ES8200092A1 - Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico - Google Patents

Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico

Info

Publication number
ES8200092A1
ES8200092A1 ES497136A ES497136A ES8200092A1 ES 8200092 A1 ES8200092 A1 ES 8200092A1 ES 497136 A ES497136 A ES 497136A ES 497136 A ES497136 A ES 497136A ES 8200092 A1 ES8200092 A1 ES 8200092A1
Authority
ES
Spain
Prior art keywords
methylpyrrole
acetamide
hydroxyphenyl
benzoyl
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497136A
Other languages
English (en)
Other versions
ES497136A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Calzada y Cia SC
Original Assignee
Calzada y Cia SC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calzada y Cia SC filed Critical Calzada y Cia SC
Priority to ES497136A priority Critical patent/ES497136A0/es
Priority to US06/285,341 priority patent/US4379793A/en
Publication of ES8200092A1 publication Critical patent/ES8200092A1/es
Publication of ES497136A0 publication Critical patent/ES497136A0/es
Priority to EP81305251A priority patent/EP0051981B1/en
Priority to DE8181305251T priority patent/DE3173904D1/de
Priority to AT81305251T priority patent/ATE18208T1/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE ESTERES DE LA N-(4''-HIDROXIFENIL) ACETAMIDA CON ACIDOS 5-BENZOIL-1-METILPIRROL-2-ACETICO. CONSISTE EN HACER REACCIONAR EN UN DISOLVENTE ORGANICO ANHIDRIDO Y A UNA TEMPERATURA DE 15 A 150, DICHOS ACIDOS CON UN HALURO O CON UN OXIHALURO DE FOSFORO O DE AZUFRE, PARA OBTENER UN HALOGENURO DE ACILO DE LOS ACIDOS 5-BENZOIL-1-METIL-PIRROL-2-ACETICO. POSTERIORMENTE SE HACE REACCIONAR EN UN DISOLVENTE ORGANICO ANHIDRIDO EL HALOGENURO DE ACILO FORMADO CON N-(4''-HIDROXIFENIL) ACETAMIDA, OBTENIENDOSE UN COMPUESTO DE FORMULA GENERAL (I), DONDE R ES UN GRUPO ALQUILO DE 1 A 4 ATOMOS DE CARBONO, DE CADENA LINEAL O RAMIFICADA, O ES UN HALOGENO. LOS COMPUESTOS RESULTANTES DE LA SINTESIS PRESENTAN ACTIVIDAD ANTIINFLAMATORIA, ANALGESICA Y ANTITERMICA DE INTERES TERAPEUTICO, USANDOSE PARA PREPARAR DIVERSAS COMPOSICIONES FARMACEUTICAS.
ES497136A 1980-11-11 1980-11-11 Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico Granted ES497136A0 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES497136A ES497136A0 (es) 1980-11-11 1980-11-11 Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico
US06/285,341 US4379793A (en) 1980-11-11 1981-07-20 Process for synthesis of esters of N-(4'-hydroxyphenyl)acetamide with derivatives of 5-benzoil-1-methyl pyrrole-2-acetic acids
EP81305251A EP0051981B1 (en) 1980-11-11 1981-11-04 Esters of n-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids
DE8181305251T DE3173904D1 (en) 1980-11-11 1981-11-04 Esters of n-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids
AT81305251T ATE18208T1 (de) 1980-11-11 1981-11-04 N-(4-hydroxyphenyl)essigsaeureamid-estern aus 5benzoyl-1-methylpyrrol-2-essigsaeure.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES497136A ES497136A0 (es) 1980-11-11 1980-11-11 Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico

Publications (2)

Publication Number Publication Date
ES8200092A1 true ES8200092A1 (es) 1981-10-16
ES497136A0 ES497136A0 (es) 1981-10-16

Family

ID=8481439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497136A Granted ES497136A0 (es) 1980-11-11 1980-11-11 Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico

Country Status (5)

Country Link
US (1) US4379793A (es)
EP (1) EP0051981B1 (es)
AT (1) ATE18208T1 (es)
DE (1) DE3173904D1 (es)
ES (1) ES497136A0 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
US4585784A (en) * 1983-01-26 1986-04-29 Mcneilab, Inc. Pyrrole-2-acetylamino acid derivative compounds
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US4187230A (en) * 1975-05-27 1980-02-05 Ethyl Corporation Preparation of 5-aroyl-pyrrole compounds
US4233309A (en) * 1977-12-06 1980-11-11 Teijin Limited Novel 1-substituted-3-acylpyrrole derivatives, platelet aggregation inhibitors containing them, as active ingredients, and processes for production of said derivatives

Also Published As

Publication number Publication date
US4379793A (en) 1983-04-12
ATE18208T1 (de) 1986-03-15
DE3173904D1 (en) 1986-04-03
EP0051981B1 (en) 1986-02-26
ES497136A0 (es) 1981-10-16
EP0051981A1 (en) 1982-05-19

Similar Documents

Publication Publication Date Title
CA1238910A (en) CARBOXYALKENOIC ACIDS
GB2124077B (en) Immunomodulating agent
ES2000604A6 (es) Un procedimiento para preparar aril-piperidin esteres
FR2368488A1 (fr) Procede pour la preparation de methoxypsoralene
FR2445318A1 (fr) Procede de preparation de 1-(3-mercapto-propanoyl)-l-prolines
ES8200092A1 (es) Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico
MY104009A (en) Process for the preparation of n-phosphonomethylglycine.
YU26081A (en) Process for preparing 2-nitro-5-(substituted-phenoxy)-benzoate esters of alpha-hydroxy alkanoates
YU179585A (en) Process for optical dividing of racemic mixtures of naphtil-propionic acids
JPS54128591A (en) Cephalosporin analog
IL90845A0 (en) Process and intermediates for the synthesis of optically active aminoacids
GB1445668A (en) Process for obtaining the optical isomers of penicillamine
CA1273347C (es)
FR2453159A1 (fr) Procede de preparation de 2-aminopyrazines substituees
FR2372842A1 (fr) Procede pour la preparation d'esters de la 2,2'-anhydro-1b-d-arabinofuranosyl-5-fluorocytosine
FR2355813A1 (fr) Procede de preparation de n-(2-cyanophenyl)-formiamidines
DE2963107D1 (en) Process for preparing amino acids and esters
FR2367770A1 (fr) Procede de preparation d'acides alcenylphosphiniques
HUT47929A (en) Process for producing 4-piperidine-carboxamide derivatives and pharmaceuticals comprising same
EP0150883A3 (en) Process for preparing n-(dibenzyloxyphosphoryl)-cyanamide, compound so obtained, processes using said compounds as intermediate for the synthesis of phosphagen substances, and substances produced in that way
FR2453160A1 (fr) Procede de preparation de quinazolinones
DK0627419T3 (da) Optisk aktive derivater af 1-phenylpyrrolidon og fremgangsmåde til fremstilling deraf
ES8404989A1 (es) Un procedimiento para preparar 4-(2-hidroxietil)-2-azetidinona opticamente activa.
DK161599C (da) Fremgangsmaade til fremstilling af lysergsyreestere
ES459897A1 (es) Un procedimiento para la produccion de acido 6,11-dihidrodi-benzo (b. e.)tiepin-11-on-3-acetico.