NO991951L - Tienopyrimidiner med fosfodiesterase V-inhiberende virkning - Google Patents
Tienopyrimidiner med fosfodiesterase V-inhiberende virkningInfo
- Publication number
- NO991951L NO991951L NO991951A NO991951A NO991951L NO 991951 L NO991951 L NO 991951L NO 991951 A NO991951 A NO 991951A NO 991951 A NO991951 A NO 991951A NO 991951 L NO991951 L NO 991951L
- Authority
- NO
- Norway
- Prior art keywords
- phosphodiesterase
- tienopyrimidines
- inhibitory effect
- treatment
- thienopyrimidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tienopyrimidiner med formel (I). samt deres fysiologisk akseptable salter, hvor,,,, X og n har de i krav 1 angitte betydninger, utviser en fosfodiesterase V-hemming og kan anvendes til behandling av syk-dommer i hjerte- og blodomløpssystemet, og til behandling og/eller terapi av potensforstyrrelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19644228A DE19644228A1 (de) | 1996-10-24 | 1996-10-24 | Thienopyrimidine |
PCT/EP1997/005530 WO1998017668A1 (de) | 1996-10-24 | 1997-10-08 | Thienopyrimidine mit pde v inhibierender wirkung |
Publications (2)
Publication Number | Publication Date |
---|---|
NO991951D0 NO991951D0 (no) | 1999-04-23 |
NO991951L true NO991951L (no) | 1999-06-17 |
Family
ID=7809880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO991951A NO991951L (no) | 1996-10-24 | 1999-04-23 | Tienopyrimidiner med fosfodiesterase V-inhiberende virkning |
Country Status (24)
Country | Link |
---|---|
US (1) | US6130223A (no) |
EP (1) | EP0934321B1 (no) |
JP (1) | JP2001502342A (no) |
KR (1) | KR100488429B1 (no) |
CN (1) | CN1105116C (no) |
AR (1) | AR008504A1 (no) |
AT (1) | ATE246689T1 (no) |
AU (1) | AU726639B2 (no) |
BR (1) | BR9712652A (no) |
CA (1) | CA2269815C (no) |
CZ (1) | CZ294027B6 (no) |
DE (2) | DE19644228A1 (no) |
DK (1) | DK0934321T3 (no) |
ES (1) | ES2201275T3 (no) |
HK (1) | HK1024484A1 (no) |
HU (1) | HUP9904680A3 (no) |
NO (1) | NO991951L (no) |
PL (1) | PL192163B1 (no) |
PT (1) | PT934321E (no) |
RU (1) | RU2197492C2 (no) |
SK (1) | SK284979B6 (no) |
TW (1) | TW457242B (no) |
WO (1) | WO1998017668A1 (no) |
ZA (1) | ZA979516B (no) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
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US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
DE19752952A1 (de) | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
US6248308B1 (en) * | 1998-04-14 | 2001-06-19 | Sepracor Inc. | Methods of using norastemizole in combination with leukotriene inhibitors to treat or prevent asthma |
DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
EP1167367A4 (en) * | 1999-03-30 | 2002-04-24 | Nippon Soda Co | THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF |
DE19928146A1 (de) * | 1999-06-19 | 2000-12-21 | Merck Patent Gmbh | Thienopyrimidine |
DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
DE19943815A1 (de) * | 1999-09-14 | 2001-03-15 | Merck Patent Gmbh | Verwendung von Thienopyrimidinen |
DE19944604A1 (de) * | 1999-09-17 | 2001-03-22 | Merck Patent Gmbh | Aminderivate |
DE10001021A1 (de) * | 2000-01-13 | 2001-07-19 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
DE10031584A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
WO2002026745A1 (fr) * | 2000-09-29 | 2002-04-04 | Nippon Soda Co., Ltd. | Composes de thienopyrimidine et leurs sels et procede de preparation |
DE10064994A1 (de) * | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
DE10103647A1 (de) * | 2001-01-27 | 2002-08-01 | Merck Patent Gmbh | Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates |
PL362408A1 (en) * | 2001-01-31 | 2004-11-02 | Merck Patent Gmbh | Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidine and nitrates or thienopyrimidines and nitrates |
CA2437085A1 (en) * | 2001-02-02 | 2002-08-15 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pharmaceutical formulation comprising pyrazolo[4,3-d]pyrimidines and endothelin receptor antagonists or thienopyrimidines and endothelin receptor antagonists |
WO2002088138A1 (en) * | 2001-04-30 | 2002-11-07 | Bayer Corporation | Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines |
DE10148883A1 (de) | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
JPWO2003035653A1 (ja) * | 2001-10-26 | 2005-02-10 | 日本曹達株式会社 | ピリドチエノピリミジン化合物およびその塩 |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
DE10224462A1 (de) * | 2002-06-03 | 2003-12-11 | Bayer Ag | Verwendung von cGMP stimulierenden Verbindungen |
AR044743A1 (es) * | 2002-09-26 | 2005-10-05 | Nihon Nohyaku Co Ltd | Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos, |
JP2004137270A (ja) * | 2002-09-26 | 2004-05-13 | Nippon Nohyaku Co Ltd | 新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法 |
ES2217956B1 (es) | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
JP4015176B2 (ja) | 2003-04-29 | 2007-11-28 | ファイザー・インク | 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類 |
DE10351436A1 (de) * | 2003-11-04 | 2005-06-09 | Merck Patent Gmbh | Verwendung von Thienopyrimidinen |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
DK1742950T3 (da) * | 2004-04-07 | 2009-03-16 | Pfizer Ltd | Pyrazolo-[4,3-D]-pyrimidiner |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
ES2259891B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
ES2259892B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
EP1908765B1 (en) * | 2005-06-14 | 2014-10-22 | ASKA Pharmaceutical Co., Ltd. | Thienopyrimidine derivative |
US20070213305A1 (en) * | 2005-11-02 | 2007-09-13 | Cytovia, Inc. | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
WO2007056208A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc. | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US20070099877A1 (en) * | 2005-11-02 | 2007-05-03 | Cytovia, Inc. | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
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EP1970373A1 (en) * | 2005-12-02 | 2008-09-17 | Mitsubishi Tanabe Pharma Corporation | Alicyclic heterocyclic compound |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
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EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
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EP2205609B1 (de) * | 2007-10-19 | 2017-03-29 | Boehringer Ingelheim International GmbH | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
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JP5634506B2 (ja) | 2009-05-12 | 2014-12-03 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 |
KR101147550B1 (ko) * | 2009-10-22 | 2012-05-17 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노[3,2-d]피리미딘 화합물 |
KR101735868B1 (ko) * | 2010-02-17 | 2017-05-15 | 다케다 야쿠힌 고교 가부시키가이샤 | 복소고리 화합물 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JP6027611B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
WO2014055801A1 (en) | 2012-10-05 | 2014-04-10 | Henkin Robert I | Phosphodiesterase inhibitors for treating taste and smell disorders |
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JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
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WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
WO2015126944A1 (en) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
MX2016014384A (es) | 2014-06-23 | 2017-01-20 | Celgene Corp | Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado. |
SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
WO2018133858A1 (en) | 2017-01-22 | 2018-07-26 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
US10588894B2 (en) * | 2017-06-21 | 2020-03-17 | SHY Therapeutics LLC | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
US5075310A (en) * | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4−アミノキナゾリン誘導体およびそれを含有する医薬品 |
PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
DE69432217T2 (de) * | 1993-04-06 | 2004-04-08 | Abbott Laboratories, Abbott Park | Tetracyclische verbindungen als dopamin-agonisten |
ATE163647T1 (de) * | 1993-08-26 | 1998-03-15 | Ono Pharmaceutical Co | 4-aminopyrimidin derivate |
US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
-
1996
- 1996-10-24 DE DE19644228A patent/DE19644228A1/de not_active Withdrawn
-
1997
- 1997-10-06 TW TW086114590A patent/TW457242B/zh not_active IP Right Cessation
- 1997-10-08 AU AU49450/97A patent/AU726639B2/en not_active Ceased
- 1997-10-08 RU RU99110944/04A patent/RU2197492C2/ru not_active IP Right Cessation
- 1997-10-08 DK DK97912139T patent/DK0934321T3/da active
- 1997-10-08 EP EP97912139A patent/EP0934321B1/de not_active Expired - Lifetime
- 1997-10-08 HU HU9904680A patent/HUP9904680A3/hu unknown
- 1997-10-08 AT AT97912139T patent/ATE246689T1/de not_active IP Right Cessation
- 1997-10-08 CN CN97180749A patent/CN1105116C/zh not_active Expired - Fee Related
- 1997-10-08 ES ES97912139T patent/ES2201275T3/es not_active Expired - Lifetime
- 1997-10-08 BR BR9712652-7A patent/BR9712652A/pt not_active Application Discontinuation
- 1997-10-08 PT PT97912139T patent/PT934321E/pt unknown
- 1997-10-08 CZ CZ19991422A patent/CZ294027B6/cs not_active IP Right Cessation
- 1997-10-08 US US09/297,186 patent/US6130223A/en not_active Expired - Fee Related
- 1997-10-08 SK SK502-99A patent/SK284979B6/sk unknown
- 1997-10-08 DE DE59710547T patent/DE59710547D1/de not_active Expired - Lifetime
- 1997-10-08 CA CA002269815A patent/CA2269815C/en not_active Expired - Fee Related
- 1997-10-08 PL PL332970A patent/PL192163B1/pl not_active IP Right Cessation
- 1997-10-08 WO PCT/EP1997/005530 patent/WO1998017668A1/de active IP Right Grant
- 1997-10-08 JP JP10518895A patent/JP2001502342A/ja active Pending
- 1997-10-08 KR KR10-1999-7003580A patent/KR100488429B1/ko not_active IP Right Cessation
- 1997-10-23 ZA ZA9709516A patent/ZA979516B/xx unknown
- 1997-10-24 AR ARP970104923A patent/AR008504A1/es not_active Application Discontinuation
-
1999
- 1999-04-23 NO NO991951A patent/NO991951L/no not_active Application Discontinuation
-
2000
- 2000-06-28 HK HK00103906A patent/HK1024484A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9712652A (pt) | 1999-10-26 |
AU726639B2 (en) | 2000-11-16 |
CN1105116C (zh) | 2003-04-09 |
CA2269815A1 (en) | 1998-04-30 |
CZ142299A3 (cs) | 1999-07-14 |
DE19644228A1 (de) | 1998-04-30 |
CA2269815C (en) | 2007-09-25 |
KR20000052772A (ko) | 2000-08-25 |
CN1240450A (zh) | 2000-01-05 |
SK284979B6 (sk) | 2006-03-02 |
HUP9904680A3 (en) | 2001-11-28 |
US6130223A (en) | 2000-10-10 |
DE59710547D1 (de) | 2003-09-11 |
JP2001502342A (ja) | 2001-02-20 |
EP0934321A1 (de) | 1999-08-11 |
CZ294027B6 (cs) | 2004-09-15 |
HK1024484A1 (en) | 2000-10-13 |
HUP9904680A2 (hu) | 2000-05-28 |
KR100488429B1 (ko) | 2005-05-10 |
RU2197492C2 (ru) | 2003-01-27 |
NO991951D0 (no) | 1999-04-23 |
PT934321E (pt) | 2003-12-31 |
SK50299A3 (en) | 2000-03-13 |
EP0934321B1 (de) | 2003-08-06 |
AR008504A1 (es) | 2000-01-19 |
TW457242B (en) | 2001-10-01 |
WO1998017668A1 (de) | 1998-04-30 |
AU4945097A (en) | 1998-05-15 |
PL192163B1 (pl) | 2006-09-29 |
ATE246689T1 (de) | 2003-08-15 |
DK0934321T3 (da) | 2003-11-03 |
ES2201275T3 (es) | 2004-03-16 |
PL332970A1 (en) | 1999-10-25 |
ZA979516B (en) | 1998-05-12 |
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