ME02307B - Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr - Google Patents
Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfrInfo
- Publication number
- ME02307B ME02307B MEP-2015-198A MEP19815A ME02307B ME 02307 B ME02307 B ME 02307B ME P19815 A MEP19815 A ME P19815A ME 02307 B ME02307 B ME 02307B
- Authority
- ME
- Montenegro
- Prior art keywords
- compound according
- signal
- indazol
- ethoxy
- additionally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (7)
1. Spoj, naznačen time što je kristalni monohidrat ((R)-(E)-2-(4-(2-(5-(1-(3,5-dik l orpiridin-4-i l)etoksi)-1H-indazol-3-il)vin il )-1H-pirazol-1-il)etanola .
2. Spoj u skladu s patentnim za htjevom l , naznačen time što je izoliran.
3. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je spoj ima karakteristični uzorak difrakcije rendgenskih zraka na prahu (Cu zračenje, λ = l ,54059 A), koji sadrži signal na 1 4,65° (2Ɵ ± 0,1°).
4. Spoj u skladu s patentnim zahtjevom 3, naznačen time što dodatno ima signal na 3,54° (2Ɵ ± O, l°).
5. Spoj u skladu s patentnim zahtjevom 3 ili patentnim zahtjevom 4, naznačen time što dodatno ima signal na 12,51° (2Ɵ ± O, l°)
6. Spoj u skladu s bilo kojim od patentnih zahtjeva 3 do 5, naznačen time što dodatno ima signal na 19,16° (2Ɵ ± O, l°)
7. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s bilo kojim od prethodnih patentnih zahtjeva, u kombinaciji s farmaceutski prihvatljivom podlogom, razrjeđivačem ili pomoćnom tvari.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38991110P | 2010-10-05 | 2010-10-05 | |
| EP11771312.3A EP2625175B1 (en) | 2010-10-05 | 2011-09-29 | Crystalline (r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h-indazol-3-yl)vinyl)-1h-pyrazol-1-yl)ethanol and its use as fgfr inhibitor |
| PCT/US2011/053798 WO2012047699A1 (en) | 2010-10-05 | 2011-09-29 | Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02307B true ME02307B (me) | 2016-06-20 |
Family
ID=44999860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-198A ME02307B (me) | 2010-10-05 | 2011-09-29 | Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8530665B2 (me) |
| EP (1) | EP2625175B1 (me) |
| JP (1) | JP5940547B2 (me) |
| KR (1) | KR101527661B1 (me) |
| CN (1) | CN103153983B (me) |
| AR (1) | AR083091A1 (me) |
| AU (1) | AU2011312485B2 (me) |
| BR (1) | BR112013006336A2 (me) |
| CA (1) | CA2813329C (me) |
| CL (1) | CL2013000884A1 (me) |
| CO (1) | CO6710911A2 (me) |
| DK (1) | DK2625175T3 (me) |
| DO (1) | DOP2013000072A (me) |
| EA (1) | EA021817B1 (me) |
| EC (1) | ECSP13012539A (me) |
| ES (1) | ES2558777T3 (me) |
| HR (1) | HRP20151299T1 (me) |
| HU (1) | HUE026379T2 (me) |
| IL (1) | IL224850A (me) |
| JO (1) | JO3062B1 (me) |
| MA (1) | MA34552B1 (me) |
| ME (1) | ME02307B (me) |
| MX (1) | MX2013003907A (me) |
| NZ (1) | NZ608482A (me) |
| PE (1) | PE20140252A1 (me) |
| PH (1) | PH12013500649A1 (me) |
| PL (1) | PL2625175T3 (me) |
| PT (1) | PT2625175E (me) |
| RS (1) | RS54457B1 (me) |
| SG (1) | SG188286A1 (me) |
| SI (1) | SI2625175T1 (me) |
| TW (1) | TWI418554B (me) |
| UA (1) | UA111725C2 (me) |
| WO (1) | WO2012047699A1 (me) |
| ZA (1) | ZA201301560B (me) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19945982A1 (de) * | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| CN103819396B (zh) * | 2014-02-26 | 2016-06-15 | 四川大学 | 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| PH12022550892A1 (en) | 2019-10-14 | 2023-05-03 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN111705099B (zh) * | 2020-07-01 | 2022-03-08 | 天津药明康德新药开发有限公司 | 一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法 |
| AU2021401741A1 (en) * | 2020-12-17 | 2023-06-29 | Blossomhill Therapeutics, Inc. | Macrocycles and their use |
| CN116635076A (zh) * | 2020-12-17 | 2023-08-22 | 荣山医药股份有限公司 | 大环化合物及其用途 |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| KR100732206B1 (ko) * | 2000-09-11 | 2007-06-27 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 티로신 키나제 억제제로서의 퀴놀리논 유도체 |
| TW200406385A (en) | 2002-05-31 | 2004-05-01 | Eisai Co Ltd | Pyrazole compound and pharmaceutical composition containing the same |
| KR100816960B1 (ko) * | 2004-03-17 | 2008-03-25 | 화이자 인코포레이티드 | 2,5-디메틸-2ｈ-피라졸-3-카르복실산｛2-플루오로-5-[3-((ｅ)-2-피리딘-2-일-비닐)-1ｈ-인다졸-6-일아미노]-페닐｝-아미드의 다형성 및 무정질 형태 |
| JP4746299B2 (ja) * | 2004-07-16 | 2011-08-10 | ジュズ インターナショナル ピーティーイー エルティーディー | 金属酸化物粉末の製造方法 |
| JP2006163651A (ja) | 2004-12-03 | 2006-06-22 | Sony Computer Entertainment Inc | 表示装置、表示装置の制御方法、プログラム及びフォントデータ |
| US20060160863A1 (en) * | 2005-01-05 | 2006-07-20 | Agouron Pharmaceuticals, Inc. | Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide |
| WO2007058626A1 (en) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
| PT2134702T (pt) * | 2007-04-05 | 2017-07-31 | Pfizer Prod Inc | Formas cristalinas de 6-[2-(metilcarbamoil)fenilsulfanil]-3-e-[2-(piridin-2-il)etenil]indazol adequadas para o tratamento de crescimento celular anormal em mamíferos |
| JO2860B1 (en) * | 2009-05-07 | 2015-03-15 | ايلي ليلي اند كومباني | Phenylendazolyl compounds |
-
2011
- 2011-09-22 JO JOP/2011/0294A patent/JO3062B1/ar active
- 2011-09-23 TW TW100134428A patent/TWI418554B/zh not_active IP Right Cessation
- 2011-09-23 AR ARP110103482A patent/AR083091A1/es unknown
- 2011-09-29 ES ES11771312.3T patent/ES2558777T3/es active Active
- 2011-09-29 ME MEP-2015-198A patent/ME02307B/me unknown
- 2011-09-29 EA EA201390275A patent/EA021817B1/ru not_active IP Right Cessation
- 2011-09-29 DK DK11771312.3T patent/DK2625175T3/en active
- 2011-09-29 PH PH1/2013/500649A patent/PH12013500649A1/en unknown
- 2011-09-29 CN CN201180048148.7A patent/CN103153983B/zh not_active Expired - Fee Related
- 2011-09-29 NZ NZ608482A patent/NZ608482A/en not_active IP Right Cessation
- 2011-09-29 US US13/248,055 patent/US8530665B2/en not_active Expired - Fee Related
- 2011-09-29 PE PE2013000789A patent/PE20140252A1/es not_active Application Discontinuation
- 2011-09-29 BR BR112013006336A patent/BR112013006336A2/pt not_active IP Right Cessation
- 2011-09-29 JP JP2013532838A patent/JP5940547B2/ja not_active Expired - Fee Related
- 2011-09-29 SI SI201130673T patent/SI2625175T1/sl unknown
- 2011-09-29 HR HRP20151299TT patent/HRP20151299T1/hr unknown
- 2011-09-29 RS RS20150828A patent/RS54457B1/sr unknown
- 2011-09-29 PT PT117713123T patent/PT2625175E/pt unknown
- 2011-09-29 EP EP11771312.3A patent/EP2625175B1/en active Active
- 2011-09-29 AU AU2011312485A patent/AU2011312485B2/en not_active Ceased
- 2011-09-29 MX MX2013003907A patent/MX2013003907A/es active IP Right Grant
- 2011-09-29 UA UAA201303378A patent/UA111725C2/uk unknown
- 2011-09-29 WO PCT/US2011/053798 patent/WO2012047699A1/en not_active Ceased
- 2011-09-29 HU HUE11771312A patent/HUE026379T2/en unknown
- 2011-09-29 PL PL11771312T patent/PL2625175T3/pl unknown
- 2011-09-29 MA MA35780A patent/MA34552B1/fr unknown
- 2011-09-29 KR KR1020137008655A patent/KR101527661B1/ko not_active Expired - Fee Related
- 2011-09-29 CA CA2813329A patent/CA2813329C/en not_active Expired - Fee Related
- 2011-09-29 SG SG2013013743A patent/SG188286A1/en unknown
-
2013
- 2013-02-21 IL IL224850A patent/IL224850A/en not_active IP Right Cessation
- 2013-02-28 ZA ZA2013/01560A patent/ZA201301560B/en unknown
- 2013-04-02 DO DO2013000072A patent/DOP2013000072A/es unknown
- 2013-04-02 CL CL2013000884A patent/CL2013000884A1/es unknown
- 2013-04-03 EC ECSP13012539 patent/ECSP13012539A/es unknown
- 2013-04-08 CO CO13090555A patent/CO6710911A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02307B (me) | Kristalni (r)-(e)-2-(4-(2-(5-(1-(3,5-diklorpiridin-4-il)etoksi)-1h-indazol- 3-il)vinil)-1h-pirazol-1-il)etanol i njegova upotreba kao inhibitora fgfr | |
| NO2025029I1 (no) | Entrectinib or isomers, tautomers, or pharmaceutically acceptable salts therof - forlenget | |
| JP2013507408A5 (me) | ||
| CN109715626A (zh) | 作为fgfr抑制剂的杂环化合物 | |
| EP2632257A4 (en) | COMPOSITIONS FOR INHIBITING INSECT CONTROL | |
| JP2009536652A5 (me) | ||
| JP2015078230A5 (me) | ||
| PT3150198T (pt) | Composições farmacêuticas de ácido 3-(6-(1-(2,2 difluorobenzo[d][1,3]dioxol-5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il)benzóico e sua administração | |
| JP2012107057A5 (me) | ||
| JP2009537554A5 (me) | ||
| JP2009524695A5 (me) | ||
| IL223543A (en) | Pharmaceutical preparation containing 1– (4– (4– (4,3-dichloro-2 – fluorophenylamino) –7 – methoxyquinazoline – 6 – Iloxy) piperidine – 1 – il) Prof. 2 – an – 1 – on or a common pharmaceutical salt His and an acidic addition | |
| PL2054411T3 (pl) | Nowe związki, ich izomery lub ich farmaceutycznie dopuszczalne sole jako antagoniści receptora waniloidowego oraz zawierające je kompozycje farmaceutyczne | |
| CO6900161A2 (es) | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alcoxi-2-ciclil-etil}-1h-[1,2,4]triazol sustituidos | |
| CO6450624A2 (es) | Compuestos vinil indazolilo | |
| CO6900158A2 (es) | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-aluiniloxi-etil}-1h-[1,2,4]triazol sustituidos | |
| CO6900159A2 (es) | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alcoxi-3-metil-butil}-1h-[1,2,4]triazol sustituidos | |
| PH12014502363A1 (en) | N-aryltriazole compounds as lpar antagonists | |
| WO2011127290A3 (en) | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid | |
| JP2009502780A5 (me) | ||
| CO6900160A2 (es) | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alcoxi-2-alquinil/alquenil-etil}-1h-[1,2,4]triazol sustituidos | |
| PH12014502789A1 (en) | N-alkyltriazole compounds as lpar antagonists | |
| JP2009538861A5 (me) | ||
| GB0520751D0 (en) | Pharmaceutical compositions for the treatment of chronic obstructive pulmonary disease | |
| PH12012502216A1 (en) | Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienyl-methylbenzene derivatives as inhibitors of sglt |