ME02307B - Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr - Google Patents

Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr

Info

Publication number
ME02307B
ME02307B MEP-2015-198A MEP19815A ME02307B ME 02307 B ME02307 B ME 02307B ME P19815 A MEP19815 A ME P19815A ME 02307 B ME02307 B ME 02307B
Authority
ME
Montenegro
Prior art keywords
dichloropyrtdtn
indazol
ethoxy
crystalline
Prior art date
Application number
MEP-2015-198A
Other languages
English (en)
Inventor
Benjamin Alan Diseroad
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02307(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME02307B publication Critical patent/ME02307B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MEP-2015-198A 2010-10-05 2011-09-29 Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr ME02307B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38991110P 2010-10-05 2010-10-05
PCT/US2011/053798 WO2012047699A1 (en) 2010-10-05 2011-09-29 Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor
EP11771312.3A EP2625175B1 (en) 2010-10-05 2011-09-29 Crystalline (r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h-indazol-3-yl)vinyl)-1h-pyrazol-1-yl)ethanol and its use as fgfr inhibitor

Publications (1)

Publication Number Publication Date
ME02307B true ME02307B (me) 2016-06-20

Family

ID=44999860

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2015-198A ME02307B (me) 2010-10-05 2011-09-29 Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr

Country Status (35)

Country Link
US (1) US8530665B2 (me)
EP (1) EP2625175B1 (me)
JP (1) JP5940547B2 (me)
KR (1) KR101527661B1 (me)
CN (1) CN103153983B (me)
AR (1) AR083091A1 (me)
AU (1) AU2011312485B2 (me)
BR (1) BR112013006336A2 (me)
CA (1) CA2813329C (me)
CL (1) CL2013000884A1 (me)
CO (1) CO6710911A2 (me)
DK (1) DK2625175T3 (me)
DO (1) DOP2013000072A (me)
EA (1) EA021817B1 (me)
EC (1) ECSP13012539A (me)
ES (1) ES2558777T3 (me)
HK (1) HK1184147A1 (me)
HR (1) HRP20151299T1 (me)
HU (1) HUE026379T2 (me)
IL (1) IL224850A (me)
JO (1) JO3062B1 (me)
MA (1) MA34552B1 (me)
ME (1) ME02307B (me)
MX (1) MX2013003907A (me)
NZ (1) NZ608482A (me)
PE (1) PE20140252A1 (me)
PL (1) PL2625175T3 (me)
PT (1) PT2625175E (me)
RS (1) RS54457B1 (me)
SG (1) SG188286A1 (me)
SI (1) SI2625175T1 (me)
TW (1) TWI418554B (me)
UA (1) UA111725C2 (me)
WO (1) WO2012047699A1 (me)
ZA (1) ZA201301560B (me)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
KR102406771B1 (ko) 2012-06-13 2022-06-13 인사이트 홀딩스 코포레이션 Fgfr 억제제로서 치환된 트리사이클릭 화합물
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP3318564B1 (en) 2013-04-19 2021-07-28 Incyte Holdings Corporation Bicyclic heterocycles as fgfr inhibitors
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
ES2751669T3 (es) 2015-02-20 2020-04-01 Incyte Corp Heterociclos bicíclicos como inhibidores FGFR
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
DK3788047T3 (da) 2018-05-04 2024-09-16 Incyte Corp Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021076602A1 (en) 2019-10-14 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
CN115151539A (zh) 2019-12-04 2022-10-04 因赛特公司 Fgfr抑制剂的衍生物
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111705099B (zh) * 2020-07-01 2022-03-08 天津药明康德新药开发有限公司 一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法
US20240182487A1 (en) * 2020-12-17 2024-06-06 Blossomhill Therapeutics, Inc. Macrocycles and their use
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
SG129306A1 (en) * 2000-09-11 2007-02-26 Chiron Corp Quinolinone derivatives as tyrosine kinase inhibitors
AU2003241925A1 (en) 2002-05-31 2003-12-19 Eisai R&D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
JP2007529500A (ja) * 2004-03-17 2007-10-25 ファイザー・インク ２，５−ジメチル−２ｈ−ピラゾール−３−カルボン酸｛２−フルオロ−５−［３−（（ｅ）−２−ピリジン−２−イル−ビニル）−１ｈ−インダゾール−６−イルアミノ］−フェニル｝−アミドの多形及び非結晶形
JP4746299B2 (ja) * 2004-07-16 2011-08-10 ジュズ インターナショナル ピーティーイー エルティーディー 金属酸化物粉末の製造方法
JP2006163651A (ja) 2004-12-03 2006-06-22 Sony Computer Entertainment Inc 表示装置、表示装置の制御方法、プログラム及びフォントデータ
US20060160863A1 (en) * 2005-01-05 2006-07-20 Agouron Pharmaceuticals, Inc. Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
ES2634866T5 (es) * 2007-04-05 2024-03-04 Pfizer Prod Inc Formas cristalinas de 6-[2-(metilcarbamoil)fenilsulfanil]-3-[2-(piridin-2-il)etenil]indazol adecuadas para el tratamiento del crecimiento celular anormal en mamíferos
AR078411A1 (es) * 2009-05-07 2011-11-09 Lilly Co Eli Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende

Also Published As

Publication number Publication date
MX2013003907A (es) 2013-06-03
IL224850A (en) 2016-09-29
KR101527661B1 (ko) 2015-06-09
US8530665B2 (en) 2013-09-10
HRP20151299T1 (hr) 2016-01-01
EA021817B1 (ru) 2015-09-30
JO3062B1 (ar) 2017-03-15
PT2625175E (pt) 2016-01-22
EA201390275A1 (ru) 2013-07-30
JP5940547B2 (ja) 2016-06-29
EP2625175A1 (en) 2013-08-14
ES2558777T3 (es) 2016-02-08
CA2813329C (en) 2015-05-26
BR112013006336A2 (pt) 2019-09-24
AU2011312485A1 (en) 2013-03-07
ECSP13012539A (es) 2013-06-28
CN103153983B (zh) 2014-11-05
CN103153983A (zh) 2013-06-12
ZA201301560B (en) 2014-08-27
PL2625175T3 (pl) 2016-04-29
AR083091A1 (es) 2013-01-30
DOP2013000072A (es) 2013-08-15
CA2813329A1 (en) 2012-04-12
PE20140252A1 (es) 2014-03-12
DK2625175T3 (en) 2016-02-01
AU2011312485B2 (en) 2014-09-04
HK1184147A1 (en) 2014-01-17
TWI418554B (zh) 2013-12-11
CL2013000884A1 (es) 2013-10-18
JP2013538875A (ja) 2013-10-17
WO2012047699A1 (en) 2012-04-12
SI2625175T1 (sl) 2016-01-29
SG188286A1 (en) 2013-04-30
CO6710911A2 (es) 2013-07-15
TW201249826A (en) 2012-12-16
UA111725C2 (uk) 2016-06-10
EP2625175B1 (en) 2015-11-18
US20120083511A1 (en) 2012-04-05
NZ608482A (en) 2014-03-28
MA34552B1 (fr) 2013-09-02
RS54457B1 (en) 2016-06-30
KR20130052680A (ko) 2013-05-22
HUE026379T2 (en) 2016-06-28

Similar Documents

Publication Publication Date Title
ME02307B (me) Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr
IL269977B (en) Compounds 2-(1-isopropyl-pyrazol-5-yl)-3-(hydroxy/chloro)methyl pyridine
HK1226069A1 (zh) 3，5 -二氨基-6-氯-n-(n-(4 -(4 -(2 -(己基(2，3，4，5，6 -五羥基己基)氨基)乙氧基)苯基)丁基)甲脒基)吡嗪-2-甲醯胺
IL242279A0 (en) Compounds of 3-chloro-3]-n-(pyrimidine-2-ylamino)phenyl]substituted propanamide and their salts
IL229954A0 (en) Fungicidal mutated compounds of 1 – {2 – [2 – halo – 4 – (4 – halogen – phenoxy) – phenyl] – 2 – alkoxy – 2 – cyclyl – ethyl} – 1h [4,2,1]triazole
ZA201108541B (en) 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4yl)-1hpyrazol-1yl]octane-or heptane-nitrile as jak inhibitors
HK1206732A1 (en) Liquid formulations of salts of 1-[2-(2,4- dimethylphenylsulfanyl)pheny]piperazine 1-[2-(24-)]
ZA201003909B (en) Crystalline 2-(4-cyclopropanesulphonyl-phenyl)-n-pyrazin-2-yl-3-(tetrahydopyran-4-yl)-propionamide
DK2878598T3 (da) Krystallinsk form af 4-[5-(pyridin-4-yl)-1h-1,2,4-triazol-3-yl]pyridin-2-carbonitril
IL220851A (en) Process for the preparation of n - (2 - (2 - (4 - (2 - (7,6-dimethoxy-4,3-dihydro-iso-quinoline-2 - (1 h))) ethyl) phenyl) - h2 - tetrazole - 5-ram (5,4-dimethoxyphenyl) -4-oxo-h4-chromium-2-carboxamide methane-sulfonate, its intermediate and intermediate preparation process
PL2722046T3 (pl) Postać krystaliczna 1 2-((R)-2-metylopirolidyn-2-ylo)-1H-benzoimidazolo-4-karboksyamidu
SI2608789T1 (sl) Terapevtske uporabe 1-(2-(2,4-dimetil-fenilsulfanil) fenil) piperazina
TH132151A (th) ((r)-(e)-2-(4-(2-(5-(1-(3,5-ไดคลอโรไพริดิน-4-อิล)เอทธอกซี)-1h-อินดาซอล-3-อิล)ไวนิล)-1h-ไพราซอล-1-อิล)เอทธานอลเชิงผลึก
TH132151B (th) ((r)-(e)-2-(4-2-(5-(1-(3,5-ไดคลอโรไพริดิน-4-อิล)เอทธอกซี)-1 h-อินดาซอล-3- อิล)ไวนิล)-1 h-ไพราซอล-1-อิล)เอทธานอลเชิงผลึก
PL393335A1 (pl) Nowe E-1,2-bis{4-[(2-(1-oxo-alkilo)-3-oxo-alkilo]fenylo) eteny oraz sposób ich otrzymywania