NO931527L - Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling - Google Patents

Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling

Info

Publication number
NO931527L
NO931527L NO93931527A NO931527A NO931527L NO 931527 L NO931527 L NO 931527L NO 93931527 A NO93931527 A NO 93931527A NO 931527 A NO931527 A NO 931527A NO 931527 L NO931527 L NO 931527L
Authority
NO
Norway
Prior art keywords
preparation
cyclic imino
procedure
preparations containing
imino derivatives
Prior art date
Application number
NO93931527A
Other languages
English (en)
Other versions
NO931527D0 (no
Inventor
Guenter Linz
Volkhard Austel
Frank Himmelsbach
Johannes Weisenberger
Thomas Mueller
Helmut Pieper
Elke Seewaldt-Becker
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO931527D0 publication Critical patent/NO931527D0/no
Publication of NO931527L publication Critical patent/NO931527L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Oppfinnelsen angår cykliske iminoderivater med den generelle formel (1) til RB er som definert i krav l, deres tautomerer, hvor X og Ra deres stereoisomerer, innbefattet deres blandinger og deres salter, spesielt deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, som oppviser verdifulle farmakologiske egenskaper, fortrinnsvis aggregasjonshemmende virkninger, legemidler som inneholder disse forbindelser og fremgangsmåter for deres fremstilling.
NO93931527A 1992-04-28 1993-04-27 Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling NO931527L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4213931A DE4213931A1 (de) 1992-04-28 1992-04-28 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
NO931527D0 NO931527D0 (no) 1993-04-27
NO931527L true NO931527L (no) 1993-10-29

Family

ID=6457642

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931527A NO931527L (no) 1992-04-28 1993-04-27 Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling

Country Status (14)

Country Link
US (1) US5489693A (no)
EP (1) EP0567968A1 (no)
JP (1) JPH0625159A (no)
KR (1) KR930021615A (no)
AU (1) AU659933B2 (no)
CA (1) CA2094964A1 (no)
DE (1) DE4213931A1 (no)
FI (1) FI931882A (no)
HU (1) HU9301223D0 (no)
IL (1) IL105518A0 (no)
MX (1) MX9302459A (no)
NO (1) NO931527L (no)
NZ (1) NZ247502A (no)
PL (1) PL298718A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
JPH0616948A (ja) * 1992-04-16 1994-01-25 Mearthane Prod Corp 導電性及び半導電性ポリマー材
DE4241632A1 (de) * 1992-12-10 1994-06-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1994022820A1 (en) * 1993-03-31 1994-10-13 G.D. Searle & Co. 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
WO1997002245A1 (fr) * 1995-07-06 1997-01-23 Japan Tobacco Inc. Derives de benzamidoxime et leur utilisation a des fins medicinales
WO1999050249A2 (en) 1998-04-01 1999-10-07 Du Pont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
US6319937B1 (en) 1998-11-18 2001-11-20 Dupont Pharmaceuticals Company Isoxazoline fibrinogen receptor antagonists
AU1735200A (en) 1998-11-18 2000-06-05 Du Pont Pharmaceuticals Company Novel isoxazoline fibrinogen receptor antagonists
DE19936789A1 (de) * 1999-08-09 2001-03-01 Vectron Therapeutics Ag Neue Pyrrolidinole und ihre Verwendung für die Tumortherapie
US8222341B2 (en) 2009-03-17 2012-07-17 Mearthane Products Corporation Semi-conductive silicone polymers
CN102206178B (zh) * 2010-03-30 2013-04-10 上海源力生物技术有限公司 制备艾瑞昔布的方法
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123288A (en) * 1982-07-16 1984-02-01 Wellcome Found Anti-thrombotic agent
EP0196184B1 (en) * 1985-03-16 1992-09-16 The Wellcome Foundation Limited Aryl derivatives
DE3823299A1 (de) * 1988-07-07 1990-01-11 Schering Ag Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln
JPH02247166A (ja) * 1989-03-17 1990-10-02 Taisho Pharmaceut Co Ltd ３―ピロリン―２―オン誘導体
US5026861A (en) * 1989-07-17 1991-06-25 Merrell Dow Pharmaceuticals Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
AU632963B2 (en) * 1990-09-07 1993-01-14 Mitsui Toatsu Chemicals Inc. 3,4-trans-4-ethyl-1-(substituted phenyl)-3-(substituted phenyl)pyrrolidin-2-ones, method for preparing the same, and herbicidal compositions containing the same as herbicidally active ingredients
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NZ247502A (en) 1995-09-26
FI931882A (fi) 1993-10-29
AU3822393A (en) 1993-11-04
EP0567968A1 (de) 1993-11-03
FI931882A0 (fi) 1993-04-27
MX9302459A (es) 1994-06-30
HU9301223D0 (en) 1993-07-28
IL105518A0 (en) 1993-08-18
AU659933B2 (en) 1995-06-01
US5489693A (en) 1996-02-06
KR930021615A (ko) 1993-11-22
PL298718A1 (en) 1994-01-24
DE4213931A1 (de) 1993-11-04
NO931527D0 (no) 1993-04-27
CA2094964A1 (en) 1993-10-29
JPH0625159A (ja) 1994-02-01

Similar Documents

Publication Publication Date Title
NO922940L (no) Fem-leddete heterocykliske forbindelser, fremgangsmaate for deres fremstilling og legemidler inneholdende dem
NO933248L (no) Cykliske urinstoffderivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
NO923466L (no) Heterocykliske forbindelser med 5 ledd, fremgangsmaate forfremstilling, samt legemidler som inneholder disse forbindelser
NO934501L (no) Karboksylsyrederivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
NO972881L (no) Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling
NO940261L (no) 5-leddete heterocykler, fremgangsmåte ved fremstilling derav og legemidler som inneholder disse forbindelser
NO932120L (no) Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
NO931526L (no) Cykliske iminoderivater, fremgangsmaate for deres fremstilling, og legemiddelpreparater inneholdende dem
MX9803954A (es) Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos.
NO984084L (no) 4-Amino-pyrimidin-derivater, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte ved fremstilling derav
NO931527L (no) Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling
HU913455D0 (en) Process for the production of imino derivatives with cyclic structure, and medical preparations containing them
EP0528369A3 (de) Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
NO20064201L (no) Glukopyranosylsubstituerte benzolderivater, medikamenter inneholdende slike forbindelser, deres anvendelse og fremstilling
NO984081L (no) Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling derav
NO940524L (no)
DE69818286D1 (de) Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen
NO995481L (no) Glykokonjugater av 20 (S)-camptothecin
EG19302A (en) Compound with gastric acid inhibitory effect and process for its preparation
NO933558L (no) Benzimidazoler, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
ATE293635T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
YU3701A (sh) Supstituisani fenilamidini sa antitrombskim dejstvom
NO963374L (no) Substituerte 4H-pyraner
EE03919B1 (et) Asendatud fenüülamidiinid, neid ühendeid sisaldavad ravimid ja meetod nende valmistamiseks
ATE252598T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen