WO2008136279A1 - ヘテロ環置換ピリジン誘導体の塩またはその結晶 - Google Patents

ヘテロ環置換ピリジン誘導体の塩またはその結晶 Download PDF

Info

Publication number
WO2008136279A1
WO2008136279A1 PCT/JP2008/057569 JP2008057569W WO2008136279A1 WO 2008136279 A1 WO2008136279 A1 WO 2008136279A1 JP 2008057569 W JP2008057569 W JP 2008057569W WO 2008136279 A1 WO2008136279 A1 WO 2008136279A1
Authority
WO
WIPO (PCT)
Prior art keywords
crystal
salt
heterocycle
pyridine derivative
substituted pyridine
Prior art date
Application number
PCT/JP2008/057569
Other languages
English (en)
French (fr)
Inventor
Jun Niijima
Kazutaka Nakamoto
Masayuki Matsukura
Keigo Tanaka
Eiichi Yamamoto
Takuma Minamisono
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to CN2008800070238A priority Critical patent/CN101622251B/zh
Priority to AU2008246798A priority patent/AU2008246798A1/en
Priority to EP08740624A priority patent/EP2143723A4/en
Priority to CA002685194A priority patent/CA2685194A1/en
Priority to JP2009512922A priority patent/JPWO2008136279A1/ja
Publication of WO2008136279A1 publication Critical patent/WO2008136279A1/ja
Priority to IL200216A priority patent/IL200216A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

　本発明の目的は、へテロ環置換ピリジン誘導体の塩またはその結晶を提供することである。本発明によれば、３－（３－（４－（ピリジン－２－イルオキシメチル）－ベンジル）－イソキサゾール－５－イル）－ピリジン－２－イルアミンの酸付加塩またはその結晶が提供される。
PCT/JP2008/057569 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶 WO2008136279A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN2008800070238A CN101622251B (zh) 2007-04-27 2008-04-18 杂环取代吡啶衍生物的盐或其结晶
AU2008246798A AU2008246798A1 (en) 2007-04-27 2008-04-18 Salt of heterocycle-substituted pyridine derivative or crystal thereof
EP08740624A EP2143723A4 (en) 2007-04-27 2008-04-18 SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME
CA002685194A CA2685194A1 (en) 2007-04-27 2008-04-18 Heterocycle-substituted pyridine derivatives salt or crystal thereof
JP2009512922A JPWO2008136279A1 (ja) 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶
IL200216A IL200216A0 (en) 2007-04-27 2009-08-03 Heterocycle-substituted pyridine derivative's salt or crystal thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91457207P 2007-04-27 2007-04-27
US60/914,572 2007-04-27
JP2007-118411 2007-04-27
JP2007118411 2007-04-27

Publications (1)

Publication Number Publication Date
WO2008136279A1 true WO2008136279A1 (ja) 2008-11-13

Family

ID=39940020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057569 WO2008136279A1 (ja) 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶

Country Status (9)

Country Link
US (1) US8058444B2 (ja)
EP (1) EP2143723A4 (ja)
JP (1) JPWO2008136279A1 (ja)
KR (1) KR20100015897A (ja)
CN (2) CN102702185A (ja)
AU (1) AU2008246798A1 (ja)
CA (1) CA2685194A1 (ja)
IL (1) IL200216A0 (ja)
WO (1) WO2008136279A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009081970A1 (ja) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の製造方法
WO2009084621A1 (ja) 2007-12-27 2009-07-09 Eisai R & D Management Co., Ltd. ヘテロ環およびホスホノキシメチル基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
WO2010047120A1 (ja) 2008-10-24 2010-04-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環及びγ－グルタミルアミノ基が置換したピリジン誘導体並びにそれらを含有する抗真菌剤
WO2011051198A2 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
EP2345328A1 (en) * 2008-09-19 2011-07-20 Sumitomo Chemical Company, Limited Composition for agricultural use
JP2013532131A (ja) * 2010-05-19 2013-08-15 サンド・アクチエンゲゼルシヤフト ポサコナゾール中間体の製造
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP2065377B1 (en) * 2006-09-21 2011-11-23 Eisai R&D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8522915B2 (en) * 2007-12-19 2013-09-03 Westerngeco L.L.C. Method and system for selecting parameters of a seismic source array
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
CN111698989B (zh) 2017-12-07 2023-08-01 安普利克斯制药公司 杂环取代的吡啶衍生物抗真菌剂
US11771688B2 (en) 2018-06-25 2023-10-03 Amplyx Pharmaceuticals, Inc. Pyridine derivatives substituted by heterocyclic ring and amino group
CN110776505A (zh) * 2018-07-29 2020-02-11 朱允涛 一种氘代的异恶唑类化合物的制备方法和用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973575A (ja) * 1982-10-05 1984-04-25 Shionogi & Co Ltd プロピニルアミノイソオキサゾ−ル誘導体
WO2002004626A1 (fr) 2000-07-07 2002-01-17 Eisai Co., Ltd. Gene de synthese de la paroi des cellules fongiques
WO2002085897A1 (en) 2001-04-05 2002-10-31 Alangudi Sankaranarayanan Heterocyclic compounds for aging-related and diabetic vascular complications
WO2003031435A1 (en) 2001-10-06 2003-04-17 Merck Patent Gmbh Pyrazole derivatives as glycine transporter inhibitors
WO2004089931A1 (de) 2003-04-05 2004-10-21 Merck Patent Gmbh Substituierte pyrazole
WO2005033079A1 (ja) 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
WO2007052615A1 (ja) * 2005-10-31 2007-05-10 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体およびそれらを含有する抗真菌剤

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB919073A (en) 1960-09-15 1963-02-20 Farmaceutici Italia Benzylamine derivatives
JPS542325A (en) 1977-06-07 1979-01-09 Sankyo Co Ltd Agricultural and horticultural pesticide
GB8311003D0 (en) 1983-04-22 1983-05-25 Shell Int Research Aniline compounds
DE3316187A1 (de) 1983-05-04 1984-11-08 Cassella Ag, 6000 Frankfurt 2-(aminomethyl)-pyrrol-derivate, verfahren zu ihrer herstellung und ihre verwendung
EP0124067B1 (de) 1983-05-04 1986-12-17 CASSELLA Aktiengesellschaft 2-(Aminoalkyl)-pyrrol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1986003203A1 (en) 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
US5070082A (en) 1986-10-23 1991-12-03 American Cyanamid Company Solubilized pro-drugs
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
JPS643162A (en) 1987-06-26 1989-01-06 Tokuyama Soda Co Ltd Sulfonamide compound
IL89028A0 (en) 1988-01-29 1989-08-15 Lilly Co Eli Quinoline,quinazoline and cinnoline derivatives
US5034393A (en) 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
JPH03161470A (ja) 1989-11-17 1991-07-11 Nisshin Flour Milling Co Ltd インドール誘導体
JPH05294935A (ja) 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
US5371086A (en) 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
US5208247A (en) 1991-08-01 1993-05-04 American Cyanamid Company Pyridinium compounds which are useful as antagonists of platelet activating factor
EP0533130A1 (de) 1991-09-19 1993-03-24 Hoechst Aktiengesellschaft 2-Hydroxymethylpyridine, die entsprechenden Pyridin-N-oxide und ihre Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung
EP0610396B1 (en) 1991-10-23 2001-01-17 Baylor College Of Medicine Fingerprinting bacterial strains using repetitive dna sequence amplification
JPH0725853A (ja) 1993-07-14 1995-01-27 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
JP2759257B2 (ja) 1993-09-28 1998-05-28 大塚製薬株式会社 糖尿病治療剤
KR100196356B1 (ko) 1993-09-28 1999-06-15 오스카 아끼히꼬 당뇨병 치료제
AU677502B2 (en) 1994-01-07 1997-04-24 Dowelanco N-(4-pyrimidinyl)amide pesticides
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
DE4434637A1 (de) 1994-09-28 1996-04-04 Hoechst Schering Agrevo Gmbh Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
JPH08175993A (ja) 1994-12-21 1996-07-09 Green Cross Corp:The 抗酸化剤
DE69618370T2 (de) 1995-04-11 2002-09-26 Mitsui Chemicals Inc Substituierte Thiophenderivate und diese als aktiver Bestandteil enthaltenden Fungizide für Land- und Gartenbauwirtschaft
US5710171A (en) 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
US5693336A (en) * 1995-06-07 1997-12-02 Nexstar Pharmaceuticals, Inc. Blood stable liposomal cyclosporin formulations
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
GB9605437D0 (en) 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
US20020111495A1 (en) * 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
NZ337698A (en) 1997-04-04 2001-07-27 Pfizer Prod Inc Nicotinamide derivatives for selective inhibition of phosphodiesterase type 4 (PDE4) and the production of tumour necrosis factor (TNF) useful for the treatment of respiratory, rheumatoid and allergic diseases
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB9718411D0 (en) * 1997-08-29 1997-11-05 3Com Ireland Network hub activity display
AU9002598A (en) 1997-09-16 1999-04-05 Takeda Chemical Industries Ltd. Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs
JPH11152275A (ja) 1997-09-16 1999-06-08 Takeda Chem Ind Ltd 含窒素縮合環化合物、その製造法および剤
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
EP1037633B1 (en) 1997-12-11 2003-09-10 Biochem Pharma Inc. Antiviral compounds
KR20010033811A (ko) 1997-12-31 2001-04-25 토마스 안 빅토리아 2차 및 3차 아민을 함유하는 약제의 물에 용해가능한프로드럭 및 그것의 제조방법
PE20000942A1 (es) 1998-07-31 2000-09-28 Lilly Co Eli Derivados de amida, carbamato y urea
JP2000178243A (ja) 1998-12-14 2000-06-27 Teijin Ltd ビフェニルアミジン誘導体
US6235728B1 (en) 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
EP1155017B1 (en) 1999-02-22 2003-01-15 Shire Biochem Inc. [1,8] naphthyridine derivatives having antiviral activity
US6319944B1 (en) 1999-05-10 2001-11-20 Merck & Co., Inc. Aryl amidines, compositions containing such compounds and methods of use
GB9919588D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
DE60029235T2 (de) 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
US6513676B2 (en) 2000-06-21 2003-02-04 Martin L. Clemmons Universal cup holder with food tray accessories
CN101285061A (zh) 2000-07-07 2008-10-15 卫材R&D管理有限公司 真菌细胞壁合成基因
MXPA03002325A (es) 2000-09-15 2003-06-24 Anormed Inc Compuestos heterociclicos que se unen a receptor de quimiocina.
US7074742B2 (en) 2000-09-18 2006-07-11 E. I. Du Pont De Nemours And Company Pyridinyl amides and imides for use as fungicides
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
EP1229034B1 (en) 2001-01-31 2005-04-13 Pfizer Products Inc. Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes
JP2002275159A (ja) 2001-03-16 2002-09-25 Japan Tobacco Inc Ｈｃｐ阻害剤及びｈｃｐ阻害活性を有する化合物
GB0109122D0 (en) 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
EP1275653A1 (en) 2001-07-10 2003-01-15 Bayer CropScience S.A. Oxazolopyridines and their use as fungicides
EP1275301A1 (en) 2001-07-10 2003-01-15 Bayer CropScience S.A. Trisubstituted heterocyclic compounds and their use as fungicides
JP2005509594A (ja) 2001-07-13 2005-04-14 バーチャル ドラッグ ディヴェロップメント、インコーポレイティッド Ｎａｄシンテターゼ阻害剤およびその使用
US20040198773A1 (en) 2001-09-26 2004-10-07 Barry Hart Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
KR100437972B1 (ko) 2001-10-27 2004-07-02 한국과학기술연구원 피롤리디논 유도체, 이의 제조 방법 및 이를 포함하는제약 조성물
US7241890B2 (en) 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
AU2002352868A1 (en) 2001-11-27 2003-06-10 Merck & Co., Inc. 4-aminoquinoline compounds
WO2003045385A1 (en) 2001-11-27 2003-06-05 F. Hoffmann-La Roche Ag Benzothiazole derivatives
US20030191158A1 (en) 2002-02-11 2003-10-09 Magee Thomas V. Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
JP4472349B2 (ja) 2002-02-12 2010-06-02 スミスクライン ビーチャム コーポレーション ｐ３８阻害薬として有用なニコチンアミド誘導体
NZ551540A (en) 2002-03-08 2009-05-31 Basf Ag Fungicidal mixtures based on prothioconazole and containing an insecticide
DE60321907D1 (de) 2002-04-26 2008-08-14 Lilly Co Eli Tachykininrezeptorantagonisten
EP1369420A1 (en) 2002-06-06 2003-12-10 Aventis Pharma Deutschland GmbH Inhibitors of the GPib - vWF interaction
AU2003244181A1 (en) 2002-06-25 2004-01-06 Yamanouchi Pharmaceutical Co., Ltd. Phenoxypyridine derivative or salt thereof
PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
WO2004029054A1 (ja) * 2002-09-27 2004-04-08 Sumitomo Pharmaceuticals Company, Limited 新規アデニン化合物及びその用途
WO2004033432A1 (ja) 2002-10-09 2004-04-22 Ssp Co., Ltd. 抗真菌活性を有する新規ピラゾール化合物
US8030336B2 (en) 2002-12-13 2011-10-04 Ym Biosciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
TW200500360A (en) 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
JP4156460B2 (ja) 2003-07-09 2008-09-24 Ｔｄｋ株式会社 ワークのピックアップ方法及びその装置、実装機
US6945431B2 (en) * 2003-07-24 2005-09-20 Fluid Management, Inc. Sanitizable piston pumps and dispensing systems incorporating the same
AU2004261589B2 (en) 2003-07-25 2008-05-22 Novartis Ag p-38 kinase inhibitors
EP1782811A4 (en) 2004-08-09 2010-09-01 Eisai R&D Man Co Ltd INNOVATIVE ANTIPALUDITIC AGENT CONTAINING A HETEROCYCLIC COMPOUND
JP4874958B2 (ja) 2005-03-30 2012-02-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリジン誘導体を含有する抗真菌剤
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2007056215A2 (en) 2005-11-02 2007-05-18 Cytovia, Inc. N-aryl-thienopyrimidin-4-amines and the use thereof
BRPI0821689A2 (pt) 2007-12-26 2015-06-16 Eisai R&D Man Co Ltd Processo para a produção de derivados de piridina substituídos por heterociclo
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973575A (ja) * 1982-10-05 1984-04-25 Shionogi & Co Ltd プロピニルアミノイソオキサゾ−ル誘導体
WO2002004626A1 (fr) 2000-07-07 2002-01-17 Eisai Co., Ltd. Gene de synthese de la paroi des cellules fongiques
WO2002085897A1 (en) 2001-04-05 2002-10-31 Alangudi Sankaranarayanan Heterocyclic compounds for aging-related and diabetic vascular complications
JP2004529154A (ja) * 2001-04-05 2004-09-24 トレント・ファーマシューティカルズ・リミテッド 老化−関連及び糖尿病性血管性合併症のための複素環式化合物
WO2003031435A1 (en) 2001-10-06 2003-04-17 Merck Patent Gmbh Pyrazole derivatives as glycine transporter inhibitors
WO2004089931A1 (de) 2003-04-05 2004-10-21 Merck Patent Gmbh Substituierte pyrazole
WO2005033079A1 (ja) 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
WO2007052615A1 (ja) * 2005-10-31 2007-05-10 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体およびそれらを含有する抗真菌剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2143723A4

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009081970A1 (ja) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の製造方法
US8410277B2 (en) 2007-12-26 2013-04-02 Eisai R&D Managment Co., Ltd. Method for manufacturing heterocycle substituted pyridine derivatives
WO2009084621A1 (ja) 2007-12-27 2009-07-09 Eisai R & D Management Co., Ltd. ヘテロ環およびホスホノキシメチル基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
EP2345328A1 (en) * 2008-09-19 2011-07-20 Sumitomo Chemical Company, Limited Composition for agricultural use
EP2345328A4 (en) * 2008-09-19 2014-06-25 Sumitomo Chemical Co COMPOSITION FOR USE IN AGRICULTURE
WO2010047120A1 (ja) 2008-10-24 2010-04-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環及びγ－グルタミルアミノ基が置換したピリジン誘導体並びにそれらを含有する抗真菌剤
WO2011051198A2 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
JP2013532131A (ja) * 2010-05-19 2013-08-15 サンド・アクチエンゲゼルシヤフト ポサコナゾール中間体の製造
US9073904B2 (en) 2010-05-19 2015-07-07 Sandoz Ag Preparation of posaconazole intermediates
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound

Also Published As

Publication number Publication date
CN102702185A (zh) 2012-10-03
US20080275244A1 (en) 2008-11-06
US8058444B2 (en) 2011-11-15
CN101622251B (zh) 2012-07-04
EP2143723A1 (en) 2010-01-13
CN101622251A (zh) 2010-01-06
CA2685194A1 (en) 2008-11-13
KR20100015897A (ko) 2010-02-12
EP2143723A4 (en) 2011-05-18
JPWO2008136279A1 (ja) 2010-07-29
AU2008246798A1 (en) 2008-11-13
IL200216A0 (en) 2010-04-29

Similar Documents

Publication Publication Date Title
WO2008136279A1 (ja) ヘテロ環置換ピリジン誘導体の塩またはその結晶
WO2008047082A3 (en) Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
DK2049487T3 (da) Fremgangsmåde til fremstilling af 2-substituerede 5-(1-alkylthio)alkylpyridiner
WO2006114415A3 (de) Physiologisch verträgliche salze von 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
ME02307B (me) Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr
HK1158627A1 (en) 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-h- pyrrole derivatives as acid secretion inhibitors
EP2076501B8 (en) Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
AU2006256778A8 (en) Polymorphs of ethyl 3-[(2-{[4-(hexyloxycarbonylamino-iminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate
WO2008110355A8 (en) Quinoline derivatives as fungicides
NO20061420L (no) 3-[(2-{4-Heksyloksykarbonylamino-Imino-metyl)-Fenylamino]-Metyl}-1-Metyl-1H-Benzimidazol-5-Karbonyl)-Pyridin-2-yl-Amino]-Propansyre Etylester Metansulfonat og
WO2009049716A3 (en) Novel fungicides
AU2008229327A8 (en) Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5- phenylimidazolone compounds as beta-secretase inhibitors
WO2007062314A3 (en) Heterocyclic cetp inhibitors
WO2008058118A3 (en) Preparation of montelukast and its salts
UA92354C2 (en) Amino acid salts of rosiglitazone
IL193670A0 (en) A new crystalline form g of (5s)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonyl-methyl]-5-methyl-imidazolidine-2,4-dione (i) and intermediates thereof
HK1134670A1 (en) Succinate salt of 2-((4-(1-methyl-4-(pyridin-4-yl)-1h-pyrazol-3-yl) phenoxy)methyl)quinoline 2-((4-(1--4-(-4-)-1h--3-)))
WO2008108309A1 (ja) 縮環ピリジン誘導体
WO2010049952A3 (en) A novel process for the preparation of eletriptan
WO2009116075A3 (en) Process for preparation of tazarotene
IL210923A0 (en) A crystalline form of 4-(5-{(ir)-1-[5-(3-chlorophenyl) isoxazol-3-yl]ethoxy}-4-methyl-4h-1,2,4,-triazol-3-yl)pyridine
AU2007905335A0 (en) A process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes
WO2008068593A3 (en) Motilide polymorphs
WO2009050595A3 (en) An improved process for preparing a 2,4-thiazolidinedione derivative
IL206613A0 (en) Process for the production of 4-(substituted phenyl) hexahydropyrido[2,1-c][1,4]oxazin-6-one

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880007023.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08740624

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008246798

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2009512922

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 4921/DELNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 200216

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2008740624

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008246798

Country of ref document: AU

Date of ref document: 20080418

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20097022312

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2685194

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE