AR022649A1 - Procedimiento para la obtencion de inhibidores de 5-lipooxigenasa con distintos sistemas de anillos heterociclos. - Google Patents
Procedimiento para la obtencion de inhibidores de 5-lipooxigenasa con distintos sistemas de anillos heterociclos.Info
- Publication number
- AR022649A1 AR022649A1 ARP000104488A ARP000104488A AR022649A1 AR 022649 A1 AR022649 A1 AR 022649A1 AR P000104488 A ARP000104488 A AR P000104488A AR P000104488 A ARP000104488 A AR P000104488A AR 022649 A1 AR022649 A1 AR 022649A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- group
- salt
- reaction mixture
- heterocicles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Un procedimiento de preparacion de compuestos de formula (1) en la que (2) es el grupo (3) que comprende: el establecimiento de una mezcla de reaccionconstituida por (4) y el grupo (5) en un disolvente aproticoen presencia de una base fuerte en formasolida seleccionada entre el grupn constituido porhidroxido de sodio NaOH, e hidroxido de potasio KOH, y opcionalmente, en presencia de una cantidad catalítica de carbonato de cesio Cs2CO3, o un catalizadorde transferencia de fase, especialmente unasal de amonio cuaternaria o sal de fosfonio, seguido del calentamiento de la citada mezcla de reaccion en atmosferade nitrogeno, produciéndose un compuesto de formula (1), y en una realizacion preferida, el disolvente aprotico es DMSO, la base fuerte en forma solida esNaOH en polvo o en gránulos, y el catalizador de transferencia de fase es cloruro de tetra-n-butilamonio (TBAC), que se utiliza para preparar un compuestopreferido, util como inhibidor de 5-lipooxigenasa, de formula (6) y especialmente la sal metanosulfonato sustancialmente pura de éste.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15161199P | 1999-08-31 | 1999-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022649A1 true AR022649A1 (es) | 2002-09-04 |
Family
ID=22539515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104488A AR022649A1 (es) | 1999-08-31 | 2000-08-29 | Procedimiento para la obtencion de inhibidores de 5-lipooxigenasa con distintos sistemas de anillos heterociclos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6344563B1 (es) |
| EP (1) | EP1081146A1 (es) |
| JP (1) | JP2001106687A (es) |
| KR (1) | KR20010050224A (es) |
| CN (1) | CN1291609A (es) |
| AR (1) | AR022649A1 (es) |
| AU (1) | AU5360700A (es) |
| BR (1) | BR0003875A (es) |
| CA (1) | CA2317001A1 (es) |
| CZ (1) | CZ20003160A3 (es) |
| HU (1) | HUP0003438A3 (es) |
| ID (1) | ID29315A (es) |
| IL (1) | IL138088A0 (es) |
| MX (1) | MXPA00008505A (es) |
| PL (1) | PL342284A1 (es) |
| RU (1) | RU2177005C1 (es) |
| TR (1) | TR200002523A2 (es) |
| YU (1) | YU52800A (es) |
| ZA (1) | ZA200004436B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02009279A (es) | 2000-03-24 | 2004-09-10 | Euro Celtique Sa | Pirazoles, triazoles y tetrazoles sustituidos con arilo como bloqueadores del canal de sodio. |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753682A (en) * | 1993-06-14 | 1998-05-19 | Pfizer Inc. | Imidazole lipoxygenase inhibitors |
| US6063928A (en) * | 1994-10-18 | 2000-05-16 | Pfizer Inc | 5-lipoxygenase inhibitors |
| US5883106A (en) * | 1994-10-18 | 1999-03-16 | Pfizer Inc. | 5-lipoxygenase inhibitors |
| SK281577B6 (sk) | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
| PT863905E (pt) * | 1995-09-18 | 2001-03-30 | Pfizer | Novos inibidores da lipoxigenase do imidazolo |
-
2000
- 2000-06-29 US US09/606,609 patent/US6344563B1/en not_active Expired - Fee Related
- 2000-08-24 YU YU52800A patent/YU52800A/sh unknown
- 2000-08-24 IL IL13808800A patent/IL138088A0/xx unknown
- 2000-08-24 AU AU53607/00A patent/AU5360700A/en not_active Abandoned
- 2000-08-28 ZA ZA200004436A patent/ZA200004436B/xx unknown
- 2000-08-28 KR KR1020000049968A patent/KR20010050224A/ko not_active Application Discontinuation
- 2000-08-29 CA CA002317001A patent/CA2317001A1/en not_active Abandoned
- 2000-08-29 TR TR2000/02523A patent/TR200002523A2/xx unknown
- 2000-08-29 ID IDP20000718D patent/ID29315A/id unknown
- 2000-08-29 AR ARP000104488A patent/AR022649A1/es unknown
- 2000-08-30 RU RU2000122713/04A patent/RU2177005C1/ru active
- 2000-08-30 BR BR0003875-0A patent/BR0003875A/pt not_active IP Right Cessation
- 2000-08-30 CZ CZ20003160A patent/CZ20003160A3/cs unknown
- 2000-08-30 EP EP00307440A patent/EP1081146A1/en not_active Withdrawn
- 2000-08-30 JP JP2000260776A patent/JP2001106687A/ja active Pending
- 2000-08-30 MX MXPA00008505A patent/MXPA00008505A/es unknown
- 2000-08-30 CN CN00126870A patent/CN1291609A/zh active Pending
- 2000-08-30 HU HU0003438A patent/HUP0003438A3/hu unknown
- 2000-08-31 PL PL00342284A patent/PL342284A1/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003438A3 (en) | 2002-08-28 |
| CA2317001A1 (en) | 2001-02-28 |
| YU52800A (sh) | 2003-08-29 |
| TR200002523A2 (tr) | 2001-04-20 |
| MXPA00008505A (es) | 2005-07-25 |
| IL138088A0 (en) | 2001-10-31 |
| PL342284A1 (en) | 2001-03-12 |
| AU5360700A (en) | 2001-03-08 |
| EP1081146A1 (en) | 2001-03-07 |
| CZ20003160A3 (cs) | 2001-10-17 |
| ZA200004436B (en) | 2002-02-28 |
| CN1291609A (zh) | 2001-04-18 |
| JP2001106687A (ja) | 2001-04-17 |
| ID29315A (id) | 2001-08-16 |
| US6344563B1 (en) | 2002-02-05 |
| RU2177005C1 (ru) | 2001-12-20 |
| BR0003875A (pt) | 2001-12-11 |
| HU0003438D0 (en) | 2000-08-30 |
| HUP0003438A2 (hu) | 2001-08-28 |
| KR20010050224A (ko) | 2001-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |