MXPA05008619A - Derivados novedosos de 2-piridincarboxamida. - Google Patents
Derivados novedosos de 2-piridincarboxamida.Info
- Publication number
- MXPA05008619A MXPA05008619A MXPA05008619A MXPA05008619A MXPA05008619A MX PA05008619 A MXPA05008619 A MX PA05008619A MX PA05008619 A MXPA05008619 A MX PA05008619A MX PA05008619 A MXPA05008619 A MX PA05008619A MX PA05008619 A MXPA05008619 A MX PA05008619A
- Authority
- MX
- Mexico
- Prior art keywords
- general formula
- novel
- sulfur
- oxygen
- iii
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Los compuestos representados por la formula general (I) o sales farmaceuticamente aceptables de los mismos, que tienen un efecto activante de la glucocinasa y que son utiles como remedios para la diabetes: (I) en donde X1 es nitrogeno, azufre, oxigeno o lo similar ; R1 es un arilo de 6 a 10 miembros, heteroarilo de 5 a 7 miembros o lo similar; D es oxigeno o azufre; R2 y R3 son cada uno, de manera independiente, hidrogeno, alquilo inferior o lo similar; el anillo A de la formula general (II): (II) es un heteroarilo de 5 a 7 miembros sustituido opcionalmente o lo similar y el anillo B de la formula general (III): (III) es un grupo heteroarilo mono o biciclico.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003034987 | 2003-02-13 | ||
JP2003342860 | 2003-10-01 | ||
JP2004014799 | 2004-01-22 | ||
PCT/JP2004/001568 WO2004081001A1 (ja) | 2003-02-13 | 2004-02-13 | 新規2-ピリジンカルボキサミド誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05008619A true MXPA05008619A (es) | 2005-11-04 |
Family
ID=32995582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05008619A MXPA05008619A (es) | 2003-02-13 | 2004-02-13 | Derivados novedosos de 2-piridincarboxamida. |
Country Status (21)
Country | Link |
---|---|
US (3) | US7629362B2 (es) |
EP (1) | EP1598349B1 (es) |
JP (1) | JP4400563B2 (es) |
KR (1) | KR20050101208A (es) |
AR (1) | AR045414A1 (es) |
AT (1) | ATE517887T1 (es) |
AU (2) | AU2004220234C1 (es) |
BR (1) | BRPI0407283A (es) |
CA (1) | CA2515841C (es) |
EC (1) | ECSP056016A (es) |
HK (1) | HK1088602A1 (es) |
IL (1) | IL169905A0 (es) |
MA (1) | MA27626A1 (es) |
MX (1) | MXPA05008619A (es) |
NO (1) | NO20054224L (es) |
NZ (1) | NZ540791A (es) |
PE (1) | PE20050194A1 (es) |
TW (1) | TWI336329B (es) |
UA (1) | UA82867C2 (es) |
WO (1) | WO2004081001A1 (es) |
ZA (1) | ZA200504852B (es) |
Families Citing this family (70)
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US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
CA2498089A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
AU2004220234C1 (en) | 2003-02-13 | 2013-01-17 | Msd K.K. | Novel 2-pyridinecarboxamide derivatives |
BRPI0418212A (pt) * | 2003-12-29 | 2007-04-27 | Banyu Pharma Co Ltd | composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidade |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
JP2007524682A (ja) * | 2004-02-12 | 2007-08-30 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体−5の調節物質としてのビピリジルアミド |
CA2560689C (en) | 2004-04-02 | 2011-03-01 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes |
CA2561157A1 (en) | 2004-04-02 | 2005-10-13 | Novartis Ag | Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
CA2582658A1 (en) | 2004-10-08 | 2006-04-13 | Banyu Pharmaceutical Co., Ltd. | Method for producing thioether compound |
CN101094847B (zh) | 2004-11-02 | 2011-06-15 | Msdk.K.公司 | 芳氧基取代的苯并咪唑衍生物 |
ZA200708144B (en) * | 2005-02-25 | 2008-11-26 | Takeda Pharmaceutical | Pyridyl acetic acid compounds |
MX2007010414A (es) | 2005-03-04 | 2007-09-25 | Hoffmann La Roche | Derivados de piridin-2-carboxamida como antagonistas de mglur5. |
EP1919885B1 (en) | 2005-08-05 | 2010-04-28 | Brystol-Myers Squibb Company | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
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GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
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JP5419706B2 (ja) | 2006-12-20 | 2014-02-19 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼアクチベーター |
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-
2004
- 2004-02-13 AU AU2004220234A patent/AU2004220234C1/en not_active Ceased
- 2004-02-13 NZ NZ540791A patent/NZ540791A/en not_active IP Right Cessation
- 2004-02-13 CA CA2515841A patent/CA2515841C/en not_active Expired - Fee Related
- 2004-02-13 KR KR1020057014827A patent/KR20050101208A/ko not_active Application Discontinuation
- 2004-02-13 WO PCT/JP2004/001568 patent/WO2004081001A1/ja active Application Filing
- 2004-02-13 MX MXPA05008619A patent/MXPA05008619A/es active IP Right Grant
- 2004-02-13 UA UAA200508682A patent/UA82867C2/uk unknown
- 2004-02-13 BR BR0407283-9A patent/BRPI0407283A/pt not_active Application Discontinuation
- 2004-02-13 AR ARP040100442A patent/AR045414A1/es unknown
- 2004-02-13 AT AT04711025T patent/ATE517887T1/de not_active IP Right Cessation
- 2004-02-13 JP JP2005503465A patent/JP4400563B2/ja not_active Expired - Fee Related
- 2004-02-13 EP EP04711025A patent/EP1598349B1/en not_active Expired - Lifetime
- 2004-02-13 US US10/545,424 patent/US7629362B2/en active Active
- 2004-02-13 PE PE2004000159A patent/PE20050194A1/es not_active Application Discontinuation
- 2004-02-13 TW TW093103493A patent/TWI336329B/zh not_active IP Right Cessation
-
2005
- 2005-06-14 ZA ZA2005/04852A patent/ZA200504852B/en unknown
- 2005-07-26 IL IL169905A patent/IL169905A0/en unknown
- 2005-08-24 MA MA28455A patent/MA27626A1/fr unknown
- 2005-09-12 NO NO20054224A patent/NO20054224L/no not_active Application Discontinuation
- 2005-09-13 EC EC2005006016A patent/ECSP056016A/es unknown
-
2006
- 2006-08-11 HK HK06108941A patent/HK1088602A1/xx not_active IP Right Cessation
-
2009
- 2009-10-23 US US12/604,835 patent/US8344003B2/en active Active
-
2010
- 2010-01-04 AU AU2010200004A patent/AU2010200004B2/en not_active Ceased
-
2012
- 2012-11-27 US US13/685,775 patent/US8765789B2/en not_active Expired - Lifetime
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