CL2004000797A1 - Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o panc - Google Patents
Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o pancInfo
- Publication number
- CL2004000797A1 CL2004000797A1 CL200400797A CL2004000797A CL2004000797A1 CL 2004000797 A1 CL2004000797 A1 CL 2004000797A1 CL 200400797 A CL200400797 A CL 200400797A CL 2004000797 A CL2004000797 A CL 2004000797A CL 2004000797 A1 CL2004000797 A1 CL 2004000797A1
- Authority
- CL
- Chile
- Prior art keywords
- colorrectal
- quinazolina
- quinasa
- panc
- aurora
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 210000000481 breast Anatomy 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000004072 lung Anatomy 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000002307 prostate Anatomy 0.000 title 1
- 210000003932 urinary bladder Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03290951 | 2003-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2004000797A1 true CL2004000797A1 (es) | 2005-05-27 |
Family
ID=33305809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200400797A CL2004000797A1 (es) | 2003-04-16 | 2004-04-14 | Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o panc |
Country Status (23)
Country | Link |
---|---|
US (1) | US7691867B2 (es) |
EP (1) | EP1613619B1 (es) |
JP (1) | JP4709139B2 (es) |
KR (1) | KR20060003351A (es) |
CN (1) | CN1809557B (es) |
AR (1) | AR043875A1 (es) |
AT (1) | ATE390422T1 (es) |
AU (1) | AU2004232527A1 (es) |
BR (1) | BRPI0409427A (es) |
CA (1) | CA2522079A1 (es) |
CL (1) | CL2004000797A1 (es) |
CO (1) | CO5640037A2 (es) |
DE (1) | DE602004012725T2 (es) |
ES (1) | ES2301981T3 (es) |
HK (1) | HK1086573A1 (es) |
IS (1) | IS8125A (es) |
MX (1) | MXPA05011076A (es) |
NO (1) | NO20054842L (es) |
RU (1) | RU2005135337A (es) |
TW (1) | TW200510392A (es) |
UY (1) | UY28271A1 (es) |
WO (1) | WO2004094410A1 (es) |
ZA (1) | ZA200508372B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2333702T3 (es) * | 2001-12-24 | 2010-02-26 | Astrazeneca Ab | Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora. |
SI1578755T1 (sl) * | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
NZ550796A (en) | 2004-05-06 | 2010-07-30 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides |
WO2006040522A1 (en) * | 2004-10-12 | 2006-04-20 | Astrazeneca Ab | Quinoline derivatives |
AU2005293336B2 (en) | 2004-10-12 | 2009-05-28 | Astrazeneca Ab | Quinazoline derivatives |
EP1802608A1 (en) * | 2004-10-12 | 2007-07-04 | AstraZeneca AB | Quinazoline derivatives for use against cancer |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
EP1819698B1 (en) | 2004-11-17 | 2011-02-23 | Rexahn Pharmaceuticals, Inc. | 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives |
GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
WO2006129064A1 (en) * | 2005-05-28 | 2006-12-07 | Astrazeneca Ab | Quinazolines and their use as aurora kinase inhibitors |
US20080269500A1 (en) * | 2005-09-22 | 2008-10-30 | Astrazeneca Ab | Process for the Preparation of 4-Aminopyrazole Derivatives |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0601215D0 (en) * | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
US20090233950A1 (en) * | 2006-03-02 | 2009-09-17 | Frederic Henri Jung | Quinazoline derivatives |
WO2007113565A1 (en) * | 2006-04-06 | 2007-10-11 | Astrazeneca Ab | Naphthyridine derivatives as anti-cancer agents |
GB0609617D0 (en) | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
FR2908409B1 (fr) * | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
AR092289A1 (es) * | 2011-11-14 | 2015-04-15 | Sunshine Lake Pharma Co Ltd | Derivados de aminoquinazolina y sus sales y metodos de uso |
CN103012428A (zh) | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
CN104098551B (zh) * | 2013-04-03 | 2019-03-22 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物 |
CN103382158B (zh) * | 2013-07-29 | 2015-11-18 | 张家港市大伟助剂有限公司 | 一种2-环戊基氨基乙醇的制备方法 |
JP6567505B2 (ja) * | 2013-09-19 | 2019-08-28 | ピエール、ファーブル、メディカマン | キナゾリン誘導体およびdnaメチルトランスフェラーゼ阻害剤としてのその使用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
TW321649B (es) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
DE69622183D1 (de) * | 1995-11-07 | 2002-08-08 | Kirin Brewery | Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen |
GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
JP4870304B2 (ja) * | 1999-09-21 | 2012-02-08 | アストラゼネカ アクチボラグ | キナゾリン誘導体およびそれらの医薬品としての使用 |
PL360439A1 (en) * | 2000-06-28 | 2004-09-06 | Astrazeneca Ab | Substituted quinazoline derivatives and their use as inhibitors |
ES2333702T3 (es) | 2001-12-24 | 2010-02-26 | Astrazeneca Ab | Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora. |
US7560558B2 (en) * | 2002-08-23 | 2009-07-14 | Kirin Beer Kabushiki Kaisha | Compound having TGFβ inhibitory activity and medicinal composition containing the same |
SI1578755T1 (sl) * | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
WO2004058782A1 (en) | 2002-12-24 | 2004-07-15 | Astrazeneca Ab | Therapeutic quinazoline derivatives |
AU2003290322A1 (en) * | 2002-12-24 | 2004-07-22 | Astrazeneca Ab | Quinazoline compounds |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
-
2004
- 2004-04-14 CA CA002522079A patent/CA2522079A1/en not_active Abandoned
- 2004-04-14 CL CL200400797A patent/CL2004000797A1/es unknown
- 2004-04-14 CN CN2004800165460A patent/CN1809557B/zh not_active Expired - Fee Related
- 2004-04-14 RU RU2005135337/04A patent/RU2005135337A/ru not_active Application Discontinuation
- 2004-04-14 EP EP04727325A patent/EP1613619B1/en not_active Expired - Lifetime
- 2004-04-14 BR BRPI0409427-1A patent/BRPI0409427A/pt not_active IP Right Cessation
- 2004-04-14 DE DE602004012725T patent/DE602004012725T2/de not_active Expired - Lifetime
- 2004-04-14 ES ES04727325T patent/ES2301981T3/es not_active Expired - Lifetime
- 2004-04-14 AT AT04727325T patent/ATE390422T1/de not_active IP Right Cessation
- 2004-04-14 KR KR1020057019633A patent/KR20060003351A/ko not_active Application Discontinuation
- 2004-04-14 US US10/552,425 patent/US7691867B2/en not_active Expired - Fee Related
- 2004-04-14 JP JP2006506123A patent/JP4709139B2/ja not_active Expired - Fee Related
- 2004-04-14 AU AU2004232527A patent/AU2004232527A1/en not_active Abandoned
- 2004-04-14 WO PCT/GB2004/001614 patent/WO2004094410A1/en active IP Right Grant
- 2004-04-14 MX MXPA05011076A patent/MXPA05011076A/es unknown
- 2004-04-16 TW TW093110602A patent/TW200510392A/zh unknown
- 2004-04-16 UY UY28271A patent/UY28271A1/es not_active Application Discontinuation
- 2004-04-16 AR ARP040101300A patent/AR043875A1/es not_active Application Discontinuation
-
2005
- 2005-10-14 ZA ZA200508372A patent/ZA200508372B/en unknown
- 2005-10-19 NO NO20054842A patent/NO20054842L/no not_active Application Discontinuation
- 2005-11-11 IS IS8125A patent/IS8125A/is unknown
- 2005-11-15 CO CO05115649A patent/CO5640037A2/es not_active Application Discontinuation
-
2006
- 2006-06-08 HK HK06106582A patent/HK1086573A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR043875A1 (es) | 2005-08-17 |
MXPA05011076A (es) | 2006-01-24 |
ATE390422T1 (de) | 2008-04-15 |
JP4709139B2 (ja) | 2011-06-22 |
RU2005135337A (ru) | 2006-06-10 |
DE602004012725T2 (de) | 2009-04-16 |
TW200510392A (en) | 2005-03-16 |
CN1809557A (zh) | 2006-07-26 |
BRPI0409427A (pt) | 2006-04-18 |
DE602004012725D1 (de) | 2008-05-08 |
CO5640037A2 (es) | 2006-05-31 |
JP2006523660A (ja) | 2006-10-19 |
EP1613619B1 (en) | 2008-03-26 |
US7691867B2 (en) | 2010-04-06 |
AU2004232527A1 (en) | 2004-11-04 |
EP1613619A1 (en) | 2006-01-11 |
KR20060003351A (ko) | 2006-01-10 |
WO2004094410A1 (en) | 2004-11-04 |
NO20054842L (no) | 2005-11-08 |
ES2301981T3 (es) | 2008-07-01 |
IS8125A (is) | 2005-11-11 |
UY28271A1 (es) | 2004-11-30 |
US20060270692A1 (en) | 2006-11-30 |
ZA200508372B (en) | 2007-04-25 |
HK1086573A1 (en) | 2006-09-22 |
CN1809557B (zh) | 2012-07-04 |
CA2522079A1 (en) | 2004-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2004000797A1 (es) | Compuestos derivados de quinazolina, inhibidores de aurora quinasa; procedimiento de preparacion; composicion farmaceutica; y su uso para preparar un medicamento para tratar cancer colorrectal, de mama, de pulmon, de prostata, de vejiga, renal o panc | |
CY2015003I1 (el) | Φαρμακευτικες συνθεσεις για θεραπεια καρκινου | |
PL1830876T3 (pl) | Zastosowanie imikwimodu do leczenia przerzutów do skóry wywodzących się od guza stanowiącego raka piersi | |
HK1102544A1 (en) | Use of herbal compositions in the manufacture of medicine for treating prostate cancer | |
CL2004000985A1 (es) | Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc | |
ZA200610132B (en) | Therapy of platinum-resistant cancer | |
BRPI0717907A2 (pt) | "composto, composição farmacêutica, métodos para tratar um câncer, para inbir ou modular a atividade da lipídeo quinase, processo para a produçãoo de uma composição farmacêutica, uso de um composto e kit" | |
IL191984A0 (en) | Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer | |
SE531352C8 (sv) | Spiroalkanderivat och användning av dessa föreningar för behandling av artrit, cancer, kardiovaskulära sjukdomar, hudsjukdomar och inflammatoriska och allergiska tillstånd | |
EP1962839A4 (en) | ADMINISTRATION OF A MNTOR INHIBITOR FOR THE TREATMENT OF PATIENTS WITH CANCER | |
BRPI0906576A2 (pt) | Composição farmacêutica, kit, uso de um composto, e, agente terapêutico para câncer | |
GEP20125469B (en) | Inhibitors of akt activity | |
IL179714A (en) | Pharmaceutical preparation containing a history of 2-biphenyl-4-ram-3,2-dehydro-1h-quinazoline-4-on and its use in the preparation of cancer drugs and blood vessel formation | |
IL202505A (en) | 2-oxo-3-benzyl-benzoxazole-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumors, drugs containing them and their uses | |
WO2006050155A3 (en) | Cancer therapeutic compositions | |
HK1105886A1 (en) | Pharmaceutical compositions comprising l-733060 for use in the treatment of cancer tumours l-733060 | |
BRPI0813928A2 (pt) | Polialilamina reticulada, composição farmacêutica, agente terapêutico ou profilático para hiperfosfatemia, método terapêutico ou profilático para hiperfosfatemia, uso da polialilamina reticulada, e, composto para terapia ou profilaxia de hiperfosfatemia | |
IL180256A0 (en) | Pyrido-pyrido pyrimidine derivatives, preparation thereof, therapeutic use thereof for treating cancer | |
IL178939A (en) | Double and triple combinations suitable for synergistic treatment of breast cancer, including pharmaceuticals and their use in the manufacture of drugs and drugs for the treatment of breast cancer | |
BR112012006062A2 (pt) | novos compostos e respectivo uso terapêutico para inibição de proteína quinase | |
WO2008144507A3 (en) | Spirooxindole inhibitors of aurora kinase | |
BRPI0717477A2 (pt) | Agente farmacêutico, método para a profilaxia ou tratamento de câncer, e, uso de um inibidor de her2 e um agente terapêutico hormonal ou agente anticâncer | |
IL175689A0 (en) | Enoxaparin for the treatment of cancer | |
DE602006013009D1 (de) | Pharmazeutische zusammensetzung von mahanin zur behandlung von prostatakrebs | |
DE112004001618D2 (de) | Pharmazeutischer Wirkstoff gegen Tumorerkrankungen |