NO20023161L - Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem - Google Patents

Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem

Info

Publication number
NO20023161L
NO20023161L NO20023161A NO20023161A NO20023161L NO 20023161 L NO20023161 L NO 20023161L NO 20023161 A NO20023161 A NO 20023161A NO 20023161 A NO20023161 A NO 20023161A NO 20023161 L NO20023161 L NO 20023161L
Authority
NO
Norway
Prior art keywords
compounds
preparation
drugs containing
processes
substituted piperidines
Prior art date
Application number
NO20023161A
Other languages
English (en)
Other versions
NO20023161D0 (no
NO323700B1 (no
Inventor
Klaus Rudolf
Wolfgang Eberlein
Alexander Dreyer
Stephan Georg Mueller
Henri Nico Doods
Eckhart Bauer
Rudolf Hurnaus
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20023161L publication Critical patent/NO20023161L/no
Publication of NO20023161D0 publication Critical patent/NO20023161D0/no
Publication of NO323700B1 publication Critical patent/NO323700B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Den foreliggende oppfinnelse vedrører substituerte piperidiner med den generelle formel (I). i hvilken A, A, R, Rog R2 er definert som i krav 1, deres tautomere, deres diastereomere, deres enantiomere, deres blandinger og deres salter, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, hvilke har verdifulle farmakologiske egenskaper, særlig CGRP-antagonistiske egenskaper, legemidler inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for deres fremstilling.
NO20023161A 1999-12-30 2002-06-28 Substituerte piperidiner, fysiologisk akseptable salter og legemidler inneholdende disse forbindelser, anvendelse av disse forbindelser for fremstilling av legemiddel og fremgangsmater for deres fremstilling. NO323700B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963868A DE19963868A1 (de) 1999-12-30 1999-12-30 Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP2000/013236 WO2001049676A1 (de) 1999-12-30 2000-12-22 Substituierte piperidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number Publication Date
NO20023161L true NO20023161L (no) 2002-06-28
NO20023161D0 NO20023161D0 (no) 2002-06-28
NO323700B1 NO323700B1 (no) 2007-06-25

Family

ID=7935059

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023161A NO323700B1 (no) 1999-12-30 2002-06-28 Substituerte piperidiner, fysiologisk akseptable salter og legemidler inneholdende disse forbindelser, anvendelse av disse forbindelser for fremstilling av legemiddel og fremgangsmater for deres fremstilling.

Country Status (29)

Country Link
US (1) US6949541B2 (no)
EP (1) EP1252153A1 (no)
JP (1) JP2003519222A (no)
KR (1) KR100736063B1 (no)
CN (1) CN1203069C (no)
AR (1) AR027113A1 (no)
AU (1) AU783275B2 (no)
BG (1) BG106848A (no)
BR (1) BR0017063A (no)
CA (1) CA2395541C (no)
CZ (1) CZ20022628A3 (no)
DE (1) DE19963868A1 (no)
EA (1) EA005600B1 (no)
EE (1) EE200200369A (no)
HK (1) HK1054026A1 (no)
HR (1) HRP20020560A2 (no)
HU (1) HUP0300002A3 (no)
IL (2) IL150377A0 (no)
MX (1) MXPA02006509A (no)
NO (1) NO323700B1 (no)
NZ (1) NZ519939A (no)
PL (1) PL356400A1 (no)
SK (1) SK9412002A3 (no)
TW (1) TWI255267B (no)
UA (1) UA75346C2 (no)
UY (1) UY26513A1 (no)
WO (1) WO2001049676A1 (no)
YU (1) YU50002A (no)
ZA (1) ZA200205181B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211770A1 (de) * 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
KR20120004541A (ko) * 2002-06-05 2012-01-12 브리스톨-마이어스 스큅 컴퍼니 칼시토닌 유전자 관련 펩티드 수용체 길항제
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
CA2522024A1 (en) * 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
AU2004252150B2 (en) * 2003-06-26 2008-11-20 Merck Sharp & Dohme Corp. Benzodiazepine CGRP receptor antagonists
JP4705912B2 (ja) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾジアゼピンｃｇｒｐ受容体拮抗物質
TW200524601A (en) * 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
JP2007524568A (ja) 2003-12-05 2007-08-30 ブリストル−マイヤーズ　スクイブ　カンパニー カルシトニン遺伝子関連ペプチドレセプターアンタゴニスト
US7820673B2 (en) * 2003-12-17 2010-10-26 Takeda Pharmaceutical Company Limited Urea derivative, process for producing the same, and use
JP4705922B2 (ja) * 2004-01-29 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体拮抗薬
DE102004006893A1 (de) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin
US20050192230A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim International Gambh Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
TW200533398A (en) * 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
US7696192B2 (en) * 2004-09-09 2010-04-13 Merck Sharp & Dohme Corp. Tricyclic anilide spirolactam CGRP receptor antagonists
CA2579850A1 (en) * 2004-09-13 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirohydantoin cgrp receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) * 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
EP1770091A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2006103701A1 (en) * 2005-04-01 2006-10-05 Pankaj Kehr Reusable metal blade handle
US7834007B2 (en) * 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
AR127170A1 (es) * 2021-09-30 2023-12-27 Crinetics Pharmaceuticals Inc Antagonistas del receptor de la hormona paratiroidea (pth) y sus usos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5011390A (no) * 1973-05-30 1975-02-05
WO1996035713A1 (en) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
BR9712023A (pt) * 1996-09-10 1999-08-31 Thomae Gmbh Dr K Aminoácidos derivados, medicamentos contendo esses compostos e processos para a sua preparação.
DE19636623A1 (de) * 1996-09-10 1998-03-12 Thomae Gmbh Dr K Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CA2345357A1 (en) * 1998-09-30 2000-04-06 Merck Sharp & Dohme Limited Benzimidazolinyl piperidines as cgrp ligands
DE10250080A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CZ20022628A3 (cs) 2002-10-16
CN1203069C (zh) 2005-05-25
CN1414960A (zh) 2003-04-30
IL150377A0 (en) 2002-12-01
WO2001049676A1 (de) 2001-07-12
HK1054026A1 (en) 2003-11-14
MXPA02006509A (es) 2002-11-29
EA200200651A1 (ru) 2002-12-26
SK9412002A3 (en) 2002-11-06
PL356400A1 (en) 2004-06-28
HUP0300002A3 (en) 2006-01-30
HUP0300002A2 (en) 2003-05-28
AU3537901A (en) 2001-07-16
EP1252153A1 (de) 2002-10-30
CA2395541C (en) 2008-09-23
US20030212057A1 (en) 2003-11-13
DE19963868A1 (de) 2001-07-12
US6949541B2 (en) 2005-09-27
HRP20020560A2 (en) 2005-04-30
CA2395541A1 (en) 2001-07-12
NO20023161D0 (no) 2002-06-28
UY26513A1 (es) 2001-07-31
TWI255267B (en) 2006-05-21
AU783275B2 (en) 2005-10-06
BG106848A (bg) 2002-12-29
EE200200369A (et) 2003-10-15
BR0017063A (pt) 2002-10-22
JP2003519222A (ja) 2003-06-17
YU50002A (sh) 2005-11-28
KR100736063B1 (ko) 2007-07-06
NZ519939A (en) 2006-08-31
IL150377A (en) 2007-06-17
KR20020073493A (ko) 2002-09-26
ZA200205181B (en) 2003-09-30
AR027113A1 (es) 2003-03-12
EA005600B1 (ru) 2005-04-28
UA75346C2 (en) 2006-04-17
NO323700B1 (no) 2007-06-25

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