HUP0003437A2 - Eljárás különböző heterociklusos gyűrűrendszereket tartalmazó 5-lipoxigenáz inhibitorok előállítására - Google Patents
Eljárás különböző heterociklusos gyűrűrendszereket tartalmazó 5-lipoxigenáz inhibitorok előállításáraInfo
- Publication number
- HUP0003437A2 HUP0003437A2 HU0003437A HUP0003437A HUP0003437A2 HU P0003437 A2 HUP0003437 A2 HU P0003437A2 HU 0003437 A HU0003437 A HU 0003437A HU P0003437 A HUP0003437 A HU P0003437A HU P0003437 A2 HUP0003437 A2 HU P0003437A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- group
- lipoxygenase inhibitors
- making
- heterocyclic ring
- Prior art date
Links
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 abstract 1
- 229910000024 caesium carbonate Inorganic materials 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány tárgya eljárás (1.3.0) általános képletű vegyületelőállítására; ahol az (1.3.1) általános képletű csoport jelentése(1.3.2), (1.3.3), (1.3.4) vagy (1.3.5) általános képletű csoport; ahola - szimbólum a csoportok kapcsolódási pontját jelzi; és - R7 és R8jelentése hidrogénatom, adott esetben szubsztituált alkilcsoport vagyarilcsoport, amelyet úgy végeznek, hogy összeállítanak egyreakcióelegyet, amely tartalmazza a (2.0.0) képletű tetrahidro-4-[3-(4-fluor-fenil)tio]fenil-2H-piran-4-karboxamidot, és egy (1.3.6),(1.3.7), (1.3.8) vagy (1.3.9) általános képletű vegyületet; ahol R7 ésR8 jelentése a fenti, aprotikus oldószert; és egy erős bázist és adottesetben katalitikus mennyiségű cézium-karbonátot vagy egyfázistranszfer katalizátort, majd a reakcióelegyet melegítik. Atalálmány az intermedier (2.0.0) képletű vegyület előállítására isvonatkozik. Az előállított vegyületek 5-lipoxigenáz inhibitorok. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15161099P | 1999-08-31 | 1999-08-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0003437D0 HU0003437D0 (en) | 2000-08-30 |
| HUP0003437A2 true HUP0003437A2 (hu) | 2001-06-28 |
| HUP0003437A3 HUP0003437A3 (en) | 2002-08-28 |
Family
ID=22539510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003437A HUP0003437A3 (en) | 1999-08-31 | 2000-08-30 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1081144A3 (hu) |
| JP (1) | JP2001106686A (hu) |
| KR (1) | KR20010050274A (hu) |
| CN (1) | CN1286251A (hu) |
| AP (1) | AP2000001909A0 (hu) |
| AR (1) | AR022650A1 (hu) |
| AU (1) | AU5370200A (hu) |
| BG (1) | BG104730A (hu) |
| BR (1) | BR0003888A (hu) |
| CA (1) | CA2316748A1 (hu) |
| CO (1) | CO5180623A1 (hu) |
| CZ (1) | CZ20003159A3 (hu) |
| EA (1) | EA200000803A3 (hu) |
| EE (1) | EE200000513A (hu) |
| GT (1) | GT200000144A (hu) |
| HR (1) | HRP20000565A2 (hu) |
| HU (1) | HUP0003437A3 (hu) |
| ID (1) | ID27128A (hu) |
| IL (1) | IL138089A0 (hu) |
| IS (1) | IS5604A (hu) |
| MA (1) | MA26750A1 (hu) |
| NO (1) | NO20004312L (hu) |
| NZ (1) | NZ506633A (hu) |
| OA (1) | OA11451A (hu) |
| PA (1) | PA8499601A1 (hu) |
| PE (1) | PE20010523A1 (hu) |
| PL (1) | PL342280A1 (hu) |
| SG (1) | SG87145A1 (hu) |
| SK (1) | SK12862000A3 (hu) |
| SV (1) | SV2002000160A (hu) |
| TN (1) | TNSN00176A1 (hu) |
| TR (1) | TR200002530A2 (hu) |
| UY (1) | UY26315A1 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112837A1 (ja) * | 2003-05-23 | 2004-12-29 | Hisamitsu Pharmaceutical Co., Inc. | 非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン－１α生成抑制剤 |
| US7674811B2 (en) | 2006-03-14 | 2010-03-09 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| CN103980312B (zh) * | 2014-05-27 | 2016-09-07 | 广州大学 | 一种n杂环双膦配体及其合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281577B6 (sk) * | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
-
2000
- 2000-08-01 SG SG200004340A patent/SG87145A1/en unknown
- 2000-08-10 PA PA20008499601A patent/PA8499601A1/es unknown
- 2000-08-11 CO CO00060138A patent/CO5180623A1/es not_active Application Discontinuation
- 2000-08-17 EP EP00307046A patent/EP1081144A3/en not_active Withdrawn
- 2000-08-18 OA OA1200000224A patent/OA11451A/en unknown
- 2000-08-24 TN TNTNSN00176A patent/TNSN00176A1/fr unknown
- 2000-08-24 IL IL13808900A patent/IL138089A0/xx unknown
- 2000-08-25 IS IS5604A patent/IS5604A/is unknown
- 2000-08-25 SK SK1286-2000A patent/SK12862000A3/sk unknown
- 2000-08-28 ID IDP20000710A patent/ID27128A/id unknown
- 2000-08-28 UY UY26315A patent/UY26315A1/es not_active Application Discontinuation
- 2000-08-29 AU AU53702/00A patent/AU5370200A/en not_active Abandoned
- 2000-08-29 CA CA002316748A patent/CA2316748A1/en not_active Abandoned
- 2000-08-29 AR ARP000104489A patent/AR022650A1/es not_active Application Discontinuation
- 2000-08-29 BG BG104730A patent/BG104730A/xx unknown
- 2000-08-29 PE PE2000000886A patent/PE20010523A1/es not_active Application Discontinuation
- 2000-08-29 GT GT200000144A patent/GT200000144A/es unknown
- 2000-08-30 CZ CZ20003159A patent/CZ20003159A3/cs unknown
- 2000-08-30 SV SV2000000160A patent/SV2002000160A/es unknown
- 2000-08-30 NZ NZ506633A patent/NZ506633A/en unknown
- 2000-08-30 HU HU0003437A patent/HUP0003437A3/hu unknown
- 2000-08-30 CN CN00126409A patent/CN1286251A/zh active Pending
- 2000-08-30 NO NO20004312A patent/NO20004312L/no not_active Application Discontinuation
- 2000-08-30 KR KR1020000050877A patent/KR20010050274A/ko active IP Right Grant
- 2000-08-30 HR HR20000565A patent/HRP20000565A2/hr not_active Application Discontinuation
- 2000-08-30 MA MA26053A patent/MA26750A1/fr unknown
- 2000-08-30 BR BR0003888-1A patent/BR0003888A/pt not_active IP Right Cessation
- 2000-08-31 PL PL00342280A patent/PL342280A1/xx not_active Application Discontinuation
- 2000-08-31 JP JP2000262200A patent/JP2001106686A/ja active Pending
- 2000-08-31 AP APAP/P/2000/001909A patent/AP2000001909A0/en unknown
- 2000-08-31 EA EA200000803A patent/EA200000803A3/ru unknown
- 2000-08-31 TR TR2000/02530A patent/TR200002530A2/xx unknown
- 2000-08-31 EE EEP200000513A patent/EE200000513A/xx unknown
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