BR0003875A - Proceso para a fabricação de inibidores de5-lipoxigenase tendo variados sistemas em anelheterocìclico - Google Patents
Proceso para a fabricação de inibidores de5-lipoxigenase tendo variados sistemas em anelheterocìclicoInfo
- Publication number
- BR0003875A BR0003875A BR0003875-0A BR0003875A BR0003875A BR 0003875 A BR0003875 A BR 0003875A BR 0003875 A BR0003875 A BR 0003875A BR 0003875 A BR0003875 A BR 0003875A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- manufacture
- naoh
- lipoxygenase inhibitors
- strong base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Patente de Invenção: "PROCESSO PARA A FABRICAçãO DEINIBIDORES DE 5-LIPOXIGENASE TENDO VARIADOSSISTEMAS EM ANEL HETEROCìCLICO". é descrito um processopara a preparação de um composto de Fórmula (1.3.0):compreendendo: a formação de uma mistura reacional constituídapor num solvente aprótico; na presença de uma base forte emforma sólida selecionada do grupo constituído por hidróxido desódio, NaOH, e hidróxido de potássio, KOH; e, facultativamente,na presença de uma quantidade catalítica de carbonato de césio,Cs~ 2~CO~ 3~, ou de um catalisador de transferência de fase,especialmente um sal de amónio quaternário ou um sal de fosfónioseguido por - aquecimento da referida mistura reacional sob umaatmosfera de nitrogênio; por meio do que é produzido um compostode Fórmula (1.3.0); e numa modalidade preferida o solventeaprótico é DMSO, a base forte em forma sólida é NAOH em formade pó ou péletes, e o catalisador de transferência de fase é cloretode tetra-n-butilamónio (TBAC), a qual é usada para preparar umcomposto preferido, útil como inibidor de 5-lipoxigenase, da fórmulaespecialmente o seu sal metanossulfonato substancialmente puro.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15161199P | 1999-08-31 | 1999-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0003875A true BR0003875A (pt) | 2001-12-11 |
Family
ID=22539515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0003875-0A BR0003875A (pt) | 1999-08-31 | 2000-08-30 | Proceso para a fabricação de inibidores de5-lipoxigenase tendo variados sistemas em anelheterocìclico |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6344563B1 (pt) |
| EP (1) | EP1081146A1 (pt) |
| JP (1) | JP2001106687A (pt) |
| KR (1) | KR20010050224A (pt) |
| CN (1) | CN1291609A (pt) |
| AR (1) | AR022649A1 (pt) |
| AU (1) | AU5360700A (pt) |
| BR (1) | BR0003875A (pt) |
| CA (1) | CA2317001A1 (pt) |
| CZ (1) | CZ20003160A3 (pt) |
| HU (1) | HUP0003438A3 (pt) |
| ID (1) | ID29315A (pt) |
| IL (1) | IL138088A0 (pt) |
| MX (1) | MXPA00008505A (pt) |
| PL (1) | PL342284A1 (pt) |
| RU (1) | RU2177005C1 (pt) |
| TR (1) | TR200002523A2 (pt) |
| YU (1) | YU52800A (pt) |
| ZA (1) | ZA200004436B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4589701A (en) | 2000-03-24 | 2001-10-08 | Cocensys Inc | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof |
| EP2424521A4 (en) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050840C (zh) * | 1993-06-14 | 2000-03-29 | 美国辉瑞有限公司 | 咪唑脂氧合酶抑制剂 |
| SK281577B6 (sk) | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
| US5883106A (en) * | 1994-10-18 | 1999-03-16 | Pfizer Inc. | 5-lipoxygenase inhibitors |
| US6063928A (en) * | 1994-10-18 | 2000-05-16 | Pfizer Inc | 5-lipoxygenase inhibitors |
| WO1997011079A1 (en) * | 1995-09-18 | 1997-03-27 | Pfizer Pharmaceuticals Inc. | Novel imidazole lipoxygenase inhibitors |
-
2000
- 2000-06-29 US US09/606,609 patent/US6344563B1/en not_active Expired - Fee Related
- 2000-08-24 YU YU52800A patent/YU52800A/sh unknown
- 2000-08-24 IL IL13808800A patent/IL138088A0/xx unknown
- 2000-08-24 AU AU53607/00A patent/AU5360700A/en not_active Abandoned
- 2000-08-28 KR KR1020000049968A patent/KR20010050224A/ko not_active Application Discontinuation
- 2000-08-28 ZA ZA200004436A patent/ZA200004436B/xx unknown
- 2000-08-29 TR TR2000/02523A patent/TR200002523A2/xx unknown
- 2000-08-29 ID IDP20000718D patent/ID29315A/id unknown
- 2000-08-29 AR ARP000104488A patent/AR022649A1/es unknown
- 2000-08-29 CA CA002317001A patent/CA2317001A1/en not_active Abandoned
- 2000-08-30 MX MXPA00008505A patent/MXPA00008505A/es unknown
- 2000-08-30 JP JP2000260776A patent/JP2001106687A/ja active Pending
- 2000-08-30 BR BR0003875-0A patent/BR0003875A/pt not_active IP Right Cessation
- 2000-08-30 RU RU2000122713/04A patent/RU2177005C1/ru active
- 2000-08-30 CN CN00126870A patent/CN1291609A/zh active Pending
- 2000-08-30 EP EP00307440A patent/EP1081146A1/en not_active Withdrawn
- 2000-08-30 CZ CZ20003160A patent/CZ20003160A3/cs unknown
- 2000-08-30 HU HU0003438A patent/HUP0003438A3/hu unknown
- 2000-08-31 PL PL00342284A patent/PL342284A1/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001106687A (ja) | 2001-04-17 |
| RU2177005C1 (ru) | 2001-12-20 |
| HUP0003438A3 (en) | 2002-08-28 |
| CN1291609A (zh) | 2001-04-18 |
| ID29315A (id) | 2001-08-16 |
| HU0003438D0 (en) | 2000-08-30 |
| KR20010050224A (ko) | 2001-06-15 |
| EP1081146A1 (en) | 2001-03-07 |
| CA2317001A1 (en) | 2001-02-28 |
| TR200002523A2 (tr) | 2001-04-20 |
| AR022649A1 (es) | 2002-09-04 |
| ZA200004436B (en) | 2002-02-28 |
| MXPA00008505A (es) | 2005-07-25 |
| CZ20003160A3 (cs) | 2001-10-17 |
| YU52800A (sh) | 2003-08-29 |
| AU5360700A (en) | 2001-03-08 |
| US6344563B1 (en) | 2002-02-05 |
| PL342284A1 (en) | 2001-03-12 |
| IL138088A0 (en) | 2001-10-31 |
| HUP0003438A2 (hu) | 2001-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A, 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |