CY1107117T1 - Παραγωγα νικοτιναμιδιου χρησιμα σαν αναστολεις της p38 - Google Patents
Παραγωγα νικοτιναμιδιου χρησιμα σαν αναστολεις της p38Info
- Publication number
- CY1107117T1 CY1107117T1 CY20071101642T CY071101642T CY1107117T1 CY 1107117 T1 CY1107117 T1 CY 1107117T1 CY 20071101642 T CY20071101642 T CY 20071101642T CY 071101642 T CY071101642 T CY 071101642T CY 1107117 T1 CY1107117 T1 CY 1107117T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- derivatives useful
- nicotinamide derivatives
- kinase
- activity
- Prior art date
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
- 239000012826 P38 inhibitor Substances 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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Abstract
Ενώσεις του τύπου (Ι) είναι αναστολείς της κινάσης p38 και είναι χρήσιμες για τη θεραπεία ενδείξεων ή καταστάσεων ασθένειας που προκαλούνται από τη δραστηριότητα της κινάσης p38 ή προκαλούνται από κυτοκίνες που παράγονται από τη δραστηριότητα της p38.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203301.7A GB0203301D0 (en) | 2002-02-12 | 2002-02-12 | Novel compounds |
GB0225385A GB0225385D0 (en) | 2002-10-31 | 2002-10-31 | Novel compounds |
PCT/GB2003/000554 WO2003068747A1 (en) | 2002-02-12 | 2003-02-10 | Nicotinamide derivates useful as p38 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107117T1 true CY1107117T1 (el) | 2012-01-25 |
Family
ID=27736200
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101642T CY1107117T1 (el) | 2002-02-12 | 2007-12-28 | Παραγωγα νικοτιναμιδιου χρησιμα σαν αναστολεις της p38 |
CY20101101128T CY1111083T1 (el) | 2002-02-12 | 2010-12-08 | Παραγωγα νικοτιναμιδιου χρησιμα ως αναστολεις της p38 |
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