FR2988722B1 - Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques - Google Patents

Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Info

Publication number
FR2988722B1
FR2988722B1 FR1253044A FR1253044A FR2988722B1 FR 2988722 B1 FR2988722 B1 FR 2988722B1 FR 1253044 A FR1253044 A FR 1253044A FR 1253044 A FR1253044 A FR 1253044A FR 2988722 B1 FR2988722 B1 FR 2988722B1
Authority
FR
France
Prior art keywords
processes
preparation
therapeutic uses
thienopyrimidine derivatives
novel thienopyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1253044A
Other languages
English (en)
Other versions
FR2988722A1 (fr
Inventor
Jean-Christophe Carry
Fabienne Chatreaux
Stephanie Deprets
Olivier Duclos
Vincent Leroy
Sergio Mallart
Dominique Melon-Manguer
Maria Mendez-Perez
Fabrice Vergne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48095815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2988722(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR1253044A priority Critical patent/FR2988722B1/fr
Priority to UAA201411826A priority patent/UA112685C2/uk
Priority to PE2014001523A priority patent/PE20150289A1/es
Priority to MX2014011921A priority patent/MX355104B/es
Priority to HUE13716241A priority patent/HUE027895T2/en
Priority to PL13716241.8T priority patent/PL2834248T3/pl
Priority to MA37384A priority patent/MA37384B1/fr
Priority to PT137162418T priority patent/PT2834248E/pt
Priority to CN201710950612.0A priority patent/CN107652303B/zh
Priority to PCT/EP2013/056958 priority patent/WO2013150036A1/fr
Priority to MYPI2014002724A priority patent/MY166151A/en
Priority to CN201380029174.4A priority patent/CN104540834B/zh
Priority to SG11201406091RA priority patent/SG11201406091RA/en
Priority to BR112014024489-8A priority patent/BR112014024489B1/pt
Priority to AU2013244992A priority patent/AU2013244992B2/en
Priority to SI201330203A priority patent/SI2834248T1/sl
Priority to CA2868685A priority patent/CA2868685C/fr
Priority to EP13716241.8A priority patent/EP2834248B1/fr
Priority to RS20160436A priority patent/RS54850B1/sr
Priority to EA201491820A priority patent/EA025558B1/ru
Priority to KR1020147030322A priority patent/KR102039764B1/ko
Priority to ES13716241.8T priority patent/ES2577382T3/es
Priority to JP2015503860A priority patent/JP6096278B2/ja
Priority to DK13716241.8T priority patent/DK2834248T3/en
Priority to US13/855,246 priority patent/US9115140B2/en
Priority to ARP130101067A priority patent/AR090572A1/es
Priority to TW102112260A priority patent/TWI579288B/zh
Priority to UY0001034725A priority patent/UY34725A/es
Publication of FR2988722A1 publication Critical patent/FR2988722A1/fr
Application granted granted Critical
Publication of FR2988722B1 publication Critical patent/FR2988722B1/fr
Priority to CR20140435A priority patent/CR20140435A/es
Priority to DO2014000216A priority patent/DOP2014000216A/es
Priority to ZA2014/07021A priority patent/ZA201407021B/en
Priority to PH12014502180A priority patent/PH12014502180A1/en
Priority to TNP2014000415A priority patent/TN2014000415A1/fr
Priority to CL2014002661A priority patent/CL2014002661A1/es
Priority to IL234960A priority patent/IL234960A/en
Priority to CO14219119A priority patent/CO7091179A2/es
Priority to HK15101753.8A priority patent/HK1201263A1/zh
Priority to US14/794,574 priority patent/US9744176B2/en
Priority to HRP20160649TT priority patent/HRP20160649T1/hr
Priority to CY20161100522T priority patent/CY1117843T1/el
Priority to US15/660,694 priority patent/US10220044B2/en
Priority to HK18107478.6A priority patent/HK1248214A1/zh
Priority to US16/245,131 priority patent/US10500212B2/en
Priority to US16/668,555 priority patent/US10736904B2/en
Priority to US16/915,782 priority patent/US10980816B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
FR1253044A 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques Active FR2988722B1 (fr)

Priority Applications (45)

Application Number Priority Date Filing Date Title
FR1253044A FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
UAA201411826A UA112685C2 (uk) 2012-04-03 2013-02-04 Тієнопіримідинові похідні, способи їхнього одержання і їхні терапевтичні застосування
CA2868685A CA2868685C (fr) 2012-04-03 2013-04-02 Derives de thienopyrimidine, ses procedes de preparation et ses usages therapeutiques
EA201491820A EA025558B1 (ru) 2012-04-03 2013-04-02 Тиенопиримидиновые производные, способы их получения и их терапевтические применения
HUE13716241A HUE027895T2 (en) 2012-04-03 2013-04-02 New thienopyrimidine derivatives, a process for their preparation and their therapeutic use
PL13716241.8T PL2834248T3 (pl) 2012-04-03 2013-04-02 Nowe pochodne tienopirymidynowe, sposoby ich otrzymywania i ich zastosowania terapeutyczne
MA37384A MA37384B1 (fr) 2012-04-03 2013-04-02 Nouveaux dérivés de thiénopyrimidine, leurs procédés de préparation et leurs utilisations thérapeutiques.
PT137162418T PT2834248E (pt) 2012-04-03 2013-04-02 Novos derivados da tienopirimidina, processos para a sua preparação e sua utilização terapêutica
CN201710950612.0A CN107652303B (zh) 2012-04-03 2013-04-02 新噻吩并嘧啶衍生物、其制备方法及其治疗用途
PCT/EP2013/056958 WO2013150036A1 (fr) 2012-04-03 2013-04-02 Nouveaux dérivés de thiénopyrimidine, leurs procédés de préparation et leurs utilisations thérapeutiques
MYPI2014002724A MY166151A (en) 2012-04-03 2013-04-02 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
CN201380029174.4A CN104540834B (zh) 2012-04-03 2013-04-02 新噻吩并嘧啶衍生物、其制备方法及其治疗用途
SG11201406091RA SG11201406091RA (en) 2012-04-03 2013-04-02 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
BR112014024489-8A BR112014024489B1 (pt) 2012-04-03 2013-04-02 derivados de tienopirimidina, processos para a preparação dos mesmos, medicamento e composição farmacêutica
AU2013244992A AU2013244992B2 (en) 2012-04-03 2013-04-02 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
SI201330203A SI2834248T1 (sl) 2012-04-03 2013-04-02 Novi derivati tienopirimidina, postopki njihove priprave in njihove terapevtske uporabe
US13/855,246 US9115140B2 (en) 2012-04-03 2013-04-02 Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
EP13716241.8A EP2834248B1 (fr) 2012-04-03 2013-04-02 Nouveaux dérivés de thiénopyrimidine, leurs procédés de préparation et leurs utilisations thérapeutiques
RS20160436A RS54850B1 (sr) 2012-04-03 2013-04-02 Novi tienopirimidin derivati, procesi za pripremu istih i terapijska korišćenja toga
MX2014011921A MX355104B (es) 2012-04-03 2013-04-02 Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos.
KR1020147030322A KR102039764B1 (ko) 2012-04-03 2013-04-02 신규 티에노피리미딘 유도체, 그의 제조 방법 및 그의 치료 용도
ES13716241.8T ES2577382T3 (es) 2012-04-03 2013-04-02 Nuevos derivados de tienopirimidina, procedimientos para su preparación, y sus usos terapéuticos
JP2015503860A JP6096278B2 (ja) 2012-04-03 2013-04-02 新規なチエノピリミジン誘導体、その製造のための方法およびその治療的使用
DK13716241.8T DK2834248T3 (en) 2012-04-03 2013-04-02 UNKNOWN THIENOPYRIMIDINE DERIVATIVES, METHODS OF PRODUCING THEREOF, AND THERAPEUTIC APPLICATIONS THEREOF
PE2014001523A PE20150289A1 (es) 2012-04-03 2013-04-02 Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
ARP130101067A AR090572A1 (es) 2012-04-03 2013-04-03 Derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
UY0001034725A UY34725A (es) 2012-04-03 2013-04-03 Nuevos derivados de tienopirimidina, procesos para su preparación y sus usos terapéuticos.
TW102112260A TWI579288B (zh) 2012-04-03 2013-04-03 新穎噻吩并嘧啶衍生物及其製備方法與治療用途
CR20140435A CR20140435A (es) 2012-04-03 2014-09-22 Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
DO2014000216A DOP2014000216A (es) 2012-04-03 2014-09-25 Nuevos derivados de tienopirimidina en particular como agentes anticancerosos mediante la inhibición de la alk quinasa, procesos para su preparación y sus usos terapéuticos
ZA2014/07021A ZA201407021B (en) 2012-04-03 2014-09-26 Novel thienopyrimidine derivatives,processes for the preparation thereof and therapeutic uses thereof
PH12014502180A PH12014502180A1 (en) 2012-04-03 2014-09-29 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
TNP2014000415A TN2014000415A1 (en) 2012-04-03 2014-09-30 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
CL2014002661A CL2014002661A1 (es) 2012-04-03 2014-10-02 Compuestos derivados de tienopirimidina o sus sales, como inhibidores de la alk quinasa; su proceso de preparacion; composicion farmaceutica que los comprende, util para el tratamiento del cancer.
IL234960A IL234960A (en) 2012-04-03 2014-10-02 Theophenimidine derivatives, their preparation processes, and their medical uses
CO14219119A CO7091179A2 (es) 2012-04-03 2014-10-03 Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
HK15101753.8A HK1201263A1 (zh) 2012-04-03 2015-02-17 新噻吩並嘧啶衍生物、其製備方法及其治療用途
US14/794,574 US9744176B2 (en) 2012-04-03 2015-07-08 Therapeutic uses of novel thienopyrimidine derivatives
HRP20160649TT HRP20160649T1 (hr) 2012-04-03 2016-06-10 Novi derivati tienopirimidina, postupci za njihovo pripremanje i njihova terapeutska uporaba
CY20161100522T CY1117843T1 (el) 2012-04-03 2016-06-15 Νεα παραγωγα θειενοπυριμιδινης, διεργασιες για την παρασκευη αυτων και θεραπευτικες χρησεις αυτων
US15/660,694 US10220044B2 (en) 2012-04-03 2017-07-26 Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
HK18107478.6A HK1248214A1 (zh) 2012-04-03 2018-06-08 新噻吩並嘧啶衍生物、其製備方法及其治療用途
US16/245,131 US10500212B2 (en) 2012-04-03 2019-01-10 Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
US16/668,555 US10736904B2 (en) 2012-04-03 2019-10-30 Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
US16/915,782 US10980816B2 (en) 2012-04-03 2020-06-29 Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1253044A FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Publications (2)

Publication Number Publication Date
FR2988722A1 FR2988722A1 (fr) 2013-10-04
FR2988722B1 true FR2988722B1 (fr) 2014-05-09

Family

ID=48095815

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1253044A Active FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Country Status (38)

Country Link
US (6) US9115140B2 (fr)
EP (1) EP2834248B1 (fr)
JP (1) JP6096278B2 (fr)
KR (1) KR102039764B1 (fr)
CN (2) CN107652303B (fr)
AR (1) AR090572A1 (fr)
AU (1) AU2013244992B2 (fr)
BR (1) BR112014024489B1 (fr)
CA (1) CA2868685C (fr)
CL (1) CL2014002661A1 (fr)
CO (1) CO7091179A2 (fr)
CR (1) CR20140435A (fr)
CY (1) CY1117843T1 (fr)
DK (1) DK2834248T3 (fr)
DO (1) DOP2014000216A (fr)
EA (1) EA025558B1 (fr)
ES (1) ES2577382T3 (fr)
FR (1) FR2988722B1 (fr)
HK (2) HK1201263A1 (fr)
HR (1) HRP20160649T1 (fr)
HU (1) HUE027895T2 (fr)
IL (1) IL234960A (fr)
MA (1) MA37384B1 (fr)
MX (1) MX355104B (fr)
MY (1) MY166151A (fr)
PE (1) PE20150289A1 (fr)
PH (1) PH12014502180A1 (fr)
PL (1) PL2834248T3 (fr)
PT (1) PT2834248E (fr)
RS (1) RS54850B1 (fr)
SG (1) SG11201406091RA (fr)
SI (1) SI2834248T1 (fr)
TN (1) TN2014000415A1 (fr)
TW (1) TWI579288B (fr)
UA (1) UA112685C2 (fr)
UY (1) UY34725A (fr)
WO (1) WO2013150036A1 (fr)
ZA (1) ZA201407021B (fr)

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Publication number Priority date Publication date Assignee Title
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
CN110372720B (zh) * 2014-05-28 2021-03-05 锦州奥鸿药业有限责任公司 一类激酶抑制剂
CN111440189B (zh) * 2015-04-24 2022-08-09 广州再极医药科技有限公司 稠环嘧啶氨基衍生物、其制备方法、中间体、药物组合物及应用
CN113549069A (zh) * 2015-12-27 2021-10-26 重庆复创医药研究有限公司 一类激酶抑制剂
MX2018013573A (es) * 2016-05-07 2019-08-01 Shanghai Fochon Pharmaceutical Co Ltd Ciertos inhibidores de la proteína cinasa.
UA126589C2 (uk) 2017-09-14 2022-11-02 Даїті Санкіо Компані, Лімітед Сполука, яка має циклічну структуру
ES2910071T3 (es) 2018-03-08 2022-05-11 Incyte Corp Compuestos de aminopirazina diol como inhibidores de PI3K-Y
CN110551142B (zh) * 2018-05-31 2023-05-12 上海再极医药科技有限公司 一种稠环嘧啶类化合物的盐、晶型及其制备方法和应用
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110922421B (zh) * 2019-12-17 2023-05-05 安徽英特美科技有限公司 一种n-甲基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
WO2021180032A1 (fr) * 2020-03-13 2021-09-16 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Nouveaux procédés thérapeutiques
CN116731035A (zh) * 2022-03-08 2023-09-12 广州再极医药科技有限公司 一种噻吩并嘧啶类化合物、中间体、其制备方法、组合物和应用

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CN1280580A (zh) * 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
EP1181296A1 (fr) 1999-06-03 2002-02-27 Abbott Laboratories Composes anti-inflammatoires inhibant l'adhesion cellulaire
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KR101402474B1 (ko) * 2006-04-26 2014-06-19 제넨테크, 인크. 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물
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EP3109249A1 (fr) * 2007-11-15 2016-12-28 YM BioSciences Australia Pty Ltd Composés hétérocycliques contenant de l'azote
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KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
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FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
PL2834248T3 (pl) 2016-09-30
US20200078370A1 (en) 2020-03-12
US10980816B2 (en) 2021-04-20
US20170319594A1 (en) 2017-11-09
HK1248214A1 (zh) 2018-10-12
IL234960A (en) 2017-06-29
UA112685C2 (uk) 2016-10-10
US10736904B2 (en) 2020-08-11
CN107652303B (zh) 2020-08-04
AR090572A1 (es) 2014-11-19
MA37384A1 (fr) 2016-06-30
EP2834248A1 (fr) 2015-02-11
US20190151330A1 (en) 2019-05-23
US9115140B2 (en) 2015-08-25
EA201491820A1 (ru) 2015-02-27
HUE027895T2 (en) 2016-10-28
ES2577382T3 (es) 2016-07-14
MA37384B1 (fr) 2017-03-31
SG11201406091RA (en) 2014-10-30
CR20140435A (es) 2015-03-13
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US20150352124A1 (en) 2015-12-10
CO7091179A2 (es) 2014-10-21
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CA2868685C (fr) 2021-01-12
FR2988722A1 (fr) 2013-10-04
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EA025558B1 (ru) 2017-01-30
CL2014002661A1 (es) 2014-12-26
JP2015512434A (ja) 2015-04-27
AU2013244992B2 (en) 2017-04-20
SI2834248T1 (sl) 2016-07-29
KR20150001781A (ko) 2015-01-06
UY34725A (es) 2013-09-30
DK2834248T3 (en) 2016-07-04
ZA201407021B (en) 2015-11-25
PT2834248E (pt) 2016-06-24
US10500212B2 (en) 2019-12-10
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CN104540834A (zh) 2015-04-22
MY166151A (en) 2018-06-06
CN107652303A (zh) 2018-02-02
PH12014502180B1 (en) 2014-12-10
CA2868685A1 (fr) 2013-10-10
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CN104540834B (zh) 2017-11-14
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US20200323874A1 (en) 2020-10-15
US9744176B2 (en) 2017-08-29
EP2834248B1 (fr) 2016-03-16
MX355104B (es) 2018-04-05
HRP20160649T1 (hr) 2016-07-15
DOP2014000216A (es) 2017-09-15
CY1117843T1 (el) 2017-05-17
TN2014000415A1 (en) 2015-12-21
BR112014024489B1 (pt) 2020-11-10
WO2013150036A1 (fr) 2013-10-10
RS54850B1 (sr) 2016-10-31
PH12014502180A1 (en) 2014-12-10
US10220044B2 (en) 2019-03-05
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PE20150289A1 (es) 2015-03-05

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