ATE370958T1 - Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung - Google Patents
Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendungInfo
- Publication number
- ATE370958T1 ATE370958T1 AT03782672T AT03782672T ATE370958T1 AT E370958 T1 ATE370958 T1 AT E370958T1 AT 03782672 T AT03782672 T AT 03782672T AT 03782672 T AT03782672 T AT 03782672T AT E370958 T1 ATE370958 T1 AT E370958T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphonooxy
- pharmaceutical use
- quinazoline derivatives
- quinazoline
- derivatives
- Prior art date
Links
- PEPCBVCPSRHOBI-UHFFFAOYSA-N quinazolin-2-yl dihydrogen phosphate Chemical class C1=CC=CC2=NC(OP(O)(=O)O)=NC=C21 PEPCBVCPSRHOBI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02293238 | 2002-12-24 | ||
EP03291315 | 2003-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE370958T1 true ATE370958T1 (de) | 2007-09-15 |
Family
ID=32683824
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07009390T ATE438644T1 (de) | 2002-12-24 | 2003-12-22 | Chinazolinderivate |
AT03782672T ATE370958T1 (de) | 2002-12-24 | 2003-12-22 | Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07009390T ATE438644T1 (de) | 2002-12-24 | 2003-12-22 | Chinazolinderivate |
Country Status (30)
Country | Link |
---|---|
US (4) | US7528121B2 (de) |
EP (2) | EP1847539B1 (de) |
JP (3) | JP4422102B2 (de) |
KR (1) | KR101010299B1 (de) |
AR (2) | AR042668A1 (de) |
AT (2) | ATE438644T1 (de) |
AU (1) | AU2003290313B2 (de) |
BR (1) | BRPI0317717B8 (de) |
CA (1) | CA2511613C (de) |
CL (1) | CL2003002731A1 (de) |
CY (2) | CY1107775T1 (de) |
DE (2) | DE60328735D1 (de) |
DK (2) | DK1847539T3 (de) |
ES (2) | ES2329623T3 (de) |
HK (2) | HK1080481A1 (de) |
IL (2) | IL169112A (de) |
IS (2) | IS2504B (de) |
MX (1) | MXPA05006918A (de) |
MY (2) | MY136174A (de) |
NO (2) | NO335193B1 (de) |
NZ (1) | NZ540698A (de) |
PL (2) | PL223998B1 (de) |
PT (2) | PT1578755E (de) |
RU (3) | RU2357971C2 (de) |
SA (1) | SA04240504B1 (de) |
SI (2) | SI1578755T1 (de) |
TW (2) | TWI336327B (de) |
UA (1) | UA83814C2 (de) |
UY (1) | UY28149A1 (de) |
WO (1) | WO2004058781A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL211694B1 (pl) * | 2001-12-24 | 2012-06-29 | Astrazeneca Ab | Podstawiona pochodna chinazoliny, jej zastosowania oraz jej kompozycja farmaceutyczna |
KR20050087863A (ko) * | 2002-12-24 | 2005-08-31 | 아스트라제네카 아베 | 퀴나졸린 화합물 |
MY136174A (en) | 2002-12-24 | 2008-08-29 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
MXPA05011076A (es) * | 2003-04-16 | 2006-01-24 | Astrazeneca Ab | Derivados de quinazolina para el tratamiento de cancer. |
JP4939220B2 (ja) * | 2003-05-15 | 2012-05-23 | アークル インコーポレイテッド | p38の阻害物質としてのイミダゾチアゾール類およびイミダゾオキサゾール誘導体 |
WO2004105764A1 (en) * | 2003-06-02 | 2004-12-09 | Astrazeneca Ab | (3- ((quinazolin-4-yl) amino )-1h-pyrazol-1-yl) acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
JP4237242B2 (ja) * | 2004-10-12 | 2009-03-11 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
US20090036474A1 (en) * | 2004-10-12 | 2009-02-05 | Patrick Ple | Quinazoline derivatives for use against cancer |
EP1812439B2 (de) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinaseinhibitoren |
US8178672B2 (en) * | 2004-10-19 | 2012-05-15 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
US7501430B2 (en) * | 2006-04-17 | 2009-03-10 | Arqule, Inc. | RAF inhibitors and their uses |
GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
GB0609619D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Combination |
GB0609617D0 (en) | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
MX2009003793A (es) | 2006-10-09 | 2009-12-14 | Takeda Pharmaceutical | Inhibidores de cinasa. |
US20110136766A1 (en) * | 2008-03-04 | 2011-06-09 | Vitae Pharmaceuticals, Inc. | Aurora kinase inhibitors |
US20110033461A1 (en) * | 2008-03-12 | 2011-02-10 | Vladimir Ratushny | Combination Therapy for the Treatment of Cancer |
WO2009134658A2 (en) | 2008-04-30 | 2009-11-05 | National Health Research Institutes | Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
WO2010002779A2 (en) * | 2008-07-03 | 2010-01-07 | Merck Serono S.A. | Naphthyridininones as aurora kinase inhibitors |
MX2011005788A (es) * | 2008-12-05 | 2011-06-21 | Arqule Inc | Inhibidores raf y sus usos. |
US7863325B2 (en) | 2008-12-11 | 2011-01-04 | Axcentua Pharmaceuticals Ab | Crystalline genistein sodium salt dihydrate |
KR101849059B1 (ko) | 2008-12-11 | 2018-04-13 | 악센투아 파마슈투칼스 아베 | 제니스테인의 결정성 형태 |
CA2747326C (en) | 2008-12-22 | 2017-05-16 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
WO2012122011A2 (en) | 2011-03-04 | 2012-09-13 | Glaxosmithkline Llc | Amino-quinolines as kinase inhibitors |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
KR102277833B1 (ko) | 2013-02-20 | 2021-07-14 | 칼라 파마슈티컬스, 인크. | 치료 화합물 및 그의 용도 |
CA2902132C (en) * | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
CA2922279C (en) * | 2013-09-16 | 2022-08-16 | Astrazeneca Ab | Therapeutic polymeric nanoparticles and methods of making and using same |
KR20160099084A (ko) | 2013-11-01 | 2016-08-19 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정질 형태 및 그의 용도 |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
WO2015085289A1 (en) | 2013-12-06 | 2015-06-11 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd30 antibodies |
US20180207173A1 (en) | 2015-07-21 | 2018-07-26 | Millennium Pharmaceuticals, Inc. | Administration of aurora kinase inhibitor and chemotherapeutic agents |
CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
AU2017324713B2 (en) | 2016-09-08 | 2020-08-13 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
BR112019004463A2 (pt) | 2016-09-08 | 2019-05-28 | Kala Pharmaceuticals Inc | formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso |
CN117883449A (zh) | 2017-09-08 | 2024-04-16 | 里兰斯坦福初级大学理事会 | Enpp1抑制剂以及它们用于治疗癌症的用途 |
WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
WO2021094379A1 (en) | 2019-11-12 | 2021-05-20 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
CN112939948B (zh) * | 2019-12-11 | 2022-05-17 | 苏州美诺医药科技有限公司 | 新型含喹唑啉类化合物及其中间体与应用 |
WO2021260582A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and aurora b inhibitor |
WO2022192139A1 (en) | 2021-03-10 | 2022-09-15 | Astrazeneca Ab | Aurora kinase b inhibitors for use for treating cancer |
Family Cites Families (33)
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IL89029A (en) | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
CA2102780C (en) | 1991-05-10 | 2007-01-09 | Alfred P. Spada | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
AU2737295A (en) | 1994-06-09 | 1996-01-04 | Glaxo Group Limited | Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
TW321649B (de) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
ATE315654T1 (de) | 1995-12-18 | 2006-02-15 | Sugen Inc | Diagnose und behandlung von mit aur-1 und/oder aur-2 assoziierten erkrankungen |
US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
PT880508E (pt) | 1996-02-13 | 2003-07-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de vegf |
AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
AU756556B2 (en) * | 1998-10-08 | 2003-01-16 | Astrazeneca Ab | Quinazoline derivatives |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
WO2001021596A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
SK18102002A3 (sk) | 2000-06-28 | 2003-07-01 | Astrazeneca Ab | Substituované chinazolínové deriváty, ich použitie a kompozícia obsahujúca tieto deriváty |
AU6623301A (en) | 2000-07-07 | 2002-01-21 | Angiogene Pharm Ltd | Colchinol derivatives as vascular damaging agents |
SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
AU2002350105A1 (en) * | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel quinazolines and uses thereof |
GB0124299D0 (en) * | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
PL211694B1 (pl) * | 2001-12-24 | 2012-06-29 | Astrazeneca Ab | Podstawiona pochodna chinazoliny, jej zastosowania oraz jej kompozycja farmaceutyczna |
MY136174A (en) * | 2002-12-24 | 2008-08-29 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
KR20050087863A (ko) * | 2002-12-24 | 2005-08-31 | 아스트라제네카 아베 | 퀴나졸린 화합물 |
MXPA05011076A (es) * | 2003-04-16 | 2006-01-24 | Astrazeneca Ab | Derivados de quinazolina para el tratamiento de cancer. |
-
2003
- 2003-12-22 MY MYPI20034944A patent/MY136174A/en unknown
- 2003-12-22 US US10/539,220 patent/US7528121B2/en active Active
- 2003-12-22 ES ES07009390T patent/ES2329623T3/es not_active Expired - Lifetime
- 2003-12-22 DE DE60328735T patent/DE60328735D1/de not_active Expired - Lifetime
- 2003-12-22 ES ES03782672T patent/ES2290529T3/es not_active Expired - Lifetime
- 2003-12-22 PL PL412704A patent/PL223998B1/pl unknown
- 2003-12-22 DE DE60315892T patent/DE60315892T2/de not_active Expired - Lifetime
- 2003-12-22 SI SI200330965T patent/SI1578755T1/sl unknown
- 2003-12-22 PT PT03782672T patent/PT1578755E/pt unknown
- 2003-12-22 JP JP2005509716A patent/JP4422102B2/ja not_active Expired - Lifetime
- 2003-12-22 SI SI200331673T patent/SI1847539T1/sl unknown
- 2003-12-22 EP EP07009390A patent/EP1847539B1/de not_active Expired - Lifetime
- 2003-12-22 RU RU2005123485/04A patent/RU2357971C2/ru active
- 2003-12-22 WO PCT/GB2003/005613 patent/WO2004058781A1/en active Application Filing
- 2003-12-22 DK DK07009390T patent/DK1847539T3/da active
- 2003-12-22 NZ NZ540698A patent/NZ540698A/en not_active IP Right Cessation
- 2003-12-22 DK DK03782672T patent/DK1578755T3/da active
- 2003-12-22 PT PT07009390T patent/PT1847539E/pt unknown
- 2003-12-22 RU RU2007121850/04A patent/RU2350611C1/ru active
- 2003-12-22 CL CL200302731A patent/CL2003002731A1/es unknown
- 2003-12-22 BR BRPI0317717A patent/BRPI0317717B8/pt active IP Right Grant
- 2003-12-22 EP EP03782672A patent/EP1578755B1/de not_active Expired - Lifetime
- 2003-12-22 AT AT07009390T patent/ATE438644T1/de active
- 2003-12-22 CA CA2511613A patent/CA2511613C/en not_active Expired - Lifetime
- 2003-12-22 PL PL377680A patent/PL221490B1/pl unknown
- 2003-12-22 AT AT03782672T patent/ATE370958T1/de active
- 2003-12-22 AU AU2003290313A patent/AU2003290313B2/en not_active Expired
- 2003-12-22 MY MYPI20071321A patent/MY147761A/en unknown
- 2003-12-22 KR KR1020057012015A patent/KR101010299B1/ko active IP Right Grant
- 2003-12-22 MX MXPA05006918A patent/MXPA05006918A/es active IP Right Grant
- 2003-12-22 UA UAA200507294A patent/UA83814C2/ru unknown
- 2003-12-23 AR ARP030104824A patent/AR042668A1/es active IP Right Grant
- 2003-12-23 UY UY28149A patent/UY28149A1/es not_active Application Discontinuation
- 2003-12-23 TW TW092136601A patent/TWI336327B/zh not_active IP Right Cessation
- 2003-12-23 TW TW099134275A patent/TWI393710B/zh not_active IP Right Cessation
-
2004
- 2004-02-18 SA SA04240504A patent/SA04240504B1/ar unknown
-
2005
- 2005-06-09 IL IL169112A patent/IL169112A/en active IP Right Grant
- 2005-06-13 NO NO20052855A patent/NO335193B1/no not_active IP Right Cessation
- 2005-07-20 IS IS7948A patent/IS2504B/is unknown
-
2006
- 2006-01-10 HK HK06100400A patent/HK1080481A1/xx not_active IP Right Cessation
-
2007
- 2007-05-16 AR ARP070102117A patent/AR057753A2/es not_active Application Discontinuation
- 2007-06-13 RU RU2007121850/04K patent/RU2007121850A/ru unknown
- 2007-06-28 JP JP2007169891A patent/JP4906608B2/ja not_active Expired - Lifetime
- 2007-08-09 IL IL185176A patent/IL185176A/en active IP Right Grant
- 2007-10-24 CY CY20071101369T patent/CY1107775T1/el unknown
-
2008
- 2008-02-13 IS IS8714A patent/IS2884B/is unknown
- 2008-02-27 HK HK08102177.3A patent/HK1111417A1/xx not_active IP Right Cessation
- 2008-10-15 JP JP2008265949A patent/JP4503090B2/ja not_active Expired - Lifetime
-
2009
- 2009-04-28 US US12/431,165 patent/US8268841B2/en active Active
- 2009-10-13 CY CY20091101054T patent/CY1109479T1/el unknown
-
2012
- 2012-08-21 US US13/590,662 patent/US9018191B2/en not_active Expired - Lifetime
-
2013
- 2013-11-01 NO NO20131444A patent/NO335446B1/no not_active IP Right Cessation
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2015
- 2015-03-18 US US14/661,657 patent/US9567358B2/en not_active Expired - Lifetime
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