MX2021006489A - Compuestos heteroaromaticos como inhibidores de vanina. - Google Patents

Compuestos heteroaromaticos como inhibidores de vanina.

Info

Publication number
MX2021006489A
MX2021006489A MX2021006489A MX2021006489A MX2021006489A MX 2021006489 A MX2021006489 A MX 2021006489A MX 2021006489 A MX2021006489 A MX 2021006489A MX 2021006489 A MX2021006489 A MX 2021006489A MX 2021006489 A MX2021006489 A MX 2021006489A
Authority
MX
Mexico
Prior art keywords
heteroaromatic compounds
compounds
vanin
inhibitors
vanin inhibitors
Prior art date
Application number
MX2021006489A
Other languages
English (en)
Inventor
Cédrickx Godbout
Jr Thomas Martin Kirrane
Hannes Fiepko Koolman
Martin Thomas Fleck
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2021006489A publication Critical patent/MX2021006489A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención abarca compuestos de fórmula I (ver Fórmula) que son adecuados para el tratamiento de enfermedades relacionadas con Vanina, y procesos para preparar estos compuestos, preparaciones farmacéuticas que contienen estos compuestos y sus métodos de uso.
MX2021006489A 2018-12-03 2019-12-02 Compuestos heteroaromaticos como inhibidores de vanina. MX2021006489A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862774412P 2018-12-03 2018-12-03
PCT/EP2019/083259 WO2020114947A1 (en) 2018-12-03 2019-12-02 Heteroaromatic compounds as vanin inhibitors

Publications (1)

Publication Number Publication Date
MX2021006489A true MX2021006489A (es) 2021-07-06

Family

ID=68766765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021006489A MX2021006489A (es) 2018-12-03 2019-12-02 Compuestos heteroaromaticos como inhibidores de vanina.

Country Status (11)

Country Link
US (1) US20220048889A1 (es)
EP (1) EP3890828A1 (es)
JP (1) JP7195436B2 (es)
KR (1) KR20210099093A (es)
CN (1) CN113226462A (es)
AU (1) AU2019392524A1 (es)
BR (1) BR112021010823A2 (es)
CA (1) CA3120037A1 (es)
EA (1) EA202191478A1 (es)
MX (1) MX2021006489A (es)
WO (1) WO2020114947A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019391279A1 (en) * 2018-12-03 2021-05-13 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors
WO2020123426A1 (en) * 2018-12-11 2020-06-18 F. Hoffmann-La Roche Ag Aminoazine amides
KR20230049673A (ko) * 2020-09-25 2023-04-13 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 피리미딘 카르복스아미드 화합물 및 이의 용도
TWI811901B (zh) * 2020-12-17 2023-08-11 大陸商上海美悅生物科技發展有限公司 一種嘧啶甲醯胺類化合物及其應用
WO2023174409A1 (zh) * 2022-03-18 2023-09-21 上海美悦生物科技发展有限公司 Vanin酶抑制剂的盐型、晶型及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103087050A (zh) * 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 芳基激酶抑制剂
US9221807B2 (en) * 2014-02-21 2015-12-29 Boehringer Ingelheim International Gmbh Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
US10308615B2 (en) * 2015-05-29 2019-06-04 Pfizer Inc. Heterocyclic compounds as inhibitors of Vanin-1 enzyme
SG11201811161YA (en) 2016-07-14 2019-01-30 Pfizer Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
AU2019391279A1 (en) * 2018-12-03 2021-05-13 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors

Also Published As

Publication number Publication date
KR20210099093A (ko) 2021-08-11
JP2022510351A (ja) 2022-01-26
EA202191478A1 (ru) 2021-10-26
AU2019392524A1 (en) 2021-07-15
CN113226462A (zh) 2021-08-06
BR112021010823A2 (pt) 2021-08-24
US20220048889A1 (en) 2022-02-17
EP3890828A1 (en) 2021-10-13
CA3120037A1 (en) 2020-06-11
WO2020114947A1 (en) 2020-06-11
JP7195436B2 (ja) 2022-12-23

Similar Documents

Publication Publication Date Title
PH12021551065A1 (en) Fused ring compounds
EA202091491A1 (ru) Новые бензиламинозамещенные пиридопиримидиноны и производные в качестве ингибиторов sos1
PH12019501985A1 (en) Fused imidazo-piperidine jak inhibitors
PH12021551280A1 (en) Heteroaromatic compounds as vanin inhibitors
MY196909A (en) Boronic acid derivatives and therapeutic uses thereof
MY197440A (en) Heteroamatic compounds as btk inhibitors
MY195427A (en) Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease
EA201891494A1 (ru) Гетероциклические соединения в качестве иммуномодуляторов
PH12021550269A1 (en) Heteroaromatic compounds as vanin inhibitors
MX2021006489A (es) Compuestos heteroaromaticos como inhibidores de vanina.
EA201790492A1 (ru) СОЕДИНЕНИЯ, КОТОРЫЕ ИНГИБИРУЮТ БЕЛОК Mcl-1
PH12019502693A1 (en) Heteroaromatic compounds as vanin inhibitors
PH12015502414A1 (en) Enhancer of zeste homolog 2 inhibitors
PH12018502314A1 (en) Enhancer of zeste homolog 2 inhibitors
EA202090414A1 (ru) Соединения и их применение
MX2021006490A (es) Compuestos heteroaromaticos como inhibidores de vanina.
MX2019000542A (es) Derivados de pirazolilaminobenzimidazol como inhibidores de jak.
MX2019014436A (es) Derivados de piridoquinazolina eficaces como inhibidores de proteina quinasa.
MX2019014438A (es) Derivados de acidos carboxilicos eficaces como inhibidores de la proteina quinasa.
EA202091327A1 (ru) Макроциклические соединения для лечения заболеваний
EA201991746A1 (ru) Производные пиразола в качестве ингибиторов бромодомена
EA201892527A1 (ru) Ингибиторы энхансера гомолога 2 белка zeste