YU50002A - Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju - Google Patents
Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnjuInfo
- Publication number
- YU50002A YU50002A YU50002A YUP50002A YU50002A YU 50002 A YU50002 A YU 50002A YU 50002 A YU50002 A YU 50002A YU P50002 A YUP50002 A YU P50002A YU 50002 A YU50002 A YU 50002A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- production
- methods
- medicaments containing
- substituted piperidines
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Ovaj se pronalazak odnosi na supstituisane piperidine, opšte formule (I), u kojoj su A1, A2, R, R1 i R2 definisani kao u zahtevu (1), na njihove tautomere, njihove dijastereomere, njihove enantiomere, njihove smeše i njihove soli, naročito njihove fiziološki podnošljive soli sa neorganskim ili organskim kiselinama ili bazama, koji ispoljavaju dragocena farmakološka svojstva, naročito CGRP-antagonistička svojstva, na lekove koji sadrže ova jedinjenja, na njihovu primenu i postupke za njihovo pripremanje.[The invention relates to substituted piperdines of general formula (I) in which A1, A2, R, R1 and R2 are defined as in Claim No. 1, to their tautomers, diastereomers, enantiomers, mixtures, and to their salts, in particular, their physiologically compatible salts with inorganic or organic acids or bases, which comprise valuable pharmacological properties, in particular, CGRP-antagonistic properties. The invention also relates to medicaments containing these compounds, to their use and to methods for the production thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19963868A DE19963868A1 (de) | 1999-12-30 | 1999-12-30 | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
YU50002A true YU50002A (sh) | 2005-11-28 |
Family
ID=7935059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU50002A YU50002A (sh) | 1999-12-30 | 2000-12-22 | Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju |
Country Status (29)
Country | Link |
---|---|
US (1) | US6949541B2 (sh) |
EP (1) | EP1252153A1 (sh) |
JP (1) | JP2003519222A (sh) |
KR (1) | KR100736063B1 (sh) |
CN (1) | CN1203069C (sh) |
AR (1) | AR027113A1 (sh) |
AU (1) | AU783275B2 (sh) |
BG (1) | BG106848A (sh) |
BR (1) | BR0017063A (sh) |
CA (1) | CA2395541C (sh) |
CZ (1) | CZ20022628A3 (sh) |
DE (1) | DE19963868A1 (sh) |
EA (1) | EA005600B1 (sh) |
EE (1) | EE200200369A (sh) |
HK (1) | HK1054026A1 (sh) |
HR (1) | HRP20020560A2 (sh) |
HU (1) | HUP0300002A3 (sh) |
IL (2) | IL150377A0 (sh) |
MX (1) | MXPA02006509A (sh) |
NO (1) | NO323700B1 (sh) |
NZ (1) | NZ519939A (sh) |
PL (1) | PL356400A1 (sh) |
SK (1) | SK9412002A3 (sh) |
TW (1) | TWI255267B (sh) |
UA (1) | UA75346C2 (sh) |
UY (1) | UY26513A1 (sh) |
WO (1) | WO2001049676A1 (sh) |
YU (1) | YU50002A (sh) |
ZA (1) | ZA200205181B (sh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10211770A1 (de) * | 2002-03-14 | 2003-10-02 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
KR20120004541A (ko) * | 2002-06-05 | 2012-01-12 | 브리스톨-마이어스 스큅 컴퍼니 | 칼시토닌 유전자 관련 펩티드 수용체 길항제 |
US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
CA2522024A1 (en) * | 2003-04-15 | 2004-10-28 | Merck & Co., Inc. | Cgrp receptor antagonists |
AU2004252150B2 (en) * | 2003-06-26 | 2008-11-20 | Merck Sharp & Dohme Corp. | Benzodiazepine CGRP receptor antagonists |
JP4705912B2 (ja) * | 2003-06-26 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ベンゾジアゼピンcgrp受容体拮抗物質 |
TW200524601A (en) * | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
JP2007524568A (ja) | 2003-12-05 | 2007-08-30 | ブリストル−マイヤーズ スクイブ カンパニー | カルシトニン遺伝子関連ペプチドレセプターアンタゴニスト |
US7820673B2 (en) * | 2003-12-17 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Urea derivative, process for producing the same, and use |
JP4705922B2 (ja) * | 2004-01-29 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Cgrp受容体拮抗薬 |
DE102004006893A1 (de) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin |
US20050192230A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim International Gambh | Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine |
TW200533398A (en) * | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
US7696192B2 (en) * | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
CA2579850A1 (en) * | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirohydantoin cgrp receptor antagonists |
US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7449586B2 (en) * | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
EP1770091A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
WO2006103701A1 (en) * | 2005-04-01 | 2006-10-05 | Pankaj Kehr | Reusable metal blade handle |
US7834007B2 (en) * | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
AR127170A1 (es) * | 2021-09-30 | 2023-12-27 | Crinetics Pharmaceuticals Inc | Antagonistas del receptor de la hormona paratiroidea (pth) y sus usos |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5011390A (sh) * | 1973-05-30 | 1975-02-05 | ||
WO1996035713A1 (en) * | 1995-05-08 | 1996-11-14 | Pfizer, Inc. | Dipeptides which promote release of growth hormone |
BR9712023A (pt) * | 1996-09-10 | 1999-08-31 | Thomae Gmbh Dr K | Aminoácidos derivados, medicamentos contendo esses compostos e processos para a sua preparação. |
DE19636623A1 (de) * | 1996-09-10 | 1998-03-12 | Thomae Gmbh Dr K | Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
CA2345357A1 (en) * | 1998-09-30 | 2000-04-06 | Merck Sharp & Dohme Limited | Benzimidazolinyl piperidines as cgrp ligands |
DE10250080A1 (de) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
-
1999
- 1999-12-30 DE DE19963868A patent/DE19963868A1/de not_active Withdrawn
-
2000
- 2000-12-22 EE EEP200200369A patent/EE200200369A/xx unknown
- 2000-12-22 MX MXPA02006509A patent/MXPA02006509A/es active IP Right Grant
- 2000-12-22 WO PCT/EP2000/013236 patent/WO2001049676A1/de active IP Right Grant
- 2000-12-22 CA CA002395541A patent/CA2395541C/en not_active Expired - Fee Related
- 2000-12-22 KR KR1020027008495A patent/KR100736063B1/ko not_active IP Right Cessation
- 2000-12-22 CZ CZ20022628A patent/CZ20022628A3/cs unknown
- 2000-12-22 US US10/169,009 patent/US6949541B2/en not_active Expired - Lifetime
- 2000-12-22 CN CNB008181063A patent/CN1203069C/zh not_active Expired - Fee Related
- 2000-12-22 UA UA2002076283A patent/UA75346C2/uk unknown
- 2000-12-22 YU YU50002A patent/YU50002A/sh unknown
- 2000-12-22 IL IL15037700A patent/IL150377A0/xx active IP Right Grant
- 2000-12-22 BR BR0017063-1A patent/BR0017063A/pt active Pending
- 2000-12-22 SK SK941-2002A patent/SK9412002A3/sk not_active Application Discontinuation
- 2000-12-22 AU AU35379/01A patent/AU783275B2/en not_active Ceased
- 2000-12-22 PL PL00356400A patent/PL356400A1/xx not_active Application Discontinuation
- 2000-12-22 JP JP2001550216A patent/JP2003519222A/ja active Pending
- 2000-12-22 EP EP00991806A patent/EP1252153A1/de not_active Withdrawn
- 2000-12-22 HU HU0300002A patent/HUP0300002A3/hu unknown
- 2000-12-22 NZ NZ519939A patent/NZ519939A/en unknown
- 2000-12-22 EA EA200200651A patent/EA005600B1/ru not_active IP Right Cessation
- 2000-12-27 AR ARP000106941A patent/AR027113A1/es not_active Suspension/Interruption
- 2000-12-28 UY UY26513A patent/UY26513A1/es not_active Application Discontinuation
- 2000-12-28 TW TW089128135A patent/TWI255267B/zh not_active IP Right Cessation
-
2002
- 2002-06-20 BG BG106848A patent/BG106848A/bg active Pending
- 2002-06-24 IL IL150377A patent/IL150377A/en not_active IP Right Cessation
- 2002-06-27 ZA ZA200205181A patent/ZA200205181B/en unknown
- 2002-06-27 HR HR20020560A patent/HRP20020560A2/hr not_active Application Discontinuation
- 2002-06-28 NO NO20023161A patent/NO323700B1/no unknown
-
2003
- 2003-09-01 HK HK03106237A patent/HK1054026A1/xx not_active IP Right Cessation
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