EA201791537A1 - Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение - Google Patents

Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение

Info

Publication number
EA201791537A1
EA201791537A1 EA201791537A EA201791537A EA201791537A1 EA 201791537 A1 EA201791537 A1 EA 201791537A1 EA 201791537 A EA201791537 A EA 201791537A EA 201791537 A EA201791537 A EA 201791537A EA 201791537 A1 EA201791537 A1 EA 201791537A1
Authority
EA
Eurasian Patent Office
Prior art keywords
docetaxel
albumin
pharmaceutical composition
nanoparticles
preparation
Prior art date
Application number
EA201791537A
Other languages
English (en)
Other versions
EA036226B1 (ru
Inventor
Чжэнсин Су
Ликай Ян
Дун Чжао
Цзин ЧЖОУ
Фэнин Шань
Личунь Ван
Цзини Ван
Original Assignee
Сычуань Кэлунь Фармасьютикал Рисерч Инститьют Ко. Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сычуань Кэлунь Фармасьютикал Рисерч Инститьют Ко. Лтд. filed Critical Сычуань Кэлунь Фармасьютикал Рисерч Инститьют Ко. Лтд.
Publication of EA201791537A1 publication Critical patent/EA201791537A1/ru
Publication of EA036226B1 publication Critical patent/EA036226B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к фармацевтической композиции на основе наночастиц доцетаксела-альбумина, способу ее получения и ее применению для изготовления лекарственных средств для лечения рака. Фармацевтическая композиция содержит доцетаксел, альбумин и аминокислоту(ы), где массовое отношение альбумина к доцетакселу составляет не более чем 50, предпочтительно составляет от 20:1 до 1:1 и массовое отношение аминокислоты(аминокислот) к доцетакселу составляет не менее чем 0,5, предпочтительно составляет от 1:1 до 20:1.
EA201791537A 2015-04-03 2016-03-28 Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение EA036226B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510157393.1A CN106137969B (zh) 2015-04-03 2015-04-03 多西他赛白蛋白纳米粒药物组合物及其制备方法及应用
PCT/CN2016/077521 WO2016155595A1 (zh) 2015-04-03 2016-03-28 多西他赛白蛋白纳米粒药物组合物及其制备方法及应用

Publications (2)

Publication Number Publication Date
EA201791537A1 true EA201791537A1 (ru) 2018-01-31
EA036226B1 EA036226B1 (ru) 2020-10-15

Family

ID=57006481

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791537A EA036226B1 (ru) 2015-04-03 2016-03-28 Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение

Country Status (9)

Country Link
US (2) US10493054B2 (ru)
EP (1) EP3278799B1 (ru)
JP (1) JP6720450B2 (ru)
CN (3) CN106137969B (ru)
AU (1) AU2016240119B2 (ru)
CA (1) CA2975766C (ru)
EA (1) EA036226B1 (ru)
ES (1) ES2905425T3 (ru)
WO (1) WO2016155595A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109562073B (zh) 2016-09-29 2021-11-09 四川科伦药物研究院有限公司 白蛋白药物组合物及其制备方法
CN108254514A (zh) * 2016-12-28 2018-07-06 四川科伦药物研究院有限公司 一种测定脂肪乳类注射液过氧化值的方法
CN111936131B (zh) * 2018-04-11 2023-08-29 珠海贝海生物技术有限公司 多西他赛制剂和组合物
US11652060B2 (en) * 2018-12-28 2023-05-16 Intel Corporation Die interconnection scheme for providing a high yielding process for high performance microprocessors
WO2022184164A1 (zh) 2021-03-05 2022-09-09 石药集团中奇制药技术（石家庄）有限公司 一种稳定的多西他赛白蛋白纳米粒组合物
CN115400115A (zh) * 2021-05-26 2022-11-29 石药集团中奇制药技术（石家庄）有限公司 多西他赛白蛋白组合物和免疫检查点抑制剂的组合及用途
KR102526793B1 (ko) * 2021-11-03 2023-04-28 주식회사 에스엔바이오사이언스 입도분포 유지 안정성이 개선된 알부민 결합 탁산 나노입자 제조방법
CN116265015A (zh) * 2021-12-16 2023-06-20 石药集团中奇制药技术（石家庄）有限公司 多西他赛白蛋白组合物与vegf抑制剂或vegfr抑制剂的组合及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
CN101291659A (zh) * 2005-08-31 2008-10-22 阿布拉科斯生物科学有限公司 包含水难溶性药剂和抗微生物剂的组合物
NZ592132A (en) 2005-08-31 2012-12-21 Abraxis Bioscience Llc Composition comprising nanoparticles of docitaxel and a citrate
US20100166872A1 (en) 2005-10-21 2010-07-01 Amarjit Singh Novel improved compositions for cancer therapy
CN101361731A (zh) * 2008-08-11 2009-02-11 张文芳 白蛋白稳定的多西紫杉醇冻干制剂及其在治疗肿瘤方面的应用
CN101357126A (zh) * 2008-08-11 2009-02-04 张文芳 一种稳定的紫杉烷类白蛋白脂质载药系统及其制备方法
CN101658516B (zh) * 2008-08-26 2011-10-05 齐鲁制药有限公司 紫杉醇类药物组合物及其制备方法
WO2011017835A1 (en) 2009-08-11 2011-02-17 Nanjing University Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding
CN101773465B (zh) * 2010-01-19 2012-11-07 南京泛太化工医药研究所 以氨基酸为稳定剂的聚合物胶束载药系统
CN101972480B (zh) * 2010-01-19 2013-01-02 南京泛太化工医药研究所 以氨基酸为稳定剂的聚合物胶束载药系统
CN103202813B (zh) * 2010-08-09 2015-09-30 南京大学 一种制备用于体内递送药理活性物质的蛋白纳米粒的方法
CN103751107A (zh) * 2013-12-18 2014-04-30 清华大学深圳研究生院 含有多烯紫杉醇和维生素e tpgs的纳米颗粒及其制备方法

Also Published As

Publication number Publication date
JP6720450B2 (ja) 2020-07-08
WO2016155595A1 (zh) 2016-10-06
EP3278799A1 (en) 2018-02-07
CN106137969B (zh) 2020-05-15
US20180028486A1 (en) 2018-02-01
CN107405328A (zh) 2017-11-28
EP3278799A4 (en) 2018-12-05
ES2905425T3 (es) 2022-04-08
US11395812B2 (en) 2022-07-26
CA2975766C (en) 2023-12-19
AU2016240119A1 (en) 2017-08-24
CA2975766A1 (en) 2016-10-06
US20200038362A1 (en) 2020-02-06
US10493054B2 (en) 2019-12-03
CN106137969A (zh) 2016-11-23
CN113398075A (zh) 2021-09-17
EP3278799B1 (en) 2022-01-19
EA036226B1 (ru) 2020-10-15
JP2018513105A (ja) 2018-05-24
CN107405328B (zh) 2021-07-16
AU2016240119B2 (en) 2020-10-22

Similar Documents

Publication Publication Date Title
EA201791537A1 (ru) Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение
EA201990071A1 (ru) Композиция пептидной вакцины
EA201990043A1 (ru) Антибактериальные соединения
CL2019001066A1 (es) Sal de (s)-csa de s-ketamina, sal de (r)-csa de s-ketamina y procesos para la preparación de s-ketamina (divisional solicitud 201702854)
CY1119615T1 (el) Διπλα εκλεκτικοι αναστολεις ρι3 δελτα και γαμμα κινασης
EA201600204A1 (ru) Производные хиназолина, фармацевтическая композиция на их основе и их применение для профилактики или лечения опухоли
EA201690962A1 (ru) Составы
BR112014028841A2 (pt) processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida
BR112019007087A2 (pt) formulações de nanopartículas e métodos de fabricação e de utilização das mesmas
EA201890815A1 (ru) Аминокислотные композиции с модифицированным высвобождением для перорального введения
CY1119957T1 (el) Θεραπεια νοσηματων με τη χρηση ανοχογονου φαρμακευτικου παρασκευασματος
EA202090014A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201691918A1 (ru) Фармацевтические составы ингибитора киназ семейства raf, способы их получения и способы их применения
EA201692481A1 (ru) Комбинация, содержащая глюкокортикоид и edo-s101
MX2022002635A (es) Anticuerpos anti proteina similar a angiopoyetina 4 y metodos de uso.
EA202191478A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
WO2016020882A3 (en) Angiopoetin-like 4 (angptl4) antibodies and methods of use
EA202190588A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201790223A1 (ru) Водный препарат, содержащий парацетамол и ибупрофен
EA201791432A1 (ru) Композиции на основе пролекарства монометилфумарата
BR112017024714A2 (pt) métodos para preparação do fator de von willebrand modificado
EA202091112A1 (ru) Сокристаллы, фармацевтические композиции на их основе и способы лечения, предусматривающие их применение
EA202090164A1 (ru) Изотретиноиновые перорально-слизистые композиции и способы их применения
EA201792445A1 (ru) Новые амидогетероарилароилгидразидэтины
EA202191477A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина