CY1113246T1 - Μεθοδος παραγωγης ενωσεων αμινοφαινολης - Google Patents
Μεθοδος παραγωγης ενωσεων αμινοφαινοληςInfo
- Publication number
- CY1113246T1 CY1113246T1 CY20121100991T CY121100991T CY1113246T1 CY 1113246 T1 CY1113246 T1 CY 1113246T1 CY 20121100991 T CY20121100991 T CY 20121100991T CY 121100991 T CY121100991 T CY 121100991T CY 1113246 T1 CY1113246 T1 CY 1113246T1
- Authority
- CY
- Cyprus
- Prior art keywords
- substituted
- group
- formula
- compound represented
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μια βιομηχανικώς πλεονεκτική μέθοδο παραγωγής ενώσεων αμινοφαινόλης που παριστάνονται με τον τύπο (1) με μια απλή και εύκολη διαδικασία σε υψηλή απόδοση και υψηλή καθαρότητα. Η παρούσα εφεύρεση παρέχει μια μέθοδο παραγωγής μιας ένωσης αμινοφαινόλης που παριστάνεται με τον τύπο (1): (όπου καθένα από τα R1 και R2, τα οποία μπορεί να είναι τα ίδια ή διαφορετικά, είναι ένα άτομο υδρογόνου, μια υποκατεστημένη ή μη υποκατεστημένη κατώτερη αλκυλο ομάδα ή τα παρόμοια· τα R1 και R2, λαμβανόμενα μαζί με το γειτονικό άτομο αζώτου, μπορεί να σχηματίσουν έναν 5- ή 6-μελή ετεροκυκλικό δακτύλιο με ή χωρίς άλλα παρεμβαλλόμενα ετεροάτομα· ο ετεροκυκλικός δακτύλιος μπορεί να είναι υποκατεστημένος με 1 έως 3 υποκατάστατες επιλεγμένους από την ομάδα που περιλαμβάνει μια υδροξυλο ομάδα, μια υποκατεστημένη ή μη υποκατεστημένη κατώτερη αλκυλο ομάδα, μια υποκατεστημένη ή μη υποκατεστημένη αρυλο ομάδα, μια υποκατεστημένη ή μη υποκατεστημένη αρυλοξυ ομάδα και τα παρόμοια· και η υδροξυλο ομάδα στον τύπο (1) είναι υποκατεστημένη στη θέση 2 ή 4 στην αμινο ομάδα επί του δακτυλίου φαινυλίου), η οποία επιτρέπει σε μια ένωση κυκλοεξανοδιόνης που παριστάνεται με τον τύπο (2) να αντιδράσει με μια ένωση αμίνης που παριστάνεται με τον τύπο (3) (όπου τα R1 και R2 είναι όπως ορίστηκαν παραπάνω), υπό μια ουδέτερη ή βασική συνθήκη.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004089652 | 2004-03-25 | ||
| EP05727512A EP1727782B1 (en) | 2004-03-25 | 2005-03-25 | Method of producing aminophenol compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113246T1 true CY1113246T1 (el) | 2016-04-13 |
Family
ID=34962553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100991T CY1113246T1 (el) | 2004-03-25 | 2012-10-23 | Μεθοδος παραγωγης ενωσεων αμινοφαινολης |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7750156B2 (el) |
| EP (1) | EP1727782B1 (el) |
| KR (1) | KR100766763B1 (el) |
| CN (1) | CN100478325C (el) |
| AR (1) | AR048043A1 (el) |
| AU (1) | AU2005226409B2 (el) |
| BR (1) | BRPI0509095B1 (el) |
| CA (1) | CA2559488C (el) |
| CY (1) | CY1113246T1 (el) |
| DK (1) | DK1727782T3 (el) |
| EG (1) | EG25686A (el) |
| ES (1) | ES2390079T3 (el) |
| HK (1) | HK1097823A1 (el) |
| MY (1) | MY143665A (el) |
| PL (1) | PL1727782T3 (el) |
| PT (1) | PT1727782E (el) |
| RU (1) | RU2376280C2 (el) |
| SI (1) | SI1727782T1 (el) |
| TW (1) | TWI380975B (el) |
| UA (1) | UA87301C2 (el) |
| WO (1) | WO2005092832A1 (el) |
| ZA (1) | ZA200607640B (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201434467A (zh) * | 2005-10-05 | 2014-09-16 | Otsuka Pharma Co Ltd | 抗結核治療藥物及含彼之套組 |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| DE102008053240A1 (de) | 2008-10-25 | 2010-04-29 | Saltigo Gmbh | Herstellung von (N-Heterozyklyl)-Arylethern |
| EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
| FR2995895B1 (fr) * | 2012-09-25 | 2015-01-30 | Fonds De Dev Des Filieres Des Oleagineux Et Proteagineux Fidop | Procede de synthese d'un compose aromatique |
| CN107406386B (zh) | 2015-03-27 | 2021-06-01 | 大塚制药株式会社 | 用于生产1-(4-羟基苯基)-4-(4-三氟甲氧基苯氧基)哌啶或其盐的方法 |
| CN106699635B (zh) * | 2015-11-12 | 2019-10-22 | 北京福元医药股份有限公司 | 一种制备Delamanid中间体的方法 |
| CN106938974A (zh) * | 2017-03-24 | 2017-07-11 | 连云港恒贸化工有限公司 | 一种一锅法生产间二乙氨基苯酚的方法 |
| CN110041334B (zh) * | 2018-01-15 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种氨基苯酚类化合物的制备方法 |
| CN109705022A (zh) * | 2018-12-28 | 2019-05-03 | 上海彩迩文生化科技有限公司 | 一种芳香胺中间体的制备方法 |
| CN110803996B (zh) * | 2019-11-13 | 2022-01-11 | 台州市创源工业技术有限公司 | 一种羟基苄胺的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2402695C3 (de) * | 1974-01-21 | 1980-05-29 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von 3-Aminophenolen |
| JPS6229557A (ja) | 1985-07-29 | 1987-02-07 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| US5202488A (en) * | 1991-04-15 | 1993-04-13 | E. I. Du Pont De Nemours And Company | Method for the manufacture of 3-aminophenol |
| US7157458B2 (en) | 2001-04-17 | 2007-01-02 | Cryolife, Inc. | Bifunctional energy-reversible acyl-compositions |
-
2005
- 2005-03-04 TW TW094106689A patent/TWI380975B/zh not_active IP Right Cessation
- 2005-03-12 MY MYPI20051053A patent/MY143665A/en unknown
- 2005-03-21 AR ARP050101090A patent/AR048043A1/es active IP Right Grant
- 2005-03-25 SI SI200531617T patent/SI1727782T1/sl unknown
- 2005-03-25 CA CA2559488A patent/CA2559488C/en not_active Expired - Fee Related
- 2005-03-25 WO PCT/JP2005/006408 patent/WO2005092832A1/en active Application Filing
- 2005-03-25 PL PL05727512T patent/PL1727782T3/pl unknown
- 2005-03-25 DK DK05727512.5T patent/DK1727782T3/da active
- 2005-03-25 EP EP05727512A patent/EP1727782B1/en not_active Not-in-force
- 2005-03-25 BR BRPI0509095-4A patent/BRPI0509095B1/pt not_active IP Right Cessation
- 2005-03-25 RU RU2006137563/04A patent/RU2376280C2/ru not_active IP Right Cessation
- 2005-03-25 UA UAA200611248A patent/UA87301C2/ru unknown
- 2005-03-25 CN CNB2005800096535A patent/CN100478325C/zh not_active Expired - Fee Related
- 2005-03-25 US US10/593,968 patent/US7750156B2/en not_active Expired - Fee Related
- 2005-03-25 ES ES05727512T patent/ES2390079T3/es active Active
- 2005-03-25 AU AU2005226409A patent/AU2005226409B2/en not_active Ceased
- 2005-03-25 ZA ZA200607640A patent/ZA200607640B/en unknown
- 2005-03-25 KR KR1020067019609A patent/KR100766763B1/ko not_active IP Right Cessation
- 2005-03-25 PT PT05727512T patent/PT1727782E/pt unknown
-
2006
- 2006-09-04 EG EGNA2006000821 patent/EG25686A/xx active
-
2007
- 2007-04-24 HK HK07104267A patent/HK1097823A1/xx not_active IP Right Cessation
-
2012
- 2012-10-23 CY CY20121100991T patent/CY1113246T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI380975B (zh) | 2013-01-01 |
| BRPI0509095B1 (pt) | 2014-09-16 |
| AU2005226409B2 (en) | 2008-04-17 |
| US7750156B2 (en) | 2010-07-06 |
| TW200531958A (en) | 2005-10-01 |
| MY143665A (en) | 2011-06-30 |
| EP1727782B1 (en) | 2012-08-22 |
| WO2005092832A1 (en) | 2005-10-06 |
| CA2559488A1 (en) | 2005-10-06 |
| RU2006137563A (ru) | 2008-04-27 |
| PL1727782T3 (pl) | 2013-01-31 |
| RU2376280C2 (ru) | 2009-12-20 |
| CN100478325C (zh) | 2009-04-15 |
| AU2005226409A1 (en) | 2005-10-06 |
| US20070219374A1 (en) | 2007-09-20 |
| KR20060123650A (ko) | 2006-12-01 |
| BRPI0509095A (pt) | 2007-08-28 |
| EG25686A (en) | 2012-05-17 |
| ZA200607640B (en) | 2008-05-28 |
| EP1727782A1 (en) | 2006-12-06 |
| KR100766763B1 (ko) | 2007-10-17 |
| AR048043A1 (es) | 2006-03-22 |
| DK1727782T3 (da) | 2012-10-08 |
| SI1727782T1 (sl) | 2012-12-31 |
| CA2559488C (en) | 2012-06-12 |
| HK1097823A1 (en) | 2007-07-06 |
| ES2390079T3 (es) | 2012-11-06 |
| UA87301C2 (ru) | 2009-07-10 |
| CN1938261A (zh) | 2007-03-28 |
| PT1727782E (pt) | 2012-08-30 |
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