AR100807A1 - Inhibidores de fosfatidilinositol 3-quinasa - Google Patents

Inhibidores de fosfatidilinositol 3-quinasa

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Publication number
AR100807A1
AR100807A1 ARP150101857A ARP150101857A AR100807A1 AR 100807 A1 AR100807 A1 AR 100807A1 AR P150101857 A ARP150101857 A AR P150101857A AR P150101857 A ARP150101857 A AR P150101857A AR 100807 A1 AR100807 A1 AR 100807A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
hydrogen
alkyl
haloalkyl
alkoxy
Prior art date
Application number
ARP150101857A
Other languages
English (en)
Inventor
Chung Yeung Suet
j watkins William
Van Veldhuizen Joshua
A Treiberg Jennifer
L Stevens Kirk
Phillips Gary
W Phillips Barton
Perreault Stephane
Patel Leena
Naduthambi Devan
Kim Musong
Kaplan Joshua
Evarts Jerry
Du Zhimin
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR100807A1 publication Critical patent/AR100807A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Reivindicación 1: Un compuesto caracterizado porque tiene la estructura de fórmula (1), en donde: n es 0, 1, 2, 3, ó 4; m es 0, 1, 2, 3, ó 4; q es 0 ó 1; W¹ y W² son independientemente C(Rʷ) o N; W³ es CH₂ o NH; Rʷ es hidrógeno, halo, o alquilo opcionalmente sustituido; A es NR⁵R⁴, OR⁴, o NR⁵C(O)R⁴; cada R¹ es independientemente halo, ciano, alquilo opcionalmente sustituido, haloalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, hidroxi, sulfonilo opcionalmente sustituido, arilo opcionalmente sustituido, alquenilo opcionalmente sustituido heteroarilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, o heterocicloalquilo opcionalmente sustituido, cada R² es independientemente halo, ciano, alquilo opcionalmente sustituido, haloalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, o sulfonilo opcionalmente sustituido; R³ es hidrógeno, alquilo opcionalmente sustituido, haloalquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, o arilo opcionalmente sustituido; R⁴ es heteroarilo opcionalmente sustituido con uno, dos o tres miembros seleccionados independientemente de halo, nitro, carboxi, ciano, alquilo opcionalmente sustituido, -NH₂, o alquinilo opcionalmente sustituido; R⁵ es hidrógeno o alquilo opcionalmente sustituido, en donde R⁵ y R³ junto con los átomos a los cuales están unidos forman opcionalmente un anillo heterocíclico opcionalmente sustituido; R⁶ es hidrógeno, alquilo opcionalmente sustituido, heteroalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, haloalquilo opcionalmente sustituido, sulfonilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterocicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, o heteroarilo opcionalmente sustituido; y R⁷ es hidrógeno; o una sal, isómero, o una mezcla de los mismos, farmacéuticamente aceptables.
ARP150101857A 2014-06-13 2015-06-11 Inhibidores de fosfatidilinositol 3-quinasa AR100807A1 (es)

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US201462011977P 2014-06-13 2014-06-13

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AR100807A1 true AR100807A1 (es) 2016-11-02

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Country Status (17)

Country Link
US (1) US10221197B2 (es)
EP (1) EP3154969B1 (es)
JP (1) JP2017522274A (es)
KR (1) KR20170010063A (es)
CN (1) CN106660994A (es)
AR (1) AR100807A1 (es)
AU (1) AU2015274628B2 (es)
BR (1) BR112016028819A2 (es)
CA (1) CA2952025A1 (es)
EA (1) EA201692267A1 (es)
ES (1) ES2763103T3 (es)
IL (1) IL248895A0 (es)
MX (1) MX2016016528A (es)
NZ (1) NZ726052A (es)
SG (1) SG11201609540TA (es)
TW (1) TW201613895A (es)
WO (1) WO2015191745A1 (es)

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WO2015191745A1 (en) 2015-12-17
EA201692267A1 (ru) 2017-06-30
TW201613895A (en) 2016-04-16
MX2016016528A (es) 2017-03-27
JP2017522274A (ja) 2017-08-10
EP3154969A1 (en) 2017-04-19
EP3154969B1 (en) 2019-10-09
AU2015274628B2 (en) 2018-03-15
SG11201609540TA (en) 2016-12-29
KR20170010063A (ko) 2017-01-25
US10221197B2 (en) 2019-03-05
ES2763103T3 (es) 2020-05-27
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CA2952025A1 (en) 2015-12-17
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