BRPI0307351B8 - composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto - Google Patents

composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto

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Publication number
BRPI0307351B8
BRPI0307351B8 BRPI0307351A BR0307351A BRPI0307351B8 BR PI0307351 B8 BRPI0307351 B8 BR PI0307351B8 BR PI0307351 A BRPI0307351 A BR PI0307351A BR 0307351 A BR0307351 A BR 0307351A BR PI0307351 B8 BRPI0307351 B8 BR PI0307351B8
Authority
BR
Brazil
Prior art keywords
compound
preparing
pharmaceutical composition
mediated
kinase activity
Prior art date
Application number
BRPI0307351A
Other languages
English (en)
Other versions
BR0307351A (pt
BRPI0307351B1 (pt
Inventor
Louise Walker Ann
Mary Aston Nicola
Bamborough Paul
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0203301.7A external-priority patent/GB0203301D0/en
Priority claimed from GB0225385A external-priority patent/GB0225385D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0307351A publication Critical patent/BR0307351A/pt
Publication of BRPI0307351B1 publication Critical patent/BRPI0307351B1/pt
Publication of BRPI0307351B8 publication Critical patent/BRPI0307351B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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Abstract

"composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto". os compostos de fórmula são inibidores da p38 quinase e são úteis no tratamento de condições ou estados de doença mediados pela atividade da p38 quinase ou mediados por citocinas produzidas pela atividade de p38.
BRPI0307351A 2002-02-12 2003-02-10 composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto BRPI0307351B8 (pt)

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NO327418B1 (no) 2009-06-22
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ES2295553T3 (es) 2008-04-16
US20100215652A1 (en) 2010-08-26
DK1474395T3 (da) 2008-02-11
US20100215661A1 (en) 2010-08-26
NZ533865A (en) 2006-02-24
US7125898B2 (en) 2006-10-24
AU2003207298B2 (en) 2009-09-03
WO2003068747A1 (en) 2003-08-21
PT1474395E (pt) 2008-01-02
ES2400486T3 (es) 2013-04-10
JP4472349B2 (ja) 2010-06-02
EP1864975A2 (en) 2007-12-12
DK1864975T3 (da) 2011-01-24
IL163090A (en) 2010-06-16
EP2258687B1 (en) 2012-12-26
ATE375980T1 (de) 2007-11-15
PT1864975E (pt) 2010-12-27
NO20043176L (no) 2004-07-26
EP1474395A1 (en) 2004-11-10
BR0307351A (pt) 2004-12-14
EP1474395B1 (en) 2007-10-17
JP2010111699A (ja) 2010-05-20
DE60334651D1 (de) 2010-12-02
EP1864975A3 (en) 2008-01-23
CY1107117T1 (el) 2012-01-25
CA2474192C (en) 2011-06-21
CY1111083T1 (el) 2015-06-11
AU2003207298A1 (en) 2003-09-04
KR20040082425A (ko) 2004-09-24
DE60316913T2 (de) 2008-11-20
CN1633416A (zh) 2005-06-29
KR101058292B1 (ko) 2011-08-22
MXPA04007838A (es) 2004-10-15
EP2258687A1 (en) 2010-12-08
BRPI0307351B1 (pt) 2018-09-04
CA2474192A1 (en) 2003-08-21
ZA200405602B (en) 2005-09-28
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PL372628A1 (en) 2005-07-25
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US20060276516A1 (en) 2006-12-07
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US8252818B2 (en) 2012-08-28
US20050176964A1 (en) 2005-08-11
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US8575204B2 (en) 2013-11-05
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ATE485275T1 (de) 2010-11-15
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