|
DE69838172T2
(de)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
EP1006113A1
(en)
|
1998-12-02 |
2000-06-07 |
Pfizer Products Inc. |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9918057D0
(en)
*
|
1999-07-30 |
1999-10-06 |
Univ Bristol |
Therapeutic agents
|
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
|
GB0010757D0
(en)
*
|
2000-05-05 |
2000-06-28 |
Astrazeneca Ab |
Chemical compounds
|
|
TR200402656T4
(tr)
*
|
2000-06-06 |
2004-11-22 |
Pfizer Products Inc. |
Antikanser ajanları olarak faydalı tiyofen türevleri
|
|
BR0113078A
(pt)
*
|
2000-08-09 |
2003-07-01 |
Astrazeneca Ab |
Uso de um composto, composto, processo para a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente
|
|
HUP0302221A3
(en)
|
2000-09-20 |
2004-01-28 |
Merck Patent Gmbh |
4-amino-quinazolines
|
|
US6503914B1
(en)
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
AUPR213700A0
(en)
|
2000-12-18 |
2001-01-25 |
Biota Scientific Management Pty Ltd |
Antiviral agents
|
|
KR20020051675A
(ko)
*
|
2000-12-23 |
2002-06-29 |
이상남 |
4-페닐아미노티에노 [3,2-디] 피리미딘 유도체 및 이의제조방법
|
|
ATE464322T1
(de)
|
2001-01-05 |
2010-04-15 |
Pfizer |
Antikörper gegen den rezeptor für den insulinähnlichen wachstumsfaktor i
|
|
DE60212487T2
(de)
*
|
2001-04-13 |
2006-12-21 |
Pfizer Products Inc., Groton |
Bizyklisch substituierte 4-Aminopyridopyrimidinderivate
|
|
AU2002345792A1
(en)
|
2001-06-21 |
2003-01-08 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
|
US7829566B2
(en)
|
2001-09-17 |
2010-11-09 |
Werner Mederski |
4-amino-quinazolines
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
JP2005516023A
(ja)
*
|
2001-12-19 |
2005-06-02 |
スミスクライン ビーチャム コーポレーション |
プロテインチロシンキナーゼ阻害剤としてのチエノピリミジン化合物
|
|
WO2003055890A1
(en)
*
|
2001-12-21 |
2003-07-10 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
AU2003202263A1
(en)
*
|
2002-01-10 |
2003-07-30 |
Bayer Healthcare Ag |
Roh-kinase inhibitors
|
|
EP1470121B1
(en)
|
2002-01-23 |
2012-07-11 |
Bayer HealthCare LLC |
Pyrimidine derivatives as rho-kinase inhibitors
|
|
MXPA04007196A
(es)
|
2002-01-23 |
2005-06-08 |
Bayer Pharmaceuticals Corp |
Inhibidores de rho-quinasa.
|
|
WO2003064428A1
(en)
*
|
2002-01-29 |
2003-08-07 |
H. Lundbeck A/S |
Furano- and thienopyrimidines as neurokinase inhibitors
|
|
AU2003216322A1
(en)
*
|
2002-02-15 |
2003-09-09 |
Rigel Pharmaceuticals, Inc. |
Inhibitors of tubulin polymerization
|
|
US20030225273A1
(en)
*
|
2002-03-21 |
2003-12-04 |
Michaelides Michael R. |
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
|
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
CA2494421A1
(en)
|
2002-08-06 |
2004-02-12 |
Astrazeneca Ab |
Condensed pyridines and pyrimidines with tie2 (tek) activity
|
|
AR042052A1
(es)
*
|
2002-11-15 |
2005-06-08 |
Vertex Pharma |
Diaminotriazoles utiles como inhibidores de proteinquinasas
|
|
US7276519B2
(en)
*
|
2002-11-25 |
2007-10-02 |
Wyeth |
Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
|
|
CL2003002287A1
(es)
|
2002-11-25 |
2005-01-14 |
Wyeth Corp |
COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
|
|
OA12977A
(en)
|
2002-12-19 |
2006-10-13 |
Pfizer |
2-(1H-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophthamic diseases.
|
|
AP2385A
(en)
|
2002-12-20 |
2012-03-23 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth.
|
|
PL216368B1
(pl)
|
2003-02-26 |
2014-03-31 |
Sugen |
Związki aminoheteroarylowe oraz ich zastosowanie
|
|
EP1651652B1
(en)
*
|
2003-07-24 |
2006-12-27 |
Bayer Pharmaceuticals Corporation |
Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
|
|
DE602004025258D1
(de)
*
|
2003-08-06 |
2010-03-11 |
Vertex Pharma |
Aminotriazol-verbindungen als proteinkinase-hemmer
|
|
EP1660090B1
(en)
|
2003-08-14 |
2012-11-21 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
|
US7501427B2
(en)
|
2003-08-14 |
2009-03-10 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
|
WO2005021554A1
(en)
|
2003-08-29 |
2005-03-10 |
Pfizer Inc. |
Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents
|
|
AR045563A1
(es)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
Anticuerpos dirigidos a m-csf
|
|
US7332521B2
(en)
*
|
2003-09-25 |
2008-02-19 |
Wyeth |
Substituted indoles
|
|
US7419978B2
(en)
|
2003-10-22 |
2008-09-02 |
Bristol-Myers Squibb Company |
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
|
|
NZ547009A
(en)
|
2003-12-23 |
2009-09-25 |
Pfizer |
Novel quinoline derivatives
|
|
US7470712B2
(en)
*
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Amino-benzazoles as P2Y1 receptor inhibitors
|
|
US20080242681A1
(en)
*
|
2004-01-22 |
2008-10-02 |
Altana Pharma Ag |
N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors
|
|
WO2005116035A1
(en)
*
|
2004-05-27 |
2005-12-08 |
Pfizer Products Inc. |
Pyrrolopyrimidine derivatives useful in cancer treatment
|
|
GB0412467D0
(en)
*
|
2004-06-04 |
2004-07-07 |
Astrazeneca Ab |
Chemical compounds
|
|
EP1763526B1
(en)
|
2004-06-28 |
2009-06-24 |
Bayer Schering Pharma AG |
4,6-disubstituted pyrimidines and their use as protein kinase inhibitors
|
|
US20050288290A1
(en)
*
|
2004-06-28 |
2005-12-29 |
Borzilleri Robert M |
Fused heterocyclic kinase inhibitors
|
|
EP1781664B1
(en)
|
2004-07-30 |
2013-09-04 |
MethylGene Inc. |
Inhibitors of vegf receptor and hgf receptor signaling
|
|
PT1786785E
(pt)
|
2004-08-26 |
2010-05-21 |
Pfizer |
Compostos amino-heteroarilo enantiomericamente puros como inibidores da proteína quinase
|
|
GB0423653D0
(en)
*
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
BRPI0517253A
(pt)
*
|
2004-10-28 |
2008-10-07 |
Irm Llc |
compostos e composições como moduladores de trajetória de ouriço
|
|
US7576080B2
(en)
*
|
2004-12-23 |
2009-08-18 |
Memory Pharmaceuticals Corporation |
Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
EP1841734B1
(en)
*
|
2005-01-19 |
2009-07-29 |
F. Hoffmann-Roche AG |
5-aminoindole derivatives
|
|
EP1861715B1
(en)
|
2005-03-16 |
2010-08-11 |
OSI Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
|
|
EP1863848A4
(en)
|
2005-03-31 |
2009-09-23 |
Agensys Inc |
CORRESPONDING ANTIBODIES AND MOLECULES THAT ATTACH PROTEINS 161P2F10B
|
|
UA95775C2
(uk)
|
2005-04-26 |
2011-09-12 |
Пфайзер Инк. |
Антитіло, яке специфічно зв'язується з р-кадгерином
|
|
CN101796055B
(zh)
|
2005-05-20 |
2013-09-04 |
梅特希尔基因公司 |
Vegf受体和hgf受体信号的抑制剂
|
|
BRPI0610382A2
(pt)
|
2005-05-20 |
2010-06-15 |
Methylgene Inc |
inibidores de sinalização de receptor de vegf e receptor de hgf
|
|
US20060281768A1
(en)
*
|
2005-06-10 |
2006-12-14 |
Gaul Michael D |
Thienopyrimidine and thienopyridine kinase modulators
|
|
US20100143341A1
(en)
*
|
2005-06-22 |
2010-06-10 |
Develogen Aktiengesellschaft |
Thienopyrimidines for pharmaceutical compositions
|
|
US7608592B2
(en)
|
2005-06-30 |
2009-10-27 |
Virobay, Inc. |
HCV inhibitors
|
|
WO2007026221A2
(en)
*
|
2005-09-02 |
2007-03-08 |
Pfizer Inc. |
Improved methods for preparing benzofused heteroaryl amide derivatives of thienopyridines
|
|
KR101536506B1
(ko)
|
2005-09-07 |
2015-07-14 |
암젠 프레몬트 인코포레이티드 |
액티빈 수용체 유사 키나제-1에 대한 인간 모노클로날 항체
|
|
JP5055284B2
(ja)
|
2005-09-20 |
2012-10-24 |
オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー |
インシュリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー
|
|
PE20070619A1
(es)
*
|
2005-09-27 |
2007-07-02 |
Wyeth Corp |
TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA
|
|
US20070099941A1
(en)
*
|
2005-11-02 |
2007-05-03 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
WO2007056214A2
(en)
*
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc |
N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof
|
|
US20070099877A1
(en)
*
|
2005-11-02 |
2007-05-03 |
Cytovia, Inc. |
N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
CA2632194C
(en)
|
2005-11-15 |
2012-01-03 |
Array Biopharma Inc. |
N4-phenyl-quinazoline-4-amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
|
|
CN101522687A
(zh)
*
|
2006-01-30 |
2009-09-02 |
阿雷生物药品公司 |
用于癌症治疗的杂二环噻吩化合物
|
|
US20080064718A1
(en)
*
|
2006-03-22 |
2008-03-13 |
Saavedra Oscar M |
Inhibitors of protein tyrosine kinase activity
|
|
JP5255559B2
(ja)
*
|
2006-03-31 |
2013-08-07 |
アボット・ラボラトリーズ |
インダゾール化合物
|
|
KR20090047391A
(ko)
|
2006-04-07 |
2009-05-12 |
데벨로겐 악틴게젤샤프트 |
약제학적 조성물을 위한 Ｍｎｋ1/Ｍｎｋ2 억제 활성을 갖는티에노피리미딘
|
|
BRPI0711358A2
(pt)
|
2006-05-09 |
2011-09-27 |
Pfizer Prod Inc |
derivados do ácido cicloalquilamino e suas composições farmacêuticas
|
|
EP1889847A1
(en)
|
2006-07-10 |
2008-02-20 |
DeveloGen Aktiengesellschaft |
Pyrrolopyrimidines for pharmaceutical compositions
|
|
CA2667487C
(en)
|
2006-11-06 |
2017-04-04 |
Supergen, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
|
AU2007329352B2
(en)
|
2006-12-07 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
|
WO2008082839A2
(en)
*
|
2006-12-29 |
2008-07-10 |
Abbott Laboratories |
Pim kinase inhibitors as cancer chemotherapeutics
|
|
CN110551105B
(zh)
*
|
2006-12-29 |
2022-10-18 |
里格尔制药公司 |
用作axl抑制剂的取代三唑
|
|
WO2008086053A1
(en)
*
|
2007-01-03 |
2008-07-17 |
Virobay, Inc. |
Hcv inhibitors
|
|
JP5539190B2
(ja)
*
|
2007-06-12 |
2014-07-02 |
エフ．ホフマン−ラ ロシュ アーゲー |
チアゾロピリミジン類及びホスファチジルイノシトール−３キナーゼのインヒビターとしてのそれらの使用
|
|
EP2014663A1
(de)
*
|
2007-07-12 |
2009-01-14 |
Bayer Schering Pharma AG |
Thienopyrimidylamine als Modulatoren des EP2-Rezeptors
|
|
EP2014662A1
(de)
*
|
2007-07-12 |
2009-01-14 |
Bayer Schering Pharma Aktiengesellschaft |
Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors
|
|
CN101932587A
(zh)
*
|
2007-09-24 |
2010-12-29 |
吉宁特有限公司 |
噻唑并嘧啶pi3k抑制剂化合物及使用方法
|
|
WO2009052138A1
(en)
*
|
2007-10-18 |
2009-04-23 |
Boehringer Ingelheim International Gmbh |
Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein
|
|
CN101909631B
(zh)
*
|
2007-10-25 |
2012-09-12 |
健泰科生物技术公司 |
制备噻吩并嘧啶化合物的方法
|
|
CA2705312C
(en)
*
|
2007-11-15 |
2013-06-25 |
Boehringer Ingelheim International Gmbh |
Inhibitors of human immunodeficiency virus replication
|
|
CA2707046A1
(en)
*
|
2007-11-28 |
2009-06-11 |
Nathanael S. Gray |
Small molecule myristate inhibitors of bcr-abl and methods of use
|
|
CA2724008A1
(en)
*
|
2008-01-11 |
2009-09-11 |
Prasada Rao V.S. Lingam |
Fused pyrimidine derivatives as trpv3 modulators
|
|
JP5718647B2
(ja)
|
2008-02-07 |
2015-05-13 |
ビロベイ，インコーポレイティド |
カテプシンｂの阻害剤
|
|
CN102015723B
(zh)
|
2008-03-05 |
2014-07-30 |
梅特希尔基因公司 |
蛋白酪氨酸激酶活性的抑制剂
|
|
US8119647B2
(en)
|
2008-04-23 |
2012-02-21 |
Glenmark Pharmaceuticals S.A. |
Fused pyrimidineone compounds as TRPV3 modulators
|
|
UY32072A
(es)
|
2008-08-26 |
2010-03-26 |
Boehringer Ingelheim Int |
Tienopirimidinas para composiciones farmacéuticas
|
|
JP5836125B2
(ja)
|
2008-10-16 |
2015-12-24 |
ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
高分子量メラノーマ関連抗原に対する完全ヒト抗体およびその使用
|
|
KR101126736B1
(ko)
*
|
2008-11-27 |
2012-04-12 |
주식회사 레고켐 바이오사이언스 |
티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
|
|
WO2010090764A1
(en)
|
2009-02-09 |
2010-08-12 |
Supergen, Inc. |
Pyrrolopyrimidinyl axl kinase inhibitors
|
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
JP2012519170A
(ja)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ，エルエルシー |
生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
|
|
TW201035088A
(en)
|
2009-02-27 |
2010-10-01 |
Supergen Inc |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
|
WO2010099364A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
KR101781654B1
(ko)
|
2009-03-12 |
2017-09-25 |
제넨테크, 인크. |
조혈 악성종양의 치료를 위한 포스포이노시티드 ３-키나제 억제제 화합물 및 화학요법제의 조합물
|
|
CN102459272B
(zh)
|
2009-05-27 |
2014-08-06 |
健泰科生物技术公司 |
对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法
|
|
SG182247A1
(en)
*
|
2009-05-27 |
2012-08-30 |
Hoffmann La Roche |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
WO2011008696A2
(en)
|
2009-07-13 |
2011-01-20 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
WO2011014726A1
(en)
|
2009-07-31 |
2011-02-03 |
Osi Pharmaceuticals, Inc. |
Mtor inhibitor and angiogenesis inhibitor combination therapy
|
|
WO2011027249A2
(en)
|
2009-09-01 |
2011-03-10 |
Pfizer Inc. |
Benzimidazole derivatives
|
|
RU2012114094A
(ru)
|
2009-09-11 |
2013-10-20 |
Дженентек, Инк. |
Способ идентификации пациента с увеличенной вероятностью ответа на противораковый агент
|
|
ES2530732T3
(es)
|
2009-09-17 |
2015-03-05 |
Hoffmann La Roche |
Procedimientos de diagnóstico para el cáncer de pulmón
|
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
|
LT3150610T
(lt)
|
2010-02-12 |
2019-11-11 |
Pfizer |
8-fluor-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ono druskos ir polimorfai
|
|
UY33241A
(es)
|
2010-02-26 |
2011-09-30 |
Boehringer Ingelheim Int |
?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
|
|
UY33245A
(es)
|
2010-02-26 |
2011-09-30 |
Boehringer Ingelheim Int |
Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas
|
|
AR080326A1
(es)
|
2010-02-26 |
2012-03-28 |
Boehringer Ingelheim Int |
Tienipirimidinas que contienen cicloalquilo para composiciones farmaceuticas
|
|
WO2011109584A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
AU2011223643A1
(en)
|
2010-03-03 |
2012-06-28 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
CN103038643A
(zh)
|
2010-04-16 |
2013-04-10 |
基因泰克公司 |
作为pi3k/akt激酶途径抑制剂效能的预测性生物标记的foxo3a
|
|
CN102250112A
(zh)
*
|
2010-05-18 |
2011-11-23 |
上海再启生物技术有限公司 |
7-溴-4-氨基噻吩并嘧啶的制备方法
|
|
DK2578590T3
(da)
*
|
2010-05-26 |
2017-11-20 |
Korea Inst Sci & Tech |
Anti-inflammatorisk forbindelse med inhibitorisk aktivitet mod flere tyrosinkinaser og farmaceutisk sammensætning indeholdende samme
|
|
WO2011149126A1
(ko)
*
|
2010-05-26 |
2011-12-01 |
한국과학기술연구원 |
타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물
|
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
|
CN103068851B
(zh)
|
2010-06-16 |
2015-03-11 |
高等教育联邦系统-匹兹堡大学 |
内质蛋白的抗体及其用途
|
|
WO2012008563A1
(ja)
|
2010-07-16 |
2012-01-19 |
協和発酵キリン株式会社 |
含窒素芳香族複素環誘導体
|
|
CN104569395A
(zh)
|
2010-07-19 |
2015-04-29 |
霍夫曼-拉罗奇有限公司 |
鉴定响应抗癌疗法的可能性升高的患者的方法
|
|
KR20130091745A
(ko)
|
2010-07-19 |
2013-08-19 |
에프. 호프만-라 로슈 아게 |
항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법
|
|
WO2012012750A1
(en)
|
2010-07-23 |
2012-01-26 |
Trustees Of Boston University |
ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
|
|
US9056832B2
(en)
|
2010-09-17 |
2015-06-16 |
Purdue Pharma L.P. |
Pyridine compounds and the users thereof
|
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
|
JP5802756B2
(ja)
|
2010-10-20 |
2015-11-04 |
ファイザー・インク |
スムーズンド受容体モジュレーターとしてのピリジン−２−誘導体
|
|
WO2012088254A1
(en)
|
2010-12-22 |
2012-06-28 |
Genentech, Inc. |
Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
|
|
CA2826295C
(en)
|
2011-02-04 |
2020-10-20 |
Duquesne University Of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
|
WO2012142164A1
(en)
|
2011-04-12 |
2012-10-18 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii
|
|
US20140178368A1
(en)
|
2011-04-19 |
2014-06-26 |
Leslie Lynne SHARP |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
CA2842190A1
(en)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
PL3409278T3
(pl)
|
2011-07-21 |
2021-02-22 |
Sumitomo Pharma Oncology, Inc. |
Heterocykliczne inhibitory kinazy białkowej
|
|
PE20141228A1
(es)
|
2011-09-22 |
2014-10-01 |
Pfizer |
Derivados de pirrolopirimidina y purina
|
|
WO2013050725A1
(en)
|
2011-10-04 |
2013-04-11 |
King's College London |
Ige anti -hmw-maa antibody
|
|
CN103087077B
(zh)
*
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
WO2013068902A1
(en)
|
2011-11-08 |
2013-05-16 |
Pfizer Inc. |
Methods of treating inflammatory disorders using anti-m-csf antibodies
|
|
JP6109193B2
(ja)
|
2012-01-10 |
2017-04-05 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
チエノピリミジン化合物
|
|
FR2988722B1
(fr)
|
2012-04-03 |
2014-05-09 |
Sanofi Sa |
Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
CN103360407B
(zh)
*
|
2012-04-10 |
2016-06-22 |
上海希迈医药科技有限公司 |
一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
CN103664991B
(zh)
*
|
2012-09-19 |
2016-12-28 |
中国科学院福建物质结构研究所 |
噻吩[2,3‑d]嘧啶衍生物、其制备方法及其用途
|
|
US9394257B2
(en)
|
2012-10-16 |
2016-07-19 |
Tolero Pharmaceuticals, Inc. |
PKM2 modulators and methods for their use
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
MX369175B
(es)
|
2013-02-25 |
2019-10-30 |
Genentech Inc |
Métodos para detectar mutantes de akt resistentes a fármacos.
|
|
EP2970205B1
(en)
|
2013-03-14 |
2019-05-08 |
Tolero Pharmaceuticals, Inc. |
Jak2 and alk2 inhibitors and methods for their use
|
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
AR096654A1
(es)
|
2013-06-20 |
2016-01-27 |
Ab Science |
Derivados de benzimidazol como inhibidores selectivos de proteína quinasa
|
|
JP6946000B2
(ja)
|
2013-10-04 |
2021-10-06 |
アプトース バイオサイエンシーズ， インコーポレイテッド |
がんの治療用組成物及び方法
|
|
UA115388C2
(uk)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
|
CN106536753B
(zh)
|
2014-04-04 |
2020-07-21 |
中美冠科生物技术（太仓）有限公司 |
用于确定对mek/erk抑制剂的应答性的方法
|
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
|
CA2947130C
(en)
|
2014-04-30 |
2018-10-02 |
Pfizer Inc. |
Cycloalkyl-linked diheterocycle derivatives
|
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
|
WO2016008011A1
(en)
*
|
2014-07-16 |
2016-01-21 |
Novogen ltd |
Functionalised and substituted indoles as anti-cancer agents
|
|
CN106999578B
(zh)
|
2014-07-31 |
2022-03-04 |
美国政府(由卫生和人类服务部的部长所代表) |
针对epha4的人类单克隆抗体和其用途
|
|
ES2746839T3
(es)
|
2014-12-18 |
2020-03-09 |
Pfizer |
Derivados de pirimidina y triazina y su uso como inhibidores de AXL
|
|
CA2982928A1
(en)
|
2015-04-20 |
2016-10-27 |
Tolero Pharmaceuticals, Inc. |
Predicting response to alvocidib by mitochondrial profiling
|
|
CN107709344B
(zh)
|
2015-05-01 |
2022-07-15 |
共晶制药股份有限公司 |
用于治疗黄病毒科病毒和癌症的核苷类似物
|
|
EP4086264B1
(en)
|
2015-05-18 |
2023-10-25 |
Sumitomo Pharma Oncology, Inc. |
Alvocidib prodrugs having increased bioavailability
|
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
|
AU2016301315C1
(en)
|
2015-08-03 |
2022-07-07 |
Sumitomo Pharma Oncology, Inc. |
Combination therapies for treatment of cancer
|
|
KR20180100125A
(ko)
|
2015-12-03 |
2018-09-07 |
아지오스 파마슈티컬스 아이엔씨. |
Mtap 널 암을 치료하기 위한 mat2a 억제제
|
|
WO2017112777A1
(en)
|
2015-12-22 |
2017-06-29 |
SHY Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
|
KR20240036709A
(ko)
*
|
2016-03-11 |
2024-03-20 |
에이씨 이뮨 에스에이 |
진단 및 치료를 위한 바이사이클릭 화합물
|
|
CN107652273B
(zh)
*
|
2016-07-26 |
2020-05-01 |
沈阳药科大学 |
嘧啶类衍生物及其制备方法和应用
|
|
US11279694B2
(en)
|
2016-11-18 |
2022-03-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
|
AU2017379847B2
(en)
|
2016-12-19 |
2022-05-26 |
Sumitomo Pharma Oncology, Inc. |
Profiling peptides and methods for sensitivity profiling
|
|
MA49458A
(fr)
|
2017-06-21 |
2020-04-29 |
SHY Therapeutics LLC |
Composés interagissant avec la superfamille ras destinés à être utilisés dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques
|
|
JP7196160B2
(ja)
|
2017-09-12 |
2022-12-26 |
スミトモ ファーマ オンコロジー， インコーポレイテッド |
Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン
|
|
US20200237766A1
(en)
|
2017-10-13 |
2020-07-30 |
Tolero Pharmaceuticals, Inc. |
Pkm2 activators in combination with reactive oxygen species for treatment of cancer
|
|
MX2021000977A
(es)
|
2018-07-26 |
2021-04-12 |
Sumitomo Pharma Oncology Inc |
Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos.
|
|
MX2021006544A
(es)
|
2018-12-04 |
2021-07-07 |
Sumitomo Pharma Oncology Inc |
Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer.
|
|
JP7458406B2
(ja)
|
2018-12-21 |
2024-03-29 |
セルジーン コーポレーション |
Ｒｉｐｋ２のチエノピリジン阻害剤
|
|
JP2022520361A
(ja)
|
2019-02-12 |
2022-03-30 |
スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド |
複素環式タンパク質キナーゼ阻害剤を含む製剤
|
|
US20220056043A1
(en)
*
|
2019-02-19 |
2022-02-24 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Nitrogen-containing fused cyclic compound, preparation method therefor and use thereof
|
|
SG11202109036WA
(en)
*
|
2019-03-01 |
2021-09-29 |
Revolution Medicines Inc |
Bicyclic heteroaryl compounds and uses thereof
|
|
JP2022525149A
(ja)
|
2019-03-20 |
2022-05-11 |
スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド |
ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
|
|
JP2022519923A
(ja)
|
2019-03-22 |
2022-03-25 |
スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド |
Ｐｋｍ２モジュレーターを含む組成物およびそれを使用する処置の方法
|
|
CN114269753B
(zh)
*
|
2019-09-29 |
2024-03-05 |
四川科伦博泰生物医药股份有限公司 |
一种含氮并环类化合物，包含其的药物组合物，其制备方法及其用途
|
|
US20230057568A1
(en)
*
|
2019-12-12 |
2023-02-23 |
Ptc Therapeutics, Inc. |
Compounds for treating familial dysautonomia
|
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
|
CN115746017A
(zh)
*
|
2022-11-30 |
2023-03-07 |
英维沃化工科技(广州)有限公司 |
一种噻吩并嘧啶类化合物及其制备方法和应用
|