EA202191478A1 - Гетероароматические соединения в качестве ингибиторов ванина - Google Patents
Гетероароматические соединения в качестве ингибиторов ванинаInfo
- Publication number
- EA202191478A1 EA202191478A1 EA202191478A EA202191478A EA202191478A1 EA 202191478 A1 EA202191478 A1 EA 202191478A1 EA 202191478 A EA202191478 A EA 202191478A EA 202191478 A EA202191478 A EA 202191478A EA 202191478 A1 EA202191478 A1 EA 202191478A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- heteroaromatic compounds
- vanin
- compounds
- inhibitors
- vanin inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к соединениям формулы Iкоторые пригодны для лечения заболеваний, связанных с ванином, и способам приготовления таких соединений, фармацевтическим препаратам, содержащим эти соединения, и способам их применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862774412P | 2018-12-03 | 2018-12-03 | |
PCT/EP2019/083259 WO2020114947A1 (en) | 2018-12-03 | 2019-12-02 | Heteroaromatic compounds as vanin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202191478A1 true EA202191478A1 (ru) | 2021-10-26 |
Family
ID=68766765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202191478A EA202191478A1 (ru) | 2018-12-03 | 2019-12-02 | Гетероароматические соединения в качестве ингибиторов ванина |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220048889A1 (ru) |
EP (1) | EP3890828A1 (ru) |
JP (1) | JP7195436B2 (ru) |
KR (1) | KR20210099093A (ru) |
CN (1) | CN113226462A (ru) |
AU (1) | AU2019392524A1 (ru) |
BR (1) | BR112021010823A2 (ru) |
CA (1) | CA3120037A1 (ru) |
EA (1) | EA202191478A1 (ru) |
MX (1) | MX2021006489A (ru) |
WO (1) | WO2020114947A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3116830A1 (en) * | 2018-12-03 | 2020-06-11 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as vanin inhibitors |
JP2022513745A (ja) * | 2018-12-11 | 2022-02-09 | エフ.ホフマン-ラ ロシュ アーゲー | アミノアジンアミド |
AU2021350973B2 (en) * | 2020-09-25 | 2024-03-07 | Shanghai Meiyue Biotech Development Co., Ltd. | Pyrimidine carboxamide compound and application thereof |
EP4265599A1 (en) * | 2020-12-17 | 2023-10-25 | Shanghai Meiyue Biotech Development Co., Ltd. | Pyrimidine carboxamide compound and use thereof |
WO2023174409A1 (zh) * | 2022-03-18 | 2023-09-21 | 上海美悦生物科技发展有限公司 | Vanin酶抑制剂的盐型、晶型及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103087050A (zh) * | 2011-10-28 | 2013-05-08 | 山东轩竹医药科技有限公司 | 芳基激酶抑制剂 |
US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
EP3303303A1 (en) | 2015-05-29 | 2018-04-11 | Pfizer Inc | Novel heterocyclic compounds as inhibitors of vanin-1 enzyme |
CA3030381A1 (en) | 2016-07-14 | 2018-01-18 | Pfizer Inc. | Pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
CA3116830A1 (en) * | 2018-12-03 | 2020-06-11 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as vanin inhibitors |
-
2019
- 2019-12-02 AU AU2019392524A patent/AU2019392524A1/en active Pending
- 2019-12-02 WO PCT/EP2019/083259 patent/WO2020114947A1/en unknown
- 2019-12-02 US US17/299,148 patent/US20220048889A1/en active Pending
- 2019-12-02 JP JP2021531394A patent/JP7195436B2/ja active Active
- 2019-12-02 BR BR112021010823-8A patent/BR112021010823A2/pt unknown
- 2019-12-02 EP EP19813499.1A patent/EP3890828A1/en active Pending
- 2019-12-02 CN CN201980079064.6A patent/CN113226462A/zh active Pending
- 2019-12-02 MX MX2021006489A patent/MX2021006489A/es unknown
- 2019-12-02 KR KR1020217020909A patent/KR20210099093A/ko unknown
- 2019-12-02 CA CA3120037A patent/CA3120037A1/en active Pending
- 2019-12-02 EA EA202191478A patent/EA202191478A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
AU2019392524A1 (en) | 2021-07-15 |
WO2020114947A1 (en) | 2020-06-11 |
US20220048889A1 (en) | 2022-02-17 |
CA3120037A1 (en) | 2020-06-11 |
MX2021006489A (es) | 2021-07-06 |
JP7195436B2 (ja) | 2022-12-23 |
KR20210099093A (ko) | 2021-08-11 |
BR112021010823A2 (pt) | 2021-08-24 |
CN113226462A (zh) | 2021-08-06 |
JP2022510351A (ja) | 2022-01-26 |
EP3890828A1 (en) | 2021-10-13 |
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