DE69432087D1 - 6-Amino-purinderivate mit PDE-IV inhibierender Wirkung - Google Patents

6-Amino-purinderivate mit PDE-IV inhibierender Wirkung

Info

Publication number
DE69432087D1
DE69432087D1 DE69432087T DE69432087T DE69432087D1 DE 69432087 D1 DE69432087 D1 DE 69432087D1 DE 69432087 T DE69432087 T DE 69432087T DE 69432087 T DE69432087 T DE 69432087T DE 69432087 D1 DE69432087 D1 DE 69432087D1
Authority
DE
Germany
Prior art keywords
purine derivatives
amino
pde
inhibitory activity
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432087T
Other languages
English (en)
Other versions
DE69432087T2 (de
Inventor
David Cavalla
Peter Hofer
Anddre Gehrig
Peter Wintergest
Mark Chasin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of DE69432087D1 publication Critical patent/DE69432087D1/de
Application granted granted Critical
Publication of DE69432087T2 publication Critical patent/DE69432087T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69432087T 1993-06-22 1994-06-21 6-Amino-purinderivate mit PDE-IV inhibierender Wirkung Expired - Fee Related DE69432087T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939312853A GB9312853D0 (en) 1993-06-22 1993-06-22 Chemical compounds

Publications (2)

Publication Number Publication Date
DE69432087D1 true DE69432087D1 (de) 2003-03-06
DE69432087T2 DE69432087T2 (de) 2003-11-06

Family

ID=10737574

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69419755T Expired - Fee Related DE69419755T2 (de) 1993-06-22 1994-06-21 Chemische verbindungen mit pde-iv inhibitierende wirkung
DE69432087T Expired - Fee Related DE69432087T2 (de) 1993-06-22 1994-06-21 6-Amino-purinderivate mit PDE-IV inhibierender Wirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69419755T Expired - Fee Related DE69419755T2 (de) 1993-06-22 1994-06-21 Chemische verbindungen mit pde-iv inhibitierende wirkung

Country Status (23)

Country Link
US (1) US5939422A (de)
EP (3) EP0916673B1 (de)
JP (1) JP3350550B2 (de)
KR (1) KR100349239B1 (de)
CN (1) CN1045778C (de)
AT (2) ATE231863T1 (de)
AU (1) AU683270B2 (de)
BG (1) BG62933B1 (de)
CA (1) CA2165433C (de)
CZ (1) CZ342595A3 (de)
DE (2) DE69419755T2 (de)
DK (1) DK0705265T3 (de)
ES (1) ES2137371T3 (de)
FI (1) FI956168A (de)
GB (1) GB9312853D0 (de)
HU (1) HUT74176A (de)
NO (1) NO955219L (de)
NZ (1) NZ267468A (de)
PL (1) PL312225A1 (de)
SK (1) SK161095A3 (de)
TW (1) TW418208B (de)
WO (1) WO1995000516A1 (de)
ZA (1) ZA944463B (de)

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US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
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EP1043324B1 (de) 1997-11-12 2004-06-16 Mitsubishi Chemical Corporation Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten
AU1722899A (en) * 1997-12-12 1999-07-05 Euro-Celtique S.A. Preparation of 3-substituted adenines
US6319928B1 (en) 1998-11-30 2001-11-20 Euro-Celtique, S.A. Purine derivatives having phosphodiesterase IV inhibition activity
JP2002541078A (ja) * 1999-04-02 2002-12-03 ユーロ−セルティーク，エス．エー． ホスホジエステラーゼｉｖ阻害活性を有するプリン誘導体
KR100747106B1 (ko) 1999-05-11 2007-08-08 미쯔비시 가가꾸 가부시끼가이샤 퓨린 유도체 이수화물, 이를 유효성분으로 함유하는 의약및 이의 제조 중간체
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DK0705265T3 (da) 2000-03-13
GB9312853D0 (en) 1993-08-04
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CZ342595A3 (en) 1996-08-14
US5939422A (en) 1999-08-17
CA2165433A1 (en) 1994-12-23
SK161095A3 (en) 1997-01-08
DE69432087T2 (de) 2003-11-06
CA2165433C (en) 2002-05-28
WO1995000516A1 (en) 1995-01-05
ZA944463B (en) 1995-02-17
PL312225A1 (en) 1996-04-01
ATE231863T1 (de) 2003-02-15
KR960703124A (ko) 1996-06-19
EP0705265B1 (de) 1999-07-28
CN1125445A (zh) 1996-06-26
EP0916673A1 (de) 1999-05-19
BG100258A (bg) 1996-11-29
DE69419755T2 (de) 2000-02-17
FI956168A0 (fi) 1995-12-21
JPH09500376A (ja) 1997-01-14
NO955219L (no) 1996-02-22
NZ267468A (en) 1997-11-24
AU6977194A (en) 1995-01-17
EP0705265A1 (de) 1996-04-10
NO955219D0 (no) 1995-12-21
HU9503545D0 (en) 1996-02-28
CN1045778C (zh) 1999-10-20
FI956168A (fi) 1996-02-01
AU683270B2 (en) 1997-11-06
ES2137371T3 (es) 1999-12-16
HUT74176A (en) 1996-11-28
KR100349239B1 (ko) 2003-01-24
JP3350550B2 (ja) 2002-11-25
EP0916673B1 (de) 2003-01-29
TW418208B (en) 2001-01-11
ATE182593T1 (de) 1999-08-15
DE69419755D1 (de) 1999-09-02

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