HUP0003174A2 - 20(S)-Kamptotecin glikokonjugátumai, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

20(S)-Kamptotecin glikokonjugátumai, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0003174A2
HUP0003174A2 HU0003174A HUP0003174A HUP0003174A2 HU P0003174 A2 HUP0003174 A2 HU P0003174A2 HU 0003174 A HU0003174 A HU 0003174A HU P0003174 A HUP0003174 A HU P0003174A HU P0003174 A2 HUP0003174 A2 HU P0003174A2
Authority
HU
Hungary
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
glycoconjugates
camptothecin
Prior art date
Application number
HU0003174A
Other languages
English (en)
Inventor
Jörg Baumgarten
Hans-Georg Lerchen
Michael Sperzel
Karsten Von Dem Bruch
Original Assignee
Bayer Aktiengesellshaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19801037A external-priority patent/DE19801037A1/de
Priority claimed from DE1998113137 external-priority patent/DE19813137A1/de
Application filed by Bayer Aktiengesellshaft filed Critical Bayer Aktiengesellshaft
Publication of HUP0003174A2 publication Critical patent/HUP0003174A2/hu
Publication of HUP0003174A3 publication Critical patent/HUP0003174A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

A találmány szerinti vegyületek (I) általános képletében R1 jelentésevalamely aminosav nagy térkitöltésű apoláros oldallánca R2 jelentésevalamely aminosav bázikus oldallánca. A találmány kiterjed a fentivegyületek előállítására és az ezeket tartalmazó daganatosmegbetegedések kezelésére szolgáló gyógyszerkészítményekre. Ó
HU0003174A 1997-05-14 1998-05-04 20(s) camptothecin glycoconjugates, process for their preparation and pharmaceutical compositions containing them HUP0003174A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19720043 1997-05-14
DE19737477 1997-08-28
DE19801037A DE19801037A1 (de) 1997-05-14 1998-01-14 Glycokonjugate von 20(S)-Camptothecin
DE1998113137 DE19813137A1 (de) 1998-03-25 1998-03-25 Glycokonjugate von 20(S)-Camptothecin
PCT/EP1998/002620 WO1998051703A1 (de) 1997-05-14 1998-05-04 Glycokonjugate von 20(s)-camptothecin

Publications (2)

Publication Number Publication Date
HUP0003174A2 true HUP0003174A2 (hu) 2001-05-28
HUP0003174A3 HUP0003174A3 (en) 2003-03-28

Family

ID=27438596

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003174A HUP0003174A3 (en) 1997-05-14 1998-05-04 20(s) camptothecin glycoconjugates, process for their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US6506734B1 (hu)
EP (1) EP0981542B1 (hu)
JP (1) JP2001526661A (hu)
CN (1) CN1255926A (hu)
AT (1) ATE272648T1 (hu)
AU (1) AU744425B2 (hu)
BG (1) BG103872A (hu)
BR (1) BR9809637A (hu)
CA (1) CA2291436A1 (hu)
HU (1) HUP0003174A3 (hu)
ID (1) ID23424A (hu)
IL (1) IL132534A0 (hu)
NO (1) NO995481D0 (hu)
NZ (1) NZ500990A (hu)
PL (1) PL336697A1 (hu)
SK (1) SK154899A3 (hu)
TR (1) TR199902775T2 (hu)
TW (1) TW495512B (hu)
WO (1) WO1998051703A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19909979A1 (de) * 1999-03-06 2000-09-07 Bayer Ag Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin
DE10005275A1 (de) * 2000-02-07 2001-08-09 Bayer Ag Neuartige Glycokonjugate
EP1219634A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
EP1238678A1 (en) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
US6933302B2 (en) 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
US7766293B2 (en) * 2006-04-25 2010-08-03 Raffel Systems, Llc Lighted cup holder for seating arrangements
EP2968381A4 (en) * 2013-03-15 2016-11-30 Sidney Hecht MEDICAMENT CONJUGATES-SUGAR BINDING SEQUENCE
US10046068B2 (en) 2013-03-15 2018-08-14 Arizona Board Of Regents On Behalf Of Arizona State University Saccharide conjugates
CN103333172B (zh) * 2013-06-28 2015-09-30 兰州大学 喜树碱缩氨基硫脲类化合物及其制备方法和用途
CN105566338B (zh) * 2014-10-08 2017-11-21 兰州大学 一种喜树碱类化合物及其制备方法和用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP2524803B2 (ja) 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体およびその製造法
EP0418099B1 (en) * 1989-09-15 2001-12-19 Research Triangle Institute Process of preparation of 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
DE4106101A1 (de) 1991-02-27 1992-09-03 Bayer Ag Fucose-markierte cytostatika
JP3126799B2 (ja) 1992-03-31 2001-01-22 第一製薬株式会社 光学活性カンプトテシン誘導体及びその製法
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
CA2134348C (en) * 1993-02-26 2007-01-02 Hideo Nogusa Polysaccharide derivatives and drug carriers
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5646262A (en) * 1994-07-28 1997-07-08 Georgetown University Antisense oligonucleotides against hepatitis B viral replication
US5496830A (en) 1994-09-14 1996-03-05 Johns Hopkins University Inhibition of hemoflagellates by camptothecin compounds
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
DE19512484A1 (de) * 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
ES2169429T3 (es) * 1996-09-30 2002-07-01 Bayer Ag Glicoconjugados de derivados modificados de la camptotecina (enlace en 20-o).
DE19640969A1 (de) 1996-10-04 1998-04-16 Bayer Ag 20-0-verknüpfte Glycokonjugate von Camptothecin

Also Published As

Publication number Publication date
BR9809637A (pt) 2000-07-11
TW495512B (en) 2002-07-21
PL336697A1 (en) 2000-07-03
BG103872A (en) 2000-07-31
NO995481L (no) 1999-11-09
US6506734B1 (en) 2003-01-14
AU744425B2 (en) 2002-02-21
ID23424A (id) 2000-04-20
CA2291436A1 (en) 1998-11-19
NZ500990A (en) 2000-09-29
NO995481D0 (no) 1999-11-09
ATE272648T1 (de) 2004-08-15
TR199902775T2 (xx) 2000-07-21
EP0981542B1 (de) 2004-08-04
CN1255926A (zh) 2000-06-07
IL132534A0 (en) 2001-03-19
WO1998051703A1 (de) 1998-11-19
EP0981542A1 (de) 2000-03-01
AU7761598A (en) 1998-12-08
HUP0003174A3 (en) 2003-03-28
JP2001526661A (ja) 2001-12-18
SK154899A3 (en) 2000-08-14

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