ATE282590T1 - Benzamid-derivate zur behandlung cytokin- vermittelter krankheiten - Google Patents
Benzamid-derivate zur behandlung cytokin- vermittelter krankheitenInfo
- Publication number
- ATE282590T1 ATE282590T1 AT99922290T AT99922290T ATE282590T1 AT E282590 T1 ATE282590 T1 AT E282590T1 AT 99922290 T AT99922290 T AT 99922290T AT 99922290 T AT99922290 T AT 99922290T AT E282590 T1 ATE282590 T1 AT E282590T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- alkoxy
- alkyl
- halogeno
- heterocyclyl
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810357.5A GB9810357D0 (en) | 1998-05-15 | 1998-05-15 | Amide derivatives |
| GBGB9822483.5A GB9822483D0 (en) | 1998-10-16 | 1998-10-16 | Amide derivatives |
| PCT/GB1999/001489 WO1999059959A1 (en) | 1998-05-15 | 1999-05-11 | Benzamide derivatives for the treatment of diseases mediated by cytokines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE282590T1 true ATE282590T1 (de) | 2004-12-15 |
Family
ID=26313678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99922290T ATE282590T1 (de) | 1998-05-15 | 1999-05-11 | Benzamid-derivate zur behandlung cytokin- vermittelter krankheiten |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6579872B1 (de) |
| EP (1) | EP1077931B1 (de) |
| JP (1) | JP2002515476A (de) |
| KR (1) | KR100629186B1 (de) |
| CN (1) | CN1185211C (de) |
| AT (1) | ATE282590T1 (de) |
| AU (1) | AU749293B2 (de) |
| BR (1) | BR9910474A (de) |
| CA (1) | CA2328927C (de) |
| DE (1) | DE69921986T2 (de) |
| ES (1) | ES2232137T3 (de) |
| HU (1) | HUP0102295A3 (de) |
| ID (1) | ID26236A (de) |
| IL (1) | IL139711A0 (de) |
| NO (1) | NO20005767D0 (de) |
| NZ (1) | NZ507144A (de) |
| PL (1) | PL195600B1 (de) |
| PT (1) | PT1077931E (de) |
| RU (1) | RU2215736C2 (de) |
| SK (1) | SK286123B6 (de) |
| TR (1) | TR200003353T2 (de) |
| WO (1) | WO1999059959A1 (de) |
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| ATE282590T1 (de) * | 1998-05-15 | 2004-12-15 | Astrazeneca Ab | Benzamid-derivate zur behandlung cytokin- vermittelter krankheiten |
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| ES2230171T3 (es) | 1999-11-23 | 2005-05-01 | Smithkline Beecham Corporation | Compuestos 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p38 quinasa. |
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| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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| WO2003035626A2 (en) * | 2001-10-23 | 2003-05-01 | Applied Research Systems Ars Holding N.V. | Azole derivatives and pharmaceutical compositions containing them |
| GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
| JP4472349B2 (ja) * | 2002-02-12 | 2010-06-02 | スミスクライン ビーチャム コーポレーション | p38阻害薬として有用なニコチンアミド誘導体 |
| DE60332717D1 (de) | 2002-04-11 | 2010-07-08 | Boehringer Ingelheim Pharma | Heterocyclische amid-derivate als cytokin-inhibitoren |
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| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| GB0308201D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
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| WO2008142623A2 (en) * | 2007-05-17 | 2008-11-27 | Piramal Life Sciences Limited | Tumor necrosis factor - alpha inhibitors |
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| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| EP2867201A1 (de) * | 2012-06-28 | 2015-05-06 | Ramot at Tel-Aviv University Ltd. | Lim-kinaseinhibitoren |
| CN102746255A (zh) * | 2012-07-24 | 2012-10-24 | 安徽中医学院 | 具有抗肿瘤活性的化合物、制备方法及应用 |
| US9718816B2 (en) | 2013-03-15 | 2017-08-01 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof |
| KR20160003647A (ko) | 2013-03-15 | 2016-01-11 | 에피자임, 인코포레이티드 | Carm1 억제제 및 이의 용도 |
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| EA202091763A1 (ru) | 2018-01-31 | 2020-12-14 | ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Комбинированная терапия для лечения мастоцитоза |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| WO2020117877A1 (en) * | 2018-12-04 | 2020-06-11 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use |
| EP3938363A1 (de) | 2019-03-11 | 2022-01-19 | Teva Pharmaceuticals International GmbH | Festkörperformen von ripretinib |
| JP7818502B2 (ja) | 2019-08-12 | 2026-02-20 | デシフェラ・ファーマシューティカルズ,エルエルシー | 胃腸間質腫瘍を治療するためのリプレチニブ |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
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-
1999
- 1999-05-11 AT AT99922290T patent/ATE282590T1/de not_active IP Right Cessation
- 1999-05-11 KR KR1020007012813A patent/KR100629186B1/ko not_active Expired - Fee Related
- 1999-05-11 NZ NZ507144A patent/NZ507144A/xx unknown
- 1999-05-11 BR BR9910474-1A patent/BR9910474A/pt not_active Application Discontinuation
- 1999-05-11 AU AU39399/99A patent/AU749293B2/en not_active Ceased
- 1999-05-11 TR TR2000/03353T patent/TR200003353T2/xx unknown
- 1999-05-11 ID IDW20002326A patent/ID26236A/id unknown
- 1999-05-11 PL PL99344164A patent/PL195600B1/pl not_active IP Right Cessation
- 1999-05-11 PT PT99922290T patent/PT1077931E/pt unknown
- 1999-05-11 HU HU0102295A patent/HUP0102295A3/hu unknown
- 1999-05-11 CA CA002328927A patent/CA2328927C/en not_active Expired - Fee Related
- 1999-05-11 JP JP2000549578A patent/JP2002515476A/ja not_active Withdrawn
- 1999-05-11 DE DE69921986T patent/DE69921986T2/de not_active Expired - Fee Related
- 1999-05-11 SK SK1718-2000A patent/SK286123B6/sk not_active IP Right Cessation
- 1999-05-11 WO PCT/GB1999/001489 patent/WO1999059959A1/en not_active Ceased
- 1999-05-11 CN CNB998061433A patent/CN1185211C/zh not_active Expired - Fee Related
- 1999-05-11 US US09/674,560 patent/US6579872B1/en not_active Expired - Fee Related
- 1999-05-11 IL IL13971199A patent/IL139711A0/xx not_active IP Right Cessation
- 1999-05-11 RU RU2000131611/04A patent/RU2215736C2/ru not_active IP Right Cessation
- 1999-05-11 EP EP99922290A patent/EP1077931B1/de not_active Expired - Lifetime
- 1999-05-11 ES ES99922290T patent/ES2232137T3/es not_active Expired - Lifetime
-
2000
- 2000-11-14 NO NO20005767A patent/NO20005767D0/no unknown
-
2003
- 2003-04-28 US US10/424,127 patent/US6956037B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1185211C (zh) | 2005-01-19 |
| PT1077931E (pt) | 2005-03-31 |
| TR200003353T2 (tr) | 2001-04-20 |
| EP1077931B1 (de) | 2004-11-17 |
| KR20010034858A (ko) | 2001-04-25 |
| NZ507144A (en) | 2002-10-25 |
| WO1999059959A1 (en) | 1999-11-25 |
| AU749293B2 (en) | 2002-06-20 |
| RU2215736C2 (ru) | 2003-11-10 |
| NO20005767L (no) | 2000-11-14 |
| EP1077931A1 (de) | 2001-02-28 |
| HK1033754A1 (en) | 2001-09-21 |
| HUP0102295A2 (hu) | 2001-11-28 |
| SK17182000A3 (sk) | 2001-05-10 |
| IL139711A0 (en) | 2002-02-10 |
| BR9910474A (pt) | 2001-01-02 |
| PL344164A1 (en) | 2001-10-08 |
| PL195600B1 (pl) | 2007-10-31 |
| HUP0102295A3 (en) | 2002-11-28 |
| US6956037B2 (en) | 2005-10-18 |
| CN1300278A (zh) | 2001-06-20 |
| ES2232137T3 (es) | 2005-05-16 |
| AU3939999A (en) | 1999-12-06 |
| ID26236A (id) | 2000-12-07 |
| CA2328927A1 (en) | 1999-11-25 |
| NO20005767D0 (no) | 2000-11-14 |
| DE69921986D1 (de) | 2004-12-23 |
| DE69921986T2 (de) | 2005-12-22 |
| CA2328927C (en) | 2008-02-19 |
| SK286123B6 (sk) | 2008-04-07 |
| US6579872B1 (en) | 2003-06-17 |
| KR100629186B1 (ko) | 2006-09-28 |
| JP2002515476A (ja) | 2002-05-28 |
| US20030212068A1 (en) | 2003-11-13 |
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