Pharmaceutical Products R&D, Inc. | Dry powder inhalable medicament comprising glycopyrronium |
| US20200324064A1 (en) * | 2019-04-10 | 2020-10-15 | Cai Gu Huang | Inhalation Device for Administering Powdered Pharmaceutical Composition |
| US20200375945A1 (en) * | 2019-06-03 | 2020-12-03 | Cai Gu Huang | Inhalable formulation of a solution containing indacaterol maleate and glycopyrronium bromide |
| CN112137957B (en) * | 2019-06-26 | 2022-07-29 | 长风药业股份有限公司 | Medicinal inhalation aerosol and preparation method thereof |
| JP2022544398A (en) * | 2019-08-15 | 2022-10-18 | アボット・ラボラトリーズ | Nutrient powder manufacturing process and powder composition using micronization |
| CA3175211A1 (en) * | 2020-04-13 | 2021-10-21 | Matthias Emanuel LIECHTI | Lsd dose identification |
| CN114344285B (en) * | 2020-10-14 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | Improved inhalable agglomerates |
| TW202237102A (en) * | 2020-12-11 | 2022-10-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | Pharmaceutical compositions for pulmonary delivery |
| CN113318097A (en) * | 2021-04-29 | 2021-08-31 | 珠海瑞思普利医药科技有限公司 | Powder inhalation for resisting idiopathic pulmonary fibrosis and preparation method thereof |
| CN117357485B (en) * | 2023-11-01 | 2024-09-24 | 山东京卫制药有限公司 | Improved inhalable carrier particles and use thereof |
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| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
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| AU2009246217B2 (en) | 2008-05-15 | 2013-01-10 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
| WO2010115937A1 (en) | 2009-04-09 | 2010-10-14 | Novartis Ag | Process for preparing pyrrolidinium salts |
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| JOP20120023B1 (en) * | 2011-02-04 | 2022-03-14 | Novartis Ag | Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases |
| US9452139B2 (en) * | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
-
2014
- 2014-03-10 US US14/202,262 patent/US9452139B2/en active Active
- 2014-03-13 AU AU2014229265A patent/AU2014229265A1/en not_active Abandoned
- 2014-03-13 KR KR1020157024586A patent/KR20150129716A/en not_active Application Discontinuation
- 2014-03-13 PE PE2015001910A patent/PE20151655A1/en not_active Application Discontinuation
- 2014-03-13 CA CA2905615A patent/CA2905615A1/en not_active Abandoned
- 2014-03-13 SG SG11201506397QA patent/SG11201506397QA/en unknown
- 2014-03-13 CN CN201480015125.XA patent/CN105188757B/en active Active
- 2014-03-13 WO PCT/IB2014/059739 patent/WO2014141135A1/en active Application Filing
- 2014-03-13 EP EP14716933.8A patent/EP2968570A1/en not_active Withdrawn
- 2014-03-13 EA EA201591729A patent/EA201591729A1/en unknown
- 2014-03-13 MX MX2015012814A patent/MX2015012814A/en unknown
- 2014-03-13 MA MA38397A patent/MA38397A1/en unknown
- 2014-03-13 BR BR112015021814A patent/BR112015021814A2/en active Search and Examination
- 2014-03-13 JP JP2015562509A patent/JP6374414B2/en active Active
-
2015
- 2015-08-11 ZA ZA2015/05768A patent/ZA201505768B/en unknown
- 2015-08-26 PH PH12015501882A patent/PH12015501882A1/en unknown
- 2015-08-31 IL IL240963A patent/IL240963A/en active IP Right Grant
- 2015-09-04 TN TN2015000395A patent/TN2015000395A1/en unknown
- 2015-09-11 CL CL2015002632A patent/CL2015002632A1/en unknown
- 2015-09-13 SA SA515361055A patent/SA515361055B1/en unknown
- 2015-09-14 GT GT201500295A patent/GT201500295A/en unknown
-
2016
- 2016-01-20 HK HK16100598.8A patent/HK1212616A1/en unknown
- 2016-08-17 US US15/238,842 patent/US9744178B2/en active Active
-
2017
- 2017-05-16 AU AU2017203258A patent/AU2017203258B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9452139B2 (en) | 2016-09-27 |
| EP2968570A1 (en) | 2016-01-20 |
| AU2017203258A1 (en) | 2017-06-08 |
| TN2015000395A1 (en) | 2017-01-03 |
| WO2014141135A1 (en) | 2014-09-18 |
| GT201500295A (en) | 2017-09-28 |
| JP2016512494A (en) | 2016-04-28 |
| KR20150129716A (en) | 2015-11-20 |
| MA38397A1 (en) | 2018-01-31 |
| BR112015021814A2 (en) | 2017-07-18 |
| HK1212616A1 (en) | 2016-06-17 |
| CL2015002632A1 (en) | 2016-03-28 |
| US20140302147A1 (en) | 2014-10-09 |
| MX2015012814A (en) | 2016-02-03 |
| US9744178B2 (en) | 2017-08-29 |
| CN105188757B (en) | 2019-04-30 |
| PE20151655A1 (en) | 2015-11-26 |
| AU2017203258B2 (en) | 2019-06-20 |
| PH12015501882A1 (en) | 2015-12-07 |
| CN105188757A (en) | 2015-12-23 |
| IL240963A0 (en) | 2015-11-30 |
| US20160354388A1 (en) | 2016-12-08 |
| IL240963A (en) | 2017-05-29 |
| ZA201505768B (en) | 2017-03-29 |
| AU2014229265A1 (en) | 2015-09-03 |
| EA201591729A1 (en) | 2016-05-31 |
| CA2905615A1 (en) | 2014-09-18 |
| SA515361055B1 (en) | 2016-11-13 |
| JP6374414B2 (en) | 2018-08-15 |
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