MX2019014438A - Derivados de acidos carboxilicos eficaces como inhibidores de la proteina quinasa. - Google Patents

Derivados de acidos carboxilicos eficaces como inhibidores de la proteina quinasa.

Info

Publication number
MX2019014438A
MX2019014438A MX2019014438A MX2019014438A MX2019014438A MX 2019014438 A MX2019014438 A MX 2019014438A MX 2019014438 A MX2019014438 A MX 2019014438A MX 2019014438 A MX2019014438 A MX 2019014438A MX 2019014438 A MX2019014438 A MX 2019014438A
Authority
MX
Mexico
Prior art keywords
protein kinase
carboxylic acid
acid derivatives
pyridoquinazolines
useful
Prior art date
Application number
MX2019014438A
Other languages
English (en)
Inventor
Kurz Guido
Camacho Gómez Juan
Original Assignee
Oncostellae S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncostellae S L filed Critical Oncostellae S L
Publication of MX2019014438A publication Critical patent/MX2019014438A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a nuevos derivados de ácido carboxílico de 11-oxo-11H-pirido [2,1-b] quinazolina-6- carboxamida como potentes inhibidores de la proteína quinasa, a composiciones farmacéuticas que los contienen y al uso de dichos compuestos para la fabricación de un medicamento para el tratamiento de afecciones o enfermedades patológicas que pueden mejorar mediante la inhibición de proteína quinasa.
MX2019014438A 2017-06-01 2018-05-31 Derivados de acidos carboxilicos eficaces como inhibidores de la proteina quinasa. MX2019014438A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201730760A ES2692433A1 (es) 2017-06-01 2017-06-01 Derivados de ácidos carboxílicos como inhibidores de proteinas quinasa
PCT/ES2018/070397 WO2018220253A1 (es) 2017-06-01 2018-05-31 Derivados de ácidos carboxílicos eficaces como inhibidores de la proteína quinasa

Publications (1)

Publication Number Publication Date
MX2019014438A true MX2019014438A (es) 2020-02-10

Family

ID=63364083

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014438A MX2019014438A (es) 2017-06-01 2018-05-31 Derivados de acidos carboxilicos eficaces como inhibidores de la proteina quinasa.

Country Status (11)

Country Link
US (1) US20200079773A1 (es)
EP (1) EP3632913A1 (es)
JP (1) JP2020521818A (es)
KR (1) KR20200012971A (es)
AU (1) AU2018278284A1 (es)
BR (1) BR112019025158A2 (es)
CA (1) CA3066011A1 (es)
EA (1) EA201992829A1 (es)
ES (1) ES2692433A1 (es)
MX (1) MX2019014438A (es)
WO (1) WO2018220253A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021190502A1 (zh) * 2020-03-23 2021-09-30 南京明德新药研发有限公司 吡啶并嘧啶酮类化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
AU5465198A (en) * 1996-11-26 1998-06-22 American Cyanamid Company Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents
WO2010061971A1 (ja) 2008-11-28 2010-06-03 興和株式会社 ピリジン－３－カルボキシアミド誘導体
EP3119781B1 (en) * 2014-03-20 2020-09-16 The Johns Hopkins University Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Also Published As

Publication number Publication date
ES2692433A1 (es) 2018-12-03
EP3632913A1 (en) 2020-04-08
AU2018278284A1 (en) 2019-12-19
WO2018220253A1 (es) 2018-12-06
EA201992829A1 (ru) 2020-08-06
CA3066011A1 (en) 2018-12-06
KR20200012971A (ko) 2020-02-05
JP2020521818A (ja) 2020-07-27
BR112019025158A2 (pt) 2020-06-23
US20200079773A1 (en) 2020-03-12

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