CY1107034T1 - ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ Ν-ΜΟΝΟΫΠΟΚΑΤΕΣΤΗΜΕΝΩΝ β-ΑΜΙΝΟ ΑΛΚΟΟΛΩΝ - Google Patents

ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ Ν-ΜΟΝΟΫΠΟΚΑΤΕΣΤΗΜΕΝΩΝ β-ΑΜΙΝΟ ΑΛΚΟΟΛΩΝ

Info

Publication number
CY1107034T1
CY1107034T1 CY20071101554T CY071101554T CY1107034T1 CY 1107034 T1 CY1107034 T1 CY 1107034T1 CY 20071101554 T CY20071101554 T CY 20071101554T CY 071101554 T CY071101554 T CY 071101554T CY 1107034 T1 CY1107034 T1 CY 1107034T1
Authority
CY
Cyprus
Prior art keywords
mono
alcohols
preparation
bated
substituted
Prior art date
Application number
CY20071101554T
Other languages
English (en)
Inventor
Dominique Michel
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34524485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1107034(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of CY1107034T1 publication Critical patent/CY1107034T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση σχετίζεται με μια μέθοδο σύνθεσης Ν-μονοϋποκατεστημένων β-αμινο αλκοολών του τύπου (Ι) και/ή ενός άλατος προσθήκης ενός πρωτονιακού οξέος, όπου τα R1 και R2 ανεξάρτητα μεταξύ τους αντιπροσωπεύουν αλκυλο, κυκλοαλκυλο, αρυλο ή αραλκυλο, το καθένα από τα οποία είναι προαιρετικώς επιπλέον υποκατεστημένο με αλκυλο, αλκοξυ και/ή αλογόνο μέσω άμεσης παρασκευής Ν-μονοϋποκατεστημένων β-αμινο κετονών του τύπου και των αλάτων προσθήκης πρωτονιακών οξέων του, όπου τα R1 και R2 είναι όπως ορίζονται παραπάνω
CY20071101554T 2002-07-09 2007-12-06 ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ Ν-ΜΟΝΟΫΠΟΚΑΤΕΣΤΗΜΕΝΩΝ β-ΑΜΙΝΟ ΑΛΚΟΟΛΩΝ CY1107034T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02015229 2002-07-09
EP03762669A EP1539673B1 (en) 2002-07-09 2003-07-09 Process for the preparation of n -monosubstituted beta-amino alcohols

Publications (1)

Publication Number Publication Date
CY1107034T1 true CY1107034T1 (el) 2012-10-24

Family

ID=34524485

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101554T CY1107034T1 (el) 2002-07-09 2007-12-06 ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ Ν-ΜΟΝΟΫΠΟΚΑΤΕΣΤΗΜΕΝΩΝ β-ΑΜΙΝΟ ΑΛΚΟΟΛΩΝ

Country Status (5)

Country Link
US (1) US20050256318A1 (el)
EP (2) EP1539673B1 (el)
CY (1) CY1107034T1 (el)
DK (1) DK1852415T3 (el)
SI (1) SI1539673T1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240026A1 (de) * 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8426178B2 (en) 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3031248A1 (de) * 1980-08-19 1982-04-01 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US4948813A (en) * 1987-11-30 1990-08-14 E. I. Du Pont De Nemours And Company Benzylketone phospholipase A2 inhibitors
CA2042346A1 (en) * 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis

Also Published As

Publication number Publication date
DK1852415T3 (da) 2010-01-25
EP1852415B1 (en) 2009-10-07
EP1852415A1 (en) 2007-11-07
SI1539673T1 (sl) 2008-02-29
EP1539673A1 (en) 2005-06-15
EP1539673B1 (en) 2007-10-03
US20050256318A1 (en) 2005-11-17

Similar Documents

Publication Publication Date Title
CY1107034T1 (el) ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ Ν-ΜΟΝΟΫΠΟΚΑΤΕΣΤΗΜΕΝΩΝ β-ΑΜΙΝΟ ΑΛΚΟΟΛΩΝ
CY1111528T1 (el) 1-αζα-δικυκλο [3.3.1] εννεανια
CY1124357T1 (el) Προσδιορισμος ανισορροπιας αλληλουχιας νουκλεϊκων οξεων
CY1114452T1 (el) Ενωσεις πυρρολιου
CY1108313T1 (el) Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
CY1123670T1 (el) Κρυσταλλικο παραγωγο 6,7-ακορεστης-7-καρβαμοϋλ μορφινανης, και μεθοδος για την παραγωγη αυτου
CY1116119T1 (el) Παραγωγα ισοξαζολο-πυριδινης
CY1111308T1 (el) Παρασκευη εσλικαρβαζεπινης και σχετικων ενωσεων με ασυμμετρη υδρογονωση
CY1109225T1 (el) ΠΑΡΑΓΩΓΑ ΜΗΛΟΝΑΜΙΔΙΟΥ ΤΑ ΟΠΟΙΑ ΠΑΡΕΜΠΟΔΙΖΟΥΝ ΤΗ ΔΡΑΣΗ ΤΗΣ γ-ΣΕΚΡΕΤΑΣΗΣ
CY1116540T1 (el) Μεθοδος παραγωγης 2'-δεοξυ-5-αζακυτιδινης (δεσιταβινη)
EA201070874A1 (ru) Производные индол-2-карбоксамидов и азаиндол-2-карбоксамидов, замещённых силанильной группой, их получение и применение в терапии
IL176075A0 (en) Process for fluorocytidine derivatives
NO331165B1 (no) Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme for fremstilling av medikamenter
CY1111980T1 (el) Παραγωγα του αμιδιου τα οποια φερουν ενα υποκαταστατο του κυκλοπροπυλαμινοκαρβονυλιου και χρησιμευουν ως αναστολεις κυτταροκινης
CY1113246T1 (el) Μεθοδος παραγωγης ενωσεων αμινοφαινολης
EA201071012A1 (ru) Производные азетидинов, способ их получения и применение их в терапии
CY1119040T1 (el) Μεθοδος για την παρασκευη 1-([1,3]διοξολαν-4-υλομεθυλο)-1η-πυραζολ-3-υλαμινης
CY1111748T1 (el) Παραγωγα 7-αλκυνυλο-1.8-ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη
CY1124948T1 (el) Συνθεσεις με αντικαρκινικη δραση
RU2014129937A (ru) Способы и промежуточные соединения для получения фармацевтических агентов
NO20062936L (no) Fremgangsmate for fremstilling av N-alkyl-2(hydroksy-4-benzoyl)-3-benzofuraner og dets mellomprodukter derav
PT1246812E (pt) Metodo para a preparacao de citalopram
ATE343385T1 (de) Verfahren zur herstellung von donepezil
MX2022002362A (es) Derivado de 2-aminoquinazolinona.
HUP0300154A2 (en) Method for the production of spirocyclic tetronic acid derivatives