NO20052781L - Forbindelser og prosesser - Google Patents
Forbindelser og prosesserInfo
- Publication number
- NO20052781L NO20052781L NO20052781A NO20052781A NO20052781L NO 20052781 L NO20052781 L NO 20052781L NO 20052781 A NO20052781 A NO 20052781A NO 20052781 A NO20052781 A NO 20052781A NO 20052781 L NO20052781 L NO 20052781L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- formula
- alkyl
- group
- dihydropyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Fremgangsmåte for fremstilling av en forbindelse med formel. og mellomprodukter anvendelige deri, er tilveiebragt. Fremgangsmåten omfatter omsetning av en forbindelse med formel RCO-CH-E med en forbindelse med formel RCi nærvær av en forbindelse med formel R3Ft4N-C(=NH)NH2 og en katalysator, for derved å danne et dihydropyrimidin; og oksidasjon av dihydro-pyrimidinet, hvilket gir forbindelsen med formel (1). Rer H eller en alkylgruppe; Rer H, en alkyl- eller arylgruppe; Rog R4 er hver, uavhengig, H, alkyl eller aryl eller Rog Rer bundet og danner, sammen med nitrogenet som de er bundet til og danner en 5- til 7-leddet, heterocyklisk ring; E er H, en usubstituert alkylgruppe, en arylgruppe eller en elektrontiltrekkende gruppe; og Xog Xer hver, uavhengig, utgående grupper, eller Xog Xrepresenterer sammen =0.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0229243A GB0229243D0 (en) | 2002-12-16 | 2002-12-16 | Compounds and process |
| GB0303589A GB0303589D0 (en) | 2003-02-17 | 2003-02-17 | Compounds and process |
| GB0318515A GB0318515D0 (en) | 2003-08-07 | 2003-08-07 | Compounds and process |
| PCT/GB2003/005359 WO2004054986A2 (en) | 2002-12-16 | 2003-12-09 | Process for the preparation of pyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20052781L true NO20052781L (no) | 2005-07-07 |
| NO330983B1 NO330983B1 (no) | 2011-08-29 |
Family
ID=32600665
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052781A NO330983B1 (no) | 2002-12-16 | 2005-06-08 | Fremgangsmate for fremstilling av pyrimidinderivater |
| NO20110366A NO20110366L (no) | 2002-12-16 | 2011-03-10 | Forbindelser og prosesser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20110366A NO20110366L (no) | 2002-12-16 | 2011-03-10 | Forbindelser og prosesser |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7524955B2 (no) |
| EP (2) | EP1578731B1 (no) |
| JP (2) | JP4579821B2 (no) |
| KR (1) | KR101060215B1 (no) |
| AR (1) | AR042355A1 (no) |
| AT (1) | ATE448209T1 (no) |
| AU (1) | AU2003288443B2 (no) |
| BR (1) | BR0317313A (no) |
| CA (1) | CA2509344C (no) |
| CY (1) | CY1110605T1 (no) |
| DE (1) | DE60330050D1 (no) |
| DK (1) | DK1578731T3 (no) |
| ES (1) | ES2335279T3 (no) |
| HK (1) | HK1080477A1 (no) |
| IL (1) | IL168884A (no) |
| MX (1) | MXPA05006425A (no) |
| MY (1) | MY138051A (no) |
| NO (2) | NO330983B1 (no) |
| NZ (1) | NZ540722A (no) |
| PT (1) | PT1578731E (no) |
| SI (1) | SI1578731T1 (no) |
| TW (1) | TWI322145B (no) |
| WO (1) | WO2004054986A2 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| EP1417180B1 (en) * | 2001-07-13 | 2006-12-27 | AstraZeneca UK Limited | Preparation of aminopyrimidine compounds |
| EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| KR20030092446A (ko) * | 2002-05-29 | 2003-12-06 | 주식회사 한국토종약초연구소 | 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물 |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| AU2003288443B2 (en) | 2002-12-16 | 2007-10-25 | Astrazeneka Uk Limited | Process for the preparation of pyrimidine compounds |
| GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| US8153791B2 (en) | 2005-12-21 | 2012-04-10 | Janssen Pharmaceutica N.V. | Substituted pyrimidinyl oxime kinase inhibitors |
| WO2007109783A2 (en) * | 2006-03-23 | 2007-09-27 | Janssen Pharmaceutica, N.V. | Substituted pyrimidine kinase inhibitors |
| TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
| CA2800118C (en) | 2010-05-21 | 2013-11-12 | Cooper Technologies Company | Adapter coupling for bushing and arrestor |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278001A (en) * | 1965-02-02 | 1966-10-11 | Charles C Andrews | Bearing assembly for auger conveyors |
| US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
| US4689414A (en) * | 1986-02-24 | 1987-08-25 | E. R. Squibb & Sons, Inc. | 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs |
| EP0367895A1 (en) * | 1988-10-06 | 1990-05-16 | Sandoz Ag | Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them |
| FR2665159B1 (fr) | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| WO1993008823A1 (en) | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
| JP3197971B2 (ja) | 1993-03-01 | 2001-08-13 | 塩野義製薬株式会社 | ５−カルボアルコキシピリミジン誘導体の合成方法 |
| US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| EE9700209A (et) | 1994-11-16 | 1998-04-15 | Synaptic Pharmaceutical Corporation | Dihüdropürimidiinid ja nende kasutamine |
| DE19517186A1 (de) * | 1995-05-11 | 1996-11-14 | Bayer Ag | Verfahren zur Herstellung substituierter 2-Fluor-pyrimidine |
| US6278001B1 (en) | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
| FR2741620B1 (fr) | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
| AU705409B2 (en) | 1995-12-14 | 1999-05-20 | Merck & Co., Inc. | Process for making dihydropyrimidinones |
| US5958934A (en) * | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
| SE9702563D0 (sv) * | 1997-07-02 | 1997-07-02 | Astra Ab | Compounds |
| CA2297889A1 (en) | 1997-08-05 | 1999-02-18 | Norihiro Ikemoto | Alpha 1a adrenergic receptor antagonist |
| GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| WO2000078730A1 (fr) | 1999-06-23 | 2000-12-28 | Ajinomoto Co., Inc. | Nouveaux derives dihydropyrimidiniques |
| DE60023296T2 (de) | 1999-07-13 | 2006-07-20 | Lonza Ag | Verfahren zur herstellung von 2-amino-4(4-fluorphenyl)-6-alkylpyrimidin-5-carbonsäureester |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| AU2000254249A1 (en) | 2000-03-28 | 2001-10-08 | Biocon India Limited | Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1- |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| GB0011163D0 (en) | 2000-05-10 | 2000-06-28 | Astrazeneca Ab | Chemical compound |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| EP1417180B1 (en) | 2001-07-13 | 2006-12-27 | AstraZeneca UK Limited | Preparation of aminopyrimidine compounds |
| EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| KR100511533B1 (ko) | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| AU2003288443B2 (en) | 2002-12-16 | 2007-10-25 | Astrazeneka Uk Limited | Process for the preparation of pyrimidine compounds |
| WO2004103977A2 (en) | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| EP1697338A2 (en) | 2003-12-24 | 2006-09-06 | Teva Pharmaceutical Industries Ltd. | Process for preparation of statins with high syn to anti ratio |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
-
2003
- 2003-12-09 AU AU2003288443A patent/AU2003288443B2/en not_active Ceased
- 2003-12-09 MX MXPA05006425A patent/MXPA05006425A/es active IP Right Grant
- 2003-12-09 WO PCT/GB2003/005359 patent/WO2004054986A2/en active Application Filing
- 2003-12-09 SI SI200331722T patent/SI1578731T1/sl unknown
- 2003-12-09 EP EP03780362A patent/EP1578731B1/en not_active Expired - Lifetime
- 2003-12-09 AT AT03780362T patent/ATE448209T1/de active
- 2003-12-09 DK DK03780362.4T patent/DK1578731T3/da active
- 2003-12-09 NZ NZ540722A patent/NZ540722A/en not_active IP Right Cessation
- 2003-12-09 EP EP09159247A patent/EP2088142A3/en not_active Ceased
- 2003-12-09 US US10/537,723 patent/US7524955B2/en not_active Expired - Fee Related
- 2003-12-09 BR BR0317313-5A patent/BR0317313A/pt not_active IP Right Cessation
- 2003-12-09 KR KR1020057010964A patent/KR101060215B1/ko not_active IP Right Cessation
- 2003-12-09 CA CA2509344A patent/CA2509344C/en not_active Expired - Fee Related
- 2003-12-09 JP JP2005502458A patent/JP4579821B2/ja not_active Expired - Fee Related
- 2003-12-09 DE DE60330050T patent/DE60330050D1/de not_active Expired - Lifetime
- 2003-12-09 ES ES03780362T patent/ES2335279T3/es not_active Expired - Lifetime
- 2003-12-09 PT PT03780362T patent/PT1578731E/pt unknown
- 2003-12-10 AR ARP030104541A patent/AR042355A1/es unknown
- 2003-12-12 MY MYPI20034768A patent/MY138051A/en unknown
- 2003-12-16 TW TW092135557A patent/TWI322145B/zh not_active IP Right Cessation
-
2005
- 2005-05-30 IL IL168884A patent/IL168884A/en not_active IP Right Cessation
- 2005-06-08 NO NO20052781A patent/NO330983B1/no not_active IP Right Cessation
-
2006
- 2006-01-12 HK HK06100506.1A patent/HK1080477A1/xx not_active IP Right Cessation
-
2009
- 2009-03-16 US US12/404,575 patent/US8273878B2/en not_active Expired - Fee Related
-
2010
- 2010-01-11 CY CY20101100025T patent/CY1110605T1/el unknown
- 2010-06-23 JP JP2010142779A patent/JP5318037B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-10 NO NO20110366A patent/NO20110366L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |