SI1847539T1 - Kinazolinski derivati - Google Patents

Kinazolinski derivati

Info

Publication number
SI1847539T1
SI1847539T1 SI200331673T SI200331673T SI1847539T1 SI 1847539 T1 SI1847539 T1 SI 1847539T1 SI 200331673 T SI200331673 T SI 200331673T SI 200331673 T SI200331673 T SI 200331673T SI 1847539 T1 SI1847539 T1 SI 1847539T1
Authority
SI
Slovenia
Prior art keywords
quinazoline derivatives
quinazoline
derivatives
Prior art date
Application number
SI200331673T
Other languages
English (en)
Inventor
Nicola Murdoch Heron
Andrew Austen Mortlock
Frederic Henri Jung
Georges Rene Pasquet
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SI1847539T1 publication Critical patent/SI1847539T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200331673T 2002-12-24 2003-12-22 Kinazolinski derivati SI1847539T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02293238 2002-12-24
EP03291315 2003-06-02
EP07009390A EP1847539B1 (en) 2002-12-24 2003-12-22 Quinazoline derivatives

Publications (1)

Publication Number Publication Date
SI1847539T1 true SI1847539T1 (sl) 2010-01-29

Family

ID=32683824

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200331673T SI1847539T1 (sl) 2002-12-24 2003-12-22 Kinazolinski derivati
SI200330965T SI1578755T1 (sl) 2002-12-24 2003-12-22 Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200330965T SI1578755T1 (sl) 2002-12-24 2003-12-22 Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba

Country Status (30)

Country Link
US (4) US7528121B2 (sl)
EP (2) EP1578755B1 (sl)
JP (3) JP4422102B2 (sl)
KR (1) KR101010299B1 (sl)
AR (2) AR042668A1 (sl)
AT (2) ATE370958T1 (sl)
AU (1) AU2003290313B2 (sl)
BR (1) BRPI0317717B8 (sl)
CA (1) CA2511613C (sl)
CL (1) CL2003002731A1 (sl)
CY (2) CY1107775T1 (sl)
DE (2) DE60328735D1 (sl)
DK (2) DK1847539T3 (sl)
ES (2) ES2290529T3 (sl)
HK (2) HK1080481A1 (sl)
IL (2) IL169112A (sl)
IS (2) IS2504B (sl)
MX (1) MXPA05006918A (sl)
MY (2) MY147761A (sl)
NO (2) NO335193B1 (sl)
NZ (1) NZ540698A (sl)
PL (2) PL221490B1 (sl)
PT (2) PT1847539E (sl)
RU (3) RU2350611C1 (sl)
SA (1) SA04240504B1 (sl)
SI (2) SI1847539T1 (sl)
TW (2) TWI336327B (sl)
UA (1) UA83814C2 (sl)
UY (1) UY28149A1 (sl)
WO (1) WO2004058781A1 (sl)

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TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
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JP2016510000A (ja) 2013-02-20 2016-04-04 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物およびその使用
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
ES2654100T3 (es) * 2013-02-21 2018-02-12 Glaxosmithkline Intellectual Property Development Limited Quinazolinas como inhibidores de quinasa
CN105555315B (zh) * 2013-09-16 2019-05-07 阿斯利康(瑞典)有限公司 治疗性聚合物纳米颗粒及其制备和使用方法
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
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CL2004000797A1 (es) * 2003-04-16 2005-05-27 Astrazeneca Ab Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o panc

Also Published As

Publication number Publication date
AU2003290313B2 (en) 2007-05-10
RU2357971C2 (ru) 2009-06-10
SA04240504B1 (ar) 2008-04-01
HK1080481A1 (en) 2006-04-28
TW201102369A (en) 2011-01-16
IS2884B (is) 2014-06-15
RU2350611C1 (ru) 2009-03-27
EP1578755B1 (en) 2007-08-22
KR20050088333A (ko) 2005-09-05
JP2009046514A (ja) 2009-03-05
EP1847539B1 (en) 2009-08-05
KR101010299B1 (ko) 2011-01-25
EP1847539A1 (en) 2007-10-24
IS8714A (is) 2008-02-13
US20100069412A1 (en) 2010-03-18
IL169112A (en) 2010-12-30
US9567358B2 (en) 2017-02-14
JP2006512418A (ja) 2006-04-13
PL377680A1 (pl) 2006-02-06
JP4503090B2 (ja) 2010-07-14
BRPI0317717B1 (pt) 2017-12-19
DK1847539T3 (da) 2009-11-09
NZ540698A (en) 2008-05-30
JP4906608B2 (ja) 2012-03-28
PL412704A1 (pl) 2015-10-12
UA83814C2 (ru) 2008-08-26
TW200510342A (en) 2005-03-16
PL221490B1 (pl) 2016-04-29
DE60328735D1 (de) 2009-09-17
NO335193B1 (no) 2014-10-20
EP1578755A1 (en) 2005-09-28
PT1578755E (pt) 2007-10-19
MY147761A (en) 2013-01-31
AR042668A1 (es) 2005-06-29
AR057753A2 (es) 2007-12-19
BR0317717A (pt) 2005-11-22
BRPI0317717B8 (pt) 2021-05-25
ATE370958T1 (de) 2007-09-15
DK1578755T3 (da) 2007-11-12
IS2504B (is) 2009-04-15
AU2003290313A1 (en) 2004-07-22
SI1578755T1 (sl) 2007-12-31
US20140162984A1 (en) 2014-06-12
TWI336327B (en) 2011-01-21
IL185176A0 (en) 2007-12-03
US20060116357A1 (en) 2006-06-01
SA04240504A (ar) 2005-12-03
IS7948A (is) 2005-07-20
TWI393710B (zh) 2013-04-21
US8268841B2 (en) 2012-09-18
JP4422102B2 (ja) 2010-02-24
ES2290529T3 (es) 2008-02-16
PL223998B1 (pl) 2016-11-30
DE60315892D1 (de) 2007-10-04
ATE438644T1 (de) 2009-08-15
WO2004058781A1 (en) 2004-07-15
CL2003002731A1 (es) 2005-01-07
UY28149A1 (es) 2004-07-30
DE60315892T2 (de) 2008-08-14
US7528121B2 (en) 2009-05-05
MXPA05006918A (es) 2005-08-18
IL185176A (en) 2011-10-31
CY1109479T1 (el) 2014-08-13
IL169112A0 (en) 2009-02-11
RU2007121850A (ru) 2008-12-20
CA2511613C (en) 2012-10-02
US20150307534A1 (en) 2015-10-29
RU2005123485A (ru) 2006-03-10
PT1847539E (pt) 2009-10-06
NO20131444L (no) 2005-08-03
JP2007326862A (ja) 2007-12-20
CY1107775T1 (el) 2013-06-19
NO335446B1 (no) 2014-12-15
MY136174A (en) 2008-08-29
CA2511613A1 (en) 2004-07-15
ES2329623T3 (es) 2009-11-27
NO20052855D0 (no) 2005-06-13
NO20052855L (no) 2005-08-03
HK1111417A1 (en) 2008-08-08
US9018191B2 (en) 2015-04-28

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