EA201590552A1 - Аминохинолины в качестве ингибиторов киназы - Google Patents

Аминохинолины в качестве ингибиторов киназы

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Publication number
EA201590552A1
EA201590552A1 EA201590552A EA201590552A EA201590552A1 EA 201590552 A1 EA201590552 A1 EA 201590552A1 EA 201590552 A EA201590552 A EA 201590552A EA 201590552 A EA201590552 A EA 201590552A EA 201590552 A1 EA201590552 A1 EA 201590552A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminohinolines
kinase inhibitors
compounds
formula
preparation
Prior art date
Application number
EA201590552A
Other languages
English (en)
Other versions
EA027984B1 (ru
Inventor
Линда Н. Касиллас
Майкл П. Демартино
Памела А. Хейл
Джон Ф. Мелманн
Джоши М. Раманджулу
Роберт мл. Сингхаус
Original Assignee
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50278701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590552(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед filed Critical Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Publication of EA201590552A1 publication Critical patent/EA201590552A1/ru
Publication of EA027984B1 publication Critical patent/EA027984B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Раскрыты соединения, имеющие формулугде R, R, R, Rи Rпредставляют собой такие, как определено в данном документе, и способы получения и применения этих соединений.
EA201590552A 2012-09-13 2013-09-13 Аминохинолины в качестве ингибиторов rip2 киназы EA027984B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261700536P 2012-09-13 2012-09-13
US201361767378P 2013-02-21 2013-02-21
PCT/US2013/059600 WO2014043437A1 (en) 2012-09-13 2013-09-13 Amino-quinolines as kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201590552A1 true EA201590552A1 (ru) 2015-06-30
EA027984B1 EA027984B1 (ru) 2017-09-29

Family

ID=50278701

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590552A EA027984B1 (ru) 2012-09-13 2013-09-13 Аминохинолины в качестве ингибиторов rip2 киназы

Country Status (21)

Country Link
US (1) US9216965B2 (ru)
EP (1) EP2895167B1 (ru)
JP (1) JP6258331B2 (ru)
KR (1) KR20150053920A (ru)
CN (1) CN104602692B (ru)
AR (1) AR092530A1 (ru)
AU (1) AU2013315387B2 (ru)
BR (1) BR112015004967A2 (ru)
CA (1) CA2883155A1 (ru)
CL (1) CL2015000615A1 (ru)
CR (1) CR20150133A (ru)
DO (1) DOP2015000059A (ru)
EA (1) EA027984B1 (ru)
ES (1) ES2713172T3 (ru)
IL (1) IL237158A0 (ru)
MX (1) MX2015003275A (ru)
PE (1) PE20150774A1 (ru)
PH (1) PH12015500345A1 (ru)
SG (1) SG11201500973WA (ru)
TW (1) TW201425307A (ru)
WO (1) WO2014043437A1 (ru)

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TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
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AU2014220300B2 (en) 2013-02-21 2016-10-13 Glaxosmithkline Intellectual Property Development Limited Quinazolines as kinase inhibitors
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
GB201516243D0 (en) 2015-09-14 2015-10-28 Glaxosmithkline Ip Dev Ltd Novel compounds
BR112018006873A2 (pt) 2015-10-05 2018-11-06 The Trustees Of Columbia University In The City Of New York ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias
CN107158385B (zh) * 2016-03-14 2020-07-14 苏州大学 Rip3抑制剂在制备抗血小板血栓药物中的用途
BR112018071408A2 (pt) 2016-04-20 2019-02-05 Glaxosmithkline Ip Dev Ltd “composto inibidor de rip2 quinase, composição farmacêutica, usos de um composto e de uma combinação, e, combinação
WO2020094613A1 (en) 2018-11-06 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Nod2 inhibitors for the treatment of hereditary periodic fevers

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Also Published As

Publication number Publication date
SG11201500973WA (en) 2015-04-29
WO2014043437A1 (en) 2014-03-20
EP2895167A1 (en) 2015-07-22
CN104602692A (zh) 2015-05-06
AU2013315387B2 (en) 2016-09-08
DOP2015000059A (es) 2015-05-15
JP2015528508A (ja) 2015-09-28
PE20150774A1 (es) 2015-05-28
CR20150133A (es) 2015-05-04
AR092530A1 (es) 2015-04-22
ES2713172T3 (es) 2019-05-20
IL237158A0 (en) 2015-04-30
AU2013315387A1 (en) 2015-02-26
EP2895167B1 (en) 2018-12-05
EA027984B1 (ru) 2017-09-29
JP6258331B2 (ja) 2018-01-10
BR112015004967A2 (pt) 2020-04-22
CN104602692B (zh) 2017-06-23
CL2015000615A1 (es) 2015-08-28
US9216965B2 (en) 2015-12-22
MX2015003275A (es) 2015-07-06
EP2895167A4 (en) 2016-03-16
PH12015500345A1 (en) 2015-04-20
CA2883155A1 (en) 2014-03-20
KR20150053920A (ko) 2015-05-19
US20150094333A1 (en) 2015-04-02
TW201425307A (zh) 2014-07-01

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