NO972881L - Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling - Google Patents
Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstillingInfo
- Publication number
- NO972881L NO972881L NO972881A NO972881A NO972881L NO 972881 L NO972881 L NO 972881L NO 972881 A NO972881 A NO 972881A NO 972881 A NO972881 A NO 972881A NO 972881 L NO972881 L NO 972881L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- methods
- piperazine derivatives
- drugs containing
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
Det beskrives piperazinderivater med den generelle formel. hvor. Ra, Yi til Yog E er som definert i krav 1, deres tautomerer, deres stereoisomerer, inklusivt deres blandinger og deres salter, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, og som oppviser verdifulle farmakologiske egenskaper, fortrinnsvis. , aggregasjonshemmende virkninger, legemidler som inneholder disse forbindelsene, deres anvendelse samt fremgangsmåter fortleres fremstilling.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19944446301 DE4446301A1 (de) | 1994-12-23 | 1994-12-23 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE19526678A DE19526678A1 (de) | 1994-12-23 | 1995-07-21 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE1995133639 DE19533639A1 (de) | 1994-12-23 | 1995-09-12 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
PCT/EP1995/005031 WO1996020173A1 (de) | 1994-12-23 | 1995-12-19 | Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972881D0 NO972881D0 (no) | 1997-06-20 |
NO972881L true NO972881L (no) | 1997-06-20 |
Family
ID=27207101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972881A NO972881L (no) | 1994-12-23 | 1997-06-20 | Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling |
Country Status (20)
Country | Link |
---|---|
US (1) | US5922717A (no) |
EP (1) | EP0799202A1 (no) |
JP (1) | JPH10511374A (no) |
CN (1) | CN1183770A (no) |
AR (1) | AR002950A1 (no) |
AU (1) | AU4432496A (no) |
BG (1) | BG101582A (no) |
BR (1) | BR9510360A (no) |
CA (1) | CA2207618A1 (no) |
CZ (1) | CZ189197A3 (no) |
EE (1) | EE9700141A (no) |
FI (1) | FI972646A (no) |
HR (1) | HRP950609A2 (no) |
IL (1) | IL116517A0 (no) |
MX (1) | MX9704745A (no) |
NO (1) | NO972881L (no) |
PL (1) | PL321003A1 (no) |
SK (1) | SK79797A3 (no) |
TR (1) | TR199501634A2 (no) |
WO (1) | WO1996020173A1 (no) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037343A (en) * | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 5員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
EP1070712A4 (en) | 1998-04-09 | 2005-01-05 | Meiji Seika Kaisha | NITROGEN-CONTAINING HETEROCYCLES WITH ANTI-BLOOD INFLAMMATION AND THEIR MEDICAL USE |
EP1533310A1 (en) * | 1999-09-29 | 2005-05-25 | Ortho-McNeil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
BR0007183A (pt) * | 1999-09-29 | 2002-02-05 | Ortho Mcneil Pharm Inc | Isonipectoamidas para o tratamento de distúrbios mediados por integrina |
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
US7081460B2 (en) * | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
ES2376399T3 (es) | 2001-08-24 | 2012-03-13 | Yale University | Compuestos de piperazinona como agentes antitumorales y anticancer�?genos. |
FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
EP1472222A1 (en) | 2002-02-08 | 2004-11-03 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
CA2558585C (en) * | 2004-02-27 | 2010-10-12 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
US7851474B2 (en) * | 2005-08-02 | 2010-12-14 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
WO2007053400A2 (en) * | 2005-10-28 | 2007-05-10 | Merck & Co., Inc. | Piperidine glycine transporter inhibitors |
CA2655159C (en) | 2006-06-28 | 2014-12-30 | Amgen Inc. | Glycine transporter-1 inhibitors |
US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
PL2076506T3 (pl) * | 2007-01-16 | 2011-03-31 | Purdue Pharma Lp | Heterocyklicznie podstawione piperydyny jako ligandy ORL-1 |
ES2920605T3 (es) * | 2007-08-31 | 2022-08-05 | Purdue Pharma Lp | Intermedios de piperidina |
WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
EA201490152A1 (ru) | 2011-06-24 | 2014-05-30 | Эмджен Инк. | Антагонисты trpm8 и их применение при лечении |
AU2012272898A1 (en) | 2011-06-24 | 2013-04-11 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
WO2013123511A1 (en) * | 2012-02-16 | 2013-08-22 | New York University | Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
JP2016510327A (ja) | 2013-01-19 | 2016-04-07 | ニューヨーク・ユニバーシティ | p53再活性化のためのオリゴオキソピペラジン |
EP3145921A4 (en) | 2014-05-21 | 2017-11-08 | New York University | Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression |
WO2023122481A2 (en) * | 2021-12-20 | 2023-06-29 | Sigma-Aldrich Co. Llc | Chemical linkers |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
ZA825719B (en) * | 1981-09-03 | 1983-06-29 | Recordati Chem Pharm | Alkanoylanilides |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
US4895846A (en) * | 1984-04-11 | 1990-01-23 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties |
US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
ZW4194A1 (en) * | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic compounds |
DK0691959T3 (da) * | 1993-03-29 | 1999-04-26 | Zeneca Ltd | Heterocykliske derivater som blodpladeaggregations-inhibitorer |
DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE4326344A1 (de) * | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
EP0721941A4 (en) * | 1994-07-15 | 1996-09-25 | Meiji Seika Co | NOVEL COMPOUNDS HAVING AN INHIBITING EFFECT ON PLATELET AGGREGATION |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
-
1995
- 1995-12-19 CA CA002207618A patent/CA2207618A1/en not_active Abandoned
- 1995-12-19 MX MX9704745A patent/MX9704745A/es unknown
- 1995-12-19 SK SK797-97A patent/SK79797A3/sk unknown
- 1995-12-19 EP EP95943168A patent/EP0799202A1/de not_active Withdrawn
- 1995-12-19 EE EE9700141A patent/EE9700141A/xx unknown
- 1995-12-19 CN CN95196854A patent/CN1183770A/zh active Pending
- 1995-12-19 JP JP8520188A patent/JPH10511374A/ja active Pending
- 1995-12-19 CZ CZ971891A patent/CZ189197A3/cs unknown
- 1995-12-19 BR BR9510360A patent/BR9510360A/pt not_active Application Discontinuation
- 1995-12-19 AU AU44324/96A patent/AU4432496A/en not_active Abandoned
- 1995-12-19 WO PCT/EP1995/005031 patent/WO1996020173A1/de not_active Application Discontinuation
- 1995-12-19 PL PL95321003A patent/PL321003A1/xx unknown
- 1995-12-20 HR HR19533639.9A patent/HRP950609A2/hr not_active Application Discontinuation
- 1995-12-21 US US08/576,528 patent/US5922717A/en not_active Expired - Fee Related
- 1995-12-21 TR TR95/01634A patent/TR199501634A2/xx unknown
- 1995-12-22 IL IL11651795A patent/IL116517A0/xx unknown
- 1995-12-22 AR ARP950100727A patent/AR002950A1/es unknown
-
1997
- 1997-06-06 BG BG101582A patent/BG101582A/xx unknown
- 1997-06-19 FI FI972646A patent/FI972646A/fi not_active Application Discontinuation
- 1997-06-20 NO NO972881A patent/NO972881L/no unknown
Also Published As
Publication number | Publication date |
---|---|
TR199501634A2 (tr) | 1996-07-21 |
JPH10511374A (ja) | 1998-11-04 |
CA2207618A1 (en) | 1996-07-04 |
WO1996020173A1 (de) | 1996-07-04 |
CZ189197A3 (cs) | 1998-01-14 |
BR9510360A (pt) | 1997-12-23 |
EP0799202A1 (de) | 1997-10-08 |
MX9704745A (es) | 1997-10-31 |
AU4432496A (en) | 1996-07-19 |
US5922717A (en) | 1999-07-13 |
BG101582A (en) | 1998-01-30 |
IL116517A0 (en) | 1996-03-31 |
NO972881D0 (no) | 1997-06-20 |
FI972646A (fi) | 1997-08-19 |
CN1183770A (zh) | 1998-06-03 |
HRP950609A2 (en) | 1997-10-31 |
EE9700141A (et) | 1997-12-15 |
PL321003A1 (en) | 1997-11-24 |
SK79797A3 (en) | 1997-11-05 |
AR002950A1 (es) | 1998-05-27 |
FI972646A0 (fi) | 1997-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO972881L (no) | Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling | |
NO934501L (no) | Karboksylsyrederivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling | |
NO923466L (no) | Heterocykliske forbindelser med 5 ledd, fremgangsmaate forfremstilling, samt legemidler som inneholder disse forbindelser | |
NO933248L (no) | Cykliske urinstoffderivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling | |
NO922940L (no) | Fem-leddete heterocykliske forbindelser, fremgangsmaate for deres fremstilling og legemidler inneholdende dem | |
NO940261L (no) | 5-leddete heterocykler, fremgangsmåte ved fremstilling derav og legemidler som inneholder disse forbindelser | |
NO932120L (no) | Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling | |
NO984084L (no) | 4-Amino-pyrimidin-derivater, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte ved fremstilling derav | |
DK0483667T3 (da) | Cykliske iminoderivater, lægemidler indholdende disse forbindelser og fremgangsmåde til fremstilling deraf | |
DK0567966T3 (da) | Cykliske aminoderivater, fremgangsmåder til deres fremstilling og lægemidler indeholdende disse forbindelser | |
MX9803954A (es) | Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos. | |
NO941677D0 (no) | Tetrazolderivater av gallesyrer, fremgangsmåter for fremstilling og deres anvendelse som legemiddel | |
NO984081L (no) | Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling derav | |
DK0496378T3 (da) | Biphenylderivater, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling | |
BR0113039A (pt) | Composto ou um seu sal ou solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica em aerossol, método para o tratamento de um indivìduo humano ou animal com uma condição antiinflamatória e/ou alérgica, e, processo para preparar um composto | |
NO942977L (no) | Piperazin og piperidinderivater og anvendelse derav som antipsykotiske midler | |
NO991761L (no) | Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse | |
MX9700020A (es) | Derivados ciclicos de una urea, medicamentos que contienen estos compuestos y procedimiento para su preparacion. | |
NO940524L (no) | ||
NO931527L (no) | Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling | |
DE59208974D1 (de) | Neue pyrazinderivative, ihre herstellung und verwendung | |
DK163581C (da) | Kondenserede pyrazol-3-oxo-propannitrilderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne | |
NO20023001L (no) | Substituerte piperazinderivater som MTP inhibitorer | |
NO20022123L (no) | Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII | |
ES555240A0 (es) | Un procedimiento para la preparacion de derivados de piridina. |