EA201491820A1 - Новые тиенопиримидиновые производные, способы их получения и их терапевтические применения - Google Patents

Новые тиенопиримидиновые производные, способы их получения и их терапевтические применения

Info

Publication number
EA201491820A1
EA201491820A1 EA201491820A EA201491820A EA201491820A1 EA 201491820 A1 EA201491820 A1 EA 201491820A1 EA 201491820 A EA201491820 A EA 201491820A EA 201491820 A EA201491820 A EA 201491820A EA 201491820 A1 EA201491820 A1 EA 201491820A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thyenopyrimidine
derivatives
recovery
new
methods
Prior art date
Application number
EA201491820A
Other languages
English (en)
Other versions
EA025558B1 (ru
Inventor
Жан-Кристоф Карри
Фабьенн Шатро
Стефани Депре
Оливье Дюкло
Венсан Леруа
Сержио Маллар
Доминик Мелон-Манге
Мария Мендес-Перес
Фабрис Вернь
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48095815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491820(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи filed Critical Санофи
Publication of EA201491820A1 publication Critical patent/EA201491820A1/ru
Publication of EA025558B1 publication Critical patent/EA025558B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение относится к соединениям формулы (I), в которой R6 представляет собой -CONHили группу -С(Rα)(Rβ)(ОН); R представляет собой замещенную фенильную или гетероарильную группу; R7 представляет собой необязательно замещенную арильную или гетероарильную группу; способу их получения и их терапевтическому применению.
EA201491820A 2012-04-03 2013-04-02 Тиенопиримидиновые производные, способы их получения и их терапевтические применения EA025558B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1253044A FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
PCT/EP2013/056958 WO2013150036A1 (en) 2012-04-03 2013-04-02 Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
EA201491820A1 true EA201491820A1 (ru) 2015-02-27
EA025558B1 EA025558B1 (ru) 2017-01-30

Family

ID=48095815

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491820A EA025558B1 (ru) 2012-04-03 2013-04-02 Тиенопиримидиновые производные, способы их получения и их терапевтические применения

Country Status (38)

Country Link
US (6) US9115140B2 (ru)
EP (1) EP2834248B1 (ru)
JP (1) JP6096278B2 (ru)
KR (1) KR102039764B1 (ru)
CN (2) CN107652303B (ru)
AR (1) AR090572A1 (ru)
AU (1) AU2013244992B2 (ru)
BR (1) BR112014024489B1 (ru)
CA (1) CA2868685C (ru)
CL (1) CL2014002661A1 (ru)
CO (1) CO7091179A2 (ru)
CR (1) CR20140435A (ru)
CY (1) CY1117843T1 (ru)
DK (1) DK2834248T3 (ru)
DO (1) DOP2014000216A (ru)
EA (1) EA025558B1 (ru)
ES (1) ES2577382T3 (ru)
FR (1) FR2988722B1 (ru)
HK (2) HK1201263A1 (ru)
HR (1) HRP20160649T1 (ru)
HU (1) HUE027895T2 (ru)
IL (1) IL234960A (ru)
MA (1) MA37384B1 (ru)
MX (1) MX355104B (ru)
MY (1) MY166151A (ru)
PE (1) PE20150289A1 (ru)
PH (1) PH12014502180B1 (ru)
PL (1) PL2834248T3 (ru)
PT (1) PT2834248E (ru)
RS (1) RS54850B1 (ru)
SG (1) SG11201406091RA (ru)
SI (1) SI2834248T1 (ru)
TN (1) TN2014000415A1 (ru)
TW (1) TWI579288B (ru)
UA (1) UA112685C2 (ru)
UY (1) UY34725A (ru)
WO (1) WO2013150036A1 (ru)
ZA (1) ZA201407021B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
JP2017516855A (ja) * 2014-05-28 2017-06-22 シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド 特定のタンパク質キナーゼ阻害剤
EP3287463A4 (en) * 2015-04-24 2018-07-11 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
CN113549069A (zh) * 2015-12-27 2021-10-26 重庆复创医药研究有限公司 一类激酶抑制剂
TWI752026B (zh) 2016-05-07 2022-01-11 大陸商上海複尚慧創醫藥研究有限公司 一類蛋白激酶抑制劑
JP7158393B2 (ja) 2017-09-14 2022-10-21 第一三共株式会社 環状構造を有する化合物
LT3762368T (lt) 2018-03-08 2022-06-10 Incyte Corporation Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
CN110551142B (zh) * 2018-05-31 2023-05-12 上海再极医药科技有限公司 一种稠环嘧啶类化合物的盐、晶型及其制备方法和应用
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110922421B (zh) * 2019-12-17 2023-05-05 安徽英特美科技有限公司 一种n-甲基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
WO2021180032A1 (en) * 2020-03-13 2021-09-16 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Novel Therapeutic Methods
WO2023169461A1 (zh) * 2022-03-08 2023-09-14 广州再极医药科技有限公司 一种噻吩并嘧啶类化合物、中间体、其制备方法、组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
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DE1470356A1 (de) * 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
ID23978A (id) 1997-11-11 2000-06-14 Pfizer Prod Inc Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker
EP1181296A1 (en) 1999-06-03 2002-02-27 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
DE10042997A1 (de) 2000-09-01 2002-03-14 Merck Patent Gmbh Thienopyrimidine
US20080108611A1 (en) 2006-01-19 2008-05-08 Battista Kathleen A Substituted thienopyrimidine kinase inhibitors
JP5291616B2 (ja) 2006-04-26 2013-09-18 ジェネンテック， インコーポレイテッド ホスホイノシチド３−キナーゼ抑制剤化合物およびその使用方法
PT2091918E (pt) 2006-12-08 2014-11-24 Irm Llc Compostos e composições como inibidores de proteína cinase
JP5489235B2 (ja) * 2007-11-15 2014-05-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド Ｎ含有複素環式化合物
DE102008017853A1 (de) 2008-04-09 2009-10-15 Merck Patent Gmbh Thienopyrimidine
KR101147550B1 (ko) * 2009-10-22 2012-05-17 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
WO2012004900A1 (en) 2010-07-09 2012-01-12 Aska Pharmaceutical Co., Ltd. Thienopyrimidine compounds
FR2988722B1 (fr) * 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
CO7091179A2 (es) 2014-10-21
US20130261106A1 (en) 2013-10-03
ES2577382T3 (es) 2016-07-14
CN107652303A (zh) 2018-02-02
WO2013150036A1 (en) 2013-10-10
TW201345914A (zh) 2013-11-16
UY34725A (es) 2013-09-30
US10500212B2 (en) 2019-12-10
CY1117843T1 (el) 2017-05-17
PH12014502180A1 (en) 2014-12-10
RS54850B1 (sr) 2016-10-31
DK2834248T3 (en) 2016-07-04
TN2014000415A1 (en) 2015-12-21
US20170319594A1 (en) 2017-11-09
MA37384B1 (fr) 2017-03-31
US10736904B2 (en) 2020-08-11
JP6096278B2 (ja) 2017-03-15
US9115140B2 (en) 2015-08-25
EA025558B1 (ru) 2017-01-30
US10220044B2 (en) 2019-03-05
HK1248214A1 (zh) 2018-10-12
IL234960A (en) 2017-06-29
MY166151A (en) 2018-06-06
CA2868685C (en) 2021-01-12
AR090572A1 (es) 2014-11-19
US10980816B2 (en) 2021-04-20
JP2015512434A (ja) 2015-04-27
EP2834248B1 (en) 2016-03-16
KR20150001781A (ko) 2015-01-06
FR2988722A1 (fr) 2013-10-04
CN104540834A (zh) 2015-04-22
MX355104B (es) 2018-04-05
US20150352124A1 (en) 2015-12-10
HK1201263A1 (zh) 2015-08-28
HRP20160649T1 (hr) 2016-07-15
PH12014502180B1 (en) 2014-12-10
MA37384A1 (fr) 2016-06-30
TWI579288B (zh) 2017-04-21
MX2014011921A (es) 2015-02-24
CN104540834B (zh) 2017-11-14
FR2988722B1 (fr) 2014-05-09
SI2834248T1 (sl) 2016-07-29
ZA201407021B (en) 2015-11-25
EP2834248A1 (en) 2015-02-11
PT2834248E (pt) 2016-06-24
BR112014024489B1 (pt) 2020-11-10
AU2013244992A1 (en) 2014-10-23
PE20150289A1 (es) 2015-03-05
US20190151330A1 (en) 2019-05-23
CR20140435A (es) 2015-03-13
US20200078370A1 (en) 2020-03-12
UA112685C2 (uk) 2016-10-10
CA2868685A1 (en) 2013-10-10
CL2014002661A1 (es) 2014-12-26
DOP2014000216A (es) 2017-09-15
HUE027895T2 (en) 2016-10-28
US20200323874A1 (en) 2020-10-15
PL2834248T3 (pl) 2016-09-30
CN107652303B (zh) 2020-08-04
SG11201406091RA (en) 2014-10-30
US9744176B2 (en) 2017-08-29
AU2013244992B2 (en) 2017-04-20
KR102039764B1 (ko) 2019-11-01

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