AR096757A1 - Inhibidores de bromodominios - Google Patents

Inhibidores de bromodominios

Info

Publication number
AR096757A1
AR096757A1 ARP140102430A ARP140102430A AR096757A1 AR 096757 A1 AR096757 A1 AR 096757A1 AR P140102430 A ARP140102430 A AR P140102430A AR P140102430 A ARP140102430 A AR P140102430A AR 096757 A1 AR096757 A1 AR 096757A1
Authority
AR
Argentina
Prior art keywords
alkyleneyl
alkylenyl
alkyl
nrjrk
haloalkyl
Prior art date
Application number
ARP140102430A
Other languages
English (en)
Inventor
D Findanze Steven
Sheppard George
Wang Le
Marjanovic Jasmina
Dai Yujia
Holms James
Liu Dachun
Mclellan William
Mdaniel Keith
Hasvold Lisa
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of AR096757A1 publication Critical patent/AR096757A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), o una sal farmacéuticamente aceptable del mismo, donde Rˣ es hidrógeno o C₁₋₃ alquilo; Rʸ es hidrógeno o C₁₋₃ alquilo; A¹ es N o CR¹, A² es N o CR², A³ es N o CR³; y A⁴ es N o CR⁴; donde cero, uno, dos o tres de A¹, A², A³, y A⁴ son N; R¹ es hidrógeno, C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, halógeno, C₁₋₆ haloalquilo, CN, NO₂; R² es hidrógeno, -S(O)₂R²ᵃ, -S(O)₂NR²ᵇR²ᶜ, -N(R²ᵇ)S(O)₂R²ᵃ, o -(C₁₋₆ alquilenil)-S(O)₂R²ᵃ; donde R²ᵃ es C₁₋₆ alquilo o C₁₋₆ haloalquilo; y R²ᵇ y R²ᶜ son en forma independiente entre sí hidrógeno, C₁₋₆ alquilo, o C₁₋₆ haloalquilo; L¹ es O, N(H), o OCH₂ donde la unidad CH₂ de OCH₂ se une a G¹; Rˣ¹, G¹, R³, y R⁴, se seleccionan entre (i), (ii), (iii), ó (iv); (i) Rˣ¹ es -CN, -Gˣ¹-Gˣ², -(C₁₋₆ alquilenil)-Gˣ¹-Gˣ², -C(O)N(Rˣᵃ)(Rˣᵇ), C₁₋₆ alquilo sustituido con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORˣᵇ, -SRˣᵇ, -S(O)Rˣᵇ, -S(O)₂Rˣᵇ, -NRˣᵃRˣᵇ, -C(O)Rˣᵇ, -C(O)ORˣᵇ, -C(O)NRˣᵃRˣᵇ, y -S(O)₂NRˣᵃRˣᵇ; C₂₋₆ alquenilo, o C₂₋₆ alquinilo; donde C₂₋₆ alquenilo y C₂₋₆ alquinilo están sustituidos en forma independiente entre sí con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORˣᶜ, -SRˣᶜ, -S(O)Rˣᶜ, -S(O)₂Rˣᶜ, -NRˣᵃRˣᶜ, -C(O)Rˣᶜ, -C(O)ORˣᶜ,-C(O)NRˣᵃRˣᶜ, -S(O)₂NRˣᵃRˣᶜ, y Gˣ¹; G¹ es fenilo, C₃₋₆ cicloalquilo, C₅₋₆ heteroarilo, o C₄₋₆ heterociclo; donde cada G¹ no está sustituido o está sustituido en forma independiente con 1, 2, 3, 4, ó 5 sustituyentes seleccionados en forma independiente entre el grupo que consiste en los grupos Rᵘ y Rᵛ, R³ es R¹ᵃ, -C(O)OH, -C(O)NR³ᵃR³ᵇ, -NR³ᵃR³ᵇ, G³ᵃ, -G³ᵃ-G³ᵇ, -(C₁₋₆ alquilenil)-OR³ᵃ, -(C₁₋₆ alquilenil)-NR³ᵃR³ᵇ, -(C₁₋₆ alquilenil)-G³ᵃ, o -(C₁₋₆ alquilenil)-G³ᵃ-G³ᵇ; y R⁴ es R¹ᵃ o G⁴; (ii) Rˣ¹ es -CN, -Gˣ¹-Gˣ², -(C₁₋₆ alquilenil)-Gˣ¹-Gˣ², -C(O)N(Rˣᵃ)(Rˣᵇ), hidrógeno, C₂₋₆ alquenilo, C₂₋₆ alquinilo, -C(O)ORᵃˣ¹, -C(O)NRᵇˣ¹Rᶜˣ¹, -C(O)Rᵈˣ¹, -S(O)₂Rᵈˣ¹, -S(O)₂NRᵇˣ¹Rᶜˣ¹, Gˣ¹, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; donde C₁₋₆ alquilo, C₂₋₆ alquenilo, y C₂₋₆ alquinilo están opcionalmente sustituidos en cada caso con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORˣᶜ, -SRˣᶜ, -S(O)Rˣᶜ, -S(O)₂Rˣᶜ, -NRˣᵃRˣᶜ, -C(O)Rˣᶜ, -C(O)ORˣᶜ, -C(O)NRˣᵃRˣᶜ, -S(O)₂NRˣᵃRˣᶜ, y Gˣ¹; G¹ es fenilo, C₃₋₆ cicloalquilo, C₅₋₆ heteroarilo, o C₄₋₆ heterociclo; donde cada G¹ está sustituido con un grupo Rᵘ y además está opcionalmente sustituido con 1, 2, 3, 4, ó 5 grupos Rᵛ; R³ es R¹ᵃ, -C(O)OH, -C(O)NR³ᵃR³ᵇ, -NR³ᵃR³ᵇ, G³ᵃ, -G³ᵃ-G³ᵇ, -(C₁₋₆ alquilenil)-OR³ᵃ, -(C₁₋₆ alquilenil)-NR³ᵃR³ᵇ, -(C₁₋₆ alquilenil)-G³ᵃ, o -(C₁₋₆ alquilenil)-G³ᵃ-G³ᵇ; y R⁴ es R¹ᵃ o G⁴; (iii) Rˣ¹ es -CN, -Gˣ¹-Gˣ², -(C₁₋₆ alquilenil)-Gˣ¹-Gˣ², C(O)N(Rˣᵃ)(Rˣᵇ), hidrógeno, C₂₋₆ alquenilo, C₂₋₆ alquinilo, -C(O)ORᵃˣ¹, -C(O)NRᵇˣ¹Rᶜˣ¹, -C(O)Rᵈˣ¹, -S(O)₂Rᵈˣ¹, -S(O)₂NRᵇˣ¹Rᶜˣ¹, Gˣ¹, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; donde C₁₋₆ alquilo, C₂₋₆ alquenilo, y C₂₋₆ alquinilo están opcionalmente sustituidos en cada caso con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORˣᶜ, -SRˣᶜ, -S(O)Rˣᶜ, -S(O)₂Rˣᶜ, -NRˣᵃRˣᶜ, -C(O)Rˣᶜ, -C(O)ORˣᶜ, -C(O)NRˣᵃRˣᶜ, -S(O)₂NRˣᵃRˣᶜ, y Gˣ¹; G¹ es fenilo, C₃₋₆ cicloalquilo, C₅₋₆ heteroarilo, o C₄₋₆ heterociclo; donde cada G¹ no está sustituido o está sustituido en forma independiente con 1, 2, 3, 4, ó 5 sustituyentes seleccionados en forma independiente entre el grupo que consiste en los grupos Rᵘ y Rᵛ; R³ es -C(O)OH, -C(O)NR³ᵃR³ᵇ, -NR³ᵃR³ᵇ, G³ᵃ, -G³ᵃ-G³ᵇ, -(C₁₋₆ alquilenil)-OR³ᵃ, -(C₁₋₆ alquilenil)-NR³ᵃR³ᵇ, -(C₁₋₆ alquilenil)-G³ᵃ, o -(C₁₋₆ alquilenil)-G³ᵃ-G³ᵇ; y R⁴ es R¹ᵃ o G⁴; (iv) Rˣ¹ es -CN, -Gˣ¹-Gˣ², -(C₁₋₆ alquilenil)-Gˣ¹-Gˣ², C(O)N(Rˣᵃ)(Rˣᵇ), hidrógeno, C₂₋₆ alquenilo, C₂₋₆ alquinilo, -C(O)ORᵃˣ¹, -C(O)NRᵇˣ¹Rᶜˣ¹, -C(O)Rᵈˣ¹, -S(O)₂Rᵈˣ¹, -S(O)₂NRᵇˣ¹Rᶜˣ¹, Gˣ¹, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; donde C₁₋₆ alquilo, C₂₋₆ alquenilo, y C₂₋₆ alquinilo están opcionalmente sustituidos en cada caso con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORˣᶜ, -SRˣᶜ, -S(O)Rˣᶜ, -S(O)₂Rˣᶜ, -NRˣᵃRˣᶜ, -C(O)Rˣᶜ, -C(O)ORˣᶜ, -C(O)NRˣᵃRˣᶜ, -S(O)₂NRˣᵃRˣᶜ, y Gˣ¹; G¹ es fenilo, C₃₋₆ cicloalquilo, C₅₋₆ heteroarilo, o C₄₋₆ heterociclo; donde cada G¹ no está sustituido o está sustituido en forma independiente con 1, 2, 3, 4, ó 5 sustituyentes seleccionados en forma independiente entre el grupo que consiste en los grupos Rᵘ y Rᵛ; R³ es R¹ᵃ, -C(O)OH, -C(O)NR³ᵃR³ᵇ, -NR³ᵃR³ᵇ, G³ᵃ, -G³ᵃ-G³ᵇ, -(C₁₋₆ alquilenil)-OR³ᵃ -(C₁₋₆ alquilenil)-NR³ᵃR³ᵇ, -(C₁₋₆alquilenil)-G³ᵃ, o -(C₁₋₆ alquilenil)-G³ᵃ-G³ᵇ; y R⁴ es G⁴; Rˣᵃ, en cada caso, es en forma independiente hidrógeno, C₁₋₆ alquilo, o C₁₋₆ haloalquilo; Rˣᵇ, en cada caso, es en forma independiente C₁₋₆ alquilo sustituido con un sustituyente seleccionado entre el grupo que consiste en - CN, -ORᵃˣ¹, -SRᵃˣ¹, -S(O)Rᵈˣ¹, -S(O)₂Rᵈˣ¹, -NRᵇˣ¹Rᶜˣ¹, -C(O)Rᵃˣ¹, -C(O)ORᵃˣ¹, -C(O)NRᵇˣ¹Rᶜˣ¹, y -S(O)₂NRᵇˣ¹Rᶜˣ¹; Rˣᶜ, en cada caso, es en forma independiente hidrógeno, C₁₋₆ alquilo, C₁₋₆ haloalquilo, Gᵃ, -(C₁₋₆ alquilenil)-Gᵃ, o Rˣᵇ; Rᵃˣ¹, Rᵇˣ¹, y Rᶜˣ¹, en cada caso, son en forma independiente entre sí hidrógeno, C₁₋₆ alquilo, C₁₋₆ haloalquilo, Gᵃ, o -(C₁₋₆ alquilenil)-Gᵃ; Rᵈˣ¹, en cada caso, es en forma independiente C₁₋₆ alquilo, C₁₋₆ haloalquilo, Gᵃ, o -(C₁₋₆ alquilenil)-Gᵃ; R¹ᵃ, en cada caso, es en forma independiente hidrógeno, C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, halógeno, C₁₋₆ haloalquilo, CN, o NO₂; R³ᵃ y R³ᵇ, en cada caso, son en forma independiente entre sí hidrógeno, C₁₋₆ alquilo, C₁₋₆ haloalquilo, G³ᵃ, -G³ᵃ-G³ᵇ, -(C₁₋₆ alquilenil)-G³ᵃ, -(C₁₋₆ alquilenil)-G³ᵃ-G³ᵇ, o C₁₋₆ alquilo sustituido con un sustituyente seleccionado entre el grupo que consiste en -CN, -ORʰ, -SRʰ, -S(O)Rⁱ, -S(O)₂Rʰ, -NRʲRᵏ, -C(O)Rʰ, -C(O)ORʰ, -C(O)NRʲRᵏ, y -S(O)₂NRʲRᵏ; G⁴, en cada caso, es en forma independiente fenilo, C₃₋₆ cicloalquilo, C₅₋₆ heteroarilo, o C₄₋₆ heterociclo; cada uno de los cuales está opcionalmente sustituido con 1, 2, 3, 4, ó 5 sustituyentes seleccionados en forma independiente entre el grupo que consiste en C₁₋₆ alquilo, NO₂, halógeno, C₁₋₆ haloalquilo, -CN, oxo, -ORʰ, -SRʰ, -S(O)₂Rʰ, y -NRʲRᵏ; Rᵘ, en cada caso, es en forma independiente -(C₁₋₆ alquilenil)-Gᵘ, -(C₂₋₆ alquinilen)-Gᵘ, -(C₁₋₆ alquilenil)-SRʰ, -C(O)-Z¹, -C(O)-NZ¹Z², -S(O)₂-Z¹, -N(Z²)Z¹, o -N(Z²)S(O)₂-Z¹; donde Z¹ es Gᵘ, -(C₁₋₆ alquilenil)-Gᵘ, -(C₂₋₆ alquenilen)-Gᵘ, -(C₁₋₆ alquilenil)-CN, -(C₁₋₆ alquilenil)-SRʰ, -(C₁₋₆ alquilenil)-ORʰ, -(C₁₋₆ alquilenil)-NRʲRᵏ, o -(C₁₋₆ alquilenil)-C₁₋₄ alcoxi-C₁₋₄ alcoxi, y Z² es hidrógeno, C₁₋₆ alquilo, o C₁₋₆ haloalquilo; Gᵘ, en cada caso, es en forma independiente arilo, heteroarilo, heterociclo, cicloalquilo, o cicloalquenilo, donde cada Gᵘ no está sustituido o está sustituido en forma independiente con 1, 2, 3, 4, ó 5 sustituyentes seleccionados en forma independiente entre el grupo que consiste en C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, halógeno, C₁₋₆ haloalquilo, -CN, oxo, NO₂, -ORʰ, -O-(C₂₋₆ alquilenil)-NRʲRᵏ, -OC(O)Rⁱ, -OC(O)NRʲRᵏ, -O-(C₁₋₆ alquilenil)-NRʲRᵏ, -SRʰ, -S(O)₂Rʰ, -S(O)₂NRʲRᵏ, -C(O)Rʰ, -C(O)ORʰ, -C(O)NRʲRᵏ, -NRʲRᵏ, -N(Rʰ)C(O)Rⁱ, -N(Rʰ)S(O)₂Rⁱ, -N(Rʰ)C(O)O(Rⁱ), -N(Rʰ)C(O)NRʲRᵏ, Gᵘᵃ, -(C₁₋₆ alquilenil)-ORʰ, -(C₁₋₆ alquilenil)-OC(O)Rⁱ, -(C₁₋₆ alquilenil)-OC(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-SRʰ, -(C₁₋₆ alquilenil)-S(O)₂Rʰ, -(C₁₋₆ alquilenil)-S(O)₂NRʲRᵏ, -(C₁₋₆ alquilenil)-C(O)Rʰ, -(C₁₋₆ alquilenil)-C(O)ORʰ, -(C₁₋₆ alquilenil)-C(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-NRʲRᵏ, -(C₁₋₆ alquilenil)-N(Rʰ)C(O)Rⁱ, -(C₁₋₆ alquiIenil)-N(Rʰ)S(O)₂Rⁱ, -(C₁₋₆ alquilenil)-N(Rʰ)C(O)O(Rⁱ), -(C₁₋₆ alquilenil)-N(Rʰ)C(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-CN, y -(C₁₋₆ alquilenil)-Gᵘᵃ; Gᵃ, Gˣ¹, Gˣ², G³ᵃ, G³ᵇ, y Gᵘᵃ, en cada caso, son en forma independiente entre sí arilo, heteroarilo, heterociclo, cicloalquilo, o cicloalquenilo, cada uno de los cuales está opcionalmente sustituido con 1, 2, 3, 4, ó 5 grupos Rᶻ; Rᶻ y Rᵛ, en cada caso, son en forma independiente entre sí C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, halógeno, C₁₋₆ haloalquilo, -CN, oxo, NO₂, -ORʰ, -OC(O)Rⁱ, -OC(O)NRʲRᵏ, -SRʰ, -S(O)₂Rʰ, -S(O)₂NRʲRᵏ, -C(O)Rʰ, -C(O)ORʰ, -C(O)NRʲRᵏ, -NRʲRᵏ, -N(Rʰ)C(O)Rⁱ, -N(Rʰ)S(O)₂Rⁱ, -N(Rʰ)C(O)O(Rⁱ), -N(Rʰ)C(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-ORʰ, -(C₁₋₆ alquilenil)-OC(O)Rⁱ, -(C₁₋₆ alquilenil)-OC(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-SRʰ, -(C₁₋₆alquilenil)-S(O)₂Rʰ, -(C₁₋₆ alquilenil)-S(O)₂NRʲRᵏ, -(C₁₋₆ alquilenil)-C(O)Rʰ, -(C₁₋₆ alquilenil)-C(O)ORʰ, -(C₁₋₆ alquilenil)-C(O)NRʲRᵏ, -(C₁₋₆ alquilenil)-NRʲRᵏ, -(C₁₋₆ alquilenil)-N(Rʰ)C(O)Rⁱ, -(C₁₋₆ alquilenil)-N(Rʰ)S(O)₂Rⁱ, -(C₁₋₆ alquilenil)-N(Rʰ)C(O)O(Rⁱ), -(C₁₋₆ alquilenil)-N(Rʰ)C(O)NRʲRᵏ, o -(C₁₋₆ alquilenil)-CN; Rʰ, Rʲ, Rᵏ, en cada caso, son en forma independiente entre sí hidrógeno, C₁₋₆ alquilo, o C₁₋₆ haloalquilo; y Rⁱ, en cada caso, es en forma independiente C₁₋₆ alquilo o C₁₋₆ haloalquilo.
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