NO995481L - Glykokonjugater av 20 (S)-camptothecin - Google Patents

Glykokonjugater av 20 (S)-camptothecin

Info

Publication number
NO995481L
NO995481L NO995481A NO995481A NO995481L NO 995481 L NO995481 L NO 995481L NO 995481 A NO995481 A NO 995481A NO 995481 A NO995481 A NO 995481A NO 995481 L NO995481 L NO 995481L
Authority
NO
Norway
Prior art keywords
camptothecin
glycoconjugates
relates
oncoses
methylated
Prior art date
Application number
NO995481A
Other languages
English (en)
Other versions
NO995481D0 (no
Inventor
Hans-Georg Lerchen
Karsten Von Dem Bruch
Joerg Baumgarten
Michael Sperzel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19801037A external-priority patent/DE19801037A1/de
Priority claimed from DE1998113137 external-priority patent/DE19813137A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO995481L publication Critical patent/NO995481L/no
Publication of NO995481D0 publication Critical patent/NO995481D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Electrically Operated Instructional Devices (AREA)

Abstract

Den foreliggende oppfinnelsen angår glykokonjugater av 20(S)-camptothecin hvori en 3-O-metylert fi-L-fukoseenhet bindes til 20-hydroksylgruppen til et camptothecinderivat via en tiourea-modifisert peptidspacer. Oppfinnelsen angår videre fremgangsmåter for fremstillingen av forbindelser ifølge oppfinnelsen og deres anvendelse som medikamenter, særlig i forbindelse med onkoser.
NO995481A 1997-05-14 1999-11-09 Glykokonjugater av 20 (S)-camptothecin NO995481D0 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19720043 1997-05-14
DE19737477 1997-08-28
DE19801037A DE19801037A1 (de) 1997-05-14 1998-01-14 Glycokonjugate von 20(S)-Camptothecin
DE1998113137 DE19813137A1 (de) 1998-03-25 1998-03-25 Glycokonjugate von 20(S)-Camptothecin
PCT/EP1998/002620 WO1998051703A1 (de) 1997-05-14 1998-05-04 Glycokonjugate von 20(s)-camptothecin

Publications (2)

Publication Number Publication Date
NO995481L true NO995481L (no) 1999-11-09
NO995481D0 NO995481D0 (no) 1999-11-09

Family

ID=27438596

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995481A NO995481D0 (no) 1997-05-14 1999-11-09 Glykokonjugater av 20 (S)-camptothecin

Country Status (19)

Country Link
US (1) US6506734B1 (no)
EP (1) EP0981542B1 (no)
JP (1) JP2001526661A (no)
CN (1) CN1255926A (no)
AT (1) ATE272648T1 (no)
AU (1) AU744425B2 (no)
BG (1) BG103872A (no)
BR (1) BR9809637A (no)
CA (1) CA2291436A1 (no)
HU (1) HUP0003174A3 (no)
ID (1) ID23424A (no)
IL (1) IL132534A0 (no)
NO (1) NO995481D0 (no)
NZ (1) NZ500990A (no)
PL (1) PL336697A1 (no)
SK (1) SK154899A3 (no)
TR (1) TR199902775T2 (no)
TW (1) TW495512B (no)
WO (1) WO1998051703A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19909979A1 (de) * 1999-03-06 2000-09-07 Bayer Ag Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin
DE10005275A1 (de) * 2000-02-07 2001-08-09 Bayer Ag Neuartige Glycokonjugate
EP1219634A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
EP1238678A1 (en) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
WO2003101998A1 (en) 2002-06-03 2003-12-11 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
US7766293B2 (en) * 2006-04-25 2010-08-03 Raffel Systems, Llc Lighted cup holder for seating arrangements
WO2014152718A1 (en) 2013-03-15 2014-09-25 Arizona Board Of Regents, For And On Behalf Of Arizona State University Saccharide conjugates
US9919055B2 (en) 2013-03-15 2018-03-20 Arizona Board Of Regents On Behalf Of Arizona State University Sugar-linker-drug conjugates
CN103333172B (zh) * 2013-06-28 2015-09-30 兰州大学 喜树碱缩氨基硫脲类化合物及其制备方法和用途
CN105566338B (zh) * 2014-10-08 2017-11-21 兰州大学 一种喜树碱类化合物及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP2524803B2 (ja) 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体およびその製造法
DK0418099T3 (da) * 1989-09-15 2002-04-02 Res Triangle Inst Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
DE4106101A1 (de) 1991-02-27 1992-09-03 Bayer Ag Fucose-markierte cytostatika
JP3126799B2 (ja) 1992-03-31 2001-01-22 第一製薬株式会社 光学活性カンプトテシン誘導体及びその製法
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
DE69425464T2 (de) * 1993-02-26 2001-05-23 Drug Delivery System Institute, Ltd. Polysaccharidderivat und wirkstoffträger
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5646262A (en) * 1994-07-28 1997-07-08 Georgetown University Antisense oligonucleotides against hepatitis B viral replication
US5496830A (en) 1994-09-14 1996-03-05 Johns Hopkins University Inhibition of hemoflagellates by camptothecin compounds
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
DE19512484A1 (de) * 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
AU4459297A (en) * 1996-09-30 1998-04-24 Bayer Aktiengesellschaft Glycoconjugates from modified camptothecin derivates (20-o-linkage)
DE19640969A1 (de) 1996-10-04 1998-04-16 Bayer Ag 20-0-verknüpfte Glycokonjugate von Camptothecin

Also Published As

Publication number Publication date
NZ500990A (en) 2000-09-29
ATE272648T1 (de) 2004-08-15
IL132534A0 (en) 2001-03-19
HUP0003174A3 (en) 2003-03-28
US6506734B1 (en) 2003-01-14
BR9809637A (pt) 2000-07-11
EP0981542A1 (de) 2000-03-01
BG103872A (en) 2000-07-31
HUP0003174A2 (hu) 2001-05-28
AU7761598A (en) 1998-12-08
ID23424A (id) 2000-04-20
CN1255926A (zh) 2000-06-07
TR199902775T2 (xx) 2000-07-21
TW495512B (en) 2002-07-21
CA2291436A1 (en) 1998-11-19
PL336697A1 (en) 2000-07-03
EP0981542B1 (de) 2004-08-04
NO995481D0 (no) 1999-11-09
JP2001526661A (ja) 2001-12-18
AU744425B2 (en) 2002-02-21
SK154899A3 (en) 2000-08-14
WO1998051703A1 (de) 1998-11-19

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