NO984081L - Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling derav - Google Patents
Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling deravInfo
- Publication number
- NO984081L NO984081L NO984081A NO984081A NO984081L NO 984081 L NO984081 L NO 984081L NO 984081 A NO984081 A NO 984081A NO 984081 A NO984081 A NO 984081A NO 984081 L NO984081 L NO 984081L
- Authority
- NO
- Norway
- Prior art keywords
- pyrimido
- pyrimidines
- preparation
- compounds
- medicaments containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Den foreliggende oppfinnelse vedrører pyrimido[5,4-d]pyrimidiner med den generelle formel. hvor. A. A& 6Aer som definert i krav 1, deres tautomerer, deres stereoisomerer og deres salter, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, og som har verdifulle farmakologiske egenskaper, særlig en hemmende virkning på signaltransduksjonen produsert av tyrosinkina-ser, deres anvendelse for behandling av sykdommer, særlig tumorsykdommer, og deres fremstilling.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19608653A DE19608653A1 (de) | 1996-03-06 | 1996-03-06 | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
PCT/EP1997/001058 WO1997032882A1 (de) | 1996-03-06 | 1997-03-03 | PYRIMIDO[5,4-d]PYRIMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984081D0 NO984081D0 (no) | 1998-09-04 |
NO984081L true NO984081L (no) | 1998-09-04 |
Family
ID=7787391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984081A NO984081L (no) | 1996-03-06 | 1998-09-04 | Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling derav |
Country Status (23)
Country | Link |
---|---|
US (1) | US5977102A (no) |
EP (1) | EP0885227A1 (no) |
JP (1) | JP2000506153A (no) |
KR (1) | KR19990087551A (no) |
CN (1) | CN1212696A (no) |
AR (1) | AR009937A1 (no) |
AU (1) | AU712072B2 (no) |
BG (1) | BG102790A (no) |
BR (1) | BR9708004A (no) |
CA (1) | CA2248316A1 (no) |
CO (1) | CO4650044A1 (no) |
CZ (1) | CZ281698A3 (no) |
DE (1) | DE19608653A1 (no) |
EE (1) | EE9800289A (no) |
HU (1) | HUP9901750A2 (no) |
IL (1) | IL125341A0 (no) |
NO (1) | NO984081L (no) |
NZ (1) | NZ331382A (no) |
PL (1) | PL328776A1 (no) |
SK (1) | SK120498A3 (no) |
TR (1) | TR199801753T2 (no) |
WO (1) | WO1997032882A1 (no) |
ZA (1) | ZA971886B (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2194181T3 (es) | 1996-02-13 | 2003-11-16 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de vegf. |
DK0885198T3 (da) | 1996-03-05 | 2002-03-25 | Astrazeneca Ab | 4-Anilinoquinazolinderivater |
UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
DE19911510A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
TR200102911T2 (tr) | 1999-04-09 | 2002-01-21 | Astrazeneca Ab | Adamantan türevleri. |
WO2000069909A1 (en) | 1999-05-14 | 2000-11-23 | The United States Of America Through The Department Of Veterans Affairs | Isolation and characterization of epidermal growth factor related protein |
US7049410B2 (en) * | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
KR100881105B1 (ko) | 1999-11-05 | 2009-02-02 | 아스트라제네카 아베 | Vegf 억제제로서의 퀴나졸린 유도체 |
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
CA2422560A1 (en) * | 2000-09-20 | 2002-03-28 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | 4-amino-quinazolines |
JP2004509876A (ja) * | 2000-09-20 | 2004-04-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 4−アミノ−キナゾリン |
UY27224A1 (es) * | 2001-03-23 | 2002-10-31 | Bayer Corp | Inhibidores de la rho-quinasa |
CA2441501C (en) * | 2001-03-23 | 2010-09-14 | Bayer Corporation | Rho-kinase inhibitors |
US7829566B2 (en) * | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
WO2003059913A1 (en) * | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
ATE381557T1 (de) * | 2002-01-23 | 2008-01-15 | Bayer Pharmaceuticals Corp | Rho-kinase inhibitoren |
MXPA04007191A (es) * | 2002-01-23 | 2005-03-31 | Bayer Pharmaceuticals Corp | Derivados de pirimidina como inhibidores de rho-quinasa. |
KR101139038B1 (ko) * | 2005-06-28 | 2012-05-02 | 삼성전자주식회사 | 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터 |
AR073501A1 (es) * | 2008-09-08 | 2010-11-10 | Boehringer Ingelheim Int | Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa |
EP2398797B1 (en) | 2009-02-17 | 2013-11-06 | Boehringer Ingelheim International GmbH | Pyrimido[5,4-d]pyrimidine derivatives for the inhibition of tyrosine kinases |
EA201101400A1 (ru) * | 2009-04-02 | 2012-07-30 | Мерк Патент Гмбх | Производные пиперидина и пиразина в качестве ингибиторов аутотаксина |
US20130023531A1 (en) | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
WO2014175370A1 (ja) * | 2013-04-25 | 2014-10-30 | 塩野義製薬株式会社 | ピロリジン誘導体およびそれらを含有する医薬組成物 |
TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
CA2955071A1 (en) | 2014-07-15 | 2016-01-21 | Grunenthal Gmbh | Substituted azaspiro(4.5)decane derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
DE3069211D1 (en) * | 1979-07-03 | 1984-10-25 | Thomae Gmbh Dr K | 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them |
DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
DE3423092A1 (de) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
DE4325900A1 (de) * | 1993-08-02 | 1995-02-09 | Thomae Gmbh Dr K | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
DE4431867A1 (de) * | 1994-09-07 | 1996-03-14 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
-
1996
- 1996-03-06 DE DE19608653A patent/DE19608653A1/de not_active Withdrawn
-
1997
- 1997-03-03 NZ NZ331382A patent/NZ331382A/xx unknown
- 1997-03-03 WO PCT/EP1997/001058 patent/WO1997032882A1/de not_active Application Discontinuation
- 1997-03-03 CN CN97192789A patent/CN1212696A/zh active Pending
- 1997-03-03 EP EP97907067A patent/EP0885227A1/de not_active Withdrawn
- 1997-03-03 TR TR1998/01753T patent/TR199801753T2/xx unknown
- 1997-03-03 PL PL97328776A patent/PL328776A1/xx unknown
- 1997-03-03 AU AU19252/97A patent/AU712072B2/en not_active Ceased
- 1997-03-03 JP JP9531445A patent/JP2000506153A/ja active Pending
- 1997-03-03 IL IL12534197A patent/IL125341A0/xx unknown
- 1997-03-03 EE EE9800289A patent/EE9800289A/xx unknown
- 1997-03-03 SK SK1204-98A patent/SK120498A3/sk unknown
- 1997-03-03 BR BR9708004A patent/BR9708004A/pt unknown
- 1997-03-03 CZ CZ982816A patent/CZ281698A3/cs unknown
- 1997-03-03 CA CA002248316A patent/CA2248316A1/en not_active Abandoned
- 1997-03-03 HU HU9901750A patent/HUP9901750A2/hu unknown
- 1997-03-03 KR KR1019980706988A patent/KR19990087551A/ko not_active Application Discontinuation
- 1997-03-05 ZA ZA971886A patent/ZA971886B/xx unknown
- 1997-03-05 AR ARP970100874A patent/AR009937A1/es unknown
- 1997-03-05 US US08/812,002 patent/US5977102A/en not_active Expired - Fee Related
- 1997-03-06 CO CO97012273A patent/CO4650044A1/es unknown
-
1998
- 1998-09-04 NO NO984081A patent/NO984081L/no unknown
- 1998-09-24 BG BG102790A patent/BG102790A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
SK120498A3 (en) | 1999-04-13 |
BR9708004A (pt) | 1999-07-27 |
JP2000506153A (ja) | 2000-05-23 |
AU712072B2 (en) | 1999-10-28 |
BG102790A (bg) | 1999-09-30 |
EP0885227A1 (de) | 1998-12-23 |
CZ281698A3 (cs) | 1999-02-17 |
US5977102A (en) | 1999-11-02 |
CA2248316A1 (en) | 1997-09-12 |
ZA971886B (en) | 1998-09-07 |
AU1925297A (en) | 1997-09-22 |
PL328776A1 (en) | 1999-02-15 |
EE9800289A (et) | 1999-02-15 |
AR009937A1 (es) | 2000-05-17 |
TR199801753T2 (xx) | 1998-12-21 |
DE19608653A1 (de) | 1997-09-11 |
NO984081D0 (no) | 1998-09-04 |
NZ331382A (en) | 1999-08-30 |
CN1212696A (zh) | 1999-03-31 |
IL125341A0 (en) | 1999-03-12 |
KR19990087551A (ko) | 1999-12-27 |
HUP9901750A2 (hu) | 1999-09-28 |
WO1997032882A1 (de) | 1997-09-12 |
CO4650044A1 (es) | 1998-09-03 |
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