BR112014028841A2 - processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida - Google Patents

processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida

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Publication number
BR112014028841A2
BR112014028841A2 BR112014028841A BR112014028841A BR112014028841A2 BR 112014028841 A2 BR112014028841 A2 BR 112014028841A2 BR 112014028841 A BR112014028841 A BR 112014028841A BR 112014028841 A BR112014028841 A BR 112014028841A BR 112014028841 A2 BR112014028841 A2 BR 112014028841A2
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BR
Brazil
Prior art keywords
indazol
ylamino
piperazin
benzamide
pyran
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BR112014028841A
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English (en)
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BR112014028841B1 (pt
Inventor
Alvaro Barbugian Natale
Orsini Paolo
Forino Romualdo
Fumagalli Tiziano
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Nerviano Medical Sciences Srl
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Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of BR112014028841A2 publication Critical patent/BR112014028841A2/pt
Publication of BR112014028841B1 publication Critical patent/BR112014028841B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo “processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida” a invenção refere-se a um processo para a preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida. novas formas sólidas deste composto, sua utilização no tratamento de doenças causadas pela atividade desregulada da proteína quinase e composições farmacêuticas que as contem são também objeto da presente invenção.
BR112014028841-0A 2012-05-23 2013-05-22 Formas cristalinas 1 e 2, composição farmacêutica, uso da forma cristalina 1 para o tratamento de um estado de doença tratável pela inibição de alk e processo para a preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metilpiperazin-1-il)-2-(tetra-hidro-piran-4-ilamino)- benzamida BR112014028841B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12169139 2012-05-23
EP12169139.8 2012-05-23
PCT/EP2013/060534 WO2013174876A1 (en) 2012-05-23 2013-05-22 Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide

Publications (2)

Publication Number Publication Date
BR112014028841A2 true BR112014028841A2 (pt) 2017-06-27
BR112014028841B1 BR112014028841B1 (pt) 2021-01-12

Family

ID=48470987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028841-0A BR112014028841B1 (pt) 2012-05-23 2013-05-22 Formas cristalinas 1 e 2, composição farmacêutica, uso da forma cristalina 1 para o tratamento de um estado de doença tratável pela inibição de alk e processo para a preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metilpiperazin-1-il)-2-(tetra-hidro-piran-4-ilamino)- benzamida

Country Status (18)

Country Link
US (3) US9085565B2 (pt)
EP (4) EP2855460B1 (pt)
JP (1) JP6231556B2 (pt)
KR (1) KR102151963B1 (pt)
CN (2) CN104395308B (pt)
AR (1) AR091138A1 (pt)
AU (2) AU2013265288B2 (pt)
BR (1) BR112014028841B1 (pt)
CA (1) CA2873979C (pt)
ES (2) ES2771100T3 (pt)
HK (1) HK1207077A1 (pt)
IL (2) IL235761B (pt)
MX (1) MX355409B (pt)
NZ (2) NZ703124A (pt)
PL (2) PL3333166T3 (pt)
RU (1) RU2602071C2 (pt)
TW (1) TWI579280B (pt)
WO (1) WO2013174876A1 (pt)

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CN104395308B (zh) 2016-08-24
AU2013265288A1 (en) 2015-01-22
ES2771100T3 (es) 2020-07-06
EP3333166B1 (en) 2019-11-06
NZ703124A (en) 2016-07-29
WO2013174876A1 (en) 2013-11-28
PL3290414T3 (pl) 2020-01-31
JP6231556B2 (ja) 2017-11-15
CA2873979C (en) 2019-11-12
BR112014028841B1 (pt) 2021-01-12
HK1207077A1 (en) 2016-01-22
EP2855460B1 (en) 2017-11-08
ES2751944T3 (es) 2020-04-02
US9649306B2 (en) 2017-05-16
MX2014013924A (es) 2015-02-17
EP2855460A1 (en) 2015-04-08
JP2015517551A (ja) 2015-06-22
RU2602071C2 (ru) 2016-11-10
CN106167485A (zh) 2016-11-30
IL235761B (en) 2018-07-31
US20150274707A1 (en) 2015-10-01
TW201400479A (zh) 2014-01-01
AU2018201037A1 (en) 2018-03-01
EP3333166A1 (en) 2018-06-13
AU2013265288A2 (en) 2015-01-29
US20150051222A1 (en) 2015-02-19
IL235761A0 (en) 2015-02-01
AR091138A1 (es) 2015-01-14
US9085565B2 (en) 2015-07-21
KR20150016352A (ko) 2015-02-11
EP3290414A1 (en) 2018-03-07
AU2018201037B2 (en) 2019-07-04
AU2013265288B2 (en) 2017-12-21
CN104395308A (zh) 2015-03-04
CA2873979A1 (en) 2013-11-28
NZ716487A (en) 2017-01-27
MX355409B (es) 2018-04-18
EP3581571A1 (en) 2019-12-18
PL3333166T3 (pl) 2020-09-07
RU2014151565A (ru) 2016-07-20
TWI579280B (zh) 2017-04-21
KR102151963B1 (ko) 2020-09-07
US9382235B2 (en) 2016-07-05
US20160279125A1 (en) 2016-09-29
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