ES2138622T3 - Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. - Google Patents
Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.Info
- Publication number
- ES2138622T3 ES2138622T3 ES93909605T ES93909605T ES2138622T3 ES 2138622 T3 ES2138622 T3 ES 2138622T3 ES 93909605 T ES93909605 T ES 93909605T ES 93909605 T ES93909605 T ES 93909605T ES 2138622 T3 ES2138622 T3 ES 2138622T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- piridazo
- mercaptoacetilamido
- diazepina
- encephalinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
LA PRESENTE INVENCION SE REFIERE A CIERTOS DERIVADOS NUEVOS DE PIRIDAZO[1,2]PIRIDAZINA, PIRAZOLO[1,2]PIRIDAZINA, PIRIDAZO[1,2-A][1,2]DIAZEPINA Y PIRAZOLO[1,2-A][1,2]DIAZEPINA DE MECAPTOACETILAMINO DE LA FORMULA (I) QUE SON UTILES COMO INHIBIDORES DE LA ENCEFALINASA Y ACE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88496392A | 1992-05-15 | 1992-05-15 | |
US4000393A | 1993-04-09 | 1993-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2138622T3 true ES2138622T3 (es) | 2000-01-16 |
Family
ID=26716641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93909605T Expired - Lifetime ES2138622T3 (es) | 1992-05-15 | 1993-04-21 | Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5366973A (es) |
EP (1) | EP0640086B1 (es) |
JP (1) | JP3360079B2 (es) |
KR (1) | KR100281450B1 (es) |
AT (1) | ATE182892T1 (es) |
AU (1) | AU669364B2 (es) |
CA (1) | CA2133963C (es) |
DE (1) | DE69325904T2 (es) |
DK (1) | DK0640086T3 (es) |
ES (1) | ES2138622T3 (es) |
FI (1) | FI108230B (es) |
GR (1) | GR3031287T3 (es) |
HU (1) | HU223663B1 (es) |
IL (1) | IL105680A (es) |
MX (1) | MX9302824A (es) |
NO (1) | NO302573B1 (es) |
NZ (1) | NZ251930A (es) |
TW (1) | TW270115B (es) |
WO (1) | WO1993023403A1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
EP0671172A4 (en) * | 1993-06-11 | 1998-09-02 | Eisai Co Ltd | AMINO ACID DERIVATIVE. |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
NZ279397A (en) * | 1994-02-14 | 1997-08-22 | Merrell Pharma Inc | Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives and pharmaceutucal compositions |
CN1069317C (zh) * | 1994-02-14 | 2001-08-08 | 默里尔药物公司 | 用作脑啡肽酶抑制剂的新的1,2-二氢化茚-2-巯基乙酰胺二硫化物衍生物 |
HUT76479A (en) * | 1994-02-14 | 1997-09-29 | Merrell Pharma Inc | Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them |
HUT75160A (en) * | 1994-03-24 | 1997-04-28 | Merrell Pharma Inc | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US6117896A (en) | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
AU748887B2 (en) * | 1998-02-12 | 2002-06-13 | Myriad Genetics, Inc. | Beta-sheet mimetics and methods relating to the use thereof |
IT1298268B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
FR2777889B1 (fr) | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
JP4588877B2 (ja) | 1998-06-17 | 2010-12-01 | ブリストル−マイヤーズ スクイブ カンパニー | Adp−受容体抗血小板物質と抗高血圧薬の組合せ投与による脳梗塞の予防 |
US6177565B1 (en) | 1998-08-19 | 2001-01-23 | Vertex Pharmaceuticals Inc. | Process for synthesizing piperazic acid |
SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
ATE303800T1 (de) * | 1999-08-30 | 2005-09-15 | Aventis Pharma Gmbh | Ramipril zur vorbeugung von kardiovaskulären vorfällen |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
EP1443919A4 (en) * | 2001-11-16 | 2006-03-22 | Bristol Myers Squibb Co | DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES |
US7053214B2 (en) | 2002-02-14 | 2006-05-30 | Myriad Genetics, Inc. | β-sheet mimetics and composition and methods relating thereto |
US7459474B2 (en) * | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7273881B2 (en) | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
WO2007011524A1 (en) * | 2005-07-14 | 2007-01-25 | Franco Folli | Daily dosage regimen for treating diabetes, obsity, metabolic syndrome and polycystic ovary syndrome |
US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
US20070238770A1 (en) * | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
MX2008015107A (es) | 2006-05-26 | 2008-12-09 | Amylin Pharmaceuticals Inc | Composicion y metodos para el tratamiento de insuficiecia cardiaca congestiva. |
US7795291B2 (en) | 2006-07-07 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method |
CN101573340A (zh) | 2006-11-01 | 2009-11-04 | 百时美施贵宝公司 | 糖皮质激素受体AP-1和/或NF-κB活性的调节剂及其用途 |
EP2089355A2 (en) | 2006-11-01 | 2009-08-19 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof |
US7994190B2 (en) | 2006-11-01 | 2011-08-09 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2009042922A2 (en) | 2007-09-27 | 2009-04-02 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of making and using same |
ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
JP2011525537A (ja) | 2008-06-24 | 2011-09-22 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体、AP−1、および/またはNF−κB活性のシクロペンタチオフェン調節剤およびその使用 |
JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
CN106674228B (zh) * | 2016-12-09 | 2018-12-04 | 河南农业大学 | 多元杂环化合物及其制备方法和用途 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
NZ204130A (en) * | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
CA1274832A (en) * | 1985-04-30 | 1990-10-02 | Richard Elmer Holmes | 7-substituted bicyclic pyrazolidinones |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
EP0533084A1 (en) * | 1991-09-16 | 1993-03-24 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation |
-
1993
- 1993-04-21 CA CA002133963A patent/CA2133963C/en not_active Expired - Fee Related
- 1993-04-21 NZ NZ251930A patent/NZ251930A/en unknown
- 1993-04-21 AU AU40332/93A patent/AU669364B2/en not_active Ceased
- 1993-04-21 EP EP93909605A patent/EP0640086B1/en not_active Expired - Lifetime
- 1993-04-21 DE DE69325904T patent/DE69325904T2/de not_active Expired - Fee Related
- 1993-04-21 KR KR1019940704065A patent/KR100281450B1/ko not_active IP Right Cessation
- 1993-04-21 AT AT93909605T patent/ATE182892T1/de not_active IP Right Cessation
- 1993-04-21 JP JP52023593A patent/JP3360079B2/ja not_active Expired - Fee Related
- 1993-04-21 DK DK93909605T patent/DK0640086T3/da active
- 1993-04-21 WO PCT/US1993/003721 patent/WO1993023403A1/en active IP Right Grant
- 1993-04-21 HU HU9403266A patent/HU223663B1/hu not_active IP Right Cessation
- 1993-04-21 ES ES93909605T patent/ES2138622T3/es not_active Expired - Lifetime
- 1993-05-11 TW TW082103682A patent/TW270115B/zh active
- 1993-05-12 IL IL105680A patent/IL105680A/en not_active IP Right Cessation
- 1993-05-14 MX MX9302824A patent/MX9302824A/es not_active IP Right Cessation
- 1993-11-03 US US08/146,857 patent/US5366973A/en not_active Expired - Fee Related
-
1994
- 1994-11-14 NO NO944335A patent/NO302573B1/no not_active IP Right Cessation
- 1994-11-14 FI FI945363A patent/FI108230B/fi not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402385T patent/GR3031287T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
MX9302824A (es) | 1994-05-31 |
NZ251930A (en) | 1996-02-27 |
HUT71099A (en) | 1995-11-28 |
US5366973A (en) | 1994-11-22 |
JPH07506832A (ja) | 1995-07-27 |
JP3360079B2 (ja) | 2002-12-24 |
FI108230B (fi) | 2001-12-14 |
GR3031287T3 (en) | 1999-12-31 |
EP0640086B1 (en) | 1999-08-04 |
DE69325904D1 (de) | 1999-09-09 |
IL105680A (en) | 1998-01-04 |
IL105680A0 (en) | 1993-09-22 |
DK0640086T3 (da) | 1999-12-06 |
NO944335L (no) | 1995-01-13 |
WO1993023403A1 (en) | 1993-11-25 |
NO944335D0 (no) | 1994-11-14 |
TW270115B (es) | 1996-02-11 |
FI945363A (fi) | 1994-11-14 |
AU669364B2 (en) | 1996-06-06 |
DE69325904T2 (de) | 1999-12-09 |
EP0640086A1 (en) | 1995-03-01 |
KR100281450B1 (ko) | 2001-02-01 |
CA2133963A1 (en) | 1993-11-25 |
NO302573B1 (no) | 1998-03-23 |
FI945363A0 (fi) | 1994-11-14 |
AU4033293A (en) | 1993-12-13 |
CA2133963C (en) | 1998-07-07 |
KR950701634A (ko) | 1995-04-28 |
HU223663B1 (hu) | 2004-11-29 |
ATE182892T1 (de) | 1999-08-15 |
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