MY196909A - Boronic acid derivatives and therapeutic uses thereof - Google Patents
Boronic acid derivatives and therapeutic uses thereofInfo
- Publication number
- MY196909A MY196909A MYPI2018002676A MYPI2018002676A MY196909A MY 196909 A MY196909 A MY 196909A MY PI2018002676 A MYPI2018002676 A MY PI2018002676A MY PI2018002676 A MYPI2018002676 A MY PI2018002676A MY 196909 A MY196909 A MY 196909A
- Authority
- MY
- Malaysia
- Prior art keywords
- acid derivatives
- boronic acid
- therapeutic uses
- blls
- preparation
- Prior art date
Links
- 150000001642 boronic acid derivatives Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, ?-lactamase inhibitors (BLls).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662357165P | 2016-06-30 | 2016-06-30 | |
PCT/US2017/039787 WO2018005662A1 (en) | 2016-06-30 | 2017-06-28 | Boronic acid derivatives and therapeutic uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MY196909A true MY196909A (en) | 2023-05-09 |
Family
ID=60785544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI2018002676A MY196909A (en) | 2016-06-30 | 2017-06-28 | Boronic acid derivatives and therapeutic uses thereof |
Country Status (23)
Country | Link |
---|---|
US (4) | US10294249B2 (en) |
EP (1) | EP3478693B1 (en) |
JP (1) | JP7060245B2 (en) |
KR (1) | KR102403296B1 (en) |
CN (1) | CN109415386B (en) |
AU (1) | AU2017290060B2 (en) |
BR (1) | BR112018077015B1 (en) |
CA (1) | CA3026582A1 (en) |
CL (1) | CL2018003681A1 (en) |
CO (1) | CO2018013978A2 (en) |
DK (1) | DK3478693T3 (en) |
ES (1) | ES2894251T3 (en) |
IL (1) | IL263450B (en) |
MX (1) | MX2018015892A (en) |
MY (1) | MY196909A (en) |
PH (1) | PH12018502747A1 (en) |
PL (1) | PL3478693T3 (en) |
PT (1) | PT3478693T (en) |
SA (1) | SA518400742B1 (en) |
SG (1) | SG11201811549UA (en) |
UA (1) | UA124464C2 (en) |
WO (1) | WO2018005662A1 (en) |
ZA (1) | ZA201808327B (en) |
Families Citing this family (26)
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WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN108472284A (en) | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | Beta-lactamase inhibitor |
ES2894251T3 (en) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
JOP20190188A1 (en) | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | Apparatus and continuous flow process for production of boronic acid derivative |
EP3592362A4 (en) | 2017-03-06 | 2020-09-02 | Venatorx Pharmaceuticals, Inc. | Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof |
US11267826B2 (en) | 2017-05-26 | 2022-03-08 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
CN110959008A (en) | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | Penicillin binding protein inhibitors |
JP7377545B2 (en) * | 2017-10-11 | 2023-11-10 | キューペックス バイオファーマ, インコーポレイテッド | Boronic acid derivatives and their synthesis |
CN112424209A (en) | 2018-04-20 | 2021-02-26 | Qpex生物制药有限公司 | Boronic acid derivatives and their therapeutic use |
WO2020112542A1 (en) * | 2018-11-29 | 2020-06-04 | VenatoRx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor and uses thereof |
WO2020257306A1 (en) | 2019-06-19 | 2020-12-24 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
TW202123945A (en) * | 2019-09-13 | 2021-07-01 | 日商鹽野義製藥股份有限公司 | Pharmaceutical composition having antibacterial activity |
AU2020371404A1 (en) * | 2019-10-25 | 2022-05-19 | Sumitomo Pharma Co., Ltd. | Novel substituted condensed ring compound |
TW202200157A (en) * | 2020-03-18 | 2022-01-01 | 美商Qpex生物製藥股份有限公司 | Crystalline form of compound ii', compound, uses thereof, method of preparing the same, and pharmaceutical composition |
KR20230020419A (en) * | 2020-05-05 | 2023-02-10 | 큐펙스 바이오파마 인코포레이티드 | Boronic Acid Derivatives and Synthesis, Polymorphic Forms, and Their Therapeutic Uses |
CN116615431A (en) | 2020-08-20 | 2023-08-18 | 辉诺生物医药科技(杭州)有限公司 | Boric acid compound |
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WO2023066292A1 (en) * | 2021-10-19 | 2023-04-27 | 上海济煜医药科技有限公司 | Tricyclic boronic acid derivative, and preparation method therefor and application thereof |
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CN114716465B (en) * | 2022-05-06 | 2024-05-24 | 上海中医药大学 | Preparation method and application of dicyclo borate compound |
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