PE20160200A1 - Inhibidores de bromodominios - Google Patents

Inhibidores de bromodominios

Info

Publication number
PE20160200A1
PE20160200A1 PE2015002684A PE2015002684A PE20160200A1 PE 20160200 A1 PE20160200 A1 PE 20160200A1 PE 2015002684 A PE2015002684 A PE 2015002684A PE 2015002684 A PE2015002684 A PE 2015002684A PE 20160200 A1 PE20160200 A1 PE 20160200A1
Authority
PE
Peru
Prior art keywords
bromodomines
inhibitors
compounds
formula
diseases
Prior art date
Application number
PE2015002684A
Other languages
English (en)
Inventor
Jasmina Marjanovic
George SHEPPARD
Steven D Fidanze
Lisa Hasvold
Le Wang
William Mcclellan
Dachun Liu
James HOLMS
Yujia Dai
Keith MCDANIEL
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20160200A1 publication Critical patent/PE20160200A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

Referida a compuestos de formula (I), done Rx y Ry son H; Rx1 es -CN, A1, A2, A3, y A4 son N, L1 es O, NH, entre otros y G1 es fenilo, C3-C6 cicloalquilo, entre otros. Dichos compuestos son utiles como agentes en el tratamiento de enfermedades y estados clinicos, incluyendo enfermedades inflamatorias, cancer, y SIDA. Tambien se proveen composiciones farmaceuticas que comprenden uno o mas compuestos de formula (I)
PE2015002684A 2013-06-28 2014-06-27 Inhibidores de bromodominios PE20160200A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361840559P 2013-06-28 2013-06-28
PCT/CN2014/077395 WO2014206150A1 (en) 2013-06-28 2014-05-13 Bromodomain inhibitors

Publications (1)

Publication Number Publication Date
PE20160200A1 true PE20160200A1 (es) 2016-05-21

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Family Applications (2)

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PE2015002662A PE20160540A1 (es) 2013-06-28 2014-05-13 Inhibidores de bromodominios
PE2015002684A PE20160200A1 (es) 2013-06-28 2014-06-27 Inhibidores de bromodominios

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PE2015002662A PE20160540A1 (es) 2013-06-28 2014-05-13 Inhibidores de bromodominios

Country Status (23)

Country Link
US (3) US10131657B2 (es)
EP (2) EP3013828A4 (es)
JP (2) JP2016525503A (es)
KR (2) KR20160027062A (es)
CN (2) CN105518007A (es)
AR (1) AR096757A1 (es)
AU (2) AU2014303193A1 (es)
BR (2) BR112015032710A2 (es)
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