ES2005746A6 - Un procedimiento para la preparacion de un haluro de piridinio. - Google Patents
Un procedimiento para la preparacion de un haluro de piridinio.Info
- Publication number
- ES2005746A6 ES2005746A6 ES8703768A ES8703768A ES2005746A6 ES 2005746 A6 ES2005746 A6 ES 2005746A6 ES 8703768 A ES8703768 A ES 8703768A ES 8703768 A ES8703768 A ES 8703768A ES 2005746 A6 ES2005746 A6 ES 2005746A6
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- preparation
- formula
- piperidine esters
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Abstract
EL COMPUESTO (II) EN QUE AR ES ARILO O ARILO SUSTITUIDO, R3 Y R4, IGUALES O DIFERENTES, SON ALQUILO Y HAL ES HALOGENO, SE OBTIENE POR CUATERNIZACION DE (III) EN QUE AR Y R4 SON LOS DEFINIDOS ANTES CON UN HALUURO DE ALQUILO HAL-R3, EN QUE HAL REPRESENTA HALOGENO Y R3 ES ALQUILO O ARILO.ESTOS COMPUESTOS TIENEN UTILIDAD COMO INTERMEDIOS EN LA PREPARACION DE ARIL-PIPERIDIN ESTERES QUE SE EMPLEAN COMO ANTIDEPRESIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858520154A GB8520154D0 (en) | 1985-08-10 | 1985-08-10 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2005746A6 true ES2005746A6 (es) | 1989-03-16 |
Family
ID=10583642
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8600961A Expired ES2000604A6 (es) | 1985-08-10 | 1986-08-08 | Un procedimiento para preparar aril-piperidin esteres |
ES8703768A Expired ES2005746A6 (es) | 1985-08-10 | 1987-12-30 | Un procedimiento para la preparacion de un haluro de piridinio. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8600961A Expired ES2000604A6 (es) | 1985-08-10 | 1986-08-08 | Un procedimiento para preparar aril-piperidin esteres |
Country Status (10)
Country | Link |
---|---|
US (1) | US4861893A (es) |
EP (1) | EP0219934B1 (es) |
JP (4) | JPH0699389B2 (es) |
CA (1) | CA1290340C (es) |
DE (1) | DE3682253D1 (es) |
ES (2) | ES2000604A6 (es) |
GB (1) | GB8520154D0 (es) |
GR (1) | GR862099B (es) |
MX (1) | MX173379B (es) |
PT (1) | PT83180B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714707D0 (en) * | 1987-06-23 | 1987-07-29 | Beecham Group Plc | Chemical process |
US5446057A (en) * | 1993-09-24 | 1995-08-29 | Warner-Lambert Company | Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists |
GB9325644D0 (en) * | 1993-12-15 | 1994-02-16 | Smithkline Beecham Plc | Novel formulation |
ES2121684B1 (es) * | 1996-03-15 | 1999-08-16 | Vita Invest Sa | Procedimiento para la obtencion de (+)-cis / (+)-trans-4-(4-fluorofenil)-1-metilpiperidina-3-carboxilato de etilo. |
JP3446468B2 (ja) | 1996-04-15 | 2003-09-16 | 旭硝子株式会社 | ピペリジンカルビノール類の製造方法 |
EP0812827B1 (en) * | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation |
CA2214288C (en) * | 1996-09-18 | 2006-07-18 | Lonza Ag | Process for the preparation of 1-acyl-4-arylpiperidines |
GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
EP0975595B9 (en) * | 1997-04-07 | 2009-09-16 | Georgetown University | Analogs of cocaine |
ATE279393T1 (de) | 1997-05-29 | 2004-10-15 | Smithkline Beecham Corp | Neues verfahren |
WO1998056787A1 (en) | 1997-06-10 | 1998-12-17 | Synthon B.V. | 4-Phenylpiperidine compounds |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
GB9924855D0 (en) * | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel processes |
GB9924882D0 (en) * | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel process |
AU1037701A (en) * | 1999-10-20 | 2001-04-30 | Smithkline Beecham Plc | Process for the preparation of 4-(fluorophenyl)piperidine esters |
US6833458B2 (en) | 2000-06-05 | 2004-12-21 | Development Center For Biotechnology | Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates |
WO2002032870A1 (en) * | 2000-10-20 | 2002-04-25 | Smithkline Beecham P.L.C. | Process of the preparation of 3-substituted-4-aryl piperidine compounds |
US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE336414C (de) * | 1919-06-21 | 1921-05-03 | Chem Fab | Verfahren zur Darstellung von Hexahydroderivaten der N-Methylpyridin-3-carbonsaeureester (N-Methylnicotinsaeureester) |
DE574137C (de) * | 1925-08-12 | 1933-04-10 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Piperidin und seinen Abkoemmlingen |
CH369132A (de) * | 1958-08-12 | 1963-05-15 | Cilag Chemie Aktiengesellschaf | Verfahren zur Herstellung von Nipecotinsäureamiden |
US3922278A (en) * | 1972-06-12 | 1975-11-25 | Sterling Drug Inc | 4-(3-Nitrophenyl)-3,5-pyridinedicarboxylic acid |
GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
DE2658804A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Kreislaufbeeinflussende mittel |
-
1985
- 1985-08-10 GB GB858520154A patent/GB8520154D0/en active Pending
-
1986
- 1986-08-06 DE DE8686306071T patent/DE3682253D1/de not_active Expired - Fee Related
- 1986-08-06 EP EP86306071A patent/EP0219934B1/en not_active Expired - Lifetime
- 1986-08-08 PT PT83180A patent/PT83180B/pt not_active IP Right Cessation
- 1986-08-08 GR GR862099A patent/GR862099B/el unknown
- 1986-08-08 ES ES8600961A patent/ES2000604A6/es not_active Expired
- 1986-08-08 JP JP61185430A patent/JPH0699389B2/ja not_active Expired - Lifetime
- 1986-08-08 MX MX006869A patent/MX173379B/es unknown
- 1986-08-08 CA CA000515597A patent/CA1290340C/en not_active Expired - Fee Related
- 1986-08-08 US US06/894,765 patent/US4861893A/en not_active Expired - Lifetime
-
1987
- 1987-12-30 ES ES8703768A patent/ES2005746A6/es not_active Expired
-
1994
- 1994-06-14 JP JP6154352A patent/JPH08810B2/ja not_active Expired - Lifetime
- 1994-06-14 JP JP6154351A patent/JPH0794443B2/ja not_active Expired - Lifetime
- 1994-06-14 JP JP6154350A patent/JPH0794442B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2000604A6 (es) | 1988-03-01 |
JPH07138231A (ja) | 1995-05-30 |
US4861893A (en) | 1989-08-29 |
JPH08810B2 (ja) | 1996-01-10 |
GB8520154D0 (en) | 1985-09-18 |
EP0219934A1 (en) | 1987-04-29 |
JPH0699389B2 (ja) | 1994-12-07 |
GR862099B (en) | 1986-12-30 |
JPH07138229A (ja) | 1995-05-30 |
MX173379B (es) | 1994-02-23 |
JPH0794442B2 (ja) | 1995-10-11 |
PT83180B (pt) | 1989-03-30 |
EP0219934B1 (en) | 1991-10-30 |
JPH07149728A (ja) | 1995-06-13 |
JPS6239568A (ja) | 1987-02-20 |
DE3682253D1 (de) | 1991-12-05 |
PT83180A (en) | 1986-09-01 |
JPH0794443B2 (ja) | 1995-10-11 |
CA1290340C (en) | 1991-10-08 |
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