CY1124635T1 - Ξηρες φαρμακευτικες συνθεσεις που περιεχουν νανοσωματιδια ενεργου παραγοντα δεσμευμενα σε σωματιδια φορεα - Google Patents

Ξηρες φαρμακευτικες συνθεσεις που περιεχουν νανοσωματιδια ενεργου παραγοντα δεσμευμενα σε σωματιδια φορεα

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Publication number
CY1124635T1
CY1124635T1 CY20201100589T CY201100589T CY1124635T1 CY 1124635 T1 CY1124635 T1 CY 1124635T1 CY 20201100589 T CY20201100589 T CY 20201100589T CY 201100589 T CY201100589 T CY 201100589T CY 1124635 T1 CY1124635 T1 CY 1124635T1
Authority
CY
Cyprus
Prior art keywords
active agent
pharmaceutical compositions
spray
particle size
particles
Prior art date
Application number
CY20201100589T
Other languages
English (en)
Inventor
Maynard Emanuel Lichty
Garry T. Gwozdz
Original Assignee
Besins Healthcare Luxembourg Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Besins Healthcare Luxembourg Sarl filed Critical Besins Healthcare Luxembourg Sarl
Publication of CY1124635T1 publication Critical patent/CY1124635T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχονται στο παρόν ξηρές φαρμακευτικές συνθέσεις κατάλληλες για διαβλεννογονική παράδοση, που περιέχουν ξηρά σωματίδια, όπως ξηρανθέντα με ψεκασμό σωματίδια, που περιλαμβάνουν νανοσωματίδια φαρμακευτικώς δραστικού παράγοντα, συνδετικό υλικό και φαρμακευτικώς αποδεκτό φορέα, όπου τα νανοσωματίδια δραστικού παράγοντα έχουν διάμετρο μέσου μεγέθους σωματιδίων πριν την επεξεργασία μικρότερη από περίπου 1 μm, και όπου ως και 10% των ξηρανθέντων με ψεκασμό σωματιδίων έχουν μέγεθος σωματιδίων μικρότερο από 10 μm• τουλάχιστον το 50% των ξηρανθέντων με ψεκασμό σωματιδίων έχουν μέγεθος σωματιδίου τουλάχιστον περίπου 15 μm• και τουλάχιστον το 90% των ξηρανθέντων με ψεκασμό σωματιδίων έχουν μέγεθος σωματιδίων ως περίπου 55 μm. Παρέχονται επίσης μέθοδοι για την παρασκευή τέτοιων φαρμακευτικών συνθέσεων και θεραπευτικών μεθόδων που περιλαμβάνουν διαβλεννογονική χορήγηση των συνθέσεων, όπως ενδορινικά ή ενδοκολπικά, ή με άλλες οδούς χορήγησης.
CY20201100589T 2013-03-04 2020-06-25 Ξηρες φαρμακευτικες συνθεσεις που περιεχουν νανοσωματιδια ενεργου παραγοντα δεσμευμενα σε σωματιδια φορεα CY1124635T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361772095P 2013-03-04 2013-03-04
PCT/US2014/019833 WO2014137877A1 (en) 2013-03-04 2014-03-03 Dry pharmaceutical compositions comprising active agent nanoparticles bound to carrier particles

Publications (1)

Publication Number Publication Date
CY1124635T1 true CY1124635T1 (el) 2022-03-24

Family

ID=47901822

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100589T CY1124635T1 (el) 2013-03-04 2020-06-25 Ξηρες φαρμακευτικες συνθεσεις που περιεχουν νανοσωματιδια ενεργου παραγοντα δεσμευμενα σε σωματιδια φορεα

Country Status (23)

Country Link
US (2) US10695295B2 (el)
EP (1) EP2964199B1 (el)
JP (1) JP6564708B2 (el)
CN (1) CN105307639B (el)
AU (1) AU2014226192B2 (el)
BR (1) BR112015021525B1 (el)
CA (1) CA2901015A1 (el)
CY (1) CY1124635T1 (el)
DK (1) DK2964199T3 (el)
ES (1) ES2804702T3 (el)
HR (1) HRP20201103T1 (el)
HU (1) HUE050050T2 (el)
IL (1) IL240867B (el)
LT (1) LT2964199T (el)
MX (1) MX375187B (el)
PL (1) PL2964199T3 (el)
PT (1) PT2964199T (el)
RS (1) RS60481B1 (el)
RU (1) RU2715714C2 (el)
SI (1) SI2964199T1 (el)
SM (1) SMT202000349T1 (el)
WO (1) WO2014137877A1 (el)
ZA (1) ZA201505852B (el)

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MX2023015529A (es) * 2021-06-25 2024-03-05 Nicoventures Trading Ltd Productos orales y metodo de fabricacion.

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Also Published As

Publication number Publication date
SI2964199T1 (sl) 2020-10-30
JP2016510742A (ja) 2016-04-11
CN105307639B (zh) 2020-06-30
HUE050050T2 (hu) 2020-11-30
WO2014137877A1 (en) 2014-09-12
PL2964199T3 (pl) 2021-01-25
RU2715714C2 (ru) 2020-03-03
BR112015021525B1 (pt) 2022-06-14
MX2015011624A (es) 2015-12-17
CA2901015A1 (en) 2014-09-12
US10695295B2 (en) 2020-06-30
US10918601B2 (en) 2021-02-16
IL240867B (en) 2020-11-30
CN105307639A (zh) 2016-02-03
AU2014226192A8 (en) 2016-04-21
RU2015141792A (ru) 2017-04-07
EP2964199B1 (en) 2020-04-22
AU2014226192A1 (en) 2015-09-03
LT2964199T (lt) 2020-08-10
EP2964199A1 (en) 2016-01-13
PT2964199T (pt) 2020-05-12
RS60481B1 (sr) 2020-08-31
JP6564708B2 (ja) 2019-08-21
ES2804702T3 (es) 2021-02-09
DK2964199T3 (da) 2020-06-15
US20200390706A1 (en) 2020-12-17
ZA201505852B (en) 2017-07-26
IL240867A0 (en) 2015-10-29
AU2014226192B2 (en) 2018-07-26
US20140248367A1 (en) 2014-09-04
BR112015021525A2 (pt) 2017-07-18
MX375187B (es) 2025-03-06
RU2015141792A3 (el) 2018-03-01
SMT202000349T1 (it) 2020-09-10
HRP20201103T1 (hr) 2021-02-05

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