NO330983B1 - Fremgangsmate for fremstilling av pyrimidinderivater - Google Patents

Fremgangsmate for fremstilling av pyrimidinderivater

Info

Publication number
NO330983B1
NO330983B1 NO20052781A NO20052781A NO330983B1 NO 330983 B1 NO330983 B1 NO 330983B1 NO 20052781 A NO20052781 A NO 20052781A NO 20052781 A NO20052781 A NO 20052781A NO 330983 B1 NO330983 B1 NO 330983B1
Authority
NO
Norway
Prior art keywords
compound
formula
alkyl
group
preparation
Prior art date
Application number
NO20052781A
Other languages
English (en)
Other versions
NO20052781L (no
Inventor
Mark Bailey
Lee Newton
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0229243A external-priority patent/GB0229243D0/en
Priority claimed from GB0303589A external-priority patent/GB0303589D0/en
Priority claimed from GB0318515A external-priority patent/GB0318515D0/en
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of NO20052781L publication Critical patent/NO20052781L/no
Publication of NO330983B1 publication Critical patent/NO330983B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Fremgangsmåte for fremstilling av en forbindelse med formel og mellomprodukter anvendelige deri, er tilveiebragt. Fremgangsmåten omfatter omsetning av en forbindelse med formel R1-CO-CH2-E med en forbindelse med formel R2-CHX1X2 i næn/ær av en forbindelse med formel B3R4N- C(=NH)NH2 og en katalysator, for derved å danne et dihydropyrimidin; og oksidasjon av dihydro- pyrimidinet, hvilket gir forbindelsen med formel (1). R1 er H eller en alkylgruppe; R2 er H, en alkyl-eller arylgruppe; R3 og R4 er hver, uavhengig, H, alkyl eller aryl eller R3 og R4 er bundet og danner, sammen med nitrogenet som de er bundet til og danner en 5- til 7-leddet, heterocyklisk ring; E er H, en usubstituert alkylgruppe, en arylgruppe eller en elektrontiltrekkende gruppe; og X1 og X2 er hver, uavhengig, utgående grupper, eller X1 og X2 representerer sammen =0.
NO20052781A 2002-12-16 2005-06-08 Fremgangsmate for fremstilling av pyrimidinderivater NO330983B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0229243A GB0229243D0 (en) 2002-12-16 2002-12-16 Compounds and process
GB0303589A GB0303589D0 (en) 2003-02-17 2003-02-17 Compounds and process
GB0318515A GB0318515D0 (en) 2003-08-07 2003-08-07 Compounds and process
PCT/GB2003/005359 WO2004054986A2 (en) 2002-12-16 2003-12-09 Process for the preparation of pyrimidine compounds

Publications (2)

Publication Number Publication Date
NO20052781L NO20052781L (no) 2005-07-07
NO330983B1 true NO330983B1 (no) 2011-08-29

Family

ID=32600665

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20052781A NO330983B1 (no) 2002-12-16 2005-06-08 Fremgangsmate for fremstilling av pyrimidinderivater
NO20110366A NO20110366L (no) 2002-12-16 2011-03-10 Forbindelser og prosesser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20110366A NO20110366L (no) 2002-12-16 2011-03-10 Forbindelser og prosesser

Country Status (23)

Country Link
US (2) US7524955B2 (no)
EP (2) EP2088142A3 (no)
JP (2) JP4579821B2 (no)
KR (1) KR101060215B1 (no)
AR (1) AR042355A1 (no)
AT (1) ATE448209T1 (no)
AU (1) AU2003288443B2 (no)
BR (1) BR0317313A (no)
CA (1) CA2509344C (no)
CY (1) CY1110605T1 (no)
DE (1) DE60330050D1 (no)
DK (1) DK1578731T3 (no)
ES (1) ES2335279T3 (no)
HK (1) HK1080477A1 (no)
IL (1) IL168884A (no)
MX (1) MXPA05006425A (no)
MY (1) MY138051A (no)
NO (2) NO330983B1 (no)
NZ (1) NZ540722A (no)
PT (1) PT1578731E (no)
SI (1) SI1578731T1 (no)
TW (1) TWI322145B (no)
WO (1) WO2004054986A2 (no)

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GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
CN100349877C (zh) * 2001-07-13 2007-11-21 阿斯特拉曾尼卡英国有限公司 氨基嘧啶化合物的制备方法
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR20030092446A (ko) * 2002-05-29 2003-12-06 주식회사 한국토종약초연구소 씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
DE60330050D1 (de) 2002-12-16 2009-12-24 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
US8153791B2 (en) 2005-12-21 2012-04-10 Janssen Pharmaceutica N.V. Substituted pyrimidinyl oxime kinase inhibitors
WO2007109783A2 (en) * 2006-03-23 2007-09-27 Janssen Pharmaceutica, N.V. Substituted pyrimidine kinase inhibitors
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
CN103004028B (zh) 2010-05-21 2016-04-06 库柏技术公司 用于套管闭锁的适配件

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CN100349877C (zh) 2001-07-13 2007-11-21 阿斯特拉曾尼卡英国有限公司 氨基嘧啶化合物的制备方法
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
DE60330050D1 (de) 2002-12-16 2009-12-24 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
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GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
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GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
US20060052604A1 (en) 2006-03-09
ES2335279T3 (es) 2010-03-24
HK1080477A1 (en) 2006-04-28
KR101060215B1 (ko) 2011-08-29
US8273878B2 (en) 2012-09-25
PT1578731E (pt) 2010-01-12
MXPA05006425A (es) 2005-08-19
IL168884A (en) 2011-01-31
TWI322145B (en) 2010-03-21
NO20110366L (no) 2005-07-07
WO2004054986A2 (en) 2004-07-01
NO20052781L (no) 2005-07-07
EP2088142A2 (en) 2009-08-12
ATE448209T1 (de) 2009-11-15
EP1578731B1 (en) 2009-11-11
NZ540722A (en) 2008-03-28
EP1578731A2 (en) 2005-09-28
TW200418809A (en) 2004-10-01
BR0317313A (pt) 2005-11-08
SI1578731T1 (sl) 2010-02-26
CY1110605T1 (el) 2015-04-29
AU2003288443B2 (en) 2007-10-25
US7524955B2 (en) 2009-04-28
CA2509344A1 (en) 2004-07-01
AR042355A1 (es) 2005-06-15
JP4579821B2 (ja) 2010-11-10
JP2006515600A (ja) 2006-06-01
WO2004054986A8 (en) 2005-07-21
EP2088142A3 (en) 2010-04-21
WO2004054986A3 (en) 2004-12-02
DE60330050D1 (de) 2009-12-24
CA2509344C (en) 2011-10-04
AU2003288443A1 (en) 2004-07-09
JP2010248222A (ja) 2010-11-04
DK1578731T3 (da) 2010-02-15
US20090264654A1 (en) 2009-10-22
KR20050085674A (ko) 2005-08-29
JP5318037B2 (ja) 2013-10-16
MY138051A (en) 2009-04-30

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