HK1221418A1 - 釋放修飾藥物的水凝膠-連接的前藥 - Google Patents
釋放修飾藥物的水凝膠-連接的前藥Info
- Publication number
- HK1221418A1 HK1221418A1 HK16109655.9A HK16109655A HK1221418A1 HK 1221418 A1 HK1221418 A1 HK 1221418A1 HK 16109655 A HK16109655 A HK 16109655A HK 1221418 A1 HK1221418 A1 HK 1221418A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- linked prodrugs
- modified drugs
- hydrogel
- releasing modified
- hydrogel linked
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13164669 | 2013-04-22 | ||
| EP13187784 | 2013-10-08 | ||
| PCT/EP2014/057753 WO2014173759A1 (en) | 2013-04-22 | 2014-04-16 | Hydrogel-linked prodrugs releasing modified drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1221418A1 true HK1221418A1 (zh) | 2017-06-02 |
Family
ID=50513261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16109655.9A HK1221418A1 (zh) | 2013-04-22 | 2016-08-12 | 釋放修飾藥物的水凝膠-連接的前藥 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11116849B2 (zh) |
| EP (1) | EP2988783A1 (zh) |
| AU (1) | AU2014257745B2 (zh) |
| CA (1) | CA2907830C (zh) |
| HK (1) | HK1221418A1 (zh) |
| WO (1) | WO2014173759A1 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2964463C (en) | 2014-10-22 | 2024-02-13 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| CN115025239A (zh) | 2016-03-01 | 2022-09-09 | 阿森迪斯药物骨疾病股份有限公司 | Pth前药 |
| AU2017336251B2 (en) * | 2016-09-29 | 2024-02-22 | Ascendis Pharma Bone Diseases A/S | PTH compounds with low peak-to-trough ratios |
| AU2017336249B2 (en) * | 2016-09-29 | 2024-08-01 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release PTH compound |
| KR101884729B1 (ko) | 2016-11-21 | 2018-08-02 | 연성정밀화학(주) | 엘더칼시톨의 제조방법 및 그를 위한 중간체 |
| CA3055985A1 (en) * | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| KR101936375B1 (ko) | 2018-04-26 | 2019-01-08 | 연성정밀화학(주) | 엘더칼시톨의 제조방법 및 그를 위한 중간체 |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣３多肽之持續遞送 |
| US20220054478A1 (en) * | 2019-01-04 | 2022-02-24 | Ascendis Pharma Oncology Division A/S | Minimization of systemic inflammation |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| CN110051622B (zh) * | 2019-04-19 | 2022-05-27 | 北京红太阳药业有限公司 | 一种改进的长效头孢噻肟钠注射剂及其制备方法 |
| CN112168820B (zh) * | 2019-07-05 | 2023-09-29 | 中国科学院生物物理研究所 | SRCAP ATPase抑制剂在结直肠癌治疗中的应用 |
| CN112826791B (zh) * | 2021-01-13 | 2023-11-03 | 中国药科大学 | 一种光控水凝胶微针阵列贴片及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| WO2005099768A2 (en) | 2004-03-23 | 2005-10-27 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
| US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
| EP1625856A1 (en) * | 2004-08-13 | 2006-02-15 | Complex Biosystems GmbH | Hydrogel polymeric conjugates of a prodrug |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| ES2904673T3 (es) | 2008-02-01 | 2022-04-05 | Ascendis Pharma As | Profármaco que comprende un conjugado de fármaco-enlazador. |
| US9173953B2 (en) | 2009-07-31 | 2015-11-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
| WO2011012721A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Carrier linked pramipexole prodrugs |
| SG177761A1 (en) * | 2009-07-31 | 2012-03-29 | Ascendis Pharma As | Biodegradable polyethylene glycol based water-insoluble hydrogels |
| WO2011089216A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
| US9561285B2 (en) | 2010-01-22 | 2017-02-07 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
| WO2011089215A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
| EP2841109A1 (en) | 2012-04-25 | 2015-03-04 | Ascendis Pharma A/S | Prodrugs of hydroxyl-comprising drugs |
-
2014
- 2014-04-16 CA CA2907830A patent/CA2907830C/en active Active
- 2014-04-16 US US14/786,481 patent/US11116849B2/en active Active
- 2014-04-16 WO PCT/EP2014/057753 patent/WO2014173759A1/en active Application Filing
- 2014-04-16 EP EP14718081.4A patent/EP2988783A1/en active Pending
- 2014-04-16 AU AU2014257745A patent/AU2014257745B2/en active Active
-
2016
- 2016-08-12 HK HK16109655.9A patent/HK1221418A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014173759A1 (en) | 2014-10-30 |
| CA2907830C (en) | 2022-03-29 |
| AU2014257745B2 (en) | 2018-10-04 |
| EP2988783A1 (en) | 2016-03-02 |
| CA2907830A1 (en) | 2014-10-30 |
| US11116849B2 (en) | 2021-09-14 |
| US20160082123A1 (en) | 2016-03-24 |
| AU2014257745A1 (en) | 2015-10-15 |
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