NO20054224L - Nye 2-pyridinkarboksamidderivater - Google Patents
Nye 2-pyridinkarboksamidderivaterInfo
- Publication number
- NO20054224L NO20054224L NO20054224A NO20054224A NO20054224L NO 20054224 L NO20054224 L NO 20054224L NO 20054224 A NO20054224 A NO 20054224A NO 20054224 A NO20054224 A NO 20054224A NO 20054224 L NO20054224 L NO 20054224L
- Authority
- NO
- Norway
- Prior art keywords
- general formula
- new
- sulfur
- oxygen
- ring
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Forbindelse representert ved den generelle formel (I) eller farmasøytisk akseptable salter derav, som har glukokinaseaktiverende effekt og er anvendbare som sukkersykemedisiner: hvor X1 er nitrogen, svovel, oksygen eller lignende; R1 er 6-10-leddet aryl, 5-7-leddet heteroaryl eller lignende; D er oksygen eller svovel; R2 og R3 er uavhengig av hverandre hydrogen, lavere alkyl eller lignende; ringen A med den generelle formel (II): er eventuelt substituert 5-7-leddet heteroaryl eller lignende; og ringen B med den generelle formel (III): er en mono- eller bisyklisk heteroarylgruppe.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003034987 | 2003-02-13 | ||
JP2003342860 | 2003-10-01 | ||
JP2004014799 | 2004-01-22 | ||
PCT/JP2004/001568 WO2004081001A1 (ja) | 2003-02-13 | 2004-02-13 | 新規2-ピリジンカルボキサミド誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20054224D0 NO20054224D0 (no) | 2005-09-12 |
NO20054224L true NO20054224L (no) | 2005-11-10 |
Family
ID=32995582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20054224A NO20054224L (no) | 2003-02-13 | 2005-09-12 | Nye 2-pyridinkarboksamidderivater |
Country Status (21)
Country | Link |
---|---|
US (3) | US7629362B2 (no) |
EP (1) | EP1598349B1 (no) |
JP (1) | JP4400563B2 (no) |
KR (1) | KR20050101208A (no) |
AR (1) | AR045414A1 (no) |
AT (1) | ATE517887T1 (no) |
AU (2) | AU2004220234C1 (no) |
BR (1) | BRPI0407283A (no) |
CA (1) | CA2515841C (no) |
EC (1) | ECSP056016A (no) |
HK (1) | HK1088602A1 (no) |
IL (1) | IL169905A0 (no) |
MA (1) | MA27626A1 (no) |
MX (1) | MXPA05008619A (no) |
NO (1) | NO20054224L (no) |
NZ (1) | NZ540791A (no) |
PE (1) | PE20050194A1 (no) |
TW (1) | TWI336329B (no) |
UA (1) | UA82867C2 (no) |
WO (1) | WO2004081001A1 (no) |
ZA (1) | ZA200504852B (no) |
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US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
CA2498089A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
NZ540791A (en) | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
JP4707560B2 (ja) * | 2003-12-29 | 2011-06-22 | Msd株式会社 | 新規2−ヘテロアリール置換ベンズイミダゾール誘導体 |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
AU2005215379A1 (en) * | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
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KR20070006816A (ko) | 2004-04-02 | 2007-01-11 | 노파르티스 아게 | 티아졸로피리딘 유도체, 이를 함유하는 제약 조성물 및글루코키나제 매개형 증상의 치료 방법 |
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BRPI0517232A (pt) | 2004-11-02 | 2008-10-07 | Banyu Pharma Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, ativador da glicocinase, e, agentes terapêuticos e/ou profiláticos para diabetes e para obesidade |
PE20061099A1 (es) * | 2005-02-25 | 2006-12-05 | Takeda Pharmaceutical | Compuestos de piridil acido acetico como inhibidores de peptidasa |
CA2599974C (en) | 2005-03-04 | 2013-12-31 | F. Hoffmann-La Roche Ag | Pyridine-2-carboxamide derivatives as mglur5 antagonists |
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US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
CA2624102A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
CA2623958C (en) * | 2005-09-30 | 2013-05-28 | Banyu Pharmaceutical Co., Ltd. | 2-heteroaryl-substituted indole derivative |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
JP4870164B2 (ja) | 2005-10-05 | 2012-02-08 | エフ.ホフマン−ラ ロシュ アーゲー | ナフチリジン誘導体 |
EP1948652B1 (en) * | 2005-11-01 | 2011-08-24 | Array Biopharma, Inc. | Glucokinase activators |
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JP5386350B2 (ja) | 2006-05-31 | 2014-01-15 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体 |
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WO2009083553A1 (en) * | 2007-12-31 | 2009-07-09 | Rheoscience A/S | Azine compounds as glucokinase activators |
KR20100117137A (ko) * | 2008-02-27 | 2010-11-02 | 메르크 파텐트 게엠베하 | 당뇨병 치료를 위한 카르복사마이드-헤테로아릴유도체 |
WO2009113637A1 (ja) * | 2008-03-12 | 2009-09-17 | 東ソー株式会社 | 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法 |
JP5455380B2 (ja) * | 2008-03-12 | 2014-03-26 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体、及びその製造方法 |
JP5498025B2 (ja) * | 2008-03-13 | 2014-05-21 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体固定化マトリックス、及びその製造方法 |
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CN104411710A (zh) | 2012-04-16 | 2015-03-11 | 卡内克制药公司 | 作为ptp-1b抑制剂前体的稠合的芳族膦酸酯衍生物 |
US9527838B2 (en) * | 2012-12-17 | 2016-12-27 | Merck Sharp & Dohme Corp. | 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment |
MX2016014755A (es) | 2014-05-13 | 2017-03-27 | Memorial Sloan Kettering Cancer Center | Moduladores de proteinas del choque termico 70 (hsp70) y metodos para fabricar y usar el mismo. |
US20240067657A1 (en) * | 2020-12-29 | 2024-02-29 | Merck Sharp & Dohme Llc | Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses |
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US7683218B2 (en) * | 2004-10-08 | 2010-03-23 | Banyu Pharmaceutical Co., Ltd. | Method for producing thioether compound |
AR063028A1 (es) * | 2006-10-06 | 2008-12-23 | Banyu Pharma Co Ltd | Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. |
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-
2004
- 2004-02-13 NZ NZ540791A patent/NZ540791A/en not_active IP Right Cessation
- 2004-02-13 KR KR1020057014827A patent/KR20050101208A/ko not_active Application Discontinuation
- 2004-02-13 AT AT04711025T patent/ATE517887T1/de not_active IP Right Cessation
- 2004-02-13 AR ARP040100442A patent/AR045414A1/es unknown
- 2004-02-13 TW TW093103493A patent/TWI336329B/zh not_active IP Right Cessation
- 2004-02-13 AU AU2004220234A patent/AU2004220234C1/en not_active Ceased
- 2004-02-13 WO PCT/JP2004/001568 patent/WO2004081001A1/ja active Application Filing
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