DE69206102D1 - Di(2-propyl)ester von 1-fluoro-2-phosphonomethoxy-3-p-toluol-sulfonyloxypropan, deren herstellung und vervendung. - Google Patents
Di(2-propyl)ester von 1-fluoro-2-phosphonomethoxy-3-p-toluol-sulfonyloxypropan, deren herstellung und vervendung.Info
- Publication number
- DE69206102D1 DE69206102D1 DE69206102T DE69206102T DE69206102D1 DE 69206102 D1 DE69206102 D1 DE 69206102D1 DE 69206102 T DE69206102 T DE 69206102T DE 69206102 T DE69206102 T DE 69206102T DE 69206102 D1 DE69206102 D1 DE 69206102D1
- Authority
- DE
- Germany
- Prior art keywords
- fluoro
- pct
- phosphonomethoxy
- propyl
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 2-PROPYL Chemical class 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- MHKHILORXQPUEL-UHFFFAOYSA-N [1-fluoro-3-(4-methylphenyl)sulfonyloxypropan-2-yl]oxymethylphosphonic acid Chemical compound CC1=CC=C(S(=O)(=O)OCC(CF)OCP(O)(O)=O)C=C1 MHKHILORXQPUEL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS911475A CZ284678B6 (cs) | 1991-05-20 | 1991-05-20 | Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití |
| PCT/CS1992/000013 WO1992020691A1 (en) | 1991-05-20 | 1992-05-19 | Di(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69206102D1 true DE69206102D1 (de) | 1995-12-21 |
| DE69206102T2 DE69206102T2 (de) | 1996-05-09 |
Family
ID=5349251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69206102T Expired - Lifetime DE69206102T2 (de) | 1991-05-20 | 1992-05-19 | Di(2-propyl)ester von 1-fluoro-2-phosphonomethoxy-3-p-toluol-sulfonyloxypropan, deren herstellung und vervendung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5352786A (de) |
| EP (1) | EP0540707B1 (de) |
| JP (1) | JP3406596B2 (de) |
| AT (1) | ATE130302T1 (de) |
| CA (1) | CA2087534C (de) |
| CZ (1) | CZ284678B6 (de) |
| DE (1) | DE69206102T2 (de) |
| WO (2) | WO1992020691A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| ATE322494T1 (de) * | 2000-01-07 | 2006-04-15 | Universitaire Instelling Antwe | Purin derivate, ihre herstellung und verwendung |
| AU2001282941C1 (en) | 2000-07-21 | 2016-12-22 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| KR100891366B1 (ko) | 2001-06-29 | 2009-04-02 | 인스티튜트 오브 오르가닉 케미스트리 앤드 바이오케미스트리, 어케더미 오브 사이언시스 오브 더 체크 리퍼블릭 | 항 바이러스 활성을 갖는 6-'2-(포스포노메톡시)알콕시 피리미딘 유도체 |
| CN1805966B (zh) * | 2003-06-16 | 2013-03-13 | 捷克科学院有机化学和生物化学研究所 | 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| ES2874774T3 (es) | 2011-12-22 | 2021-11-05 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ285420B6 (cs) * | 1990-04-24 | 1999-08-11 | Ústav Organické Chemie A Biochemie Avčr | N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití |
| CS276072B6 (en) * | 1990-08-06 | 1992-03-18 | Ustav Organicke Chemie A Bioch | (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF |
-
1991
- 1991-05-20 CZ CS911475A patent/CZ284678B6/cs not_active IP Right Cessation
-
1992
- 1992-05-19 US US07/969,852 patent/US5352786A/en not_active Expired - Lifetime
- 1992-05-19 WO PCT/CS1992/000013 patent/WO1992020691A1/en active IP Right Grant
- 1992-05-19 EP EP92910013A patent/EP0540707B1/de not_active Expired - Lifetime
- 1992-05-19 AT AT92910013T patent/ATE130302T1/de not_active IP Right Cessation
- 1992-05-19 DE DE69206102T patent/DE69206102T2/de not_active Expired - Lifetime
- 1992-05-19 JP JP50948392A patent/JP3406596B2/ja not_active Expired - Lifetime
- 1992-05-19 CA CA002087534A patent/CA2087534C/en not_active Expired - Lifetime
- 1992-05-20 WO PCT/US1992/004269 patent/WO1992020692A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US5352786A (en) | 1994-10-04 |
| DE69206102T2 (de) | 1996-05-09 |
| WO1992020691A1 (en) | 1992-11-26 |
| EP0540707B1 (de) | 1995-11-15 |
| JP3406596B2 (ja) | 2003-05-12 |
| WO1992020692A1 (en) | 1992-11-26 |
| ATE130302T1 (de) | 1995-12-15 |
| CA2087534C (en) | 2003-01-07 |
| EP0540707A1 (de) | 1993-05-12 |
| CA2087534A1 (en) | 1992-11-21 |
| JPH06502654A (ja) | 1994-03-24 |
| CZ284678B6 (cs) | 1999-01-13 |
| CS147591A3 (en) | 1992-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: MOSELPATENT TRIERPATENT, 54290 TRIER |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: PATENTANWAELTE SERWE & DR. WAGNER, 54290 TRIER |
|
| R071 | Expiry of right |
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