PA8499601A1 - Procedimientos para preparar inhibidores de 5-lipoxigenasa que tienen sistemas anuladores heterociclicos variados - Google Patents
Procedimientos para preparar inhibidores de 5-lipoxigenasa que tienen sistemas anuladores heterociclicos variadosInfo
- Publication number
- PA8499601A1 PA8499601A1 PA20008499601A PA8499601A PA8499601A1 PA 8499601 A1 PA8499601 A1 PA 8499601A1 PA 20008499601 A PA20008499601 A PA 20008499601A PA 8499601 A PA8499601 A PA 8499601A PA 8499601 A1 PA8499601 A1 PA 8499601A1
- Authority
- PA
- Panama
- Prior art keywords
- naoh
- solvent
- formula
- koh
- reaction mixture
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA (1.3.0): EN LA CUAL (ICLUYE DIBUJOS) QUE COMPRENDE: ESTABLECER UNA MEZCLA DE REACCIÓN COMPUESTA POR (INCLUYE DIBUJOS) EN UN DISOLVENTE APRÓTICO; EN PRESENCIA DE NAOH Ó DE KOH; OPCIONALMENTE EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE, EN ESPECIAL UNA SAL DE AMONIO CUATERNARI O UNA SAL DE FOSFONIO; SEGUIDO POR CALENTAR DICHA MEZCLA DE REACCIÓN BAJO UNA ATMOSFERA DE NITRÓGENO; EN UNA REALIZACIÓN PREFERIDA, EL DISOLVENTE APRÓTICO ES DMSO, LA LA BASE FUERTE EN FORMA SÓLIDA ES NAOH EN FORMA DE POLVO O DE GRANULOS, Y EL CATALIZADOR DE TRANSFERENCIA DE FASE CLORO DE TETRA-N-BUTILAMONIO (TBAC), EN EL CUAL EL MATERIAL DE PARTIDA DE FORMULA (2.0.0) ES PREPARADO DE LA MANERA SIGUIENTE: SE HACEN REACCIONR JUNTOS EN UN DISOLVENTE COMPUESTO POR UN ALCOHOL ALIFÁTICO DE CADENA LINEAL O RAMIFICADA; EN PRESENCIA DE UNA BASE FUERTE COMPUESTA POR NAOH Ó KOH; EN PRESENCIA DE METAL DE TRANSICIÓN QUE COMPRENDE UN COMPLEJO DE METAL PALADIO; Y AÚN ADEMÁS EN PRESENCIA DE UN LIGANDO AUXILIAR QUE COMPRENDE UN COMPUESTO AROMÁTICO BIDENTADO, QUIRAL, AUXIALMENTE DISIMÉTRICO, DE FORMULA (5.5.0) Ó (5.5.1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15161099P | 1999-08-31 | 1999-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8499601A1 true PA8499601A1 (es) | 2002-02-21 |
Family
ID=22539510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20008499601A PA8499601A1 (es) | 1999-08-31 | 2000-08-10 | Procedimientos para preparar inhibidores de 5-lipoxigenasa que tienen sistemas anuladores heterociclicos variados |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP1081144A3 (es) |
JP (1) | JP2001106686A (es) |
KR (1) | KR20010050274A (es) |
CN (1) | CN1286251A (es) |
AP (1) | AP2000001909A0 (es) |
AR (1) | AR022650A1 (es) |
AU (1) | AU5370200A (es) |
BG (1) | BG104730A (es) |
BR (1) | BR0003888A (es) |
CA (1) | CA2316748A1 (es) |
CO (1) | CO5180623A1 (es) |
CZ (1) | CZ20003159A3 (es) |
EA (1) | EA200000803A3 (es) |
EE (1) | EE200000513A (es) |
GT (1) | GT200000144A (es) |
HR (1) | HRP20000565A2 (es) |
HU (1) | HUP0003437A3 (es) |
ID (1) | ID27128A (es) |
IL (1) | IL138089A0 (es) |
IS (1) | IS5604A (es) |
MA (1) | MA26750A1 (es) |
NO (1) | NO20004312L (es) |
NZ (1) | NZ506633A (es) |
OA (1) | OA11451A (es) |
PA (1) | PA8499601A1 (es) |
PE (1) | PE20010523A1 (es) |
PL (1) | PL342280A1 (es) |
SG (1) | SG87145A1 (es) |
SK (1) | SK12862000A3 (es) |
SV (1) | SV2002000160A (es) |
TN (1) | TNSN00176A1 (es) |
TR (1) | TR200002530A2 (es) |
UY (1) | UY26315A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004112837A1 (ja) * | 2003-05-23 | 2004-12-29 | Hisamitsu Pharmaceutical Co., Inc. | 非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン-1α生成抑制剤 |
EP1834953A1 (en) * | 2006-03-14 | 2007-09-19 | Ranbaxy Laboratories Limited | Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors |
CN103980312B (zh) * | 2014-05-27 | 2016-09-07 | 广州大学 | 一种n杂环双膦配体及其合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK281577B6 (sk) * | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
-
2000
- 2000-08-01 SG SG200004340A patent/SG87145A1/en unknown
- 2000-08-10 PA PA20008499601A patent/PA8499601A1/es unknown
- 2000-08-11 CO CO00060138A patent/CO5180623A1/es not_active Application Discontinuation
- 2000-08-17 EP EP00307046A patent/EP1081144A3/en not_active Withdrawn
- 2000-08-18 OA OA1200000224A patent/OA11451A/en unknown
- 2000-08-24 TN TNTNSN00176A patent/TNSN00176A1/fr unknown
- 2000-08-24 IL IL13808900A patent/IL138089A0/xx unknown
- 2000-08-25 IS IS5604A patent/IS5604A/is unknown
- 2000-08-25 SK SK1286-2000A patent/SK12862000A3/sk unknown
- 2000-08-28 UY UY26315A patent/UY26315A1/es not_active Application Discontinuation
- 2000-08-28 ID IDP20000710A patent/ID27128A/id unknown
- 2000-08-29 PE PE2000000886A patent/PE20010523A1/es not_active Application Discontinuation
- 2000-08-29 CA CA002316748A patent/CA2316748A1/en not_active Abandoned
- 2000-08-29 AU AU53702/00A patent/AU5370200A/en not_active Abandoned
- 2000-08-29 AR ARP000104489A patent/AR022650A1/es not_active Application Discontinuation
- 2000-08-29 GT GT200000144A patent/GT200000144A/es unknown
- 2000-08-29 BG BG104730A patent/BG104730A/xx unknown
- 2000-08-30 CZ CZ20003159A patent/CZ20003159A3/cs unknown
- 2000-08-30 SV SV2000000160A patent/SV2002000160A/es unknown
- 2000-08-30 CN CN00126409A patent/CN1286251A/zh active Pending
- 2000-08-30 HR HR20000565A patent/HRP20000565A2/hr not_active Application Discontinuation
- 2000-08-30 NO NO20004312A patent/NO20004312L/no not_active Application Discontinuation
- 2000-08-30 NZ NZ506633A patent/NZ506633A/en unknown
- 2000-08-30 MA MA26053A patent/MA26750A1/fr unknown
- 2000-08-30 KR KR1020000050877A patent/KR20010050274A/ko active IP Right Grant
- 2000-08-30 BR BR0003888-1A patent/BR0003888A/pt not_active IP Right Cessation
- 2000-08-30 HU HU0003437A patent/HUP0003437A3/hu unknown
- 2000-08-31 EE EEP200000513A patent/EE200000513A/xx unknown
- 2000-08-31 TR TR2000/02530A patent/TR200002530A2/xx unknown
- 2000-08-31 JP JP2000262200A patent/JP2001106686A/ja active Pending
- 2000-08-31 PL PL00342280A patent/PL342280A1/xx not_active Application Discontinuation
- 2000-08-31 EA EA200000803A patent/EA200000803A3/ru unknown
- 2000-08-31 AP APAP/P/2000/001909A patent/AP2000001909A0/en unknown
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