NO20053928L - Fremgangsmate for a fremstille ondansetron og intermediater derav. - Google Patents

Fremgangsmate for a fremstille ondansetron og intermediater derav.

Info

Publication number
NO20053928L
NO20053928L NO20053928A NO20053928A NO20053928L NO 20053928 L NO20053928 L NO 20053928L NO 20053928 A NO20053928 A NO 20053928A NO 20053928 A NO20053928 A NO 20053928A NO 20053928 L NO20053928 L NO 20053928L
Authority
NO
Norway
Prior art keywords
formula
intermediates
producing
salt
compound
Prior art date
Application number
NO20053928A
Other languages
English (en)
Other versions
NO20053928D0 (no
Inventor
Dusan Hesoun
Jiri Hykl
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of NO20053928D0 publication Critical patent/NO20053928D0/no
Publication of NO20053928L publication Critical patent/NO20053928L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Impact Printers (AREA)
  • Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Forging (AREA)
  • Pressure Welding/Diffusion-Bonding (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte for å produsere en forbindelse med formel (1), hvori et karbazolon med formel (2), formaldehyd eller en formaldehydforløper, et amin med formel (3) eller et salt derav hvori R1 og R2 hver uavhengig representerer en C1- til C4-alkylgruppe eller sammen med nitrogenatomet danner de en 5- eller 6-medlemsring, og et imidazol med formel (5) eller et salt derav reageres ved høy temperatur i et ikke-vandig polart løsemiddel og i nærvær av et vannbindemiddel for å danne forbindelsen med formel (1).
NO20053928A 2003-01-24 2005-08-23 Fremgangsmate for a fremstille ondansetron og intermediater derav. NO20053928L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44205503P 2003-01-24 2003-01-24
PCT/EP2003/002743 WO2004065381A1 (en) 2003-01-24 2003-03-14 Process for making ondansetron and intermediates thereof

Publications (2)

Publication Number Publication Date
NO20053928D0 NO20053928D0 (no) 2005-08-23
NO20053928L true NO20053928L (no) 2005-10-24

Family

ID=23755350

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053928A NO20053928L (no) 2003-01-24 2005-08-23 Fremgangsmate for a fremstille ondansetron og intermediater derav.

Country Status (10)

Country Link
US (1) US7041834B2 (no)
EP (1) EP1585744B1 (no)
AT (1) ATE344258T1 (no)
AU (2) AU2003222763A1 (no)
DE (1) DE60309511T2 (no)
FR (1) FR2850381B1 (no)
GB (1) GB2398071B (no)
NL (1) NL1022894C2 (no)
NO (1) NO20053928L (no)
WO (1) WO2004065381A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100566317B1 (ko) * 2003-10-16 2006-03-30 주식회사유한양행 카바졸온 유도체 제조 방법
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
EP1828141A4 (en) * 2004-10-26 2009-04-01 Ipca Lab Ltd STAINING METHOD FOR PREPARING THE ANTIEMETIC 1,2,3,9-TETRAHYDRO-9-METHYL-3 - [(2-METHYL) -1H-IMIDAZOLE-1-YL) METHYL] -4H-CARBAZOLE-4-ON
EP2273880B1 (en) * 2008-04-28 2014-12-31 Zogenix, Inc. Novel formulations for treatment of migraine
CN109020871A (zh) * 2018-10-03 2018-12-18 淮安安莱生物科技有限公司 一种昂丹司琼杂质a的制备方法
CN115677561B (zh) * 2022-11-01 2024-04-05 常州兰陵制药有限公司 一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920003064B1 (ko) * 1984-01-25 1992-04-13 글락소 그룹 리미티드 헤테로시클릭 화합물의 제조방법
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
CN1107474A (zh) 1994-03-31 1995-08-30 北京四达生物技术研究所 一种四氢咔唑酮衍生物的制备方法
CN1040644C (zh) 1994-04-29 1998-11-11 北京天衡时代科技集团 一种4-氢咔唑酮衍生物的制备方法
CN1035672C (zh) * 1994-08-08 1997-08-20 上海医科大学 3-(甲基咪唑基)-甲基-四氢-咔唑酮新的制备方法
WO1999064046A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5-ht3 receptors
TR200401460T3 (no) * 2001-01-11 2004-08-23 Teva Pharmaceutical Industries Ltd.

Also Published As

Publication number Publication date
GB2398071A (en) 2004-08-11
FR2850381B1 (fr) 2006-06-09
NO20053928D0 (no) 2005-08-23
EP1585744B1 (en) 2006-11-02
DE60309511T2 (de) 2007-06-28
FR2850381A1 (fr) 2004-07-30
ATE344258T1 (de) 2006-11-15
US20040181076A1 (en) 2004-09-16
AU2003203585A1 (en) 2004-08-12
AU2003222763A1 (en) 2004-08-13
NL1022894C2 (nl) 2004-07-28
GB2398071B (en) 2006-06-07
US7041834B2 (en) 2006-05-09
GB0304924D0 (en) 2003-04-09
DE60309511D1 (de) 2006-12-14
EP1585744A1 (en) 2005-10-19
WO2004065381A1 (en) 2004-08-05

Similar Documents

Publication Publication Date Title
NO20052781L (no) Forbindelser og prosesser
NO20053928L (no) Fremgangsmate for a fremstille ondansetron og intermediater derav.
YU44898A (sh) Postupak za dobijanje magnezijumove soli supstituisanog heterocikličnog sulfinila
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
CA2461060A1 (en) Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof
HUP0000524A2 (hu) Eljárás tiazolszármazékok és intermedierjeik előállítására
DK1858878T3 (da) Konvertering af 2-pyrazoliner til pyrazoler ved hjælp af brom
Gong et al. Construction of fluorescence-tunable pyrido-fused benzimidazoles via direct intramolecular C–H amination under transition-metal-free conditions
JP2009502802A5 (no)
Ou et al. Preparation of homoallylic amines via a three-component coupling process
CN107501153B (zh) 一种2-(2,2,2-三氟乙基)-3-芳基-2h-氮杂丙烯啶化合物的制备方法
WO2010104027A1 (ja) チアゾール誘導体およびその製造方法
CN103613593B (zh) 一种酰胺基脲衍生物的制备方法
CN108299303B (zh) 一种四芳基吡唑类化合物的合成新方法
NO20055991L (no) Fremgangsmate for syntetisering av heterocykliske forbindelser
DK0786459T3 (da) Fremgangsmåde til fremstilling af en heterobicyklisk alkoholenantiomer
NO20070610L (no) Fremgangsmate for fremstilling av synteseintermediater anvendelige ved fremstilling av pyrazolforbindelser.
CN108191862B (zh) 4-羟基-2-取代吡唑并吡啶类化合物的合成方法
CA2649506A1 (en) 2-alkenyl-3-aminothiophene derivative and process for producing thereof
TW200730495A (en) Process for producing 2-oxindole compound
JP6499606B2 (ja) 含硫黄環化化合物の製造方法
Alam et al. POCl3 Mediated Staudinger Reaction of Imines with Ketenes: Synthesis of Monocyclic β-Lactam and 1, 3-Oxazinone Derivatives
KR790001653B1 (ko) S-트리아졸로[3, 4-b] 벤조티아졸류의 제조방법
Al-Zaydi et al. Functionally substituted 1-alkylbenzotriazoles in heterocyclic synthesis: Synthesis and reactivity of benzotriazol-1-yl amides
Maettner et al. Synthesis and reactions of 1, 2, 3-triazinium salts

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application