DE60315146D1 - Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase - Google Patents
Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinaseInfo
- Publication number
- DE60315146D1 DE60315146D1 DE60315146T DE60315146T DE60315146D1 DE 60315146 D1 DE60315146 D1 DE 60315146D1 DE 60315146 T DE60315146 T DE 60315146T DE 60315146 T DE60315146 T DE 60315146T DE 60315146 D1 DE60315146 D1 DE 60315146D1
- Authority
- DE
- Germany
- Prior art keywords
- kinase
- inhibitors
- heteroarylsubstituted
- biphenyl derivatives
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0209891 | 2002-04-30 | ||
GBGB0209891.1A GB0209891D0 (en) | 2002-04-30 | 2002-04-30 | Novel compounds |
PCT/GB2003/001834 WO2003093248A1 (en) | 2002-04-30 | 2003-04-29 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60315146D1 true DE60315146D1 (de) | 2007-09-06 |
DE60315146T2 DE60315146T2 (de) | 2008-04-17 |
Family
ID=9935812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60315146T Expired - Lifetime DE60315146T2 (de) | 2002-04-30 | 2003-04-29 | Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase |
Country Status (9)
Country | Link |
---|---|
US (1) | US7425555B2 (de) |
EP (1) | EP1499600B1 (de) |
JP (1) | JP2005535586A (de) |
AT (1) | ATE368034T1 (de) |
AU (1) | AU2003226572A1 (de) |
DE (1) | DE60315146T2 (de) |
ES (1) | ES2290486T3 (de) |
GB (1) | GB0209891D0 (de) |
WO (1) | WO2003093248A1 (de) |
Families Citing this family (41)
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GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
NZ533865A (en) * | 2002-02-12 | 2006-02-24 | Smithkline Beecham Corp | Nicotinamide derivates useful as p38 inhibitors |
GB0209891D0 (en) | 2002-04-30 | 2002-06-05 | Glaxo Group Ltd | Novel compounds |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
ATE482205T1 (de) | 2003-07-25 | 2010-10-15 | Novartis Ag | P-38-kinasehemmer |
GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
GB0402140D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402138D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402137D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
US7683097B2 (en) * | 2004-05-27 | 2010-03-23 | Propharmacon Inc. | Topoisomerase inhibitors |
US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
WO2006044975A2 (en) * | 2004-10-19 | 2006-04-27 | Compass Pharmaceuticals Llc | Compositions and their use as anti-tumor agents |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
CN101184734B (zh) | 2004-12-28 | 2013-05-29 | 金克斯医药品有限公司 | 治疗细胞增殖紊乱的化合物和方法 |
GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
PT1940786E (pt) * | 2005-09-16 | 2010-10-04 | Arrow Therapeutics Ltd | Derivados de bifenilo e sua utilização no tratamento de hepatite c |
GB0612026D0 (en) | 2006-06-16 | 2006-07-26 | Smithkline Beecham Corp | New use |
AU2007265373B2 (en) | 2006-06-29 | 2013-02-21 | Atnx Spv, Llc | Biaryl compositions and methods for modulating a kinase cascade |
AU2007281774A1 (en) | 2006-08-04 | 2008-02-14 | Astrazeneca Ab | Human antibodies to ErbB 2 |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
US20100278776A1 (en) * | 2007-10-20 | 2010-11-04 | Kinex Pharmaceuticals, Llc | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為vap-1抑制劑之用途 |
EP2307012A1 (de) * | 2008-07-04 | 2011-04-13 | Institut National De La Sante Et De La Recherche Medicale | Stickstoff-heterozyklus-derivate als proteasom-modulatoren |
EP2558085B1 (de) | 2010-04-16 | 2017-08-30 | Athenex, Inc. | Zusammensetzungen und verfahren zur prävention und behandlung von krebs |
EP2651915B1 (de) | 2010-12-17 | 2016-05-25 | Mitsubishi Tanabe Pharma Corporation | Durchgehend arycyclische verbindung |
WO2013187496A1 (ja) | 2012-06-15 | 2013-12-19 | 田辺三菱製薬株式会社 | 芳香族複素環化合物 |
HUE037637T2 (hu) | 2012-08-30 | 2018-09-28 | Athenex Inc | N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-IL) acetamid, mint fehérje tirozin kináz modulátorok |
JP6424173B2 (ja) | 2013-02-04 | 2018-11-14 | ヤンセン ファーマシューティカ エヌ.ベー. | Flap調節因子 |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
BR112020006677A2 (pt) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | uso de inibidores p38 para reduzir a expressão de dux4 |
CA3094324A1 (en) | 2018-03-26 | 2019-10-03 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
Family Cites Families (17)
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TW240217B (de) * | 1992-12-30 | 1995-02-11 | Glaxo Group Ltd | |
JPH09506101A (ja) * | 1993-12-07 | 1997-06-17 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht1d拮抗薬として有用な複素環式ビフェニリルアミド類 |
ATE224878T1 (de) * | 1996-11-04 | 2002-10-15 | Aventis Cropscience Sa | 1-polyarylpyrazole als pestizide |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124932D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124928D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
NZ533865A (en) | 2002-02-12 | 2006-02-24 | Smithkline Beecham Corp | Nicotinamide derivates useful as p38 inhibitors |
GB0209891D0 (en) | 2002-04-30 | 2002-06-05 | Glaxo Group Ltd | Novel compounds |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
-
2002
- 2002-04-30 GB GBGB0209891.1A patent/GB0209891D0/en not_active Ceased
-
2003
- 2003-04-29 AT AT03747504T patent/ATE368034T1/de not_active IP Right Cessation
- 2003-04-29 JP JP2004501387A patent/JP2005535586A/ja active Pending
- 2003-04-29 US US10/513,095 patent/US7425555B2/en not_active Expired - Fee Related
- 2003-04-29 WO PCT/GB2003/001834 patent/WO2003093248A1/en active IP Right Grant
- 2003-04-29 AU AU2003226572A patent/AU2003226572A1/en not_active Abandoned
- 2003-04-29 DE DE60315146T patent/DE60315146T2/de not_active Expired - Lifetime
- 2003-04-29 EP EP03747504A patent/EP1499600B1/de not_active Expired - Lifetime
- 2003-04-29 ES ES03747504T patent/ES2290486T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20060089393A1 (en) | 2006-04-27 |
WO2003093248A1 (en) | 2003-11-13 |
EP1499600A1 (de) | 2005-01-26 |
DE60315146T2 (de) | 2008-04-17 |
GB0209891D0 (en) | 2002-06-05 |
JP2005535586A (ja) | 2005-11-24 |
ES2290486T3 (es) | 2008-02-16 |
EP1499600B1 (de) | 2007-07-25 |
US7425555B2 (en) | 2008-09-16 |
AU2003226572A1 (en) | 2003-11-17 |
ATE368034T1 (de) | 2007-08-15 |
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