BR0313265A - Compostos e respectivos processos de preparação, uso e formulações farmacêuticas e métodos de prevenção e/ou tratamento de distúrbios mediados por receptor mglur5 e de inbição da ativação de receptores mglu r5. - Google Patents
Compostos e respectivos processos de preparação, uso e formulações farmacêuticas e métodos de prevenção e/ou tratamento de distúrbios mediados por receptor mglur5 e de inbição da ativação de receptores mglu r5.Info
- Publication number
- BR0313265A BR0313265A BR0313265-0A BR0313265A BR0313265A BR 0313265 A BR0313265 A BR 0313265A BR 0313265 A BR0313265 A BR 0313265A BR 0313265 A BR0313265 A BR 0313265A
- Authority
- BR
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- Prior art keywords
- compounds
- preparation
- pharmaceutical formulations
- methods
- mglur5
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"COMPOSTOS E RESPECTIVOS PROCESSOS DE PREPARAçãO, USO E FORMULAçõES FARMACêUTICAS E MéTODOS DE PREVENçãO E/OU TRATAMENTO DE DISTúRBIOS MEDIADOS POR RECEPTOR MGLUR5 E DE INIBIçãO DA ATIVAçãO DE RECEPTORES MGLUR5". A presente invenção refere-se a novos compostos da fórmula (I), a um processo para a sua preparação e novos intermediários nele preparados, a formulações farmacêuticas contendo os referidos compostos e ao uso dos citados compostos em terapia. Em particular, há compostos de acordo com a presente invenção que são potentes e seletivos para o receptor do Grupo I do mGluR e, mais particularmente, para o mGluR5. Assim, espera-se que os compostos da invenção sejam bem adequados para a prevenção e/ou tratamento de desordens mediadas pelo receptor mGluR5, tais como desordens neurológicas e psiquiátricas agudas e crónicas e desordens dolorosas agudas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40204002P | 2002-08-09 | 2002-08-09 | |
PCT/US2003/024846 WO2004014881A2 (en) | 2002-08-09 | 2003-08-08 | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313265A true BR0313265A (pt) | 2005-07-05 |
Family
ID=31715777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313265-0A BR0313265A (pt) | 2002-08-09 | 2003-08-08 | Compostos e respectivos processos de preparação, uso e formulações farmacêuticas e métodos de prevenção e/ou tratamento de distúrbios mediados por receptor mglur5 e de inbição da ativação de receptores mglu r5. |
Country Status (20)
Country | Link |
---|---|
US (2) | US20040152699A1 (pt) |
EP (1) | EP1529045A2 (pt) |
JP (2) | JP4637578B2 (pt) |
KR (1) | KR20050033070A (pt) |
CN (2) | CN1894241A (pt) |
AR (1) | AR040847A1 (pt) |
AU (1) | AU2003259068B2 (pt) |
BR (1) | BR0313265A (pt) |
CA (1) | CA2494987C (pt) |
IL (1) | IL166510A0 (pt) |
IS (1) | IS7733A (pt) |
MX (1) | MXPA05001594A (pt) |
NO (1) | NO20051225L (pt) |
NZ (1) | NZ538225A (pt) |
PL (1) | PL375256A1 (pt) |
RU (1) | RU2352568C9 (pt) |
TW (1) | TWI341314B (pt) |
UA (1) | UA87653C2 (pt) |
WO (1) | WO2004014881A2 (pt) |
ZA (1) | ZA200500886B (pt) |
Families Citing this family (82)
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CA2554894A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Triazole compounds and their use as metabotropic glutamate receptor antagonists |
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-
2003
- 2003-08-08 PL PL03375256A patent/PL375256A1/xx unknown
- 2003-08-08 US US10/637,012 patent/US20040152699A1/en not_active Abandoned
- 2003-08-08 IL IL16651003A patent/IL166510A0/xx unknown
- 2003-08-08 AR AR20030102891A patent/AR040847A1/es unknown
- 2003-08-08 AU AU2003259068A patent/AU2003259068B2/en not_active Ceased
- 2003-08-08 WO PCT/US2003/024846 patent/WO2004014881A2/en active Application Filing
- 2003-08-08 CA CA2494987A patent/CA2494987C/en not_active Expired - Fee Related
- 2003-08-08 RU RU2005106844/04A patent/RU2352568C9/ru not_active IP Right Cessation
- 2003-08-08 CN CNA038238454A patent/CN1894241A/zh active Pending
- 2003-08-08 UA UAA200501100A patent/UA87653C2/ru unknown
- 2003-08-08 MX MXPA05001594A patent/MXPA05001594A/es active IP Right Grant
- 2003-08-08 BR BR0313265-0A patent/BR0313265A/pt not_active Application Discontinuation
- 2003-08-08 JP JP2004527872A patent/JP4637578B2/ja not_active Expired - Fee Related
- 2003-08-08 CN CN200910208474A patent/CN101723941A/zh active Pending
- 2003-08-08 TW TW092121880A patent/TWI341314B/zh not_active IP Right Cessation
- 2003-08-08 KR KR1020057002101A patent/KR20050033070A/ko not_active Application Discontinuation
- 2003-08-08 EP EP03785036A patent/EP1529045A2/en not_active Withdrawn
- 2003-08-08 NZ NZ538225A patent/NZ538225A/en not_active IP Right Cessation
-
2005
- 2005-01-31 ZA ZA200500886A patent/ZA200500886B/en unknown
- 2005-03-09 IS IS7733A patent/IS7733A/is unknown
- 2005-03-09 NO NO20051225A patent/NO20051225L/no unknown
- 2005-11-14 US US11/274,611 patent/US7456200B2/en not_active Expired - Fee Related
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2010
- 2010-06-14 JP JP2010135508A patent/JP2010248214A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PL375256A1 (en) | 2005-11-28 |
JP2006503009A (ja) | 2006-01-26 |
TW200413361A (en) | 2004-08-01 |
MXPA05001594A (es) | 2005-09-20 |
KR20050033070A (ko) | 2005-04-08 |
US20040152699A1 (en) | 2004-08-05 |
CA2494987A1 (en) | 2004-02-19 |
IS7733A (is) | 2005-03-09 |
NZ538225A (en) | 2008-05-30 |
NO20051225L (no) | 2005-05-09 |
CN101723941A (zh) | 2010-06-09 |
AR040847A1 (es) | 2005-04-20 |
US7456200B2 (en) | 2008-11-25 |
JP4637578B2 (ja) | 2011-02-23 |
CA2494987C (en) | 2012-04-17 |
TWI341314B (en) | 2011-05-01 |
WO2004014881B1 (en) | 2004-07-15 |
US20060122397A1 (en) | 2006-06-08 |
UA87653C2 (en) | 2009-08-10 |
RU2352568C9 (ru) | 2009-06-27 |
CN1894241A (zh) | 2007-01-10 |
ZA200500886B (en) | 2006-07-26 |
IL166510A0 (en) | 2006-01-15 |
JP2010248214A (ja) | 2010-11-04 |
AU2003259068B2 (en) | 2009-07-02 |
AU2003259068A1 (en) | 2004-02-25 |
RU2005106844A (ru) | 2005-08-27 |
RU2352568C2 (ru) | 2009-04-20 |
EP1529045A2 (en) | 2005-05-11 |
WO2004014881A3 (en) | 2004-05-27 |
WO2004014881A2 (en) | 2004-02-19 |
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